84 research outputs found
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole-genome sequencing to perform an unbiased comprehensive screen to discover the somatic mutations in a sample from an individual with sAML and genotyped the loci containing these mutations in the matched MDS sample. Here we show that a missense mutation affecting the serine at codon 34 (Ser34) in U2AF1 was recurrently present in 13 out of 150 (8.7%) subjects with de novo MDS, and we found suggestive evidence of an increased risk of progression to sAML associated with this mutation. U2AF1 is a U2 auxiliary factor protein that recognizes the AG splice acceptor dinucleotide at the 3' end of introns, and the alterations in U2AF1 are located in highly conserved zinc fingers of this protein. Mutant U2AF1 promotes enhanced splicing and exon skipping in reporter assays in vitro. This previously unidentified, recurrent mutation in U2AF1 implicates altered pre-mRNA splicing as a potential mechanism for MDS pathogenesis
First Observation of Coherent Production in Neutrino Nucleus Interactions with 2 GeV
The MiniBooNE experiment at Fermilab has amassed the largest sample to date
of s produced in neutral current (NC) neutrino-nucleus interactions at
low energy. This paper reports a measurement of the momentum distribution of
s produced in mineral oil (CH) and the first observation of coherent
production below 2 GeV. In the forward direction, the yield of events
observed above the expectation for resonant production is attributed primarily
to coherent production off carbon, but may also include a small contribution
from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino
flux, the sum of the NC coherent and diffractive modes is found to be (19.5
1.1 (stat) 2.5 (sys))% of all exclusive NC production at
MiniBooNE. These measurements are of immediate utility because they quantify an
important background to MiniBooNE's search for
oscillations.Comment: Submitted to Phys. Lett.
'Education, education, education' : legal, moral and clinical
This article brings together Professor Donald Nicolson's intellectual interest in professional legal ethics and his long-standing involvement with law clinics both as an advisor at the University of Cape Town and Director of the University of Bristol Law Clinic and the University of Strathclyde Law Clinic. In this article he looks at how legal education may help start this process of character development, arguing that the best means is through student involvement in voluntary law clinics. And here he builds upon his recent article which argues for voluntary, community service oriented law clinics over those which emphasise the education of students
Model-independent search for CP violation in D0âKâK+ÏâÏ+ and D0âÏâÏ+Ï+Ïâ decays
A search for CP violation in the phase-space structures of D0 and View the MathML source decays to the final states KâK+ÏâÏ+ and ÏâÏ+Ï+Ïâ is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0 fbâ1 collected in 2011 by the LHCb experiment in pp collisions at a centre-of-mass energy of 7 TeV. For the KâK+ÏâÏ+ final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the ÏâÏ+Ï+Ïâ final state is partitioned into 128 bins, each bin with approximately 2500 decays. The p-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity
Test of Lorentz and CPT violation with Short Baseline Neutrino Oscillation Excesses
The sidereal time dependence of MiniBooNE electron neutrino and anti-electron
neutrino appearance data are analyzed to search for evidence of Lorentz and CPT
violation. An unbinned Kolmogorov-Smirnov test shows both the electron neutrino
and anti-electron neutrino appearance data are compatible with the null
sidereal variation hypothesis to more than 5%. Using an unbinned likelihood fit
with a Lorentz-violating oscillation model derived from the Standard Model
Extension (SME) to describe any excess events over background, we find that the
electron neutrino appearance data prefer a sidereal time-independent solution,
and the anti-electron neutrino appearance data slightly prefer a sidereal
time-dependent solution. Limits of order 10E-20 GeV are placed on combinations
of SME coefficients. These limits give the best limits on certain SME
coefficients for muon neutrino to electron neutrino and anti-muon neutrino to
anti-electron neutrino oscillations. The fit values and limits of combinations
of SME coefficients are provided.Comment: 14 pages, 3 figures, and 2 tables, submitted to Physics Letters
Search for violation in the phase space of decays
A search for time-integrated violation in the Cabibbo-suppressed decay
\mbox{D^0\rightarrow\pi^+\pi^-\pi^+\pi^-} is performed using an unbinned,
model-independent technique known as the energy test. This is the first
application of the energy test in four-body decays. The search is performed for
-even asymmetries and, for the first time, is extended to probe the
-odd case. Using proton-proton collision data corresponding to an integrated
luminosity of 3.0 fb collected by the LHCb detector at centre-of-mass
energies of 7 TeV and 8 TeV, the world's best sensitivity to
violation in this decay is obtained. The data are found to be consistent with
the hypothesis of symmetry with a -value of in the
-even case, and marginally consistent with a -value of in
the -odd case, corresponding to a significance for non-conservation of
2.7 standard deviations.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-044.htm
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