108 research outputs found
The Design and Installation of a Combined Concentrating Power Station, Solar Cooling System and Domestic Hot Water System
AbstractThe University of Technology, Sydney (UTS) has built a unique tri-generation system that provides chilled water, hot water, and electricity to their new Faculty of Engineering and Information Technology (FEIT) building. It integrates parabolic trough collectors, flat plate collectors, photovoltaic panels, and wind power as generators with thermal and chemical energy storage. The heat from the parabolic trough collectors is used to run a small-scale Organic Rankine Cycle (ORC) unit as well as a small-scale ammonia/water absorption chiller to provide either electricity or chilled water, respectively. The condenser heat from both units is fed into the domestic hot water (DHW) supply of the building in addition to the solar heat from the flat plate and the parabolic trough collectors. The design concept including the main system components and the system control strategy are described in detail. Further, the lessons learned during the installation and commissioning of the complex tri-generation system are given. As a novelty in this area, the tri-generation system has been specifically designed to allow students and researchers to work with it, hence this paper also describes the wide range of teaching opportunities for undergraduate and graduate engineering students as well as post-doc researchers
Expansion of the ligand knowledge base for chelating P,P-donor ligands (LKB-PP)
[Image: see text] We have expanded the ligand knowledge base for bidentate P,P- and P,N-donor ligands (LKB-PP, Organometallics2008, 27, 1372–1383) by 208 ligands and introduced an additional steric descriptor (nHe(8)). This expanded knowledge base now captures information on 334 bidentate ligands and has been processed with principal component analysis (PCA) of the descriptors to produce a detailed map of bidentate ligand space, which better captures ligand variation and has been used for the analysis of ligand properties
Pan-chromatic observations of the remarkable nova LMC 2012
We present the results of an intensive multiwavelength campaign on nova LMC
2012. This nova evolved very rapidly in all observed wavelengths. The time to
fall two magnitudes in the V band was only 2 days. In X-rays the super soft
phase began 135 days after discovery and ended around day 50 after
discovery. During the super soft phase, the \Swift/XRT and \Chandra\ spectra
were consistent with the underlying white dwarf being very hot, 1 MK,
and luminous, 10 erg s. The UV, optical, and near-IR
photometry showed a periodic variation after the initial and rapid fading had
ended. Timing analysis revealed a consistent 19.240.03 hr period in all
UV, optical, and near-IR bands with amplitudes of 0.3 magnitudes which
we associate with the orbital period of the central binary. No periods were
detected in the corresponding X-ray data sets. A moderately high inclination
system, = 6010^{\arcdeg}, was inferred from the early optical
emission lines. The {\it HST}/STIS UV spectra were highly unusual with only the
\ion{N}{5} (1240\AA) line present and superposed on a blue continuum. The lack
of emission lines and the observed UV and optical continua from four epochs can
be fit with a low mass ejection event, 10 M, from a hot
and massive white dwarf near the Chandrasekhar limit. The white dwarf, in turn,
significantly illuminated its subgiant companion which provided the bulk of the
observed UV/optical continuum emission at the later dates. The inferred extreme
white dwarf characteristics and low mass ejection event favor nova LMC 2012
being a recurrent nova of the U Sco subclass.Comment: 18 figures, 6 tables (one online only containing all the photometry
Swift X-Ray Observations of Classical Novae. II. The Super Soft Source sample
The Swift GRB satellite is an excellent facility for studying novae. Its
rapid response time and sensitive X-ray detector provides an unparalleled
opportunity to investigate the previously poorly sampled evolution of novae in
the X-ray regime. This paper presents Swift observations of 52
Galactic/Magellanic Cloud novae. We included the XRT (0.3-10 keV) X-ray
instrument count rates and the UVOT (1700-8000 Angstroms) filter photometry.
Also included in the analysis are the publicly available pointed observations
of 10 additional novae the X-ray archives. This is the largest X-ray sample of
Galactic/Magellanic Cloud novae yet assembled and consists of 26 novae with
super soft X-ray emission, 19 from Swift observations. The data set shows that
the faster novae have an early hard X-ray phase that is usually missing in
slower novae. The Super Soft X-ray phase occurs earlier and does not last as
long in fast novae compared to slower novae. All the Swift novae with
sufficient observations show that novae are highly variable with rapid
variability and different periodicities. In the majority of cases, nuclear
burning ceases less than 3 years after the outburst begins. Previous
relationships, such as the nuclear burning duration vs. t_2 or the expansion
velocity of the eject and nuclear burning duration vs. the orbital period, are
shown to be poorly correlated with the full sample indicating that additional
factors beyond the white dwarf mass and binary separation play important roles
in the evolution of a nova outburst. Finally, we confirm two optical phenomena
that are correlated with strong, soft X-ray emission which can be used to
further increase the efficiency of X-ray campaigns.Comment: Accepted to ApJ Supplements. Full data for Table 2 and Figure 17
available in the electronic edition. New version of the previously posted
paper since the earlier version was all set in landscape mod
X-Ray Spectroscopic Diagnosis of a Wind-Collimated Blast Wave and Metal-Rich Ejecta from the 2006 Explosion of RS Ophiuchi
Chandra HETG observations of RS Ophiuchi at day 13.9 of the 2006 outburst reveal a rich spectrum of emission lines from abundant ions formed over a wide temperature range (∼ 3 × 10 6 to 60 × 10 6 K) indicative of shock heating of the circumstellar medium by the expanding blast wave. Lines are asymmetric and strongly broadened (v ∼ 2400 km s −1 at zero intensity). Using simple analytical model profiles, we show how the lines are shaped by differential absorption in the red giant wind and explosion ejecta, and that shock heating to multimillion degree temperatures appears to have occurred preferentially in the direction perpendicular to the line of sight. We conclude that the asymmetric nature of the offset 1/r 2 density profile and likely equatorial circumstellar density enhancement in which the explosion occurred are responsible for both the shock collimation and broad range in plasma temperature observed. The ejecta mass deduced from X-ray absorption is more easily reconciled with the expected mass accretion rate for material enhanced in metals by up to an order of magnitude
The state of the Martian climate
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
Correction for Johansson et al., An open challenge to advance probabilistic forecasting for dengue epidemics.
Correction for “An open challenge to advance probabilistic forecasting for dengue epidemics,” by Michael A. Johansson, Karyn M. Apfeldorf, Scott Dobson, Jason Devita, Anna L. Buczak, Benjamin Baugher, Linda J. Moniz, Thomas Bagley, Steven M. Babin, Erhan Guven, Teresa K. Yamana, Jeffrey Shaman, Terry Moschou, Nick Lothian, Aaron Lane, Grant Osborne, Gao Jiang, Logan C. Brooks, David C. Farrow, Sangwon Hyun, Ryan J. Tibshirani, Roni Rosenfeld, Justin Lessler, Nicholas G. Reich, Derek A. T. Cummings, Stephen A. Lauer, Sean M. Moore, Hannah E. Clapham, Rachel Lowe, Trevor C. Bailey, Markel García-Díez, Marilia Sá Carvalho, Xavier Rodó, Tridip Sardar, Richard Paul, Evan L. Ray, Krzysztof Sakrejda, Alexandria C. Brown, Xi Meng, Osonde Osoba, Raffaele Vardavas, David Manheim, Melinda Moore, Dhananjai M. Rao, Travis C. Porco, Sarah Ackley, Fengchen Liu, Lee Worden, Matteo Convertino, Yang Liu, Abraham Reddy, Eloy Ortiz, Jorge Rivero, Humberto Brito, Alicia Juarrero, Leah R. Johnson, Robert B. Gramacy, Jeremy M. Cohen, Erin A. Mordecai, Courtney C. Murdock, Jason R. Rohr, Sadie J. Ryan, Anna M. Stewart-Ibarra, Daniel P. Weikel, Antarpreet Jutla, Rakibul Khan, Marissa Poultney, Rita R. Colwell, Brenda Rivera-García, Christopher M. Barker, Jesse E. Bell, Matthew Biggerstaff, David Swerdlow, Luis Mier-y-Teran-Romero, Brett M. Forshey, Juli Trtanj, Jason Asher, Matt Clay, Harold S. Margolis, Andrew M. Hebbeler, Dylan George, and Jean-Paul Chretien, which was first published November 11, 2019; 10.1073/pnas.1909865116. The authors note that the affiliation for Xavier Rodó should instead appear as Catalan Institution for Research and Advanced Studies (ICREA) and Climate and Health Program, Barcelona Institute for Global Health (ISGlobal). The corrected author and affiliation lines appear below. The online version has been corrected
Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial
SummaryBackgroundThe optimum endocrine treatment for postmenopausal women with advanced hormone-receptor-positive breast cancer that has progressed on non-steroidal aromatase inhibitors (NSAIs) is unclear. The aim of the SoFEA trial was to assess a maximum double endocrine targeting approach with the steroidal anti-oestrogen fulvestrant in combination with continued oestrogen deprivation.MethodsIn a composite, multicentre, phase 3 randomised controlled trial done in the UK and South Korea, postmenopausal women with hormone-receptor-positive breast cancer (oestrogen receptor [ER] positive, progesterone receptor [PR] positive, or both) were eligible if they had relapsed or progressed with locally advanced or metastatic disease on an NSAI (given as adjuvant for at least 12 months or as first-line treatment for at least 6 months). Additionally, patients had to have adequate organ function and a WHO performance status of 0–2. Participants were randomly assigned (1:1:1) to receive fulvestrant (500 mg intramuscular injection on day 1, followed by 250 mg doses on days 15 and 29, and then every 28 days) plus daily oral anastrozole (1 mg); fulvestrant plus anastrozole-matched placebo; or daily oral exemestane (25 mg). Randomisation was done with computer-generated permuted blocks, and stratification was by centre and previous use of an NSAI as adjuvant treatment or for locally advanced or metastatic disease. Participants and investigators were aware of assignment to fulvestrant or exemestane, but not of assignment to anastrozole or placebo. The primary endpoint was progression-free survival (PFS). Analyses were by intention to treat. This trial is registered with ClinicalTrials.gov, numbers NCT00253422 (UK) and NCT00944918 (South Korea).FindingsBetween March 26, 2004, and Aug 6, 2010, 723 patients underwent randomisation: 243 were assigned to receive fulvestrant plus anastrozole, 231 to fulvestrant plus placebo, and 249 to exemestane. Median PFS was 4·4 months (95% CI 3·4–5·4) in patients assigned to fulvestrant plus anastrozole, 4·8 months (3·6–5·5) in those assigned to fulvestrant plus placebo, and 3·4 months (3·0–4·6) in those assigned to exemestane. No difference was recorded between the patients assigned to fulvestrant plus anastrozole and fulvestrant plus placebo (hazard ratio 1·00, 95% CI 0·83–1·21; log-rank p=0·98), or between those assigned to fulvestrant plus placebo and exemestane (0·95, 0·79–1·14; log-rank p=0·56). 87 serious adverse events were reported: 36 in patients assigned to fulvestrant plus anastrozole, 22 in those assigned to fulvestrant plus placebo, and 29 in those assigned to exemestane. Grade 3–4 adverse events were rare; the most frequent were arthralgia (three in the group assigned to fulvestrant plus anastrozole; seven in that assigned to fulvestrant plus placebo; eight in that assigned to exemestane), lethargy (three; 11; 11), and nausea or vomiting (five; two; eight).InterpretationAfter loss of response to NSAIs in postmenopausal women with hormone-receptor-positive advanced breast cancer, maximum double endocrine treatment with 250 mg fulvestrant combined with oestrogen deprivation is no better than either fulvestrant alone or exemestane.FundingCancer Research UK and AstraZeneca
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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