Estimated IR and phosphorescence emission fluxes for specific Polycyclic Aromatic Hydrocarbons in the Red Rectangle

Following the tentative identification of the blue luminescence in the Red Rectangle by Vijh et al. (2005), we compute absolute fluxes for the vibrational IR emission and phosphorescence bands of three small polycyclic aromatic hydrocarbons. The calculated IR spectra are compared with available ISO observations. A subset of the emission bands are predicted to be observable using presently available facilities, and can be used for an immediate, independent, discriminating test on their alleged presence in this well-known astronomical object.Comment: accepted for publication on A&

Post-starburst galaxies: more than just an interesting curiosity

From the VIMOS VLT DEEP Survey (VVDS) we select a sample of 16 galaxies with spectra which identify them as having recently undergone a strong starburst and subsequent fast quenching of star formation. These post-starburst galaxies lie in the redshift range 0.510^9.75Msun. They have a number density of 1x10^-4 per Mpc^3, almost two orders of magnitude sparser than the full galaxy population with the same mass limit. We compare with simulations to show that the galaxies are consistent with being the descendants of gas rich major mergers. Starburst mass fractions must be larger than ~5-10% and decay times shorter than ~10^8 years for post-starburst spectral signatures to be observed in the simulations. We find that the presence of black hole feedback does not greatly affect the evolution of the simulated merger remnants through the post-starburst phase. The multiwavelength spectral energy distributions of the post-starburst galaxies show that 5/16 have completely ceased the formation of new stars. These 5 galaxies correspond to a mass flux entering the red-sequence of rhodot(A->Q, PSB) = 0.0038Msun/Mpc^3/yr, assuming the defining spectroscopic features are detectable for 0.35Gyr. If the galaxies subsequently remain on the red sequence, this accounts for 38(+4/-11)% of the growth rate of the red sequence. Finally, we compare our high redshift results with a sample of galaxies with 0.05<z<0.1 observed in the SDSS and UKIDSS surveys. We find a very strong redshift evolution: the mass density of strong post-starburst galaxies is 230 times lower at z~0.07 than at z~0.7.Comment: 18 pages, 12 figures, to match version accepted to MNRAS. Minor reordering of text in places and Sec 2.2 on SPH simulation comparisons expande

Non-equilibrium transitions in fully frustrated Josephson junction arrays

We study the effect of thermal fluctuations in a fully frustrated Josephson junction array driven by a current I larger than the apparent critical current I_c(T). We calculate numerically the behavior of the chiral order parameter of Z_2 symmetry and the transverse helicity modulus (related to the U(1) symmetry) as a function of temperature. We find that the Z_2 transition occurs at a temperature T_{Z_2}(I) which is lower than the temperature T_{U(1)}(I) for the U(1) transition. Both transitions could be observed experimentally from measurements of the longitudinal and transverse voltages.Comment: 4 pages, 4 figure

Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells

Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of human skin with these appendages would be beneficial, but is challenging. Here, we describe a detailed protocol for generating hair-bearing skin tissue entirely from a homogeneous population of human pluripotent stem cells in a three-dimensional in vitro culture system. Defined culture conditions are used over a 2-week period to induce differentiation of pluripotent stem cells to surface ectoderm and cranial neural crest cells, which give rise to the epidermis and dermis, respectively, in each organoid unit. After 60 d of incubation, the skin organoids produce hair follicles. By day similar to 130, the skin organoids reach full complexity and contain stratified skin layers, pigmented hair follicles, sebaceous glands, Merkel cells and sensory neurons, recapitulating the cell composition and architecture of fetal skin tissue at week 18 of gestation. Skin organoids can be maintained in culture using this protocol for up to 150 d, enabling the organoids to be used to investigate basic skin biology, model disease and, further, reconstruct or regenerate skin tissue.Disorders of the head and nec

Multiorder coherent Raman scattering of a quantum probe field

We study the multiorder coherent Raman scattering of a quantum probe field in a far-off-resonance medium with a prepared coherence. Under the conditions of negligible dispersion and limited bandwidth, we derive a Bessel-function solution for the sideband field operators. We analytically and numerically calculate various quantum statistical characteristics of the sideband fields. We show that the multiorder coherent Raman process can replicate the statistical properties of a single-mode quantum probe field into a broad comb of generated Raman sidebands. We also study the mixing and modulation of photon statistical properties in the case of two-mode input. We show that the prepared Raman coherence and the medium length can be used as control parameters to switch a sideband field from one type of photon statistics to another type, or from a non-squeezed state to a squeezed state and vice versa.Comment: 12 pages, 7 figures, to be published in Phys. Rev.

Quantifying the burden of rhodesiense sleeping sickness in Urambo district, Tanzania

Sleeping sickness (human African trypanosomiasis - HAT) is a disease transmitted by tsetse flies and is always fatal if left untreated. The disease occurs in foci affecting poor communities with limited access to health service provision and as such the disease is often left undiagnosed, mistaken for more common afflictions. Even if diagnosed, sleeping sickness is costly to treat, both for health services and patients and their families in terms of costs of diagnosis, transport, hospital care, and the prolonged period of convalescence. Here we estimate the health burden of the acute form T. b. rhodesiense sleeping sickness in Urambo District, Tanzania in terms of Disability Adjusted Life Years (DALYs), the yardstick commonly used by policy makers to prioritize disease management practices, representing a year of healthy life lost to disease. In this single district, the burden of the disease over one year was estimated at 979 DALYs and the estimated monetary costs to health services for the 143 treated patients at US$11,841 and to the patients themselves at US$ 3,673 for direct medical costs and US$ 9,781 for indirect non-medical costs. Sleeping sickness thus places a considerable burden on the affected rural communities and health services

Melting and transverse depinning of driven vortex lattices in the periodic pinning of Josephson junction arrays

We study the non-equilibrium dynamical regimes of a moving vortex lattice in the periodic pinning of a Josephson junction array (JJA) for {\it finite temperatures} in the case of a fractional or submatching field. We obtain a phase diagram for the current driven JJA as a function of the driving current I and temperature T. We find that when the vortex lattice is driven by a current, the depinning transition at $T_p(I)$ and the melting transition at $T_M(I)$ become separated even for a field for which they coincide in equilibrium. We also distinguish between the depinning of the vortex lattice in the direction of the current drive, and the {\it transverse depinning} in the direction perpendicular to the drive. The transverse depinning corresponds to the onset of transverse resistance in a moving vortex lattice at a given temperature $T_{tr}$. For driving currents above the critical current we find that the moving vortex lattice has first a transverse depinning transition at low T, and later a melting transition at a higher temperature, $T_{M}>T_{tr}$.Comment: 17 pages, 19 figure

A Measurement of the Interference Structure Function, R_LT, for the 12C(e,e'p) reaction in the Quasielastic Region

The coincidence cross-section and the interference structure function, R_LT, were measured for the 12C(e,e'p) 11B reaction at quasielastic kinematics and central momentum transfer of q=400 MeV/c. The measurement was at an opening angle of theta_pq=11 degrees, covering a range in missing energy of E_m = 0 to 65 MeV. The R_LT structure function is found to be consistent with zero for E_m > 50 MeV, confirming an earlier study which indicated that R_L vanishes in this region. The integrated strengths of the p- and s-shell are compared with a Distorted Wave Impulse Approximation calculation. The s-shell strength and shape are compared with a Hartree Fock-Random Phase Approximation calculation. The DWIA calculation overestimates the cross sections for p- and s-shell proton knockout as expected, but surprisingly agrees with the extracted R_LT value for both shells. The HF-RPA calculation describes the data more consistently, which may be due to the inclusion of 2-body currents in this calculation.Comment: 8 Pages LaTex, 5 postscript figures. Submitted to Phys. Rev.

Thermally Triggered Hydrogel Injection Into Bovine Intervertebral Disc Tissue Explants Induces Differentiation Of Mesenchymal Stem Cells And Restores Mechanical Function.

We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into collagenase digested bovine discs filled micro and macro fissures, were maintained within the disc during loading and restored IVD stiffness. The mechanical support of the L-pNIPAM-co-DMAc hydrogel, to restore disc height, could provide immediate symptomatic pain relief, whilst the delivery of MSCs over time regenerates the NP extracellular matrix; thus the L-pNIPAM-co-DMAc hydrogel could provide a combined cellular and mechanical repair approach

The Strange Quark Mass From Flavor Breaking in Hadronic Tau Decays

The strange quark mass is extracted from a finite energy sum rule (FESR) analysis of the flavor-breaking difference of light-light and light-strange quark vector-plus-axial-vector correlators, using spectral functions determined from hadronic tau decay data. We point out problems for existing FESR treatments associated with potentially slow convergence of the perturbative series for the mass-dependent terms in the OPE over certain parts of the FESR contour, and show how to construct alternate weight choices which not only cure this problem, but also (1) considerably improve the convergence of the integrated perturbative series, (2) strongly suppress contributions from the region of s values where the errors on the strange current spectral function are still large and (3) essentially completely remove uncertainties associated with the subtraction of longitudinal contributions to the experimental decay distributions. The result is an extraction of m_s with statistical errors comparable to those associated with the current experimental uncertainties in the determination of the CKM angle, V_{us}. We find m_s(1 GeV)=158.6\pm 18.7\pm 16.3\pm 13.3 MeV (where the first error is statistical, the second due to that on V_{us}, and the third theoretical).Comment: 13 pages, 2 figures; final version to appear in Phys. Rev. D; expanded versions of Figure 2 and Reference 3