63 research outputs found
LA COMPTABILITÉ ENVIRONNEMENTALE : UN OUTIL DE PRISE DE DÉCISION
International audienceNous présentons dans les pages qui suivent, un modèle de la comptabilité environnementale qui, nous l'espérons, aidera le dirigeant d'entreprise à gérer de façon plus éclairée les questions environnementales. Ce modèle regroupe trois composantes : l'identification des besoins d'information découlant de la gestion environnementale, le cycle de vie et la reddition de comptes. Le modèle proposé de la comptabilité environnementale vise à donner à l'entité des outils d'aide à la prise de décision et à l'amélioration de la performance facilitant ainsi la reddition de comptes en matière de gestion environnementale
LA COMPTABILITÉ ENVIRONNEMENTALE : UN OUTIL DE PRISE DE DÉCISION
Nous présentons dans les pages qui suivent, un modèle de la comptabilité environnementale qui, nous l'espérons, aidera le dirigeant d'entreprise à gérer de façon plus éclairée les questions environnementales. Ce modèle regroupe trois composantes : l'identification des besoins d'information découlant de la gestion environnementale, le cycle de vie et la reddition de comptes. Le modèle proposé de la comptabilité environnementale vise à donner à l'entité des outils d'aide à la prise de décision et à l'amélioration de la performance facilitant ainsi la reddition de comptes en matière de gestion environnementale.comptabilité environnementale; outil de prise de décision
La relation chômage-santé : une étude prospective. Présentation sommaire et premiers résultats d’une recherche
Les auteurs ont entrepris en 1984 une importante étude sur les multiples interrelations entre le chômage et la santé. La méthodologie retenue est prospective, longitudinale, avec groupe contrôle. Ils présentent d'abord une synthèse des travaux effectués puis exposent les résultats obtenus jusqu'à maintenant. Ces résultats vont dans le sens des quatre hypothèses posées a priori. Cependant, ces résultats ne sont pas définitifs. L'analyse se poursuit.In 1984, the authors undertook a major study on the multiple interrelations between unemployment and health. Tlie methodology in use is prospective, longitudinal, with a control group. Their presentation consists of a synthesis of work carried out so far followed by corresponding results. These results are in compliance with the four hypotheses developed through a priori reasoning. However, these results are not definitive. The analysis continues
Clocking the formation of today's largest galaxies: Wide field integral spectroscopy of Brightest Cluster Galaxies and their surroundings
The formation and evolution of local brightest cluster galaxies (BCGs) is
investigated by determining the stellar populations and dynamics from the
galaxy core, though the outskirts and into the intracluster light (ICL).
Integral spectroscopy of 23 BCGs observed out to 4 r_e is collected and high
signal-to-noise regions are identified. Stellar population synthesis codes are
used to determine the age, metallicity, velocity, and velocity dispersion of
stars within each region. The intracluster light (ICL) spectra are best modeled
with populations that are younger and less metal-rich than those of the BCG
cores. The average BCG core age of the sample is 13.3 2.8 Gyr and the
average metallicity is [Fe/H] = 0.30 0.09, whereas for the ICL the
average age is 9.23.5 Gyr and the average metallicity is [Fe/H] =
0.180.16. The velocity dispersion profile is seen to be rising or flat in
most of the sample (17/23), and those with rising values reach the value of the
host cluster's velocity dispersion in several cases. The most extended BCGs are
closest to the peak of the cluster's X-ray luminosity. The results are
consistent with the idea that the BCG cores and inner regions formed quickly
and long ago, with the outer regions and ICL forming more recently, and
continuing to assemble through minor merging. Any recent star formation in the
BCGs is a minor component, and is associated with the cluster cool core status.Comment: 22 pages, 21 figures, MNRAS, accepte
Detection of Batrachochytrium dendrobatidis in amphibians imported into the UK for the pet trade
There is increasing evidence that the global spread of the fungal pathogen Batrachochytrium dendrobatidis (Bd) has been facilitated by the international trade in amphibians. Bd was first detected in the UK in 2004, and has since been detected in multiple wild amphibian populations. Most amphibians imported into the UK for the pet trade from outside the European Union enter the country via Heathrow Animal Reception Centre (HARC), where Bd positive animals have been previously detected. Data on the volume, diversity and origin of imported amphibians were collected for 59 consignments arriving at HARC between November 2009 and June 2012, along with a surveillance study to investigate the prevalence of Bd in these animals. Forty three amphibian genera were recorded, originating from 12 countries. It was estimated that 5000 – 7000 amphibians are imported through HARC into the UK annually for the pet trade. Bd was detected in consignments from the USA and Tanzania, in six genera, resulting in an overall prevalence of 3.6%. This suggests that imported amphibians are a source of Bd within the international pet trade
Blunted hypertrophic response in old mouse muscle is associated with a lower satellite cell density and is not alleviated by resveratrol
Background
Sarcopenia contributes to the decreased quality of life in the older person. While resistance exercise is an effective measure to increase muscle mass and strength, the hypertrophic response may be blunted in old age.
Objectives
To determine 1) whether hypertrophy in the m. plantaris of old mice was blunted compared to adult and 2) whether this was related to a reduced satellite cell (SC) density and 3) how resveratrol affects hypertrophy in old mice.
Methods
In adult (7.5 months, n = 11), old (23.5 months, n = 10) and old-resveratrol-treated (n = 10) male C57BL/6J mice, hypertrophy of the left m. plantaris was induced by denervation of its synergists. The contralateral leg served as control.
Results
After six weeks, overload-induced myofiber hypertrophy and IIB–IIA shift in myofiber type composition were less pronounced in old than adult mice (P = 0.03), irrespective of resveratrol treatment. Muscles from old mice had a lower SC density than adult muscles (P = 0.002). Overload-induced SC proliferation (P < 0.05) resulted in an increased SC density in old, but not adult muscles (P = 0.02), while a decrease occurred after resveratrol supplementation (P = 0.044). Id2 and myogenin protein expression levels were higher in old than adult muscles (P < 0.05). Caspase-3 was expressed more in hypertrophied than control muscles and was reduced with resveratrol (P < 0.05).
Conclusion
The blunted hypertrophic response in old mice was associated with a lower SC density, but there was no evidence for a lower capacity for proliferation. Resveratrol did not rescue the hypertrophic response and even reduced, rather than increased, the number of SCs in hypertrophied muscles
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Handicapped student services : a multi-media presentation
There is no abstract available for this creative project.Thesis (M.A.
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