Atypical basic movement kinematics in autism spectrum conditions

Individuals with autism spectrum conditions have difficulties in understanding and responding appropriately to others. Additionally, they demonstrate impaired perception of biological motion and problems with motor control. Here we investigated whether individuals with autism move with an atypical kinematic profile, which might help to explain perceptual and motor impairments, and in principle may contribute to some of their higher level social problems. We recorded trajectory, velocity, acceleration and jerk while adult participants with autism and a matched control group conducted horizontal sinusoidal arm movements. Additionally, participants with autism took part in a biological motion perception task in which they classified observed movements as ‘natural’ or ‘unnatural’. Results show that individuals with autism moved with atypical kinematics; they did not minimize jerk to the same extent as the matched typical control group, and moved with greater acceleration and velocity. The degree to which kinematics were atypical was correlated with a bias towards perceiving biological motion as ‘unnatural’ and with the severity of autism symptoms as measured by the Autism Diagnostic Observation Schedule. We suggest that fundamental differences in movement kinematics in autism might help to explain their problems with motor control. Additionally, developmental experience of their own atypical kinematic profiles may lead to disrupted perception of others’ actions

Dual-specificity MAP kinase phosphatases in health and disease

Source at https://doi.org/10.1016/j.bbamcr.2018.09.002.It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions between MAP kinase pathways and other key signalling modules. As our knowledge of the regulation, substrate specificity and catalytic mechanisms of MKPs has matured, more recent work using genetic models has revealed key physiological functions for MKPs and also uncovered potentially important roles in regulating the pathophysiological outcome of signalling with relevance to human diseases. These include cancer, diabetes, inflammatory and neurodegenerative disorders. It is hoped that this understanding will reveal novel therapeutic targets and biomarkers for disease, thus contributing to more effective diagnosis and treatment for these debilitating and often fatal conditions

Russia and its shared neighbourhoods: a comparative analysis of Russia-EU and Russia-China relations in the EU's Eastern neighbourhood and Central Asia

This article examines the conditions under which great powers succeed or fail to shape a cooperative security agenda in their shared neighbourhoods. It compares Russia's interactions with the EU and with China in their respective shared neighbourhoods: the EU's Eastern Neighbourhood region and Central Asia. The article applies a synthetic framework. It analyses how the interplay between three factors–ideas, capabilities and circumstantial factors such, as the personalities of leading politicians,–shape the process of interaction between great powers. It starts from a comparison of the images of the two regions in Russia's mind-set because such images provide cognitive lenses through which powers make sense of political developments in shared neighbourhoods. The article then moves to show how change in the balance of power (soft and hard) created enabling conditions for competition/collaboration. Finally, the article shows how specific circumstantial factors led to or shaped the Russian-European conflict. At the same time, similar factors prevented Russian-Chinese conflict in Central Asia. © 2017 Informa UK Limited, trading as Taylor & Francis Group