57 research outputs found
Translation correlations in anisotropically scattering media
Controlling light propagation across scattering media by wavefront shaping
holds great promise for a wide range of communications and imaging
applications. However, finding the right wavefront to shape is a challenge when
the mapping between input and output scattered wavefronts (i.e. the
transmission matrix) is not known. Correlations in transmission matrices,
especially the so-called memory-effect, have been exploited to address this
limitation. However, the traditional memory-effect applies to thin scattering
layers at a distance from the target, which precludes its use within thick
scattering media, such as fog and biological tissue. Here, we theoretically
predict and experimentally verify new transmission matrix correlations within
thick anisotropically scattering media, with important implications for
biomedical imaging and adaptive optics.Comment: main article (18 pages) and appendices (6 pages
Neurons of the Dentate Molecular Layer in the Rabbit Hippocampus
The molecular layer of the dentate gyrus appears as the main entrance gate for information into the hippocampus, i.e., where the perforant path axons from the entorhinal cortex synapse onto the spines and dendrites of granule cells. A few dispersed neuronal somata appear intermingled in between and probably control the flow of information in this area. In rabbits, the number of neurons in the molecular layer increases in the first week of postnatal life and then stabilizes to appear permanent and heterogeneous over the individuals’ life span, including old animals. By means of Golgi impregnations, NADPH histochemistry, immunocytochemical stainings and intracellular labelings (lucifer yellow and biocytin injections), eight neuronal morphological types have been detected in the molecular layer of developing adult and old rabbits. Six of them appear as interneurons displaying smooth dendrites and GABA immunoreactivity: those here called as globoid, vertical, small horizontal, large horizontal, inverted pyramidal and polymorphic. Additionally there are two GABA negative types: the sarmentous and ectopic granular neurons. The distribution of the somata and dendritic trees of these neurons shows preferences for a definite sublayer of the molecular layer: small horizontal, sarmentous and inverted pyramidal neurons are preferably found in the outer third of the molecular layer; vertical, globoid and polymorph neurons locate the intermediate third, while large horizontal and ectopic granular neurons occupy the inner third or the juxtagranular molecular layer. Our results reveal substantial differences in the morphology and electrophysiological behaviour between each neuronal archetype in the dentate molecular layer, allowing us to propose a new classification for this neural population
The Spin Structure of the Nucleon
We present an overview of recent experimental and theoretical advances in our
understanding of the spin structure of protons and neutrons.Comment: 84 pages, 29 figure
Price probabilities: A class of Bayesian and non-Bayesian prediction rules
This paper examines the implications of the market selection hypothesis on the accuracy of the probabilities implied by equilibrium prices and on the “learning” mechanism of markets. I use the standard machinery of dynamic general equilibrium models to generate a rich class of probabilities, price probabilities, and discuss their properties. This class includes the Bayes’ rule and known non-Bayesian rules. If the prior support is well-specified, I prove that all members of this class perform as well as Bayes’ rule in terms of likelihood. If the prior support is misspecified in that the Bayesian prior does not converge, I demonstrate that some members of price probabilities significantly outperform Bayes’. Because these members are never worse and sometimes better than Bayes, my result challenges the prevailing opinion that Bayes’ rule is the only rational way to learn
Fragile x syndrome and autism: from disease model to therapeutic targets
Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS), one of the first identified and leading causes of autism, has been modeled in mice using molecular genetic manipulation. These Fmr1 knockout mice have recently been used to identify a new putative therapeutic target, the metabotropic glutamate receptor 5 (mGluR5), for the treatment of FXS. Moreover, mGluR5 signaling cascades interact with a number of synaptic proteins, many of which have been implicated in autism, raising the possibility that therapeutic targets identified for FXS may have efficacy in treating multiple other causes of autism
Relative Modification of Prompt psi(2S) and J/psi Yields from pp to PbPb Collisions at root(S)(NN)=5.02 TeV
Peer reviewe
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Breast cancer stem-like cells (CSCs) are an important therapeutic target as they are purported to be responsible for tumor initiation, maintenance, metastases, and disease recurrence. Interleukin-8 (IL-8) is upregulated in breast cancer compared with normal breast tissue and is associated with poor prognosis. IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastases and is upregulated in HER2-positive cancers. Recently, we and others have established that IL-8 via its cognate receptors, CXCR1 and CXCR2, is also involved in regulating breast CSC activity. Our work demonstrates that in metastatic breast CSCs, CXCR1/2 signals via transactivation of HER2. Given the importance of HER2 in breast cancer and in regulating CSC activity, a pathway driving the activation of these receptors would have important biological and clinical consequences, especially in tumors that express high levels of IL-8 and other CXCR1/2-activating ligands. Here, we review the IL-8 signaling pathway and the role of HER2 in maintaining an IL-8 inflammatory loop and discuss the potential of combining CXCR1/2 inhibitors with other treatments such as HER2-targeted therapy as a novel approach to eliminate CSCs and improve patient survival
- …