27 research outputs found

    New hints towards a precision medicine strategy for IDH wild-type glioblastoma.

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    Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of disease subtypes based on mutational profiling, gene expression and DNA methylation has so far failed to translate into improved clinical outcomes. However, new knowledge emerging from the subtyping effort in the IDH-wild-type setting may provide directions for future precision therapies. Here, we review recent learnings in the field, and further consider how tumour microenvironment differences across subtypes may reveal novel contexts of vulnerability. We discuss recent treatment approaches and ongoing trials in the IDH-wild-type glioblastoma setting, and propose an integrated discovery stratagem incorporating multi-omics, single-cell technologies and computational approaches

    Search for narrow resonances in dilepton mass spectra in proton-proton collisions at root s=13 TeV and combination with 8 TeV data

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    Search for heavy gauge W ' bosons in events with an energetic lepton and large missing transverse momentum at root s=13TeV

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    Multiplicity and rapidity dependence of strange hadron production in pp, pPb, and PbPb collisions at the LHC

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    Evidence for collectivity in pp collisions at the LHC

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    Measurements of two- and multi-particle angular correlations in pp collisions at View the MathML sources=5,7, and 13TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of View the MathML source1.0pb−1 (5 TeV), View the MathML source6.2pb−1 (7 TeV), and View the MathML source0.7pb−1 (13 TeV), were collected using the CMS detector at the LHC. The second-order (v2v2) and third-order (v3v3) azimuthal anisotropy harmonics of unidentified charged particles, as well as v2v2 of View the MathML sourceKS0 and View the MathML sourceΛ/Λ‾ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v2v2 values of charged hadrons (mostly pions), View the MathML sourceKS0, and View the MathML sourceΛ/Λ‾, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below View the MathML sourcepT≈2GeV/c. For 13 TeV data, the v2v2 signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions

    Search for single production of a heavy vector-like T quark decaying to a Higgs boson and a top quark with a lepton and jets in the final state

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    A search for single production of vector-like top quark partners (T) decaying into a Higgs boson and a top quark is performed using data from pp collisions at a centre-of-mass energy of 13 TeV collected by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of 2.3 fb−1. The top quark decay includes an electron or a muon while the Higgs boson decays into a pair of b quarks. No significant excess over standard model backgrounds is observed. Exclusion limits on the product of the production cross section and the branching fraction are derived in the T quark mass range 700 to 1800 GeV. For a mass of 1000 GeV, values of the product of the production cross section and the branching fraction greater than 0.8 and 0.7 pb are excluded at 95% confidence level, assuming left- and right-handed coupling of the T quark to standard model particles, respectively. This is the first analysis setting exclusion limits on the cross section of singly produced vector-like T quarks at a centre-of-mass energy of 13 TeV

    Search for single production of a vector-like T quark decaying to a Z boson and a top quark in proton–proton collisions at √s = 13 TeV

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    A search is presented for single production of a vector-like quark (T) decaying to a Z boson and a top quark, with the Z boson decaying leptonically and the top quark decaying hadronically. The search uses data collected by the CMS experiment in proton–proton collisions at a center-of-mass energy of 13 TeV in 2016, corresponding to an integrated luminosity of 35.9 fb⁻¹. The presence of forward jets is a particular characteristic of single production of vector-like quarks that is used in the analysis. For the first time, different T quark width hypotheses are studied, from negligibly small to 30% of the new particle mass. At the 95% confidence level, the product of cross section and branching fraction is excluded above values in the range 0.26–0.04 pb for T quark masses in the range 0.7–1.7 TeV, assuming a negligible width. A similar sensitivity is observed for widths of up to 30% of the T quark mass. The production of a heavy Z′ boson decaying to Tt, with T→tZ, is also searched for, and limits on the product of cross section and branching fractions for this process are set between 0.13 and 0.06 pb for Z′ boson masses in the range from 1.5 to 2.5 TeV

    Search for heavy gauge W ′ bosons in events with an energetic lepton and large missing transverse momentum at √s = 13 TeV

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    A search is presented for W′ bosons in events with an electron or muon and large missing transverse momentum, using proton–proton collision data at √s=13 TeV collected with the CMS detector in 2015 and corresponding to an integrated luminosity of 2.3 fb−1. No evidence of an excess of events relative to the standard model expectations is observed. For a W′ boson described by the sequential standard model, upper limits at 95% confidence level are set on the product of the production cross section and branching fraction and lower limits are established on the new boson mass. Masses below 4.1 TeV are excluded combining electron and muon decay channels, significantly improving upon the results obtained with the 8 TeV data. Exclusion limits at 95% confidence level on the product of the W′ production cross section and branching fraction are also derived in combination with the 8 TeV data. Finally, exclusion limits are set for the production of generic W′ bosons decaying into this final state using a model-independent approach

    Search for top squark pair production in compressed-mass-spectrum scenarios in proton-proton collisions at √s=8 TeV using the αT_{T} variable

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    An inclusive search is performed for supersymmetry in final states containing jets and an apparent imbalance in transverse momentum, (p) over right arrow (miss)(T),due to the production of unobserved weakly interacting particles in pp collisions at a centre-of-mass energy of 8 TeV. The data, recorded with the CMS detector at the CERN LHC, correspond to an integrated luminosity of 18.5fb(-1). The dimensionless kinematic variable alpha(T) is used to discriminate between events with genuine (p) over right arrow (miss)(T)associated with unobserved particles and spurious values of (p) over right arrow (miss)(T) Tarising from jet energy mismeasurements. No excess of event yields above the expected standard model backgrounds is observed. The results are interpreted in terms of constraints on the parameter space of several simplified models of supersymmetry that assume the pair production of top squarks. The search provides sensitivity to a broad range of top squark ((t) over tilde) decay modes, including the two-body decay (t)over tilde> -> c (chi) over tilde (0)(1),where c is a charm quark (chi) over tilde (0)(1) and is the lightest neutralino, as well as the four-body decay (t)over tilde> -> bf (f) over bar' (chi) over bar (0)(1),where b is a bottom quark and f and (f) over bar' are fermions produced in the decay of an intermediate off-shell W boson. These modes dominate in scenarios in which the top squark and lightest neutralino are nearly degenerate in mass. For these modes, top squarks with masses as large as 260 and 225 GeV are excluded, respectively, for the two-and four-body decays. (C) 2017 The Author. Published by Elsevier B.V

    Observation of the decay B⁺ → ψ(2S)ϕ(1020)K⁺ in pp collisions at √s=8TeV

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    The decay B+→ψ(2S)ϕ(1020)K+B+→ψ(2S)ϕ(1020)K+ is observed for the first time using data collected from pp collisions at View the MathML sources=8TeV by the CMS experiment at the LHC, corresponding to an integrated luminosity of 19.6View the MathML sourcefb−1. The branching fraction of this decay is measured, using the mode B+→ψ(2S)K+B+→ψ(2S)K+ as normalization, to be View the MathML source(4.0±0.4(stat)±0.6(syst)±0.2(B))×10−6, where the third uncertainty is from the measured branching fraction of the normalization channe
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