Pirmoji minimaliai invazinės skrandžio vėžio chirurgijos patirtis Vilniaus universiteto ligoninėje Santaros klinikose ir Nacionaliniame vėžio institute: klinikinių atvejų serija ir literatūros apžvalga

Background. Gastric cancer remains one of the most common cancers in Lithuania and Worldwide. Surgical treatment is the only potentially curative treatment option for it. Historically open gastrectomy was considered as the gold standard approach. Although, the development of minimally invasive surgery and accumulation of the clinical data has led to the adoption of minimally invasive gastrectomy. Clinical cases. We present a series of 8 clinical cases who underwent minimally invasive surgery for early or locally advanced gastric cancer in Vilnius University Hospital Santaros Klinikos and the National Cancer Institute. Discussion. Large scale randomized controlled trials in Asia have proved that laparoscopic surgery is safe and oncologically effective for clinical stage I distal gastric cancer. The increa­sing amount of data supports the safety of minimally invasive gastrectomy for advanced or proximal gastric cancer. Most of the trials performed in Asia confirmed, that laparoscopic gastrectomy has some advantages, including: decreased blood loss, decreased post­operative pain, and morbidity. Recent randomized controlled trials of Western countries proved the safety of laparoscopic gastrectomy and the comparable 1-year long-term outcomes. Although, they failed to show improved recovery after minimally invasive surgery. Currently, there is sufficient evidence to adopt minimally invasive gastrectomy for gastric cancer into routine clinical practice in Lithuania. Conclusions. The first experience of minimally invasive gastric cancer surgery in Vilnius University Hospital Santaros Klinikos and the National Cancer Institute was successful. All gastrectomies were radical, and without major postoperative complications.Įvadas. Skrandžio vėžys išlieka aktuali onkologinė problema Lietuvoje ir pasaulyje. Chirurginis gydymas – galimai vienintelis pasveikti leidžiantis gydymo metodas. Ilgą laiką chirurginio gydymo standartu buvo laikomos atvirosios operacijos. Vis labiau tobulėjant minimaliai invazyviai chirurgijai, susidomėta galimybe šį metodą taikyti skrandžio vėžiui gydyti. Klinikiniai atvejai. Pristatomi 8 klinikiniai atvejai pacientų, kurie dėl ankstyvojo ar pažengusio skrandžio vėžio buvo operuoti minimaliai invaziniu būdu Vilniaus universiteto ligoninėje Santaros klinikose ir Nacionaliniame vėžio institute. Diskusija. Didelių imčių randomizuoti kontroliniai tyrimai, atlikti Azijos šalyse, įrodė, kad laparoskopinė skrandžio vėžio chirurgija yra saugi ir onkologiškai efektyvi, kai operuojamas kliniškai I stadijos distalinės dalies skrandžio vėžys. Daugėja įrodymų apie onkologinį saugumą, atliekant gastrektomiją ar operuojant pažengusį skrandžio vėžį. Dauguma Azijoje atliktų tyrimų nurodo, kad laparoskopinė skrandžio vėžio chirurgija išsiskiria minimaliai invazinei chirurgijai būdingais pranašumais: mažesniu skausmu po operacijos, mažesniu pooperacinių komplikacijų dažniu, mažesniu nukraujavimu operacijos metu. Neseniai pasirodė pirmieji randomizuoti kontroliniai Vakarų populiacijos tyrimai, kuriais įrodyta, jog laparoskopinė skrandžio vėžio chirurgija yra saugi, o vienų metų atokieji gydymo rezultatai yra vienodi. Vis dėlto vakarietiškosios studijos nepagrindžia, kad laparoskopiškai operuoti pacientai greičiau ir sklandžiau sveiksta po operacijos. Šiandien sukaupta pakankamai duomenų, kad minimaliai invazinės skrandžio vėžio chirurgijos programos galėtų būti saugiai taikomos Lietuvoje kaip rutininės klinikinės praktikos dalis. Išvados. Nacionaliniame vėžio institute ir Vilniaus universiteto ligoninės Santaros klinikose pirmosios minimaliai invazinės skrandžio vėžio operacijos atliktos sėkmingai. Operacijos buvo radikalios, didžiųjų pooperacinių komplikacijų nenustatyta

Ranka asistuojamoji laparoskopinė gaubtinės ir tiesiosios žarnos chirurgija: vieno centro 473 ligonių patirtis

Background / Objective Hand-assisted laparoscopic surgery (HALS) has been introduced into clinical practice for almost three decades. It combines the advantages of both laparoscopic (minimally invasive) and conventional open surgery. Despite all the published data, there are still scepticism in surgical community regarding this hybrid form of laparoscopic surgery and the role of HALS is still being defined. Our study aimed to review 10 year experience in treating patients at single centre with colonic and rectal pathology using HALS.Methods This study was a retrospective analysis of prospectively collected data of 473 patients undergoing hand assisted laparoscopic colorectal surgery for colon and rectal disease, mainly cancer, in a single tertiary care institution, National Cancer Institute, from January, 2006, to July, 2016. All consented patient with colonic and rectal pathology were included in the analysis. Results The patients’ mean age was 64.14 ± 9.75 years. Female and male ratio was similar 240 (50.73%) vs. 233 (49.27%). The mean length of postoperative hospital stay was 6.92, ranging from 2 to 34 days. Histological examination revealed mean lymph node harvest was 16.97 ± 12.10. Stage I, II, III cancer groups were similar accounting for 142 (30.02%), 139 (29.35%) and 153 (32.35%) cases respectively, stage IV – 36 (7.61%) and three cases of benign origin. Segmental colectomies were performed in 53.0% cases, 45.3% patients had rectal resections and “other” 1.7%. Surgical re-intervention was required for 10 patients (2.11%). Complication rate was 6.55%, and mortality documented in only 2 cases (0.42%).Conclusion HALS is safe and feasible technique, which maintains all the benefits of laparoscopic colectomy and can be performed for numerous indications, while affording the surgeon to carry out complex cases in a minimally invasive fashion.Įvadas / tikslas Ranka asistuojamoji laparoskopinė chirurgija (HALS) į klinikinę praktiką įdiegta jau beveik tris dešimtmečius. Ji jungia atviros chirurgijos ir laparoskopinės (minimaliai invazinės) chirurgijos būdus. Nepaisant paskelbtų duomenų, chirurgų bendruomenė vis dar skeptiškai žvelgia į šią hibridinę laparoskopijos formą. Straipsnio tikslas – apžvelgti vieno centro 10 metų patirtį taikant HALS metodiką.Metodai Tai retrospektyvioji duomenų analizė. Apžvelgti 473 pacientai, gydyti Nacionaliniame vėžio institute dėl kolorektalinės pato­logijos nuo 2006 m. sausio iki 2016 m. liepos mėn. Šie pacientai buvo operuoti HALS būdu.Rezultatai Pacientų amžiaus vidurkis buvo 64,14 ± 9,75 metai. Moterų – 240 (50,73 %), vyrų – 233 (49,27 %). Vidutinė hospitalizacijos tru­kmė buvo 6,92 dienos (nuo 2 iki 34 d.). Histologinio tyrimo duomenimis, vidutinis pašalintų limfmazgių skaičius 16,97 ± 12,10. I, II, III ir IV stadijų grupes sudarė atitinkamai 142 (30,02 %), 139 (29,35 %), 153 (32,35 %) ir 36 (7,61 %) pacientai. Trims pa­cientams patologija buvo gerybinė. Segmentinės kolektomijos atliktos 53 % pacientų, tiesiosios žarnos rezekcijos – 45,3 % pacientų, kitos operacijos sudarė 1,7 %. Pakartotinės intervencijos prireikė 10 pacientų (2,11 %). Komplikacijų dažnis buvo 6,55 %, 2 pacientai (0,42 %) mirė.Išvada HALS yra saugi ir efektyvi technika, kuri leidžia pasinaudoti visais laparoskopinės kolektomijos privalumais bei minimaliai invaziniu būdu gali būti pritaikyta sudėtingais klinikiniais atvejais

Neįprastas tiesiosios žarnos vėžio metastazavimas: atvejo pristatymas

Metastasis of rectal cancer to the penis is a very rare condition with less than 40 cases found in the literature. The prognosis is poor and life expectancy is short. The mechanism of rectal cancer metastasis spread to penis is unknown. The most popular theory is retrograde venous spread. There are several treatment options, but no single treatment option has emerged with superior results. The authors report a case of a 41 old man who was diagnosed with rectal cancer, treated with neoadjuvant radiotherapy, underwent rectal resection, had adjuvant chemotherapy, and despite that, 2 years after had penal metastasis. After diagnosis, he survived 2 months.Labai retai tiesiosios žarnos vėžio metastazės plinta į varpą. Literatūros duomenimis, tokių atvejų yra aprašyta mažiau kaip 40. Prognozė yra bloga ir išgyvenamumas trumpas. Tiesiosios žarnos vėžio metastazių plitimo į varpą mechanizmas nežinomas. Populiariausia teorija yra apie retrogradinį veninį plitimą. Aprašoma keletas gydymo metodų, tačiau nė vienas nėra pranašesnis. Autoriai pristato 41 metų amžiaus vyro klinikinį atvejį. Vyrui buvo diagnozuotas tiesiosios žarnos vėžys, prieš operaciją taikyta radioterapija, paskui operacinis gydymas ir pooperacinė chemoterapija. Nepaisant to, po dvejų metų išsivystė metastazės varpoje. Po metastazių diagnozės ligonis išgyveno du mėnesius

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Kepenų angiomiolipoma: klinikinis atvejis ir literatūros apžvalga

Background.&nbsp;Hepatic angiomyolipomas are uncommon non-cancerous mesenchymal tumors that belong to the perivascular epithelioid cell tumour group. Smooth muscle cells, fat cells and blood vessels can be observed in these types of neoplasm.&nbsp;Case presentation.&nbsp;We present the case of a 50-year-old patient. The patient was referred to the National Cancer Institute after an abdominal ultrasound, which incidentally revealed a mass in the liver. A whole body computed tomography scan showed a large liver mass, in the VII/VIII/V/VI segments. Trisegmenthomy of the right liver lobe was performed. Pathological examination revealed a rare, but benign tumour – angiomyolipoma. The postoperative course was uneventful and the patient was discharged on postoperative day 9. Two months following the surgery, the patient has no recurrence or late complications.&nbsp;Conclusion.&nbsp;Hepatic angiomyolipoma is a rare, usually benign tumour with malignant potential. It is can be diagnosed by radiological tests, biopsy or after surgery. The most common treatment is surgical resection.&nbsp;Įvadas.&nbsp;Kepenų angiomiolipomos yra gana reti, dažniausiai gerybiniai navikai, priklausantys epitelioidinių ląstelių navikų grupei. Šio tipo navikus sudaro lygiųjų raumenų ir riebalinės ląstelės bei kraujagyslės.&nbsp;Klinikinio atvejo pristatymas.&nbsp;Straipsnyje aptariamas 50&nbsp;m. paciento atvejis. Pacientas atsiųstas į Nacionalinį vėžio institutą atlikus ultragarsinį pilvo tyrimą, kurio metu atsitiktinai aptiktas darinys kepenyse. Atlikus viso kūno kompiuterinės tomografijos tyrimą, VII/VIII/V/V/VI segmentuose nustatytas didelis kepenų darinys. Atlikta dešiniosios kepenų skilties trisegmentomija. Patologinis tyrimas atskleidė esant retą gerybinį naviką – angiomiolipomą. Pooperacinė eiga buvo sklandi, devintą pooperacinę dieną pacientas išleistas gydytis ambulatoriškai. Po operacijos praėjus dviem mėnesiams pacientui nepasireiškė jokių recidyvų ar vėlyvųjų komplikacijų.&nbsp;Išvada.&nbsp;Kepenų angiomiolipoma yra retas, įprastai gerybinis navikas, kurio eiga gali būti piktybinio pobūdžio. Angiomiolipomą galima diagnozuoti radiologiniais tyrimais, atlikus biopsiją ar operaciją. Dažniausiai taikomas gydymas – chirurginė rezekcija