The Taming of Desire: Unspecific Postponement Reduces Desire for and Consumption of Postponed Temptations

The present investigation began with the conjecture that people may do better by saying “some other time” instead of “no, not ever” in response to temptations. Drawing from learning theories, we hypothesized that people interpret unspecific postponement (“I can have it some other time”) as a signal that they do not strongly value the postponed temptation. In this way, unspecific postponement may reduce desire for and consumption of postponed temptations, both in the present moment and over time. Four experiments tested those hypotheses. A multi-phase study using the free-choice paradigm supported the learning account for the effects of postponement: unspecific postponement reduced immediate desire for a self-selected temptation which in turn statistically accounted for diminished consumption during the week following the manipulation – but only when postponement was induced, not when it was imposed (Experiment 1). Supporting the hypothesis that unspecific but not specific postponement connotes weak valuation, only unspecific postponement reduced attention to (Experiment 2) and consumption of (Experiment 3) the postponed temptation. Additionally, unspecific postponement delayed consumption primarily among those who were highly motivated to forgo consumption of the temptation (Experiment 3). A final multi-phase experiment compared the effectiveness of unspecific postponement to the classic self-control mechanism of restraint, finding that unspecific postponement (vs. restraint) reduced consumption of the temptation in the heat of the moment and across one week post-manipulation (Experiment 4). The current research provides novel insight into self-control facilitation, the modification of desire, and the differential effects of unspecific and specific intentions for reducing unwanted behavior

The in-plane paraconductivity in La_{2-x}Sr_xCuO_4 thin film superconductors at high reduced-temperatures: Independence of the normal-state pseudogap

The in-plane resistivity has been measured in $La_{2-x}Sr_xCuO_4$ (LSxCO) superconducting thin films of underdoped ($x=0.10,0.12$), optimally-doped ($x=0.15$) and overdoped ($x=0.20,0.25$) compositions. These films were grown on (100)SrTiO$_3$ substrates, and have about 150 nm thickness. The in-plane conductivity induced by superconducting fluctuations above the superconducting transition (the so-called in-plane paraconductivity, $\Delta\sigma_{ab}$) was extracted from these data in the reduced-temperature range 10^{-2}\lsim\epsilon\equiv\ln(T/\Tc)\lsim1. Such a $\Delta\sigma_{ab}(\epsilon)$ was then analyzed in terms of the mean-field--like Gaussian-Ginzburg-Landau (GGL) approach extended to the high-$\epsilon$ region by means of the introduction of a total-energy cutoff, which takes into account both the kinetic energy and the quantum localization energy of each fluctuating mode. Our results strongly suggest that at all temperatures above Tc, including the high reduced-temperature region, the doping mainly affects in LSxCO thin films the normal-state properties and that its influence on the superconducting fluctuations is relatively moderate: Even in the high-$\epsilon$ region, the in-plane paraconductivity is found to be independent of the opening of a pseudogap in the normal state of the underdoped films.Comment: 35 pages including 10 figures and 1 tabl

Topological Defects and CMB anisotropies : Are the predictions reliable ?

We consider a network of topological defects which can partly decay into neutrinos, photons, baryons, or Cold Dark Matter. We find that the degree-scale amplitude of the cosmic microwave background (CMB) anisotropies as well as the shape of the matter power spectrum can be considerably modified when such a decay is taken into account. We conclude that present predictions concerning structure formation by defects might be unreliable.Comment: 14 pages, accepted for publication in PR

Multimessenger astronomy with the Einstein Telescope

Gravitational waves (GWs) are expected to play a crucial role in the development of multimessenger astrophysics. The combination of GW observations with other astrophysical triggers, such as from gamma-ray and X-ray satellites, optical/radio telescopes, and neutrino detectors allows us to decipher science that would otherwise be inaccessible. In this paper, we provide a broad review from the multimessenger perspective of the science reach offered by the third generation interferometric GW detectors and by the Einstein Telescope (ET) in particular. We focus on cosmic transients, and base our estimates on the results obtained by ET's predecessors GEO, LIGO, and Virgo.Comment: 26 pages. 3 figures. Special issue of GRG on the Einstein Telescope. Minor corrections include

The Top Quark Decay Vertex in Standard Model Extensions

New physics interactions can affect the strength and structure of the $tbW$ vertex. We investigate the magnitudes and phases of "anomalous" contributions to this vertex in a two-Higgs doublet and the minimal supersymmetric extension of the standard model, and in a top-color assisted technicolor (TC2) model. While the magnitudes of the anomalous couplings remain below 1 percent in the first two models, TC2 interactions can reduce the left-chiral coupling $f_L$ by several percent.Comment: Latex, 27 pages, 14 figure

CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment

Specific language impairment (SLI) is a common developmental disorder characterized by difficulties in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors. We performed a high-density screen of SLI1, a region of chromosome 16q that shows highly significant and consistent linkage to nonword repetition, a measure of phonological short-term memory that is commonly impaired in SLI. Using two independent language-impaired samples, one family-based (211 families) and another selected from a population cohort on the basis of extreme language measures (490 cases), we detected association to two genes in the SLI1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 × 10−7 at rs6564903) and that encoding calcium-transporting ATPase, type2C, member2 (ATP2C2, minP = 2.0 × 10−5 at rs11860694). Regression modeling indicated that each of these loci exerts an independent effect upon nonword repetition ability. Despite the consistent findings in language-impaired samples, investigation in a large unselected cohort (n = 3612) did not detect association. We therefore propose that variants in CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment. As such, this investigation supports the hypothesis that some causes of language impairment are distinct from factors that influence normal language variation. This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition

The Genome of the Netherlands: Design, and project goals

Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. The parent-offspring trios include adult individuals ranging in age from 19 to 87 years (mean=53 years; SD=16 years) from birth cohorts 1910-1994. Sequencing was done on blood-derived DNA from uncultured cells and accomplished coverage was 14-15x. The family-based design represents a unique resource to assess the frequency of regional variants, accurately reconstruct haplotypes by family-based phasing, characterize short indels and complex structural variants, and establish the rate of de novo mutational events. GoNL will also serve as a reference panel for imputation in the available genome-wide association studies in Dutch and other cohorts to refine association signals and uncover population-specific variants. GoNL will create a catalog of human genetic variation in this sample that is uniquely characterized with respect to micro-geographic location and a wide range of phenotypes. The resource will be made available to the research and medical community to guide the interpretation of sequencing projects. The present paper summarizes the global characteristics of the project

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of 769 individuals from 250 Dutch families, and provide a haplotype-resolved map of 1.9 million genome variants across 9 different variant classes, including novel forms of complex indels, and retrotransposition-mediated insertions of mobile elements and processed RNAs. A large proportion are previously under reported variants sized between 21 and 100 bp. We detect 4 megabases of novel sequence, encoding 11 new transcripts. Finally, we show 191 known, trait-associated SNPs to be in strong linkage disequilibrium with SVs and demonstrate that our panel facilitates accurate imputation of SVs in unrelated individuals

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Measurement of relative branching fractions of B decays to ψ(2S)\psi(2S) and J/ψJ/\psi mesons

The relative rates of B-meson decays into $J/\psi$ and $\psi(2S)$ mesons are measured for the three decay modes in pp collisions recorded with the LHCb detector. The ratios of branching fractions ($\mathcal{B}$) are measured to be $\frac{\mathcal{B}(B^+ \to \psi(2S) K^+)}{\mathcal{B}(B^+ \to J/\psi K^+)} = 0.594 \pm 0.006 (stat) \pm 0.016 (syst) \pm 0.015 (R_{\psi})$, $\frac{\mathcal{B}(B^0 \to \psi(2S) K^{*0})}{\mathcal{B}(B^0 \to J/\psi K^{*0})} = 0.476 \pm 0.014 (stat) \pm 0.010 (syst) \pm 0.012\,(R_{\psi})$, $\frac{\mathcal{B}^{0}_{s}(B^0_s \to \psi(2S)\phi)}{\mathcal{B}(B^0_s \to J/\psi\phi)} = 0.489 \pm 0.026 (stat) \pm 0.021 (syst) \pm 0.012\,(R_{\psi})$ where the third uncertainty is from the ratio of the $\psi(2S)$ and $J/\psi$ branching fractions to $\mu\mu$.Comment: 14 pages, 1 figur