A new look at the cosmic ray positron fraction

The positron fraction in cosmic rays was found to be a steadily increasing in function of energy, above $\sim$ 10 GeV. This behaviour contradicts standard astrophysical mechanisms, in which positrons are secondary particles, produced in the interactions of primary cosmic rays during the propagation in the interstellar medium. The observed anomaly in the positron fraction triggered a lot of excitement, as it could be interpreted as an indirect signature of the presence of dark matter species in the Galaxy. Alternatively, it could be produced by nearby astrophysical sources, such as pulsars. Both hypotheses are probed in this work in light of the latest AMS-02 positron fraction measurements. The transport of the primary and secondary positrons in the Galaxy is described using a semi-analytic two-zone model. MicrOMEGAs is used to model the positron flux generated by dark matter species. The description of the positron fraction from astrophysical sources is based on the pulsar observations included in the ATNF catalogue. We find that the mass of the favoured dark matter candidates is always larger than 500 GeV. The only dark matter species that fulfils the numerous gamma ray and cosmic microwave background bounds is a particle annihilating into four leptons through a light scalar or vector mediator, with a mixture of tau (75%) and electron (25%) channels, and a mass between 0.5 and 1 TeV. The positron anomaly can also be explained by a single astrophysical source and a list of five pulsars from the ATNF catalogue is given. Those results are obtained with the cosmic ray transport parameters that best fit the B/C ratio. Uncertainties in the propagation parameters turn out to be very significant. In the WIMP annihilation cross section to mass plane for instance, they overshadow the error contours derived from the positron data.Comment: 20 pages, 16 figures, accepted for publication in A&A, corresponds to published versio

Recent advances in nanocarrier-loaded gels: Which drug delivery technologies against which diseases?

The combination of pharmaceutical technologies can be a wise choice for developing innovative therapeutic strategies. The association of nanocarriers and gels provides new therapeutic possibilities due to the combined properties of the two technologies. Gels support the nanocarriers, localize their administration to the target tissue, and sustain their release. In addition to the properties afforded by the gel, nanocarriers can provide additional drug sustained release or different pharmacokinetic and biodistribution profiles than those from nanocarriers administered by the conventional route to improve the drug therapeutic index. This review focuses on recent (over the last ten years) in vivo data showing the advances and advantages of using nanocarrier-loaded gels. Liposomes, micelles, liquid and solid lipid nanocapsules, polymeric nanoparticles, dendrimers, and fullerenes are all nanotechnologies which have been recently assessed for medical applications, such as cancer therapy, the treatment of cutaneous and infectious diseases, anesthesia, the administration of antidepressants, and the treatment of unexpected diseases, such as alopecia

Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths

We review observations of several classes of neutron-star-powered outflows: pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe interacting directly with interstellar medium (ISM), and magnetar-powered outflows. We describe radio, X-ray, and gamma-ray observations of PWNe, focusing first on integrated spectral-energy distributions (SEDs) and global spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering array of morphologies, with jets, trails, and other structures. Several of the 23 so far identified magnetars show evidence for continuous or sporadic emission of material, sometimes associated with giant flares, and a few possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts and Blazars: Physics of Extreme Energy Release

Planck 2015 results. XIII. Cosmological parameters

We present results based on full-mission Planck observations of temperature and polarization anisotropies of the CMB. These data are consistent with the six-parameter inflationary LCDM cosmology. From the Planck temperature and lensing data, for this cosmology we find a Hubble constant, H0= (67.8 +/- 0.9) km/s/Mpc, a matter density parameter Omega_m = 0.308 +/- 0.012 and a scalar spectral index with n_s = 0.968 +/- 0.006. (We quote 68% errors on measured parameters and 95% limits on other parameters.) Combined with Planck temperature and lensing data, Planck LFI polarization measurements lead to a reionization optical depth of tau = 0.066 +/- 0.016. Combining Planck with other astrophysical data we find N_ eff = 3.15 +/- 0.23 for the effective number of relativistic degrees of freedom and the sum of neutrino masses is constrained to < 0.23 eV. Spatial curvature is found to be |Omega_K| < 0.005. For LCDM we find a limit on the tensor-to-scalar ratio of r <0.11 consistent with the B-mode constraints from an analysis of BICEP2, Keck Array, and Planck (BKP) data. Adding the BKP data leads to a tighter constraint of r < 0.09. We find no evidence for isocurvature perturbations or cosmic defects. The equation of state of dark energy is constrained to w = -1.006 +/- 0.045. Standard big bang nucleosynthesis predictions for the Planck LCDM cosmology are in excellent agreement with observations. We investigate annihilating dark matter and deviations from standard recombination, finding no evidence for new physics. The Planck results for base LCDM are in agreement with BAO data and with the JLA SNe sample. However the amplitude of the fluctuations is found to be higher than inferred from rich cluster counts and weak gravitational lensing. Apart from these tensions, the base LCDM cosmology provides an excellent description of the Planck CMB observations and many other astrophysical data sets

Dark matter and LHC: Complementarities and limitations

It is well known that dark matter density measurements, indirect and direct detection experiments, importantly complement the LHC in setting strong constraints on new physics scenarios. Yet, dark matter searches are subject to limitations which need to be considered for realistic analyses. For illustration, we explore the parameter space of the phenomenological MSSM and discuss the interplay of the constraints from dark matter searches and the LHC, and analyse the impact of the astrophysical uncertainties in some detail

Combined analysis of AMS-02 (Li,Be,B)/C, N/O,

Context. The Alpha Magnetic Spectrometer (AMS-02) measured several secondary-to-primary ratios enabling a detailed study of Galactic cosmic-ray transport. Aims. We constrain previously derived benchmark scenarios (based on AMS-02 B/C data only) using other secondary-to-primary ratios to test the universality of transport and the presence of a low-rigidity diffusion break. Methods. We use the 1D thin disc/thick halo propagation model of USINE

Robustness of dark matter constraints and interplay with collider searches for New Physics

Abstract We study the implications of dark matter searches, together with collider constraints, on the phenomenological MSSM with neutralino dark matter and focus on the consequences of the related uncertainties in some detail. We consider, inter alia, the latest results from AMS-02, Fermi-LAT and XENON1T. In particular, we examine the impact of the choice of the dark matter halo profile, as well as the propagation model for cosmic rays, for dark matter indirect detection and show that the constraints on the MSSM differ by one to two orders of magnitude depending on the astrophysical hypotheses. On the other hand, our limited knowledge of the local relic density in the vicinity of the Earth and the velocity of Earth in the dark matter halo leads to a factor 3 in the exclusion limits obtained by direct detection experiments. We identified the astrophysical models leading to the most conservative and the most stringent constraints and for each case studied the complementarities with the latest LHC measurements and limits from Higgs, SUSY and monojet searches. We show that combining all data from dark matter searches and colliders, a large fraction of our supersymmetric sample could be probed. Whereas the direct detection constraints are rather robust under the astrophysical assumptions, the uncertainties related to indirect detection can have an important impact on the number of the excluded points

Galactic halo size in the light of recent AMS-02 data

The vertical diffusive halo size of the Galaxy, $L$, is a key parameter for dark matter indirect searches. It can be better determined thanks to recent AMS-02 data. We set constraints on $L$ from Be/B and $^{10}$Be/Be data, and we performed a consistency check with positron data. We detail the dependence of Be/B and $^{10}$Be/Be on $L$ and forecast on which energy range better data would be helpful for future $L$ improvements. We used USINE v3.5 for the propagation of nuclei, and $e^+$ were calculated with the pinching method of Boudaud et al. (2017). The current AMS-02 Be/B ($\sim3\%$ precision) and ACE-CRIS $^{10}$Be/Be ($\sim 10\%$ precision) data bring similar and consistent constraints on $L$. The AMS-02 Be/B data alone constrain $L=5^{+3}_{-2}$~kpc at a 68\% confidence level (spanning different benchmark transport configurations), a range for which most models do not overproduce positrons. Future experiments need to deliver percent-level accuracy on $^{10}$Be/$^9$Be anywhere below 10 GV to further constrain $L$. Forthcoming AMS-02, HELIX, and PAMELA $^{10}$Be/$^9$Be results will further test and possibly tighten the limits derived here. Elemental ratios involving radioactive species with different lifetimes (e.g. Al/Mg and Cl/Ar) are also awaited to provide complementary and robuster constraints.Comment: 15 pages, 10 figures, 6 tables. Additional references and few clarifications (matches A&A accepted version