Improvement of manufacturing technologies through a modelling approach: an air-steam sterilization case-study

Abstract A milestone of Industry 4.0 is the improvement of the design procedures requiring models of complex processes. Models can be used to simulate the process, being accurate even if complex, and to predict process behaviour for control action, requiring simplicity and stability. In the last years, machine learning approaches came up alongside of the standard identification techniques for prediction purposes. In this work we propose two models of an industrial autoclave to describe the evolution of temperature and pressure. The first model (PhM) involves a physical structure with data-driven adaptation of the parameters, the second one is a Long Short-Term Memory network (LSTM), trained ensuring Input-to-State stability. Both models obtained good performance: FIT of 94.26% (91.55%) for the temperature (pressure) with PhM; 84.59% (78.31 %) for the temperature (pressure) with the LSTM. Future developments involve the synthesis of an MPC based on the LSTM to be tested in simulation via PhM

Active deformation in old oceanic lithosphere and significance for earthquake hazard: Seismic imaging of the Coral Patch Ridge area and neighboring abyssal plains (SW Iberian Margin)

Martínez-Loriente, S. ... et al.-- 26 pages, 13 figures, 1 tableRecently acquired high-resolution multichannel seismic profiles together with bathymetric and sub-bottom profiler data from the external part of the Gulf of Cadiz (Iberia-Africa plate boundary) reveal active deformation involving old (Mesozoic) oceanic lithosphere. This area is located 180 km offshore the SW Iberian Peninsula and embraces the prominent NE-SW trending Coral Patch Ridge, and part of the surrounding deep Horseshoe and Seine abyssal plains. E-W trending dextral strike-slip faults showing surface deformation of flower-like structures predominate in the Horseshoe Abyssal Plain, whereas NE-SW trending compressive structures prevail in the Coral Patch Ridge and Seine Hills. Although the Coral Patch Ridge region is characterized by subdued seismic activity, the area is not free from seismic hazard. Most of the newly mapped faults correspond to active blind thrusts and strike-slip faults that are able to generate large magnitude earthquakes (Mw 7.2-8.4). This may represent a significant earthquake and tsunami hazard that has been overlooked so far. Key Points New active structures have been mapped in the Coral Patch Ridge area The newly mapped faults are able to generate large magnitude earthquakes (Mw>7) These new structures may represent a significant earthquake and tsunami hazard ©2013. American Geophysical Union. All Rights ReservedThe authors acknowledge the support of the Spanish Ministry of Science and Innovation (MICINN) through National Projects EVENT (CGL2006–12861-C02-02) and SHAKE (CGL2011–30005-C02-02); the European Transnational Access SALVADORE program of the EU (RITA-CT-2004–505322), the ESF EuroMargins SWIM project (01- LEG-EMA09F and REN2002–11234E-MAR), the EU program ‘‘Global Change and Ecosystems’’ contract n. 037110 (NEAREST), the ESF TopoEurope TOPOMED project (CGL2008–03474-E/BTE), and the SWIMGLO project (PTDC/MAR/100522/2008). We also acknowledge funding from the MICINN through the ‘‘Ramon y Cajal’’ program (R. Bartolome) and from the CSIC through a JAE Pre-Doc fellowship (S. Martínez-Loriente)Peer Reviewe

A tribute to Marie Tharp: Mapping the seafloor of back-arc basins, mid-ocean ridges, continental margins and plate boundaries

European Geosciences Union (EGU) General Assembly 2020, 4-8 May 2020Marie Tharp (1920-2006) was a pioneer of modern oceanography. She was an American geologist and oceanographic cartographer who, together with his husband Bruce Heezen, generated the first bathymetric map of the Atlantic Ocean floor. Tharp's work revealed the detailed topography and geological landscape of the seafloor. Her work revealed the presence of a continuous rift valley along the Mid-Atlantic Ridge axis, causing a paradigm in earth sciences that led to the acceptance of plate tectonics and continental drift theories. Piecing maps together in the late 1940s and early 1950s, Marie and his partner Bruce Heezen discovered the 75.000 km underwater ridge bounding around the globe. By this finding, they laid the conclusion from geophysical data that the seafloor spreads from mid-ocean ridges and that continents are in motion with respect to one another¿a revolutionary geological theory at that time. Many years later, satellite images demonstrate that Tharp¿s maps were accurate. In this contribution, we focus on detailed bathymetric maps collected from year 1992 to today, which include bathymetric maps from diverse parts of the world. For instance, we will show a) Back-arc basins (i.e. the Bransfield Basin, Antarctica; and the North Fiji Basin, SW Pacific); b) Mid-ocean ridges and fracture zones (i.e. the MAR at the South of Azores, the MAR at the Oceanographer-Hayes, and the St. Paul Fracture Zone at the Equator), and c) Active tectonic structures from the Gulf of Cadiz and Alboran Sea, located at the Africa-Eurasia plate boundary (Gibraltar Arc). Regarding this last area, we will characterize the seafloor expression of the fault systems, as well as the subsurface structure of the faults in the Gulf of Cadiz and Alboran Sea. This zone is characterized by a moderate seismicity, mainly reverse and strike-slip focal mechanisms; although large historical (AD1755, AD1829) and instrumental earthquakes or large/great magnitude also occurred, such as the earthquakes of 1969, 1994, 2004 and 2016. In addition, the Gulf of Cadiz-Alboran Sea area is compartmentalized in different crustal domains, bounded by active strike-slip fault systems. We adopted a multi-scale approach, including morphological analysis of shipboard multibeam bathymetry, near-bottom bathymetry obtained with Autonomous Underwater Vehicles (AUVs) at a resolution of 1-2 m, and medium to deep penetration multi-channel seismic (MCS) data. Finally, we will also show a couple of videos from recent marine cruises in the Gibraltar Arc (SHAKE-2015 and INSIGHT-2018), both using state-of-the-art high-resolution marine technologie

Seabed mapping in the Pelagie Islands marine protected area (Sicily Channel, southern Mediterranean) using Remote Sensing Object Based Image Analysis (RSOBIA)

In this paper we present the seabed maps of the shallow-water areas of Lampedusa and Linosa, belonging to the Pelagie Islands Marine Protected Area. Two surveys were carried out (“Lampedusa 2015” and “Linosa 2016”) to collect bathymetric and acoustic backscatter data through the use of a Reson SeaBat 7125 high-resolution multibeam system. Ground-truth data, in the form of grab samples and diver video-observations, were also collected during both surveys. Sediment samples were analyzed for grain size, while video images were analyzed and described revealing the acoustic seabed and other bio-physical characteristics. A map of seabed classification, including sediment types and seagrass distribution, was produced using the tool Remote Sensing Object Based Image Analysis (RSOBIA) by integrating information derived from backscatter data and bathy-morphological features, validated by ground-truth data. This allows to create a first seabed maps (i.e. benthoscape classification), of Lampedusa and Linosa, at scale 1:20 000 and 1:32 000, respectively, that will be checked and implemented through further surveys. The results point out a very rich and largely variable marine ecosystem on the seabed surrounding the two islands, with the occurrence of priority habitats, and will be of support for a more comprehensive maritime spatial planning of the Marine Protected Area

Compressional tectonic inversion of the Algero-Balearic basin: Latemost Miocene to present oblique convergence at the Palomares margin (Western Mediterranean)

Interpretation of new multichannel seismic reflection profiles indicates that the Palomares margin was formed by crustal-scale extension and coeval magmatic accretion during middle to late Miocene opening of the Algero-Balearic basin. The margin formed at the transition between thinned continental crust intruded by arc volcanism and back-arc oceanic crust. Deformation produced during the later positive inversion of the margin offshore and onshore is partitioned between ~N50°E striking reverse faults and associated folds like the Sierra Cabrera and Abubacer anticlines and N10–20°E sinistral strike-slip faults like Palomares and Terreros faults. Parametric subbottom profiles and multibeam bathymetry offshore, structural analysis, available GPS geodetic displacement data, and earthquake focal mechanisms jointly indicate that tectonic inversion of the Palomares margin is currently active. The Palomares margin shows a structural pattern comparable to the north Maghrebian margins where Africa-Eurasia plate convergence is accommodated by NE-SW reverse faults, NNW-SSE sinistral faults, and WNW-ESE dextral ones. Contractive structures at this margin contribute to the general inversion of the Western Mediterranean since ~7 Ma, coeval to inversion at the Algerian margin. Shortening at the Alboran ridge and Al-Idrisi faults occurred later, since 5 Ma, indicating a westward propagation of the compressional inversion of the Western Mediterranean

Tectonic evolution, geomorphology and influence of bottom currents along a large submarine canyon system: The São Vicente Canyon (SW Iberian margin)

A multi-scale dataset consisting of multi-beam echo-sounder, 2D multi-channel seismic and sidescan sonar (TOBI) data allows us to identify a large variety of morphologies originating from sedimentary and tectonic processes along the São Vicente Canyon (SVC), which is the largest submarine canyon developed in the external part of the Gulf of Cadiz. The SVC is located in one of the most seismogenic areas of Western Europe. The convergence between the Eurasian and African plates has controlled the formation and evolution of the canyon. The SVC is tectonically controlled by three main thrust faults: the Marquês de Pombal Fault, the São Vicente Fault and the Horseshoe Fault. No major rivers feed sediment to the canyon head, but the main sediment source is related to the dismantling of canyon flanks and the MOW (Mediterranean Overflow Water). This current contributes sediments by two different processes: a) conturites deposition at the head and flanks of the SVC that periodically fail into the canyon; and b) the coarser-grained and denser sediment of the MOW might be trapped at the head of the canyon and could develops into hyperpycnal flows. The SVC is characterized by retrogressive erosion being submarine landslide deposits and scars the main seafloor morphologies. The tectonic and stratigraphic interpretation of seismic profiles indicate that the SVC is a clear example of a diachronous and segmented canyon developed since the Late Miocene in an area of present-day active plate tectonics. This study investigates the interaction between active tectonics, the dynamics of submarine canyons and the resulting geomorphologies

Geohazard features of the north-western Sicily and Pantelleria

9 pages, 3 figures, supplemental material https://doi.org/10.1080/17445647.2024.2342931.-- Data availability statement: Department of Earth and Marine Science of the University of Palermo for institutional purposes, so their access will be available by contacting the reference people (attilio.sulliunipa.it) upon reasonable requestWe present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013. These seafloor features were recognized using high-resolution bathymetry data and rely on the morphological expression of the seafloor and shallow sub-surface processes. The north-western Sicily is a complex continental margin, affected by morphodynamic, depositional, and tectonic processes. The Egadi offshore is controlled by fault escarpments and alternating retreating and progradational processes. Ustica and Pantelleria submerged edifices show the effect of volcanic activity. The Ustica seafloor is interested in volcanic, tectonic, and gravitational instability processes, while the Pantelleria offshore underwent erosive-depositional processes and the effect of bottom currents. Two levels of interpretation are represented: the physiographic domain at a scale of 1:250.000 and the morphological units and morpho-bathymetric elements at a 1:100.000 scaleThe Magic Project has been funded by the Italian Civil Protection Department. [...] With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry

: To characterize clinical and laboratory signs of patients with still's disease experiencing macrophage activation syndrome (MAS) and identify factors associated with MAS development. patients with still's disease classified according to internationally accepted criteria were enrolled in the autoInflammatory disease alliance (AIDA) still's disease registry. clinical and laboratory features observed during the inflammatory attack complicated by MAS were included in univariate and multivariate logistic regression analysis to identify factors associated to MAS development. A total of 414 patients with Still's disease were included; 39 (9.4%) of them developed MAS during clinical history. At univariate analyses, the following variables were significantly associated with MAS: classification of arthritis based on the number of joints involved (p = 0.003), liver involvement (p = 0.04), hepatomegaly (p = 0.02), hepatic failure (p = 0.01), axillary lymphadenopathy (p = 0.04), pneumonia (p = 0.03), acute respiratory distress syndrome (p < 0.001), platelet abnormalities (p < 0.001), high serum ferritin levels (p = 0.009), abnormal liver function tests (p = 0.009), hypoalbuminemia (p = 0.002), increased LDH (p = 0.001), and LDH serum levels (p < 0.001). at multivariate analysis, hepatomegaly (OR 8.7, 95% CI 1.9-52.6, p = 0.007) and monoarthritis (OR 15.8, 95% CI 2.9-97.1, p = 0.001), were directly associated with MAS, while the decade of life at Still's disease onset (OR 0.6, 95% CI 0.4-0.9, p = 0.045), a normal platelet count (OR 0.1, 95% CI 0.01-0.8, p = 0.034) or thrombocytosis (OR 0.01, 95% CI 0.0-0.2, p = 0.008) resulted to be protective. clinical and laboratory factors associated with MAS development have been identified in a large cohort of patients based on real-life data

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication