Elevated romantic love and jealousy if relationship status is declared on Facebook

Declared relationship status on Facebook can serve as a public commitment and as an extra layer of a couple’s security. However, the question arises: do those who report the relationship status feel stronger romantic love and jealousy towards their partners than those who do not share such information publicly? To test this assumption, profile information and questionnaire data of romantic love and jealousy were gathered from 292 (230 females) respondents that were in a relationship. Our results suggest that announcing the relationship status is associated with elevated romantic love and jealousy. Therefore, being “Facebook official” can be interpreted as a tie-sign indicating that the couple is “out of the market”, and can promote their unity as a “digital wedding ring”

The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions

The authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009).Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system stimulation mediated mainly by activation of carotid body (CB) chemoreflexes and/or asphyxia, and, by no means the least important, the systemic effects of chronic intermittent hypoxia (CIH). The use of animal models has revealed that CIH is the critical stimulus underlying sympathetic activity and hypertension, and that this effect requires the presence of functional arterial chemoreceptors, which are hyperactive in CIH. These models of CIH mimic the HT observed in humans and allow the study of CIH independently without the mechanical obstruction component. The effect of continuous positive airway pressure (CRAP), the gold standard treatment for OSA patients, to reduce blood pressure seems to be modest and concomitant antihypertensive therapy is still required. We focus this review on the efficacy of pharmacological interventions to revert HT associated with CIH conditions in both animal models and humans. First, we explore the experimental animal models, developed to mimic HT related to CIH, which have been used to investigate the effect of antihypertensive drugs (AHDs). Second, we review what is known about drug efficacy to reverse HT induced by CIH in animals. Moreover, findings in humans with OSA are cited to demonstrate the lack of strong evidence for the establishment of a first-line antihypertensive regimen for these patients. Indeed, specific therapeutic guidelines for the pharmacological treatment of HT in these patients are still lacking. Finally, we discuss the future perspectives concerning the non-pharmacological and pharmacological management of this particular type of HT.publishersversionpublishe

The "ram effect": new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions

Reproduction in mammals is controlled by the hypothalamo-pituitary-gonadal (HPG) axis under the influence of external and internal factors such as photoperiod, stress, nutrition, and social interactions. Sheep are seasonal breeders and stop mating when day length is increasing (anestrus). However, interactions with a sexually active ram during this period can override the steroid negative feedback responsible for the anoestrus state, stimulate LH secretion and eventually reinstate cyclicity. This is known as the ram effect and research into the mechanisms underlying it is shedding new light on HPG axis regulation. The first step in the ram effect is increased LH pulsatile secretion in anestrus ewes exposed to a sexually active male or only to its fleece, the latter finding indicating a pheromone-like effect. Estradiol secretion increases in all ewes and this eventually induces a LH surge and ovulation, just as during the breeding season. An exception is a minority of ewes that exhibit a precocious LH surge (within 4h) with no prior increase in estradiol. The main olfactory system and the cortical nucleus of the amygdala are critical brain structures in mediating the ram effect since it is blocked by their inactivation. Sexual experience is also important since activation (increased c-fos expression) in these and other regions is greatly reduced in sexually naïve ewes. In adult ewes kisspeptin neurons in both arcuate and preoptic regions and some preoptic GnRH neurons are activated 2h after exposure to a ram. Exposure to rams also activates noradrenergic neurons in the locus coeruleus and A1 nucleus and increased noradrenalin release occurs in the posterior preoptic area. Pharmacological modulation of this system modifies LH secretion in response to the male or his odor. Together these results show that the ram effect can be a fruitful model to promote both a better understanding of the neural and hormonal regulation of the HPG axis in general and also the spe

Un cas de carcinome transitionnel prostatique

A case of prostatic transitional carcinoma is described. A 9 year old castrated dog presented with tenesmus, dyschezia, dysuria and strangury. A diagnosis of a prostatic problem was found after imagery examinations of the caudal abdomen and neoplastic infiltration of the prostatic transitional epithelium was confirmed by cytological analysis. The dog was euthanased after a short period of symptomatic treatment and chemotherapy based on an anti-COX-2. The risk factors, the pathophysiology and also methods of diagnosis and treatment of prostatic tumours are discussed in this article

Un cas de carcinome transitionnel prostatique

A case of prostatic transitional carcinoma is described. A 9 year old castrated dog presented with tenesmus, dyschezia, dysuria and strangury. A diagnosis of a prostatic problem was found after imagery examinations of the caudal abdomen and neoplastic infiltration of the prostatic transitional epithelium was confirmed by cytological analysis. The dog was euthanased after a short period of symptomatic treatment and chemotherapy based on an anti-COX-2. The risk factors, the pathophysiology and also methods of diagnosis and treatment of prostatic tumours are discussed in this article

Place de l'imagerie dans la datation de la gestation

In absence of information on the timing of oestrus, it is useful to verify the period of pregnancy in order to decide the birth date or caesarean date. Radiography can be used to confirm pregnancy and facilitate aging of the foetus from 45 days after LH (luteinising hormone) peak. Ultrasonography can establish pregnancy diagnosis from 19 to 21 days after LH peak to term. In addition, the viability of the foetus and stress during parturition can be assessed using this technique. The age of the foetus can be estimated reasonably reliably in the first and second half of pregnancy using foetal and extrafoetal ultrasonography measurements