Synthesis and Reactivity of 6-Iodo-4H-3,1-Benzoxazin-4-one Towards Nitrogen Nucleophiles and Their Antimicrobial Activities

In attempt to find new pharmacological active molecules, we synthesized 6-iodo-4H-3,1-benzoxazin-4-one and allowed it to react with some nitrogen nucleophiles namely; hydroxylamine hydrochloride, hydrazine hydrate, fomamide, aliphatic amine, aromatic amines, aralkyl amine, different amino acids, heteryl amines, ethanolamine and sodium azide to afford annelated quinazolinone derivatives and other related systems. The synthesized compounds were characterized with the help of spectroscopic techniques including IR, 1H-NMR and Mass spectra. Also their antimicrobial activities were screened against different strains of bacteria and fungi. Keywords: 6-Iodo-4H-3,1-benzoxazin-4-one; quinazolinone derivatives;  nitrogen nucleophiles; antimicrobial activity

Synthesis, surface properties and biological activity of N,N,N-tris(hydroxymethyl)-2-oxo-2-(2-(2-(alkanoyloxy) ethoxy)ethoxy) ethanaminium chloride surfactants

A new series of some cationic surfactants were synthesized namely: 2-(2-(2-(dodecanoyloxy)ethoxy)ethoxy)-N,N,N-tris(hydroxymethyl)-2-oxoethanaminium (DDAC); N,N,N-tris(hydroxymethyl)-2-oxo-2-(2-(2-(tetradecanoyloxy) ethoxy)ethoxy) ethanaminium (TDAC) and N,N,N-tris(hydroxymethyl)-2-oxo-2-(2-(2-(hexadecanoyloxy)ethoxy)ethoxy)ethanaminium (HDAC). The chemical structures of the synthesized cationic surfactants were confirmed using FT-IR and 1H-NMR spectroscopies. The surface tension of the synthesized cationic surfactants was measured at 25, 40 and 55 °C. The surface parameters were determined from the surface tension measurements. The emulsification power and foaming power measurements showed the applicability of these surfactants in the oil field. The biological activity of the synthesized surfactants was measured against pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and fungi (Candida albicans and Aspergllus niger) using inhibition zone diameters. The obtained data revealed that the dodecanoate derivative (DDAC) has more antimicrobial activity against the investigated microorganisms than tetradecanoate and hexadecanoate derivatives (TDAC and HDAC)