588 research outputs found
The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
- Author
- A Ationu
- A Kurniawan
- A Kurniawan-Atmadja
- AA Cortes-Figueroa
- AA Da'dara
- AG Tielens
- Agnes Kurniawan
- AM Lambeir
- AP Yatsuda
- AR Singh
- AS Schneider
- C Bandi
- CL Cass
- DA Denham
- DA Harn
- DA Kuntz
- Dominik Rückerl
- DW Banner
- E Ghedin
- E Ghedin
- E Pearlman
- E Sartono
- EA Reis
- Edward Mitre
- H Furuya
- HJ McSorley
- HJ McSorley
- J Barrett
- James P. Hewitson
- Janice Murray
- JP Hewitson
- JP Hewitson
- JP Hewitson
- JR Knowles
- JS McCarthy
- Judith E. Allen
- LA Pereira
- Lauren M. Webb
- LR Ash
- M Taylor
- M Yazdanbakhsh
- MB Lutz
- MJG Johnston
- P Köhler
- QY Liu
- R Ikeda
- RA Lawrence
- RA Wilson
- Rick M. Maizels
- RS Curwen
- S Babu
- S Bellafiore
- S Bennuru
- S Bennuru
- S Enriquez-Flores
- S Raverdy
- S Ziewer
- SA Babayan
- Simon A. Babayan
- SK Singh
- SR Reynolds
- V Olivares-Illana
- WF Gregory
- WF Gregory
- WH Hoffmann
- XX Zang
- Y Moreno
- Y Zhu
- Yvonne Harcus
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently been subject to in-depth proteomic analysis. Surprisingly, the most abundant secreted protein of adult Brugia malayi is triose phosphate isomerase (TPI), a glycolytic enzyme usually associated with the cytosol. We now show that while TPI is a prominent target of the antibody response to infection, there is little antibody-mediated inhibition of catalytic activity by polyclonal sera. We generated a panel of twenty-three anti-TPI monoclonal antibodies and found only two were able to block TPI enzymatic activity. Immunisation of jirds with B. malayi TPI, or mice with the homologous protein from the rodent filaria Litomosoides sigmodontis, failed to induce neutralising antibodies or protective immunity. In contrast, passive transfer of neutralising monoclonal antibody to mice prior to implantation with adult B. malayi resulted in 60–70% reductions in microfilarial levels in vivo and both oocyte and microfilarial production by individual adult females. The loss of fecundity was accompanied by reduced IFNγ expression by CD4+ T cells and a higher proportion of macrophages at the site of infection. Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections
Fatal Disseminated Cryptococcus gattii Infection in New Mexico
- Author
- AE Brouwer
- Annette Fothergill
- B Speed
- Brian Wickes
- Carla J. Walraven
- Carolina Firacative
- DH Ellis
- DH Mitchell
- DJ Springer
- E Galanis
- E Galanis
- EJ Byrnes
- EJ Byrnes 3rd
- EJ Byrnes 3rd
- EJ Byrnes 3rd
- F Gatti
- F Hagen
- FL Wormley Jr
- Floyd Wormley
- H Ma
- JA Fraser
- Joy Sturtevant
- JR Harris
- JR Perfect
- Julie Gober-Wilcox
- Julie R. Harris
- K Datta
- K Okamoto
- K Tamura
- K Voelz
- KJ Kwon-Chung
- L MacDougall
- Larry Massie
- LR Castanon-Olivares
- LR Olivares
- ME Brandt
- N Iqbal
- P Ngamskulrungroj
- PY Cheng
- PY Cheng
- R Lopez-Martinez
- S Chaturvedi
- S Huerfano
- Samuel A. Lee
- Sarah E. Hardison
- SE Hardison
- SE Hardison
- SE Kidd
- SE Kidd
- Shawn R. Lockhart
- T Pfeiffer
- T. S. Neil Ku
- TC Sorrell
- TC Sorrell
- W Meyer
- W Meyer
- W Meyer
- Wendy Gerstein
- Wieland Meyer
- Y Loperena-Alvarez
- Y Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro Guimarães da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
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- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
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- Bertella C
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- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
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- Bianchi RM
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- Bieniek SP
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- Bilokon H
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- Blair RE
- Blanchard JB
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- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
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- Boddy CR
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- Chafaq A
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- Chalupkova I
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- Chapman JD
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- Charlton DG
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- Chekanov S
- Chekulaev SV
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- Chernyatin V
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- Di Micco B
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- Diehl EB
- Dietrich J
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- Ghazlane H
- Ghodbane N
- Giacobbe B
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- Gianotti F
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- Gilchriese M
- Gillam TP
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- Gingrich DM
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- Gladilin LK
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- Goddard JR
- Godfrey J
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- Sandoval C
- Sandoval T
- Sandstroem R
- Sankey DP
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- Santoyo Castillo I
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- Schaarschmidt J
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- Schnoor U
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- Schorlemmer AL
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- Schultens MJ
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- Schulz H
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- Scifo E
- Sciolla G
- Scott WG
- Searcy J
- Sedov G
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- Seixas JM
- Sekhniaidze G
- Sekula SJ
- Selbach KE
- Seliverstov DM
- Sellden B
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- Shapiro M
- Shatalov PB
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- Shimojima M
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- Shiyakova M
- Shmeleva A
- Shochet MJ
- Short D
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- Shupe MA
- Sicho P
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- Sinev NB
- Sipica V
- Siragusa G
- Sircar A
- Sisakyan AN
- Sivoklokov SY
- Sjursen TB
- Sjölin J
- Skinnari LA
- Skottowe HP
- Skovpen K
- Skubic P
- Slater M
- Slavicek T
- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smith BC
- Smith KM
- Smizanska M
- Smolek K
- Snesarev AA
- Snidero G
- Snow J
- Snow SW
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- Sobie R
- Sodomka J
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- Solc J
- Soldatov EY
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- Solfaroli Camillocci E
- Solodkov AA
- Solovyanov OV
- Solovyev V
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- Starchenko EA
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- Stekl I
- Stelzer B
- Stelzer HJ
- Stelzer-Chilton O
- Stenzel H
- Stern S
- Stewart GA
- Stillings JA
- Stockton MC
- Stoebe M
- Stoerig K
- Stoicea G
- Stonjek S
- Strachota P
- Stradling AR
- Straessner A
- Strandberg J
- Strandberg S
- Strandlie A
- Strang M
- Strauss E
- Strauss M
- Strizenec P
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- Strong JA
- Stroynowski R
- Ströhmer R
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- Subramaniam R
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- Susinno G
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- Suzuki Y
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- Tan KG
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- Tanaka S
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- Tapprogge S
- Tardif D
- Tarem S
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- Tartarelli GF
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- Taylor W
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- Teischinger FA
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- Therhaag J
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- Thomas JP
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- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
- Thomson E
- Thomson M
- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
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- Tikhonov YA
- Timoshenko S
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- Todorova-Nova S
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- Tojo J
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- Tokár S
- Tollefson K
- Tomlinson L
- Tomoto M
- Tompkins L
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- Tonoyan A
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- Topilin ND
- Torrence E
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- Torró Pastor E
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- Tripiana MF
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- Trischuk W
- Trocmé B
- Troncon C
- Trottier-McDonald M
- Trovatelli M
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- Trzebinski M
- Trzupek A
- Tsarouchas C
- Tseng JC
- Tsiakiris M
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsung JW
- Tsuno S
- Tsybychev D
- Tua A
- Tudorache A
- Tudorache V
- Tuggle JM
- Turala M
- Turecek D
- Turk Cakir I
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Tzanakos G
- Uchida K
- Ueda I
- Ueno R
- Ughetto M
- Ugland M
- Uhlenbrock M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Urbaniec D
- Urquijo P
- Usai G
- Vacavant L
- Vacek V
- Vachon B
- Vahsen S
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- Van Berg R
- Van Der Deijl PC
- van der Geer R
- van der Graaf H
- Van Der Leeuw R
- van der Poel E
- van der Ster D
- van Eldik N
- van Gemmeren P
- Van Nieuwkoop J
- van Vulpen I
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- Vannucci F
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vassilakopoulos VI
- Vazeille F
- Vazquez Schroeder T
- Veloso F
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vest A
- Vetterli MC
- Vichou I
- Vickey Boeriu OE
- Vickey T
- Viehhauser GH
- Viel S
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
- Virzi J
- Vitells O
- Viti M
- Vivarelli I
- Vives Vaque F
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- Volpini G
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorwerk V
- Vos M
- Voss R
- Vossebeld JH
- Vranjes Milosavljevic M
- Vranjes N
- Vrba V
- Vreeswijk M
- Vu Anh T
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlen H
- Wahrmund S
- Wakabayashi J
- Walch S
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walsh B
- Wang C
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
- Wang R
- Wang SM
- Wang T
- Wang X
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watanabe I
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh AT
- Waugh BM
- Weber MS
- Webster JS
- Weidberg AR
- Weigell P
- Weingarten J
- Weiser C
- Wells PS
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Wetter J
- Weydert C
- Whalen K
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LA
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Williams S
- Willis W
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- Zeniš T
- Zerwas D
- Zevi Della Porta G
- Zhang D
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivković L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Revisiting the five-facet structure of mindfulness
- Author
- A Maydeu-Olivares
- AB Siegling
- AB Siegling
- AJ Bravo
- B De Raad
- B De Raad
- B De Raad
- B Wheaton
- C Bergomi
- C Bergomi
- C-HH Li
- CJ Soto
- D Magnusson
- D McNeish
- DL Paulhus
- E Diener
- E Diener
- G Feldman
- GJ Tellis
- H Walach
- HW Marsh
- I Trizano-Hermosilla
- J Gu
- J Higgins
- J Kabat-Zinn
- J Kucinskas
- J Kucinskas
- JL Horn
- JL Lilja
- KW Brown
- L Cardaciotto
- L Hu
- LE Carlson
- LR Goldberg
- LW Glorfeld
- Michael A. Pirson
- MJ Williams
- MR Pearson
- NT Van Dam
- P Chadwick
- PJ Corr
- R Silberzahn
- RA Baer
- RA Baer
- RC MacCallum
- S Sauer
- SA Blasberg
- SH Schwartz
- W Bonifay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The current study aimed to replicate the development of the Five-Facet Mindfulness Questionnaire (FFMQ) in a sample of 399 undergraduate students. We factor analyzed the Mindful Attention and Awareness Questionnaire (MAAS), the Freiburg Mindfulness Scale, the Southampton Mindfulness Questionnaire (SMQ), the Cognitive Affective Mindfulness Scale Revised (CAMS-R), and the Kentucky Inventory of Mindfulness Skills (KIMS), but also extended the analysis by including a conceptually related measure, the Philadelphia Mindfulness Scale (PHLMS), and a conceptually unrelated measure, the Langer Mindfulness Scale (LMS). Overall, we found a partial replication of the five-factor structure, with the exception of non-reacting and non-judging which formed a single factor. The PHLMS items loaded as expected with theoretically related factors, whereas the LMS items emerged as separate factor. Finally, we found a new factor that was mostly defined by negatively worded items indicating possible item wording artifacts within the FFMQ. Our conceptual validation study indicates that some facets of the FFMQ can be recovered, but item wording factors may threaten the stability of these facets. Additionally, measures such as the LMS appear to measure not only theoretically, but also empirically different constructs
Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin
- Author
- A Avdeef
- A Bruyere
- A Dokoumetzidis
- A Dokoumetzidis
- A Dokoumetzidis
- A Okazaki
- A Olivares-Morales
- A Olivares-Morales
- A Rostami-Hodjegan
- A Rostami-Hodjegan
- A Shibukawa
- Amin Rostami-Hodjegan
- Andrés Olivares-Morales
- AS Darwich
- Avijit Ghosh
- B Agoram
- C Tannergren
- D Cong
- D Hallifax
- DM Mudie
- E Chen
- E Hénin
- E Sjogren
- E Sjogren
- E Sjögren
- EM Howgate
- G Langdon
- G Sathyan
- G Sathyan
- GL Amidon
- H Lennernas
- H Lennernas
- H Mizushima
- HF Helander
- I Poggesi
- IA Nestorov
- International Commission on Radiological Protection
- J Douchamps
- J Valentin
- J Wang
- J Yang
- J Yang
- JA Foster
- JA Jacquez
- JC Kolars
- K Johnson
- K Rowland Yeo
- K Sugano
- K Sugano
- K Sugano
- K Thelen
- KC Johnson
- KR Godfrey
- Leon Aarons
- LR Williams
- LX Yu
- LX Yu
- LX Yu
- LX Yu
- M Anguelova
- M Bouchoucha
- M Bouchoucha
- M Gertz
- M Jamei
- M Jamei
- M Pitsiu
- M Rowland
- M Taketani
- M Yaich
- M Zur
- MF Paine
- MF Paine
- MN Martinez
- MV Varma
- N Parrott
- N Tsamandouras
- NW Read
- P Poulin
- P Zhao
- P Zhao
- PJ Matheson
- R Bauer
- R Conley
- RJ Hintz
- S Willmann
- SK Gupta
- SK Gupta
- SS Davis
- T Rodgers
- T Rodgers
- Y Cao
- Y Sato
- Publication venue
- 'American Association of Pharmaceutical Scientists (AAPS)'
- Publication date
- Field of study
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction
- Author
- A Hall
- A Patapoutian
- AD Cash
- AM Winter-Vann
- Armando Varela-Ramirez
- Arshad M Khan
- B Aguilar
- B Lotto
- B Stoyanov
- BS Reinoso
- C Conde
- C Lema
- CG Dotti
- CM Stern
- D Cartelli
- D Cartelli
- D Purves
- E M Hur
- EE Govek
- EH Wu
- EH Wu
- EJ Yoon
- Ellen M Walker
- EMM Manders
- F Goubaeva
- FQ Zhou
- G Banker
- GA Buxton
- H Okae
- H Towbin
- H Tummala
- I Azpiazu
- I Azpiazu
- I Cushman
- J Garcia-Olivares
- JA Harrill
- JC Bulinski
- JC He
- Jessica Martinez-Jurado
- JH Kwon
- Jorge A Sierra-Fonseca
- JZ Yu
- K Sanada
- K Wang
- KJ De Vos
- LA Greene
- LC Cantley
- LL Gomez
- LR Stephens
- M Igarashi
- M Koehl
- MA Franker
- Manuel Miranda
- MH Gelb
- MX Ibrahim
- N Macrez
- Nazarius S Lamango
- NS Lamango
- NS Lamango
- NS Lamango
- Omar Najera
- P Sachdev
- S Millecamps
- S Roychowdhury
- S Roychowdhury
- S Roychowdhury
- S Tahirovic
- SK Powell
- Sukla Roychowdhury
- T Blackmer
- T Mitchison
- T Sarma
- U Marklund
- UK Laemmli
- V Montoya
- VC Dang
- WJ Koch
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/11/2014
- Field of study
Background: Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA. G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. However, the possible connection between these pathways and how they might ultimately converge to regulate the assembly and organization of MTs during neurite outgrowth is not well understood. Results: Here, we report that Gβγ, an important component of the GPCR pathway, is critical for NGF-induced neuronal differentiation of PC12 cells. We have found that NGF promoted the interaction of Gβγ with MTs and stimulated MT assembly. While Gβγ-sequestering peptide GRK2i inhibited neurite formation, disrupted MTs, and induced neurite damage, the Gβγ activator mSIRK stimulated neurite outgrowth, which indicates the involvement of Gβγ in this process. Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro, small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. We found that these inhibitors disrupted Gβγ and ΜΤ organization and affected cellular morphology and neurite outgrowth. In further support of a role of Gβγ-MT interaction in neuronal differentiation, it was observed that overexpression of Gβγ in PC12 cells induced neurite outgrowth in the absence of added NGF. Moreover, overexpressed Gβγ exhibited a pattern of association with MTs similar to that observed in NGF-differentiated cells. Conclusions: Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. Electronic supplementary material The online version of this article (doi:10.1186/s12868-014-0132-4) contains supplementary material, which is available to authorized users
Epidemiology of Invasive Fungal Infections in Latin America
- Author
- A Bonifaz
- A Bonifaz
- A Bonifaz
- A Bruder-Nascimento
- A Lindenberg
- AG Silva-Hernández
- AG Tichellio
- AL Colombo
- AL Colombo
- AL Colombo
- AL Leal
- AM Miranda-Paniago
- AMR Hernández-Dueñas
- B Muñoz
- B Ruddy
- BC Quinet-Leiman
- C Nunes Mdo
- C Pérez
- C Ramírez
- C Tsang
- CA Arce-Salinas
- CA Diaz-Granados
- CE Canteros
- CF Pinzan
- Costa Freitas RM de
- D Matute
- Dora E. Corzo-León
- DP Kontoyiannis
- DP Kontoyiannis
- EO Tapia
- ER Cunha Colombo da
- F Queiroz-Telles
- G Davel
- G Giusiano
- G San-Blas
- G Velasquez-Uribe
- GM González
- H Yun-Sun
- J Batista Jr
- J Cadena
- J Cermeño
- J Lizarazo
- J Shankar
- JA Cortés
- JJ Ayala-Gaytán
- JN Galgiani
- Jose Sifuentes-Osornio
- JW Baddley
- K Karimi
- L Rodero
- L Trilles
- L. Alfredo Ponce-de-León
- LB Pontes
- LC Ribeiro
- LC Severo
- LJ Wheat
- LK Souza
- LR Castañon-Olivares
- LZ Goldani
- M Auxiliadora-Martínez
- M Nucci
- M Nucci
- M Nucci
- M Nucci
- M Nucci
- M Pappalardo
- M Prado
- M Saravia-Flores
- M Villarroel
- MA Pfaller
- MA Pfaller
- MA Pfaller
- MA Sánchez-Alemán
- MC Ajenjo
- ME Gutierrez
- ME Gutiérrez
- MG Frías-De León
- ML Taylor
- MM Durkin
- MM Panizo
- MT Brazao-Silva
- NM Ampel
- NM Arcaya
- O Leroy
- PE Santos
- PG Pappas
- R Cruz
- R Laniado-Laborin
- R Laniado-Laborín
- R Negroni
- R Rabagliati
- RF Hector
- RS Bercovitch
- S Córdoba
- S Mata-Essayag
- S Nouér
- SA Messer
- SJ Reséndiz
- V Rodrigues-Aquino
- VM Carvalho-Dias
- W Meyer
- X Lin
- XS Passos
- Publication venue
- Current Science Inc.
- Publication date
- 01/01/2012
- Field of study
The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also been a focus of attention by public health officials, as endemic mycoses have provoked a number of outbreaks. An extensive search of medical literature from Latin America suggests that the incidence of IFIs from both endemic and opportunistic fungi has increased. The increase in endemic mycoses is probably related to population changes (migration, tourism, and increased population growth), whereas the increase in opportunistic mycoses may be associated with the greater number of people at risk. In both cases, the early and appropriate use of diagnostic procedures has improved diagnosis and outcome
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction
- Author
- A Hall
- A Patapoutian
- AD Cash
- AM Winter-Vann
- Armando Varela-Ramirez
- Arshad M Khan
- B Aguilar
- B Lotto
- B Stoyanov
- BS Reinoso
- C Conde
- C Lema
- CG Dotti
- CM Stern
- D Cartelli
- D Cartelli
- D Purves
- E M Hur
- EE Govek
- EH Wu
- EH Wu
- EJ Yoon
- Ellen M Walker
- EMM Manders
- F Goubaeva
- FQ Zhou
- G Banker
- GA Buxton
- H Okae
- H Towbin
- H Tummala
- I Azpiazu
- I Azpiazu
- I Cushman
- J Garcia-Olivares
- JA Harrill
- JC Bulinski
- JC He
- Jessica Martinez-Jurado
- JH Kwon
- Jorge A Sierra-Fonseca
- JZ Yu
- K Sanada
- K Wang
- KJ De Vos
- LA Greene
- LC Cantley
- LL Gomez
- LR Stephens
- M Igarashi
- M Koehl
- MA Franker
- Manuel Miranda
- MH Gelb
- MX Ibrahim
- N Macrez
- Nazarius S Lamango
- NS Lamango
- NS Lamango
- NS Lamango
- Omar Najera
- P Sachdev
- S Millecamps
- S Roychowdhury
- S Roychowdhury
- S Roychowdhury
- S Tahirovic
- SK Powell
- Sukla Roychowdhury
- T Blackmer
- T Mitchison
- T Sarma
- U Marklund
- UK Laemmli
- V Montoya
- VC Dang
- WJ Koch
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nocturnal plasma levels of melatonin in quails (Coturnix japonica) injected with l-5-hydroxy-tryptophan
- Author
- AC. Almeida
- BADAUÊ-PASSOS D. Jr.
- BOADLE-BIBER MC.
- CAVALLO A.
- EL. Olivares
- FERNSTROM JD.
- FOULKES NS.
- HADLEY Mac E.
- HUETHER G.
- KO. Nonaka
- LC. Reis
- LEANDER P.
- LR. Castilhos
- MA. Medeiros
- MATSUURA T.
- MC. Ribeiro
- McINTYRE IM.
- NAMBOODIRI MA.
- NATESAN A.
- NATHAN PJ.
- PA. Polo
- REIS LC.
- REITER RJ.
- STEARDO L.
- STOKKAN KA.
- SUGDEN D.
- TYCE GM.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
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- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
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- Alejandro R
- Alejo GC
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- Alhamdi Y
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- Alkan A
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- Almudevar PM
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- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
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- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
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- Antonucci E
- Antón DG
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- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
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- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
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- Arslantas MK
- Artiguenave M
- Aslanian P
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- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
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- Brasseur A
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- Breitkreutz R
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- CAPCRI Study
- Capellier G
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- Chernyshuk S
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- Coss-Bu JA
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- Cotton H
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- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
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- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
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- De Backer A
- De Brito-Ashurst I
- De Cassai A
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- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
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- Jeong IY
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
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- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katira BH
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- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
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- Keller E
- Kellner F
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- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
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- King HS
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- Kirca H
- Kirman M
- Kirwan CJ
- Kittnar O
- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
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- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
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- Kovacikova L
- Kox M
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- Kristof J
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- Ku NS
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- Kubik M
- Kubota K
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- Kunze-Szikszay N
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- Kurth T
- Kurtz P
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- Kwon HM
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- Kye YC
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagonidis D
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- Lissonde F
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- Litchfield K
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- Sonneville R
- Sosa M
- Sossou A
- Sousa SC
- Soussi S
- Souza VA
- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
- Talan L
- Tamura T
- Tanaka H
- Tanaka S
- Tanaka S
- Tane N
- Tang KB
- Tang LK
- Tapia A
- Tapponnier R
- Tapponnier R
- Tapponnier R
- Tarabrin O
- Tarabrin P
- Tavazzi G
- Tavazzi G
- Teboul JL
- Telli S
- Temprano-Gómez I
- Tena SA
- Tencé N
- Terzi N
- Terzi N
- Terzi N
- Terzi N
- Thabut G
- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- Tomás MA
- Tonelotto BF
- Tonetti T
- Tonetti T
- Topcu L
- Tormos P
- Torner MM
- Torner MM
- Torrance HD
- Torrent RL
- Torrent RL
- Torres A
- Torres E
- Torres JC
- Torriglia F
- Torriglia F
- Torriglia F
- Torsvik M
- Tosi F
- Touratier S
- Touw HR
- Toval S
- Tran N
- Trapp O
- Travierso C
- Travieso PM
- Traynor T
- Trefler S
- Trenado J
- Trenado J
- Treso-Geira M
- Trifan B
- Triulzi F
- Troeltzsch M
- Troncoso I
- Trouiller P
- Tseng CJ
- Tsirigotis P
- Tsukahara K
- Tsunano Y
- Tsunoda M
- Tsunoda M
- Tsutui T
- Tucci MR
- Tudor BA
- Tuinman PR
- Tullo L
- Turel M
- Turon R
- Twisk JW
- Törnblom S
- Ugawa T
- Ujike Y
- Ulla DV
- Ullman A
- Unal M
- Urbanaviciute I
- Uriona S
- Urli T
- Usón MC
- Vaahersalo J
- Vaara S
- Vaid N
- Vakalos A
- Valbuena BL
- Valbuena BL
- Valeiras-Valero A
- Vallecoccia MS
- Vallejo-Báez J
- Vallverdu M
- Vallverdu M
- Vallverdú I
- Vallés J
- van den Boogaard M
- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
- van Galen T
- van Ieperen SN
- Van Logten T
- van Nes M
- van Putten MJ
- van Thiel RJ
- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
- Varpula T
- Vatsik MV
- Vazquez D
- Vedage D
- Vega LM
- Veigas P
- Vela JL
- Velasquez T
- Venkatesan K
- Venn R
- Venn R
- Venot M
- Venrdramin A
- Ventura-Rosado A
- Vergani G
- Verginella F
- Verhaeghe R
- Verhage R
- Vermeir P
- Veronesi M
- Vezzani A
- Vezzani A
- Vianna G
- Viciana R
- Vidal A
- Vidal MV
- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
- Viera MA
- Vigne C
- Villa G
- Villa P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
- …