LHC sensitivity to the decay of a Higgs boson to tau mu

We study the sensitivity of the LHC, with 20 inverse-fb of data, to lepton flavour violating Higgs boson decays h -> tau+ mu- (and h -> tau+ e-). We consider the large population of Higgses produced in gluon fusion, combined with leptonic decays of the tau, and estimate that the LHC could set a 95 % confidence level bound BR(h -> tau mu) < 4.5 \times 10^{-3}. This correponds to a coupling of order the Cheng-Sher ansatz y_{tau mu} = sqrt{m_tau m_mu/v^2}.Comment: 6 pages, 4 figures, references adde

Of Contact Interactions and Colliders

The hierarchy of scales which would allow dimension-six contact interactions to parametrise New Physics may not be verified at colliders. Instead, we explore the feasability and usefulness of parametrising the high-energy tail of distributions at the LHC using form factors. We focus on the process pp -> l+l- in the presence of t (or s)-channel New Physics, guess a form factor from the partonic cross-section, and attempt to use data to constrain its coefficients, and the coefficients to constrain models. We find that our choice of form factor decribes t-channel exchange better than a contact interaction, and the coefficients in a particular model can be obtained from the partonic cross-section. We estimate bounds on the coefficients by fitting the form factors to available data. For the parametrisation corresponding to the contact interaction approximation, our expected bounds on the scale $\Lambda$ are within ~ 15% of the latest limits from the LHC experiments.Comment: 5 pages, 4 figure

Leptoquarks decaying to a top quark and a charged lepton at hadron colliders

We study the sensitivity of the Tevatron and the 7 TeV LHC to a leptoquark S coupling to a top quark and a charged lepton L (= e, mu, or tau). For the Tevatron, we focus on the case m_S < m_t, where the leptoquark pair production cross section is large, and the decay is three-body: S --> W b L^{\pm}. We argue that existing Tevatron observations could exclude m_S \lsim 160 GeV. For m_S > m_t, we show that the LHC experiments with low integrated luminosity could be sensitive to such leptoquarks decaying to tl^{\pm} with l= mu or tau.Comment: 13 pages, 6 figures, minor changes (typos

Collider Signature of T-quarks

Little Higgs models with T Parity contain new vector-like fermions, the T-odd quarks or "T-quarks", which can be produced at hadron colliders with a QCD-strength cross section. Events with two acoplanar jets and large missing transverse energy provide a simple signature of T-quark production. We show that searches for this signature with the Tevatron Run II data can probe a significant part of the Little Higgs model parameter space not accessible to previous experiments, exploring T-quark masses up to about 400 GeV. This reach covers parts of the parameter space where the lightest T-odd particle can account for the observed dark matter relic abundance. We also comment on the prospects for this search at the Large Hadron Collider (LHC).Comment: 5 pages, 3 figure

LHC sensitivity to lepton flavour violating Z boson decays

We estimate that the LHC could set bounds BR(Z -> mu^\pm e^\mp) < 4.1 * 10^{-7} and BR(Z -> tau^\pm mu^\mp)< 3.5 * 10^{-6} (at 95% C.L.) with 20 inverse fb of data at 8 TeV. A similar sensitivity can be anticipated for Z -> tau^\pm e^\mp, because we consider leptonic tau decays such that Z -> tau^+ mu^- gives e^+ \mu^- +$ invisibles. These limits can be compared to the LEP1 bounds of order 10^{-5} to 10^{-6}. Such collider searches are sensitive to a flavour-changing effective Z coupling which is energy dependent, so are complementary to bounds obtained from tau to 3mu and mu to 3e.Comment: 11 pages, 2 figures, version for publicatio

Efficacy of colistin alone and in various combinations for the treatment of experimental osteomyelitis due to carbapenemase-producing Klebsiella pneumoniae

Objectives: In a new experimental model of carbapenemase-producing Klebsiella pneumoniae osteomyelitis we evaluated the efficacy of colistin alone and in various combinations and examined the emergence of colistin-resistant strains and cross- resistance to host defence peptides (HDPs).Methods: KPC-99YC is a clinical strain with intermediate susceptibility to meropenem (MIC = 4 mg/L) and full susceptibility to gentamicin, colistin and tigecycline (MICs = 1 mg/L) and fosfomycin (MIC = 32 mg/L). Time–kill curves were performed at 4× MIC. Osteomyelitis was induced in rabbits by tibial injection of 2 × 108 cfu. Treatment started 14 days later for 7 days in seven groups: (i) control; (ii) colistin; (iii) colistin + gentamicin; (iv) colistin + tigecycline; (v) colistin + meropenem; (vi) colistin + meropenem + gentamicin; and (vii) colistin +  fosfomycin.Results: In vitro, colistin was rapidly bactericidal, but regrowth occurred after 9 h. Combinations of colistin with meropenem or fosfomycin were synergistic, whereas combination with tigecycline was antagonistic. In vivo, colistin alone was not effective. Combinations of colistin with meropenem or fosfomycin were bactericidal (P  < 0.001) and the addition of gentamicin enhanced the efficacy of colistin + meropenem (P = 0.025). Tigecycline reduced the efficacy of colistin (P = 0.007). Colistin-resistant strains emerged in all groups except colistin + fosfomycin and two strains showed cross-resistance to HDP LL-37.Conclusions: In this model, combinations of colistin plus meropenem, with or without gentamicin, or colistin plus fosfomycin were the only effective therapies. The combination of colistin and tigecycline should be administered with caution, as it may be antagonistic in vitro and in vivo

Deciphering the Structure, Growth and Assembly of Amyloid-Like Fibrils Using High-Speed Atomic Force Microscopy

Formation of fibrillar structures of proteins that deposit into aggregates has been suggested to play a key role in various neurodegenerative diseases. However mechanisms and dynamics of fibrillization remains to be elucidated. We have previously established that lithostathine, a protein overexpressed in the pre-clinical stages of Alzheimer's disease and present in the pathognomonic lesions associated with this disease, form fibrillar aggregates after its N-terminal truncation. In this paper we visualized, using high-speed atomic force microscopy (HS-AFM), growth and assembly of lithostathine protofibrils under physiological conditions with a time resolution of one image/s. Real-time imaging highlighted a very high velocity of elongation. Formation of fibrils via protofibril lateral association and stacking was also monitored revealing a zipper-like mechanism of association. We also demonstrate that, like other amyloid ß peptides, two lithostathine protofibrils can associate to form helical fibrils. Another striking finding is the propensity of the end of a growing protofibril or fibril to associate with the edge of a second fibril, forming false branching point. Taken together this study provides new clues about fibrillization mechanism of amyloid proteins

Measurement of the Tau Lepton Polarisation at LEP2

A first measurement of the average polarisation P_tau of tau leptons produced in e+e- annihilation at energies significantly above the Z resonance is presented. The polarisation is determined from the kinematic spectra of tau hadronic decays. The measured value P_tau = -0.164 +/- 0.125 is consistent with the Standard Model prediction for the mean LEP energy of 197 GeV.A first measurement of the average polarisation Pτ of tau leptons produced in e + e − annihilation at energies significantly above the Z resonance is presented. The polarisation is determined from the kinematic spectra of tau hadronic decays. The measured value Pτ=−0.164±0.125 is consistent with the Standard Model prediction for the mean LEP energy of 197 GeV.A first measurement of the average polarisation P_tau of tau leptons produced in e+e- annihilation at energies significantly above the Z resonance is presented. The polarisation is determined from the kinematic spectra of tau hadronic decays. The measured value P_tau = -0.164 +/- 0.125 is consistent with the Standard Model prediction for the mean LEP energy of 197 GeV

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI