“Fuentes de N,P,k, y micronutrientes en presencia y ausencia de fierro quelatado en el cultivo de sacha inchi (plukenetia volubilis L.).- tarapoto-San Martín”

The research took place in the Quarantine estate area ceded by the Regional Oirectorate of Agricutture m San Martin-(ORASAM) ·focated in 1he wmict of Tarapoto, province and region of San Martin. lt is geographically located at 06 º 30 '39' 'south latitude and 76 º 22' 53" west longitude atan altitude of 260 msnmm in August 2013 and ended in Mareh 2614 at the tnstitute of Amazorrian Researetr Peruana (ttAP - San Martin). The reseatch is to~ ''SOURCES OF ·tt, P, K and' MtCRONUTRtENT tN THE PRESENCE ANO ABSENCE OF IRON CHELA TED GROWING SACHA INCHI (Plukenetia volubilis L.). - TARAPOTO- SAN MARTIN, PERU" To ·studf 1he biolog.cat assay m pots, we used 1he Ptica'dpa eootfPe from ttre native community of Lamas - "Pucallpa" which were selected from free plantations phytosanitary problems in high yield and soil material used from the 2 May hamlet, dtsbict of San Pabto, Betfavista provitrce, depattment of San Malfut. A completely randomized design factorial arrangement of 2 x 6 with sources (arr.monium nmate, tF.pte superphosphate ar.O- potassram etdortde wittr 100-60 -100) and micronutrients (OLIGOMIX) with three replications and six treatments presence without presence of chelated iron was the type of design applied to this research. The variabtes ewk:tcñ~ ami statisticaHy analJzed were 1nitfat· analysis ot son·, ptant height, and stem diameter, number of leaves, root volume and dry matter (leaf, stem and root). Y4fth- the appfieaf.oo of ehetated Fe ~ of 1he ~ of HPK + Mieron, the largest average plant height, stem diameter, number of leaves, fresh volume of roots, fresh weight of root and leaf fresh weight were obtained with 137.04 cm, 5.53 mm, 35.1teaves,49.72mt, 33.56gand 17.33g~~ The absence of chelated iron in soils with high levels of calcium carbonates in vegetative ~ of sacha 'inchi· crop aHows the presence of iron ch1orosis in its development.La investigación se llevó a cabo en agosto del año 2013 y finalizo en marzo del 2014 en et tnstituto de hwestjgación de 'la Amazonia Pen:iarva (ttA?' - San Marfm-), en et fundo Cuarentenario área cedida por la dirección regional de agricultura de San Martín (DRASAN), ubicado en el distrito de la Tarapoto, provincia y región de San Martin, ·focaffzado geográficamente a tW· 30' 39" tatitud sur y 16º 22' 53", tongitud oeste a una altitud de 260 msnmm. B trabajo consistió en evaluar ·"Ftr~TES DE ff, ?, K, y MiCRONUTR1ENTES EN PRESENCIA Y AUSENCIA DE FIERRO QUELATADO EN EL CULTIVO DE SACHA INCHI (Plukenetia volubilis L.). -TARAPOTO-SAN MARTIN, PERU". Para et estudio del' ensayo biológjco en- maeeteria se utmzó et ecotipo Pucaffpa procedente de la comunidad nativa de Lamas - "Pucallpa", seleccionadas de plantaciones libres de problemas fitosanitarios, con alto rendimiento y el material sue1o que se uti'rlzó toe feeoiedado det casero Dos de Mayo tffS'trito de San Pablo, provincia de Bellavista, departamento de San Martín. Se realizó un diseño completamente al azar con arreglo factorial de 2 x 6, con fuentes de (Nitrato de Amonio, superfosfato 1ripte y ctomro de potasfo con 100 - 80 - 100) y Micronutrientes (OLIGOMIX) con tres repeticiones, y 6 tratamientos con presencia y sin presencia de hierro quelatado. las variabtes -e---m'.uadas y arnm:zadas -estadísticamente fueron:· ariátisis de suero inicial, altura de la planta, diámetro de tallo, número de hojas, volumen de la raíz y la materia seca (hoja, tallo y raíz). Con ta aplicación de Fe quelatado e iifdependientemente de ias dosis de N'PK + Micron, se obtuvieron los mayores promedios de altura de planta, diámetro del tallo, número de hojas, volumen fresco de raíces, peso fresco de raíces y peso fresco de hojas, con 137.04 em, 5.53 mm, 35.1 'hojas, 49.72 mt~ 33.56 g y 1-7.33 g respectivamente. La ausencia de hierro quelatado en suelos con alto índice de carbonatos de calcio en el desarrollo vegetativo del cultivo de sacha inchi permite la presencia de ctoTosis férr'ica en su desafrotto.Tesi

Resonant spaces

My work is concerned with memory and the aspects of a significant place or experience that impress themselves upon the mind of an individual. Pulling my imagery from places significant to my own personal history, I use abstraction and distortion to point to the distance between recollection and reality. I use very solid, clearly defined, hard-edged forms and highly specific color to translate places that are no longer accessible to me in any tangible way and exist only in the nebulous, and fallible, realm of my memory. Elements of these spaces are translated in a way that acknowledges the separation from the reality of the actual time and place, while still striving to make them feel concrete and present

Glycogene Expression Alterations Associated with Pancreatic Cancer Epithelial-Mesenchymal Transition in Complementary Model Systems

The ability to selectively detect and target cancer cells that have undergone an epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers such as pancreatic cancer. The remodeling of cellular glycosylation previously has been associated with cell differentiation and may represent a valuable class of molecular targets for EMT.As a first step toward investigating the nature of glycosylation alterations in EMT, we characterized the expression of glycan-related genes in three in-vitro model systems that each represented a complementary aspect of pancreatic cancer EMT. These models included: 1) TGFβ-induced EMT, which provided a look at the active transition between states; 2) a panel of 22 pancreatic cancer cell lines, which represented terminal differentiation states of either epithelial-like or mesenchymal-like; and 3) actively-migrating and stationary cells, which provided a look at the mechanism of migration. We analyzed expression data from a list of 587 genes involved in glycosylation (biosynthesis, sugar transport, glycan-binding, etc.) or EMT. Glycogenes were altered at a higher prevalence than all other genes in the first two models (p<0.05 and <0.005, respectively) but not in the migration model. Several functional themes were shared between the induced-EMT model and the cell line panel, including alterations to matrix components and proteoglycans, the sulfation of glycosaminoglycans; mannose receptor family members; initiation of O-glycosylation; and certain forms of sialylation. Protein-level changes were confirmed by Western blot for the mannose receptor MRC2 and the O-glycosylation enzyme GALNT3, and cell-surface sulfation changes were confirmed using Alcian Blue staining.Alterations to glycogenes are a major component of cancer EMT and are characterized by changes to matrix components, the sulfation of GAGs, mannose receptors, O-glycosylation, and specific sialylated structures. These results provide leads for targeting aggressive and drug resistant forms of pancreatic cancer cells

Under treatment of pneumonia among children under 5 years of age in a malaria-endemic area: population-based surveillance study conducted in Manhica district- rural, Mozambique

BACKGROUND: Integrated Management of Childhood Illness (IMCI) guidelines were developed to decrease morbidity and mortality, yet implementation varies across settings. Factors associated with poor adherence are not well understood. METHODS: We used data from Manhica District Hospital outpatient department and five peripheral health centers to examine pneumonia management for children <5 years old from January 2008 to June 2011. Episodes of IMCI-defined pneumonia (cough or difficult breathing plus tachypnea), severe pneumonia (pneumonia plus chest wall in-drawing), and/or clinician-diagnosed pneumonia (based on discharge diagnosis) were included. RESULTS: Among severe pneumonia episodes, 96.2% (2,918/3,032) attended in the outpatient department and 70.0% (291/416) attended in health centers were appropriately referred to the emergency department. Age<1 year, malnutrition and various physical exam findings were associated with referral. For non-severe pneumonia episodes, antibiotics were prescribed in 45.7% (16,094/35,224). Factors associated with antibiotic prescription included age <1 year, abnormal auscultatory findings, and clinical diagnosis of pneumonia; diagnosis of malaria or gastroenteritis and pallor were negatively associated with antibiotic prescription. CONCLUSION: Adherence to recommended management of severe pneumonia was high in a hospital outpatient department, but suboptimal in health centers. Antibiotics were prescribed in fewer than half of non-severe pneumonia episodes, and diagnosis of malaria was the strongest risk factor for incorrect management

Spectroscopic confirmation of a Coma Cluster progenitor at z~2.2

We report the spectroscopic confirmation of a new protocluster in the COSMOS field at z ∼ 2.2, originally identified as an overdensity of narrow-band selected Hα emitting candidates. With only two masks of Keck/MOSFIRE near-IR spectroscopy in both H (∼ 1.47-1.81 μm) and K (∼ 1.92- 2.40 μm) bands (∼ 1.5 hour each), we confirm 35 unique protocluster members with at least two emission lines detected with S/N > 3. Combined with 12 extra members from the zCOSMOS-deep spectroscopic survey (47 in total), we estimate a mean redshift, line-of-sight velocity dispersion, and total mass of zmean=2.23224 ± 0.00101, σlos=645 ± 69 km s−1, and Mvir ∼ (1 − 2)×10^14 M⊙ for this protocluster, respectively. We estimate a number density enhancement of δg ∼ 7 for this system and we argue that the structure is likely not virialized at z ∼ 2.2. However, in a spherical collapse model, δg is expected to grow to a linear matter enhancement of ∼ 1.9 by z=0, exceeding the collapse threshold of 1.69, and leading to a fully collapsed and virialized Coma-type structure with a total mass of Mdyn(z=0) ∼ 9.2×10^14 M⊙ by now. This observationally efficient confirmation suggests that large narrow-band emission-line galaxy surveys, when combined with ancillary photometric data, can be used to effectively trace the large-scale structure and protoclusters at a time when they are mostly dominated by star-forming galaxies

Análise epidemiológica dos casos de dengue no município de Porto Velho – RO / Epidemiological analysis of dengue cases in the municipality of Porto Velho – RO

RESUMO A dengue é uma doença infecciosa frequente no Brasil e um dos principais problemas de saúde pública no mundo. Dessa forma, este trabalho objetiva analisar os dados de notificação compulsória da dengue, no município de Porto Velho – RO, entre os primeiros semestres dos anos de 2016 – 2020, com a finalidade de sumarizar o comportamento epidemiológico da doença. Nesse interim, foram obtidos dados epidemiológicos junto à secretaria municipal de saúde da cidade de Porto Velho – RO (SEMUSA), concomitante ao desenvolvimento de um questionário quantitativo semiestruturado, o qual evidenciou a percepção da população referente ao combate do Aedes aegypti, durante a pandemia de COVID – 19. Os resultados obtidos demonstraram que 96% dos pesquisados relataram ausência de visitas domiciliares, 83% não observaram ações sociais e 77% não notaram propagandas conscientizadoras, relacionado ao combate ao vetor. Ademais, os dados de notificação compulsória demonstraram que houve queda anual dos casos de dengue desde 2017 – 2019, porém, em 2020, houve uma inversão no padrão do gráfico, registrando elevação de 240% dos casos em relação ao ano anterior, principalmente no primeiro quadrimestre do ano. Dentre as causas para tal elevação, ressalta-se, o clima tropical chuvoso, a falta de insumos e recursos humanos no combate ao vetor e a elevação do índice de infestação predial. Portanto, observa-se que as medidas de prevenção são fundamentais e eficientes na redução do número de contágios por dengue, sendo necessário, que tais ações sejam intensificadas por meio de propagandas conscientizadoras, visitas domiciliares, aplicação de inseticida, campanhas de limpeza, dentre outras

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

Lewy body disease is a heterogeneous group of neurodegenerative disorders characterized by α-synuclein accumulation that includes dementia with Lewy bodies (DLB) and Parkinson's Disease (PD). Recent evidence suggests that impairment of lysosomal pathways (i.e. autophagy) involved in α-synuclein clearance might play an important role. For this reason, we sought to examine the expression levels of members of the autophagy pathway in brains of patients with DLB and Alzheimer's Disease (AD) and in α-synuclein transgenic mice.By immunoblot analysis, compared to controls and AD, in DLB cases levels of mTor were elevated and Atg7 were reduced. Levels of other components of the autophagy pathway such as Atg5, Atg10, Atg12 and Beclin-1 were not different in DLB compared to controls. In DLB brains, mTor was more abundant in neurons displaying α-synuclein accumulation. These neurons also showed abnormal expression of lysosomal markers such as LC3, and ultrastructural analysis revealed the presence of abundant and abnormal autophagosomes. Similar alterations were observed in the brains of α-synuclein transgenic mice. Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of α-synuclein in transgenic mice and amelioration of associated neurodegenerative alterations.This study supports the notion that defects in the autophagy pathway and more specifically in mTor and Atg7 are associated with neurodegeneration in DLB cases and α-synuclein transgenic models and supports the possibility that modulators of the autophagy pathway might have potential therapeutic effects

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery