430 research outputs found
A new look at last mile planning : Insights and ideas from the LASTMILE.info project
- Publication venue
- Publication date
- 18/10/2023
- Field of study
A new look at last mile planning : Insights and ideas from the LASTMILE.info project
- Publication venue
- Publication date
- 18/10/2023
- Field of study
Verslag project Learning Community ‘Logistiek in de Leefbare Stad’ (LiLS).
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Een nieuwe kijk op last-mile planning en navigatie.
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Een nieuwe kijk op last-mile planning en navigatie.
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta MV
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Androsov K
- Antonelli L
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arneodo M
- Arora S
- Asavapibhop B
- Asawatangtrakuldee C
- Asghar MI
- Asin I
- Askew A
- Aslanoglou X
- Assran Y
- Ata M
- Attikis A
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- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
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- Azhgirey I
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- Azzi P
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- Zumerle G
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
NeuroML: A Language for Describing Data Driven Models of Neurons and Networks with a High Degree of Biological Detail
- Author
- Andrew P. Davison
- AP Davison
- AP Davison
- AV Herz
- C Koch
- CM Lloyd
- D Gardner
- D Gardner
- D Goodman
- D Pecevski
- DV Buonomano
- E De Schutter
- E De Schutter
- F Gabbiani
- F Zubler
- GA Ascoli
- Guy O. Billings
- H Cornelis
- H Kitano
- JM Bower
- JM Eppler
- JS Rothman
- Karl J. Friston
- M Bartos
- M Bazhenov
- M Djurfeldt
- M Hucka
- M Migliore
- M Tsodyks
- M-O Gewaltig
- Matteo Farinella
- MH Kole
- Michael L. Hines
- ML Hines
- ML Hines
- ML Hines
- MO Cunningham
- N Le Novere
- NH Goddard
- NT Carnevale
- P Gleeson
- P Poirazi
- Padraig Gleeson
- PC Bush
- R Ausbrooks
- R Brette
- R Cannon
- R Maex
- R. Angus Silver
- RD Traub
- Robert C. Cannon
- S Crook
- S Grillner
- S Kunec
- S Ray
- S Song
- Sharon Crook
- Simon R. Barnes
- SM Solinas
- Subhasis Ray
- T Bray
- T Jarsky
- Thomas M. Morse
- Upinder S. Bhalla
- V Santhakumar
- W Rall
- Yoana D. Dimitrova
- ZF Mainen
- Publication venue
- Public Library of Science
- Publication date
- 01/06/2010
- Field of study
Biologically detailed single neuron and network models are important for understanding how ion channels, synapses and anatomical connectivity underlie the complex electrical behavior of the brain. While neuronal simulators such as NEURON, GENESIS, MOOSE, NEST, and PSICS facilitate the development of these data-driven neuronal models, the specialized languages they employ are generally not interoperable, limiting model accessibility and preventing reuse of model components and cross-simulator validation. To overcome these problems we have used an Open Source software approach to develop NeuroML, a neuronal model description language based on XML (Extensible Markup Language). This enables these detailed models and their components to be defined in a standalone form, allowing them to be used across multiple simulators and archived in a standardized format. Here we describe the structure of NeuroML and demonstrate its scope by converting into NeuroML models of a number of different voltage- and ligand-gated conductances, models of electrical coupling, synaptic transmission and short-term plasticity, together with morphologically detailed models of individual neurons. We have also used these NeuroML-based components to develop an highly detailed cortical network model. NeuroML-based model descriptions were validated by demonstrating similar model behavior across five independently developed simulators. Although our results confirm that simulations run on different simulators converge, they reveal limits to model interoperability, by showing that for some models convergence only occurs at high levels of spatial and temporal discretisation, when the computational overhead is high. Our development of NeuroML as a common description language for biophysically detailed neuronal and network models enables interoperability across multiple simulation environments, thereby improving model transparency, accessibility and reuse in computational neuroscience
The potential of antisense oligonucleotide therapies for inherited childhood lung diseases.
- Author
- A Agrawal
- A Faro
- A Gupta
- A Hamvas
- A Khvorova
- A Quint
- AD Burdick
- B Miskew Nichols
- C Béroud
- C Ferec
- CE Wainwright
- CF Adkin
- CF Bennett
- CL Lorson
- CS Chu
- D Castanotto
- DM Paton
- E Lach-Trifilieff
- E Wong
- EO Lillie
- EWM Ng
- F Van Goor
- FJ Accurso
- FM de Benedictis
- G Han
- G Lacerra
- G Riboldi
- H Donis-Keller
- H Schmidli
- H Yin
- J Don Hayes
- J Zhao
- JA Wambach
- JA Whitsett
- JG Karras
- JH Chan
- JL Kreindler
- JP Dassie
- JR Crosby
- KJ Friedman
- KL Greer
- L Mologni
- LM Nogee
- M Griese
- M Williamson
- MA Havens
- ME McGarry
- MJ Welsh
- ML Stephenson
- MM Evers
- MR Alam
- N Aronin
- N Dias
- N Wathion
- NK Singh
- NN Kipshidze
- P Jarver
- PC Zamecnik
- PM Moreno
- Q Yang
- QL Lu
- R Kole
- R Radpour
- RA Fey
- RJ Massie
- RL Juliano
- RS Finkel
- RS Geary
- S Agrawal
- S Igreja
- S Lefebvre
- S Mulugeta
- SA Moschos
- SA Moschos
- SA Moschos
- SD Wilton
- SE Wert
- SF Williamson
- ST Crooke
- ST Crooke
- ST Crooke
- T Sterne-Weiler
- T Yokota
- W Beumer
- W Duan
- W-J Wang
- WA Gower
- WE Highsmith
- Z Dominski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design. Through targeting the pre-mRNA, antisense oligonucleotides can alter splicing and induce a specific spliceoform or disrupt the reading frame, target an RNA transcript for degradation through RNaseH activation, block ribosome initiation of protein translation or disrupt miRNA function. The recent accelerated approval of eteplirsen (renamed Exondys 51™) by the Food and Drug Administration, for the treatment of Duchenne muscular dystrophy, and nusinersen, for the treatment of spinal muscular atrophy, herald a new and exciting era in splice-switching antisense oligonucleotide applications to treat inherited diseases. This review considers the potential of antisense oligonucleotides to treat inherited lung diseases of childhood with a focus on cystic fibrosis and disorders of surfactant protein metabolism
Observation of the diphoton decay of the Higgs boson and measurement of its properties
- Author
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- Abbiendi G
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agapitos A
- Agram JL
- Ahmad A
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- Albajar C
- Albayrak EA
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- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
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- Alexander J
- Alimena J
- Alverson G
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- Anagnostou G
- Anderson I
- Anderson J
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- Banerjee S
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- Pol ME
- Polatoz A
- Polese G
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- Poll A
- Pollack B
- Pompili A
- Pooth O
- Popov A
- Popov V
- Potenza A
- Potenza R
- Poyraz D
- Pozdnyakov A
- Pozdnyakov I
- Pozzobon N
- Prado Da Silva WL
- Preuten M
- Primavera F
- Prokofyev O
- Prosper H
- Psallidas A
- Ptochos F
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- Pugliese G
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- Python Q
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- Razis PA
- Re V
- Rebane L
- Rebassoo F
- Redaelli N
- Redjimi R
- Redondo I
- Regnard S
- Reid ID
- Reis T
- Reithler H
- Rekovic V
- Renker D
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- Rezaei Hosseinabadi F
- Ribeiro Cipriano PM
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- Ricci-Tam F
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- Richman J
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- Rizzi A
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- Rodozov M
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- Rodrigues Antunes J
- Rodriguez JL
- Rodríguez-Marrero AY
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- Roland B
- Roland C
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- Rosowsky A
- Ross I
- Rossi AM
- Rossini M
- Rougny R
- Rovelli C
- Rovelli T
- Rovere M
- Roy D
- Ruchti R
- Ruiz Alvarez JD
- Ruiz-Jimeno A
- Rumerio P
- Rusack R
- Rusakov SV
- Ruspa M
- Russ J
- Ryckbosch D
- Ryd A
- Rykaczewski H
- Ryu G
- Ryu MS
- Ryutin R
- Röcker S
- Sabes D
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- Safonov A
- Safronov G
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- Sakuma T
- Salazar Ibarguen HA
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- Salfeld-Nebgen J
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- Sanabria JC
- Sanchez-Hernandez A
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- Sandoval Gonzalez ID
- Sani M
- Santanastasio F
- Santaolalla J
- Santocchia A
- Santoro A
- Saoulidou N
- Sarangi T
- Sarkar S
- Sauvan JB
- Savin A
- Savoy-Navarro A
- Savrin V
- Saxena P
- Scarborough T
- Schael S
- Schettler H
- Schizzi A
- Schleper P
- Schlieckau E
- Schmidt A
- Schmitt M
- Schmitz SA
- Schnetzer S
- Schoerner-Sadenius T
- Schröder M
- Schulte JF
- Schwick C
- Schäfer C
- Schöfbeck R
- Scodellaro L
- Seez C
- Seidel M
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- Seitz C
- Seixas J
- Sekaric J
- Sekmen S
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- Senkin S
- Serban AT
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- Sexton-Kennedy E
- Sgandurra L
- Sguazzoni G
- Shalhout S
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- Shchutska L
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- Sheldon P
- Shepherd-Themistocleous CH
- Shi X
- Shipsey I
- Shmatov S
- Shoaib M
- Shrinivas A
- Shukla P
- Shumeiko N
- Siegrist P
- Sigamani M
- Sikler F
- Silkworth C
- Silva P
- Silvers D
- Silvestris L
- Simon M
- Simon S
- Simonetto F
- Simonis HJ
- Singh G
- Singh JB
- Singovsky A
- Sinthuprasith T
- Sirois Y
- Siroli GP
- Sirunyan AM
- Skatchkov N
- Skhirtladze N
- Skinnari L
- Skovpen K
- Skuja A
- Smirnov I
- Smirnov V
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- Spiegel L
- Spiezia A
- Spiga D
- Spiridonov A
- Spiropulu M
- Squillacioti P
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- St John J
- Stadie H
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- Staiano A
- Starodumov A
- Steggemann J
- Steinbrück G
- Stenson K
- Stephans GS
- Stickland D
- Stieger B
- Stiliaris E
- Stober FM
- Stolin V
- Stolp D
- Stone R
- Stoye M
- Stoykova S
- Stoynev S
- Strauss J
- Stringer R
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- Strologas J
- Strom D
- Stuart D
- Stupak J
- Sturdy J
- Suarez Gonzalez J
- Suarez I
- Sudhakar K
- Sudic L
- Sulak L
- Sulimov V
- Sultanov G
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- Sumowidagdo S
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- Tabarelli de Fatis T
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- Teo WD
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- Thea A
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- Trocino D
- Trocsanyi ZL
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- Tsai JF
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- Tsirou A
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- Tuominen E
- Tuominiemi J
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- Ujvari B
- Ulmer KA
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- Veeraraghavan V
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- Velkovska J
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- Venturi A
- Verdier P
- Verdini PG
- Veres GI
- Vergili M
- Vernieri C
- Verwilligen P
- Verzetti M
- Veszpremi V
- Vesztergombi G
- Veverka J
- Vidal Marono M
- Vidal R
- Vila I
- Vilar Cortabitarte R
- Vilela Pereira A
- Villella I
- Vinogradov A
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- Vorobiev I
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- Vorobyev A
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- Wickramage N
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- Wissing C
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- Wolf R
- Wolfe E
- Wolfe H
- Wollny H
- Womersley WJ
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- Wood JS
- Woodard A
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- Worm SD
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- Wulsin HW
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- Wyslouch B
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- Xiao H
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- Xie S
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- Zabel J
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- Zaganidis N
- Zakaria M
- Zalewski P
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- Zarubin A
- Zeinali M
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- Zeyrek M
- Zhang F
- Zhang J
- Zhang L
- Zhokin A
- Zhu RY
- Zhukov V
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- Zotto P
- Zou W
- Zsigmond AJ
- Zucchetta A
- Zumerle G
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- Zvada M
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
- …