466 research outputs found
La visiĂłn parkinsoniana de la figura compleja de Rey-Osterrieth
Visuospatial impairment has been frequently reported in Parkinsonâs disease (PD). We present the progressive
distorsioned performance of the Rey-Osterrieth complex figure in parkinsonian patients at different stages of the disease (PD
de novo, PD on long-term treatment, PD with phychosis and PD with dementia
Inventariação e propagação de Thymus mastichina na Beira Interior
Integrado no Programa Agro, Medida 8.1, Projecto nÂş 800, foram elaborados
estudos de distribuição e propagação da espÊcie Thymus mastichina L., existentes
espontaneamente na Beira Interior. Foram avaliadas seis zonas ecolĂłgicas distintas
denominadas Vale do Tejo, Beira Interior Sul, Cova da Beira, Beira Interior Norte,
Serra da Estrela e Serra da Gardunha.
Durante dois anos fez-se prospecção no campo em cada zona ecológica e
recolheu-se material vegetal. Realizaram-se ensaios de germinação em laboratório em
condiçþes de temperatura alterna 10º/20ºC (dia) e temperatura constante 23ºC (dia),
com fotoperĂodo de 8 e 16 horas/dia, respectivamente. Testou-se ainda a capacidade
germinativa em estufa, na Primavera e efectuaram-se ensaios de enraizamento, com
estacas terminais, em condiçþes de Outono/Inverno e Primavera/Verão.
Na Beira Interior foram encontrados 36 locais onde se verificou a ocorrĂŞncia de
Thymus mastichina. Em cada zona ecolĂłgica onde foram encontrados indivĂduos da
espĂŠcie em estudo, foi seleccionado um local para recolha de 20 plantas-mĂŁe, que foram
posteriormente instaladas no campo de caracterização/demonstração da ESACB.
Nos ensaios de germinação verificaram-se taxas entre os 80% e 94% em
laboratório e entre os 76% e 84%, em viveiro. Nos ensaios de propagação vegetativa de
estacas terminais obtiveram-se taxas de enraizamento entre os 20% e 100%
Trastornos neuropsiquiĂĄtricos en la enfermedad de Parkinson
This paper reviews the main neuropsychiatric disorders associated with Parkinsonâs disease (PD) and
describes the neuropathological hypothesis proposed to explain these symptoms. Development. This disease is usually associated
with neuropsychiatric complications such as depression, anxiety and apathy. Besides, psychiatric symptoms are one of the
most common side effects of antiparkinsonian drug-therapy. Conclusions. Depression is the most frequent emotional disorder
reported in patients with PD. Up to 20% of parkinsonian patients meet DSM-IV criteria for major depressive episode and another
20% for dysthymia, while the prevalence of depression in normal aged population is about 2-8%. The relationship between PD
and depression has not been fully established. Some investigators have suggested that depressive symptoms in PD are causally
related to the underlying neuropathological process, affecting predominantly serotoninergic and dopaminergic pathways.
Alternatively, depression in PD may represent a normal reaction to the progressive physical impairment induced by the disease.
Otherwise, up to 20% of parkinsonian patients present levodopa-induced psychiatric complications. Visual hallucinations are
the commonest, but delusions, confusional states, sexual disorders and sleep disorders have also been described. Serotonine and
dopamine have been implicated in the neuropathological basis of these disorders
Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study
Objective: To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body
fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarkers in
patients with and without CA.
Background: Excess abdominal fat might facilitate progressive changes in nociceptive thresholds causing central
sensitization, clinically reflected as CA, which could drive migraine progression.
Methods: This prospective cohort study included 80 patients with migraine (mean age 39 years, 81.2% female) and
39 non-migraine controls. We analysed each participantâs height, body weight, and body mass index (BMI). The
amount and distribution of BF was also assessed by air displacement plethysmography (ADP) and ViScan,
respectively. We analysed serum levels of markers of inflammation, during interictal periods.
Results: We studied 52 patients with episodic migraine (EM) and 28 with chronic migraine (CM). Of the 80 patients,
53 (53.8%) had CA. Migraineurs with CA had a higher proportion of abdominal fat values than patients without CA
(p = 0.04). The independent risk factors for CA were the use of migraine prophylaxis (OR 3.26, 95% CI [1.14 to 9.32];
p = 0.03), proportion of abdominal fat (OR 1.13, 95% CI [1.01 to 1.27]; p = 0.04), and presence of sleep disorders (OR
1.13, 95% CI [00.01 to 1.27]; p = 0.04). The concordance correlation coefficient between the ADP and BMI
measurements was 0.51 (0.3681 to 0.6247). CA was not correlated with the mean plasma levels of inflammatory
biomarkers.
Conclusions: There is a relation between excess abdominal fat and CA. Abdominal obesity might contribute to the
development of central sensitization in migraineurs, leading to migraine chronification
Experiencia clĂnica del tratamiento con onabotulinumtoxin A en pacientes con migraĂąa refractaria
To analyse our experience in the treatment of refractory chronic migraine,
episodic frequent refractory migraine (>= 10 days/month), with onabotulinumtoxin
A (OnabotA). PATIENTS AND METHODS. Retrospective analysis of patients with
refractory migraine who underwent, at least two sessions of OnabotA pericranial
injections following the PREEMPT protocol between 2008 and 2012. The efficacy of
OnabotA was evaluated comparing the basal situation with 12-16 weeks after the
second session. We analysed the subjective improvement of the patients, number of
days with headache, preventive and abortive drugs consumption, and adverse
effects. RESULTS. Forty-one patients (37 women, 4 male) were identified. 65.8%
patients experienced subjective improvement after OnabotA treatment. 36.58%
responded (reduction of > 50% in headache days). Differences between days with
headache before the first session (24.5 +/- 7.3), and 12-16 weeks after the
second session (17.4 +/- 11.6), as well as the differences between the number of
abortive drugs taken before the first session (26.8 +/- 23.1) and 12-16 weeks
after the second session (16.7 +/- 19.3), were statistically significant (p <
0.001). Subgroups analysis showed that all differences were significant, except
for the reduction of the number of days with headache in patients with episodic
frequent refractory migraine. CONCLUSION. Our work shows that treatment with
OnabotA is safe and useful in patients with episodic and chronic refractory
migraine, including those patients with medication overuse headache
Star Formation Efficiencies at Giant Molecular Cloud Scales in the Molecular Disk of the Elliptical Galaxy NGC 5128 (Centaurus A)
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
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