Hemorragia digestiva e insuficiencia cardiaca como forma de presentación de mieloma múltiple

AL cardiac amyloidosis is caused by extracellular deposition of immunoglobulin light chains in the heart. It is a multisystemic disease that can affect multiple organs, and around 10% of the cases are associated with multiple myeloma. The presence of AL amyloidosis is an independent factor of poor prognosis, not only for symptomatic multiple myeloma but also for latent multiple myeloma. We present below an unusual case of IgA-lambda multiple myeloma that manifested with recurrent gastrointestinal bleeding and heart failure.La amiloidosis cardiaca AL está causada por el depósito extracelular de cadenas ligeras de inmunoglobulinas en el corazón. Se trata de una enfermedad multisistémica que puede afectar a múltiples órganos y alrededor del 10% de los casos se asocia a mieloma múltiple. La presencia de amiloidosis AL es un factor independiente de mal pronóstico, no solo para el mieloma múltiple sintomático sino también para el mieloma múltiple latente. A continuación, presentamos un caso inusual de mieloma múltiple IgA-lambda que debutó con hemorragias digestivas de repetición e insuficiencia cardiaca

Caso atípico de enfermedad de Kimura en varón de 66 años

Kimura disease should be suspected when there are lymphoid masses or nodules in the head and neck, with subcutaneous cellular tissue involvement and regional lymphadenopathy, with minor inflammation and few systemic symptoms. It is usually associated with blood eosinophilia and elevated serum IgE. Even without treatment, it has a good prognosis, although recurrence is common. We present the case of a 66-year-old Caucasian male with a rapidly appearing laterocervical mass whose final diagnosis was made by biopsy. Biopsy showed mixed findings of Kimura disease and angiolymphoid hyperplasia with eosinophilia (ALHE), once thought to be the same disorder.La enfermedad de Kimura se debe sospechar ante masas o nódulos linfoides en cabeza y cuello, con afectación del tejido celular subcutáneo y linfadenopatías regionales, con poca inflamación y pocos síntomas sistémicos, habitualmente acompañadas de eosinofilia periférica y elevación de IgE sérica. Presenta buen pronóstico incluso sin tratamiento, aunque con tendencia a la recidiva. Se presenta el caso de un varón caucásico de 66 años con una masa laterocervical de rápida aparición cuyo diagnóstico final se realizó con la biopsia, en la que se encontraron hallazgos mixtos con hiperplasia angiolinfoide con eosinofilia (HALE), que antes se pensaba que era la misma entidad

Riesgos laborales, prevalencia del síndrome de Burnout en trabajadores del sector salud y en funcionarios de un distrito judicial en Colombia

El libro es un producto resultado de investigación de los trabajos desarrollados en la maestría en gestión de la seguridad y salud en el trabajo y en la especialización en seguridad y salud en el trabajo, gerencia y control de riesgos, se convierte en un elemento clave para la retroalimentación del currículo en cada uno de los programas académicos, ya que permite comprender los fenómenos, que afectan el bienestar laboral, desde sus orígenes y causas para encontrar soluciones. Este libro permitirá a profesores, estudiantes y público en general identificar los factores de riesgo psicosociales derivados del síndrome de burnout, en diferentes ambientes laborales y grupos ocupacionales. Libros como éste, donde cada capítulo es un producto de exhaustivas investigaciones que hacen visible a los ojos del lector realidades que de otra manera permanecerían veladas para el conocimiento. Es así como la Universidad Libre en su riguroso proceso de formación, proyecta todo su esfuerzo en la formación integral de sus egresados acorde con las necesidades fundamentales de la sociedad, haciendo suyo muchos compromisos de orden democrático, pluralista, tolerante y cultor de la diferencia. El contenido de este libro y haciendo referencia sobre la relación entre los factores de riesgo y sus efectos en la salud, se menciona la Facultad de Ciencias de la Salud, se tiene una preocupación constante por asumir el conocimiento y posterior a la intervención de las problemáticas que aquejan a todos los sectores poblacionales; se viene interesando particularmente por el estudio de ciertos fenómenos de la salud pública y concretamente de la salud en el trabajo que para los efectos de esta publicación hace referencia al Síndrome de Burnout en trabajadores de distintos escenarios laborales, tal es el caso de los profesionales de la salud y funcionarios de la rama judicial, quienes de manera frecuente en compañía de los profesores, son asociados a una alta prevalencia del síndrome. Por estas razones es motivo de preocupación desde la academia por abordar estas temáticas, primero desde su conocimiento en profundidad para recomendar intervenciones que posibiliten el mantenimiento de unas condiciones y la modificación de otras que de alguna manera afectan la salud de los trabajadores colombianos. Las afectaciones comunes de ansiedad y depresión son las principales ma5 Universidad Libre Pereira - Facultad De Ciencias de la Salud nifestaciones del síndrome de Burnout, que en un principio para los trabajadores solo se extienden al ámbito laboral, y que no tardan en permear las esferas personales, familiares y sociales de los trabajadores afectados, constituyéndose en uno de los principales motivos de las incapacidades laborales. Se plantean en este libro las formas como este trastorno emocional está vinculado con el ámbito laboral de funcionarios judiciales y trabajadores de la salud y se hacen recomendaciones para mejorar el entorno laboral. Se pretende entonces, evidenciar como las condiciones laborales, la percepción del riesgo, el falta de empoderamiento en el autocuidado y la poca existencia en programas de prevención y promoción para brindar entornos laborales seguros especialmente en la prevención del riesgo psicosocial, puede derivar en la prevalencia del síndrome de Burnout que afecta la calidad de vida del trabajador, su contexto laboral y familiar, siendo necesario documentar a través de proyectos de investigación, las diferentes formas de manifestación de este fenómeno y sus respectivas recomendaciones como parte de la responsabilidad social del programa de Maestría en Seguridad y Salud en el Trabajo, para la solución a esta problemática y alcanzar entornos laborales seguros y saludables

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Bose-Einstein correlations of charged hadrons in proton-proton collisions at s\sqrt s = 13 TeV

Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s}$ = 7 TeV, as well as with theoretical predictions.[graphic not available: see fulltext]Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s} =$ 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s} =$ 7 TeV, as well as with theoretical predictions

Search for dark matter in events with a leptoquark and missing transverse momentum in proton-proton collisions at 13 TeV

A search is presented for dark matter in proton-proton collisions at a center-of-mass energy of root s= 13 TeV using events with at least one high transverse momentum (p(T)) muon, at least one high-p(T) jet, and large missing transverse momentum. The data were collected with the CMS detector at the CERN LHC in 2016 and 2017, and correspond to an integrated luminosity of 77.4 fb(-1). In the examined scenario, a pair of scalar leptoquarks is assumed to be produced. One leptoquark decays to a muon and a jet while the other decays to dark matter and low-p(T) standard model particles. The signature for signal events would be significant missing transverse momentum from the dark matter in conjunction with a peak at the leptoquark mass in the invariant mass distribution of the highest p(T) muon and jet. The data are observed to be consistent with the background predicted by the standard model. For the first benchmark scenario considered, dark matter masses up to 500 GeV are excluded for leptoquark masses m(LQ) approximate to 1400 GeV, and up to 300 GeV for m(LQ) approximate to 1500 GeV. For the second benchmark scenario, dark matter masses up to 600 GeV are excluded for m(LQ) approximate to 1400 GeV. (C) 2019 The Author(s). Published by Elsevier B.V.Peer reviewe