G. B. Vico: el establecimiento del orden natural a través de la noción de providencia

El objeto de este trabajo de investigación es el de analizar uno de los conceptos más importantes del pensamiento de g.b. vico: la providencia. A través de dicho concepto el filósofo napolitano logra introducir en su concepción iusfilosofica e histórica la importante noción del orden natural. Para ello, se han estudiado todas las interpretaciones que se han realizado sobre la filosofía viquiana, dando lugar a una importante conclusión: la exegesis inmanentista de vico no ha logrado explicar con claridad y rigor la posición que ocupa el concepto de providencia en el pensamiento global del napolitano; en cambio, si lo ha conseguido la exegesis trascendental, cuya interpretación de tal concepto pone de manifiesto la verdadera significación del mismo en el pensamiento histórico e iusfilosófico de vico. A la luz de esta ultima interpretación, cobran sentido todas las nociones más importantes del pensamiento viquiano, cuya deuda con la tradición de la filosofía cristiano-católica es ineludible

iGREEN. An Integrated Emission Model for Mixed Bus Fleets

The environmental concern has become central for many bus companies, but estimating pollutant emissions can be difficult for many reasons (little knowledge or underestimation of the problem; scarce know-how; reluctance to acknowledge the pollutant potential of bus fleets because either of small size or composed by too many old-generation vehicles). To facilitate this task, an integrated, user-friendly model, iGREEN, is presented. The paper describes the methodology for the development of this tool, which is specifically designed to help transit operators in assessing the pollutants emitted by fleets where the amount of old buses is not negligible. This is not a minor issue, given the large number of obsolete vehicles still circulating and the unsuitability of some models when calculating emissions in case of buses with protracted mileage. Results from two case studies are reported and commented, with the final aim to advance knowledge farther afield. This gives rise to a discussion on the relevance of such environmental concerns also in light of the contemporary pandemic which seem to have generated different priorities in the public transport management

Long-term follow-up of Zoon balanitis: a retrospective cohort study

Dear Editor, Zoon balanitis (ZB) is an infammatory disease afecting genital mucosa, particularly the glans and the inside of the foreski

Dual-Wavelength ALMA Observations of Dust Rings in Protoplanetary Disks

We present new Atacama Large Millimeter/submillimeter Array (ALMA) observations for three protoplanetary disks in Taurus at 2.9\,mm and comparisons with previous 1.3\,mm data both at an angular resolution of $\sim0.''1$ (15\,au for the distance of Taurus). In the single-ring disk DS Tau, double-ring disk GO Tau, and multiple-ring disk DL Tau, the same rings are detected at both wavelengths, with radial locations spanning from 50 to 120\,au. To quantify the dust emission morphology, the observed visibilities are modeled with a parametric prescription for the radial intensity profile. The disk outer radii, taken as 95\% of the total flux encircled in the model intensity profiles, are consistent at both wavelengths for the three disks. Dust evolution models show that dust trapping in local pressure maxima in the outer disk could explain the observed patterns. Dust rings are mostly unresolved. The marginally resolved ring in DS Tau shows a tentatively narrower ring at the longer wavelength, an observational feature expected from efficient dust trapping. The spectral index ($\alpha_{\rm mm}$) increases outward and exhibits local minima that correspond to the peaks of dust rings, indicative of the changes in grain properties across the disks. The low optical depths ($\tau\sim$0.1--0.2 at 2.9\,mm and 0.2--0.4 at 1.3\,mm) in the dust rings suggest that grains in the rings may have grown to millimeter sizes. The ubiquitous dust rings in protoplanetary disks modify the overall dynamics and evolution of dust grains, likely paving the way towards the new generation of planet formation.Comment: accepted for publication in Ap

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therapeutic molecules that can be delivered to the site of diseases, through their capacity to home pathological tissues. We have recently demonstrated that MSCs, upon in vitro priming with anti-cancer drug, become drug-releasing mesenchymal cells (Dr-MCs) able to strongly inhibit cancer cells growth

Gaps and Rings in an ALMA Survey of Disks in the Taurus Star-forming Region

Rings are the most frequently revealed substructure in ALMA dust observations of protoplanetary disks, but their origin is still hotly debated. In this paper, we identify dust substructures in 12 disks and measure their properties to investigate how they form. This subsample of disks is selected from a high-resolution ($\sim0.12''$) ALMA 1.33 mm survey of 32 disks in the Taurus star-forming region, which was designed to cover a wide range of sub-mm brightness and to be unbiased to previously known substructures. While axisymmetric rings and gaps are common within our sample, spiral patterns and high contrast azimuthal asymmetries are not detected. Fits of disk models to the visibilities lead to estimates of the location and shape of gaps and rings, the flux in each disk component, and the size of the disk. The dust substructures occur across a wide range of stellar mass and disk brightness. Disks with multiple rings tend to be more massive and more extended. The correlation between gap locations and widths, the intensity contrast between rings and gaps, and the separations of rings and gaps could all be explained if most gaps are opened by low-mass planets (super-Earths and Neptunes) in the condition of low disk turbulence ($\alpha=10^{-4}$). The gap locations are not well correlated with the expected locations of CO and N$_2$ ice lines, so condensation fronts are unlikely to be a universal mechanism to create gaps and rings, though they may play a role in some cases.Several ERC grants

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands

La Escuela Europea del Derecho Natural

La Reforma protestante del siglo XVI introduce en el pensamiento occidental un cambio de mentalidad: se puso en marcha el proceso de secularización que ha afectado a todos los aspectos de la especulación humana. El Derecho no escapó a esos cambios, siendo su primera manifestación ideológica la representada por la Escuela europea del Derecho Natural. En este artículo se analizan los rasgos más notables de esta corriente iusfilosófica