RETRATO PRELIMINAR DA PRODUÇÂO EM EDUCAÇÃO FÍSICA/MÍDIA NO BRASIL

o texto apresenta relatório preliminar de pesquisa coletiva realizada como estratégia didática no Seminário Avançado de Pesquisa em Educação Física e Mídia do PPG/Educação Física/UFSC, em 2005/1. O objetivo do seminário foi efetuar um levantamento em fontes bibliográficas nacionais para identificar, entre outros aspectos, tendências e lacunas teóricometodológicas nos estudos em Educação Física e Mídia. A interpretação dos dados foi procedida em textos específicos de três subgrupos, disponibilizados na página do LaboMídia

Slégami Open Access - Manuale d'uso per ricercatori

Il seguente documento nasce nell’ambito delle attività svolte dal Gruppo di Lavoro (GdL) APRE dedicato al tema dell’Open Science e si sviluppa come un manuale d’uso per i ricercatori, con specifico riguardo all’Open Access e all’Open Data. La sua redazione ha coinvolto attivamente tutti i membri del GdL, i cui membri sono rappresentanti delle biblioteche e degli uffici di supporto alla ricerca di diverse università e centri di ricerca italiani (è possibile consultare la lista dei partecipanti nell’ultima pagina di questo documento). Il lavoro è un aggiornamento del manuale originariamente pubblicato nel 2019 e la cui prima edizione era il risultato di un lavoro svolto in 3 fasi: 1) un’iniziale raccolta delle domande più comuni poste dai ricercatori presso le strutture di supporto (siano esse biblioteche o uffici di supporto alla ricerca) degli enti partecipanti in materia di Open Access e Open Data; 2) una fase di consolidamento e classificazione delle domande raccolte in 6 categorie; 3) un’ultima fase di redazione, da parte di alcuni membri del GdL, delle risposte alle domande poste e successivamente emendate a più riprese dall’intero gruppo. Nel 2021 il GdL si è riunito nuovamente per lavorare ad un aggiornamento del manuale in ottica Horizon Europe. Seguendo lo stesso schema di lavoro in 3 fasi (raccolta, classificazione ed elaborazione), il gruppo ha identificato 76 domande aggiuntive rispetto al documento originale, le quali a loro volta sono state successivamente raggruppate e classificate in 10 categorie

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements