What light does Matthew’s use of Mark in Matthew 1–4 throw on Matthew’s theological location?

This article approaches the issue of Matthew’s theological context by examining Matthew’s use of Mark, including through redaction and supplementation, in Matthew 1–4. This is undertaken in two parts: Matthew 1–2, which is largely additional material, and Matthew 3–4, followed by a concluding assessment. Issues addressed or alluded to in these chapters frequently find resonance in the remainder of Matthew’s gospel and so give important clues about Matthew’s concerns and their relevance for understanding its context. Such issues include the importance of messiahship; continuity with Israel, but also with John the Baptist and the Church; defence against slander; heightened christological claims; soteriology; Gentile mission; the status of Torah; and Jesus as judge to come. The article suggests a location within a Jewish religious context with a Jewish self-understanding, separate from the synagogue, but claiming to belong where its opponents would claim it did not; and a Christian tradition where the approach of ‘Q’ to Torah is upheld in contrast to Mark’s, while embracing and expanding Mark’s Christology and restoring the common understanding of Gentile mission as a post- Easter phenomenon

Same-sex relationships : a 1st-century perspective

Read in the light of other Jewish literature of the time, not least, Philo of Alexandria, Paul’s comments in Romans 1 about same-sex relations should be seen as a rhetorical ploy to gain a sympathetic hearing for his argument from the Roman recipients of his letter by appealing to common ground in deploring the sins of the Gentile world before turning to challenge them about the fact that all have sinned, and so need the good news of God’s righteousness revealed in Christ. Typically Paul’s focus is not just acts, but attitude and misdirected passions, which he sees as the result of misdirected and perverted understandings of God. Based on the Genesis creation stories, Paul assumes that all people are heterosexual and that the prohibitions of Leviticus should apply also to lesbian relations. Where these assumptions are not shared, Paul’s conclusions must be revisited in the light of informed compassion and responsible ethical insight.http://www.hts.org.zaam201

Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis.

To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response

The Safe Lambda Calculus

Safety is a syntactic condition of higher-order grammars that constrains occurrences of variables in the production rules according to their type-theoretic order. In this paper, we introduce the safe lambda calculus, which is obtained by transposing (and generalizing) the safety condition to the setting of the simply-typed lambda calculus. In contrast to the original definition of safety, our calculus does not constrain types (to be homogeneous). We show that in the safe lambda calculus, there is no need to rename bound variables when performing substitution, as variable capture is guaranteed not to happen. We also propose an adequate notion of beta-reduction that preserves safety. In the same vein as Schwichtenberg's 1976 characterization of the simply-typed lambda calculus, we show that the numeric functions representable in the safe lambda calculus are exactly the multivariate polynomials; thus conditional is not definable. We also give a characterization of representable word functions. We then study the complexity of deciding beta-eta equality of two safe simply-typed terms and show that this problem is PSPACE-hard. Finally we give a game-semantic analysis of safety: We show that safe terms are denoted by `P-incrementally justified strategies'. Consequently pointers in the game semantics of safe lambda-terms are only necessary from order 4 onwards

Sarcoendoplasmic Reticulum Ca2+ ATPase. A Critical Target in Chlorine Inhalation–Induced Cardiotoxicity

Autopsy specimens from human victims or experimental animals that die due to acute chlorine gas exposure present features of cardiovascular pathology. We demonstrate acute chlorine inhalation–induced reduction in heart rate and oxygen saturation in rats. Chlorine inhalation elevated chlorine reactants, such as chlorotyrosine and chloramine, in blood plasma. Using heart tissue and primary cardiomyocytes, we demonstrated that acute high-concentration chlorine exposure in vivo (500 ppm for 30 min) caused decreased total ATP content and loss of sarcoendoplasmic reticulum calcium ATPase (SERCA) activity. Loss of SERCA activity was attributed to chlorination of tyrosine residues and oxidation of an important cysteine residue, cysteine-674, in SERCA, as demonstrated by immunoblots and mass spectrometry. Using cardiomyocytes, we found that chlorine-induced cell death and damage to SERCA could be decreased by thiocyanate, an important biological antioxidant, and by genetic SERCA2 overexpression. We also investigated a U.S. Food and Drug Administration–approved drug, ranolazine, used in treatment of cardiac diseases, and previously shown to stabilize SERCA in animal models of ischemia–reperfusion. Pretreatment with ranolazine or istaroxime, another SERCA activator, prevented chlorine-induced cardiomyocyte death. Further investigation of responsible mechanisms showed that ranolazine- and istaroxime-treated cells preserved mitochondrial membrane potential and ATP after chlorine exposure. Thus, these studies demonstrate a novel critical target for chlorine in the heart and identify potentially useful therapies to mitigate toxicity of acute chlorine exposure.This work was supported by the CounterACT Program, National Institutes of Health, Office of the Director, and the National Institute of Environmental Health Sciences grant U54 ES015678 (C.W.W.), and by Children’s Hospital of Colorado/Colorado School of Mines Pilot Award G0100394 and a Children’s Hospital of Colorado Research Institute’s Pilot Award (S.A.)

Arctic hydroclimate variability during the last 2000 years: current understanding and research challenges

Reanalysis data show an increasing trend in Arctic precipitation over the 20th century, but changes are not homogenous across seasons or space. The observed hydroclimate changes are expected to continue and possibly accelerate in the coming century, not only affecting pan-Arctic natural ecosystems and human activities, but also lower latitudes through the atmospheric and ocean circulations. However, a lack of spatiotemporal observational data makes reliable quantification of Arctic hydroclimate change difficult, especially in a long-term context. To understand Arctic hydroclimate and its variability prior to the instrumental record, climate proxy records are needed. The purpose of this review is to summarise the current understanding of Arctic hydroclimate during the past 2000 years. First, the paper reviews the main natural archives and proxies used to infer past hydroclimate variations in this remote region and outlines the difficulty of disentangling the moisture from the temperature signal in these records. Second, a comparison of two sets of hydroclimate records covering the Common Era from two data-rich regions, North America and Fennoscandia, reveals inter- and intra-regional differences. Third, building on earlier work, this paper shows the potential for providing a high-resolution hydroclimate reconstruction for the Arctic and a comparison with last-millennium simulations from fully coupled climate models. In general, hydroclimate proxies and simulations indicate that the Medieval Climate Anomaly tends to have been wetter than the Little Ice Age (LIA), but there are large regional differences. However, the regional coverage of the proxy data is inadequate, with distinct data gaps in most of Eurasia and parts of North America, making robust assessments for the whole Arctic impossible at present. To fully assess pan-Arctic hydroclimate variability for the last 2 millennia, additional proxy records are required.</p

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Global Boundary Stratotype Section and Point (GSSP) for the Anthropocene Series: Where and how to look for potential candidates

International audienc

Social Justice and Gender

This article examines the impact of the widespread pattern of unequal age at marriage which led men to conclude that not only were their wives less experienced and mature, they were also inferior by nature. It examines the ideological underpinning for the view of women’s inferiority in Plato and the Genesis creation stories, especially in their Greek translation. It then traces the way this value system found expression in the traditional allocation of gender roles, women taking responsibility for the internal affairs of the household and men for the external affairs, including public discourse. There were exceptions both within Judaism and within the early Christian movement. These and the egalitarian thoughts in Christian beginnings had the potential to subvert these norms, over time, but a long time