6,442 research outputs found
Estimating the Prevalence and Correlates of Psychiatric Disorders and Mental Health Problems among Undocumented Mexican Immigrants using the National Latino and Asian American Study
This study examines the prevalence and correlates of psychiatric disorders and mental health problems among undocumented Mexican immigrants using the National Latino and Asian American Study (NLAAS). Two approaches were used to obtain estimates for likely undocumented Mexican immigrants (LUMIs): (1) creation of a proxy variable, and (2) multiple imputation using chained equations. Results indicated that LUMIs had greater prevalence rates for specific anxiety disorders, depressive disorders and poor self-rated mental health compared to documented Mexican immigrants. Next, potential mediators of poor mental health were identified. Finally, LUMIs were compared with other Latino groups by nativity status. This study concludes with a discussion of the results and implications for future research
S-PRAC: Fast Partial Packet Recovery with Network Coding in Very Noisy Wireless Channels
Well-known error detection and correction solutions in wireless
communications are slow or incur high transmission overhead. Recently, notable
solutions like PRAC and DAPRAC, implementing partial packet recovery with
network coding, could address these problems. However, they perform slowly when
there are many errors. We propose S-PRAC, a fast scheme for partial packet
recovery, particularly designed for very noisy wireless channels. S-PRAC
improves on DAPRAC. It divides each packet into segments consisting of a fixed
number of small RLNC encoded symbols and then attaches a CRC code to each
segment and one to each coded packet. Extensive simulations show that S-PRAC
can detect and correct errors quickly. It also outperforms DAPRAC significantly
when the number of errors is high
Microwave Kinetic Inductance Detector (MKID) Camera Testing for Submillimeter Astronomy
Developing kilopixel focal planes for incoherent submm- and mm-wave detectors remains challenging due to either the large hardware overhead or the complexity of multiplexing standard detectors. Microwave kinetic inductance detectors (MKIDs) provide a efficient means to produce fully lithographic background-limited kilopixel focal planes. We are constructing an MKID-based camera for the Caltech Submillimeter Observatory with 576 spatial pixels each simultaneously sensitive in 4 bands at 230, 300, 350, and 400 GHz. The novelty of MKIDs has required us to develop new techniques for detector characterization. We have measured quasiparticle lifetimes and resonator Qs for detector bath temperatures between 200 mK and 400 mK. Equivalent lifetime measurements were made by coupling energy into the resonators either optically or by driving the third harmonic of the resonator. To determine optical loading, we use both lifetime and internal Q measurements, which range between 15,000 and 30,000 for our resonators. Spectral bandpass measurements confirm the placement of the 230 and 350 GHz bands. Additionally, beam maps measurements conform to expectations. The same device design has been characterized on both sapphire and silicon substrates, and for different detector geometries. We also report on the incorporation of new shielding to reduce detector sensitivity to local magnetic fields
IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System
PURPOSE:
To improve persistence of adoptively transferred T-cell receptor (TCR)-engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application.
EXPERIMENTAL DESIGN:
HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were coadministered to myelodepleted HLA-A2/Kb mice within a formal Good Laboratory Practice (GLP)-compliant study to demonstrate safety, persistence, and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, Good Manufacturing Practice (GMP)-compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use.
RESULTS:
TCR genetically modified and ex vivo-cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and coadministration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSC's differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality.
CONCLUSIONS:
Coadministration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this article led to the FDA approval of IND 17471
Transiting exoplanets from the CoRoT space mission VIII. CoRoT-7b: the first Super-Earth with measured radius
We report the discovery of very shallow (DF/F = 3.4 10-4), periodic dips in
the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite,
which we interpret as due to the presence of a transiting companion. We
describe the 3-colour CoRoT data and complementary ground-based observations
that support the planetary nature of the companion. Methods. We use CoRoT color
information, good angular resolution ground-based photometric observations in-
and out- of transit, adaptive optics imaging, near-infrared spectroscopy and
preliminary results from Radial Velocity measurements, to test the diluted
eclipsing binary scenarios. The parameters of the host star are derived from
optical spectra, which were then combined with the CoRoT light curve to derive
parameters of the companion. We examine carefully all conceivable cases of
false positives, and all tests performed support the planetary hypothesis.
Blends with separation larger than 0.40 arcsec or triple systems are almost
excluded with a 8 10-4 risk left. We conclude that, as far as we have been
exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which
we derive a period of 0.853 59 +/- 3 10-5 day and a radius of Rp = 1.68 +/-
0.09 REarth. Analysis of preliminary radial velocity data yields an upper limit
of 21 MEarth for the companion mass, supporting the finding.
CoRoT-7b is very likely the first Super-Earth with a measured radius.Comment: Accepted in Astronomy and Astrophysics; typos and language
corrections; version sent to the printer w few upgrade
HerMES: Candidate Gravitationally Lensed Galaxies and Lensing Statistics at Submillimeter Wavelengths
We present a list of 13 candidate gravitationally lensed submillimeter
galaxies (SMGs) from 95 square degrees of the Herschel Multi-tiered
Extragalactic Survey, a surface density of 0.14\pm0.04deg^{-2}. The selected
sources have 500um flux densities (S_500) greater than 100mJy. Gravitational
lensing is confirmed by follow-up observations in 9 of the 13 systems (70%),
and the lensing status of the four remaining sources is undetermined. We also
present a supplementary sample of 29 (0.31\pm0.06deg^{-2}) gravitationally
lensed SMG candidates with S_500=80--100mJy, which are expected to contain a
higher fraction of interlopers than the primary candidates. The number counts
of the candidate lensed galaxies are consistent with a simple statistical model
of the lensing rate, which uses a foreground matter distribution, the intrinsic
SMG number counts, and an assumed SMG redshift distribution. The model predicts
that 32--74% of our S_500>100mJy candidates are strongly gravitationally lensed
(mu>2), with the brightest sources being the most robust; this is consistent
with the observational data. Our statistical model also predicts that, on
average, lensed galaxies with S_500=100mJy are magnified by factors of ~9, with
apparently brighter galaxies having progressively higher average magnification,
due to the shape of the intrinsic number counts. 65% of the sources are
expected to have intrinsic 500micron flux densities less than 30mJy. Thus,
samples of strongly gravitationally lensed SMGs, such as those presented here,
probe below the nominal Herschel detection limit at 500 micron. They are good
targets for the detailed study of the physical conditions in distant dusty,
star-forming galaxies, due to the lensing magnification, which can lead to
spatial resolutions of ~0.01" in the source plane.Comment: ApJ in press. 31 pages, 16 figures, 5 tables. This version updated to
match accepted versio
Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV
A search for new physics is presented based on an event signature of at least
three jets accompanied by large missing transverse momentum, using a data
sample corresponding to an integrated luminosity of 36 inverse picobarns
collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector
at the LHC. No excess of events is observed above the expected standard model
backgrounds, which are all estimated from the data. Exclusion limits are
presented for the constrained minimal supersymmetric extension of the standard
model. Cross section limits are also presented using simplified models with new
particles decaying to an undetected particle and one or two jets
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
The production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
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