Theories of deviant sexual fantasy

Deviant sexual fantasies have long been regarded as an important factor in sexual offending, with research showing that they serve multiple functions (e.g., inducing arousal, planning behavior) and interrelate with numerous other factors (e.g., emotional states, personality). However, within this chapter, an evaluation of the existing theoretical accounts is provded, which indicates that the construct is not well understood or conceptualized. As a result, the authors present a new model; The Dual-Process Model of Sexual Thinking (DPM-ST). This account is developed by drawing upon relevant research from socio-cognitive psychology and mental imagery and knitting it with existing research on deviant sexual fantasies. The DPM-ST states that associative processes are involved in the generation of intrusive sexual thoughts, whereas controlled processes are responsible for the deliberate, effortful, and goal-oriented act of sexual fantasizing. Research supporting the model is outlined, as are various implications for future research and clinical practice

Impact of socio-economic deprivation on death rates after surgery for upper gastrointestinal tract cancer

We hypothesised that socio-economic deprivation in England may be a prognostic factor for death after oesophagectomy or gastrectomy for cancer of the upper gastrointestinal tract. We analysed statistical data from hospital records linked to death records for patients who underwent operations for oesophageal and gastric cancer in England from April 1998 to March 2002. The patients were stratified into quintiles according to the index of multiple deprivation (IMD) (2000) for their place (ward) of residence. Age and sex standardised death rates at 30 and 90 days for each deprivation quintile were calculated. Following oesophagectomy, death rates showed a significant association with IMD. They increased with increasing levels of deprivation: the odds ratio for death, comparing highest with lowest quintile for deprivation, was 1.37 (95% confidence interval 1.03–1.85) at 30 days and 1.30 (1.04–1.64) at 90 days. Following gastrectomy, the death rates showed smaller and nonsignificant associations with IMD with odds ratios of 1.16 (0.84–1.62) and 1.10 (0.86–1.41), respectively. There is a significant association between social deprivation and death after oesophagectomy, but less of an association, if any, after gastrectomy in current UK practice

Split Tickets? On the Strategic Allocation of Presidential Versus Vice Presidential Visits in 2016

This article analyzes the strategic allocation of presidential campaign visits in 2016. In particular, we test whether each campaign disproportionately targeted its presidential versus vice presidential candidates’ visits toward voters with whom they shared a salient demographic or political characteristic. Our purpose in doing so is to discern whether—and, if so, among which groups—the campaigns perceived the candidates as having a strategic advantage in appealing to affiliated voters. To this end, we analyze an original database of 2016 campaign visits that includes local population characteristics for each host site. Our results indicate that each ticket’s visits were highly coordinated across states, but frequently divergent within states. At the substate level, we find several systematic differences in the populations visited by presidential versus vice presidential candidates—in some cases aligning with a candidate’s personal characteristics. We discuss these findings’ implications with respect to campaign strategy and vice presidential selection

Light-induced regulation of ligand-gated channel activity

The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field

Unreflective Partisans? Policy Information and Evaluation in the Development of Partisanship

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/1/pops12480.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/2/pops12480-sup-0002-suppinfo2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/3/pops12480-sup-0001-suppinfo1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/4/pops12480_am.pd

The local roots of the participation gap: Inequality and voter turnout

It is generally accepted that the rich are more likely to participate in politics than the poor. It is also generally accepted that the probability than an individual will participate in elections is influenced by the gap between the rich and the poor. There is little agreement, however, about whether inequality across time and space increases or decreases participation. In this paper we examine the impact of inequality across space. We suggest that the impact of inequality depends crucially on whether it is defined in terms of variations between geographical units (‘segregation’) or within geographical units (‘heterogeneity’). Evidence to support this argument is drawn from multi-level British data. Heterogeneity has a mildly positive effect on participation but this effect seems to be outweighed by the negative impact of segregation. The effect of segregation, moreover, is most pronounced among the poorer sections of the population, indicating that geographical isolation among the poor ('ghettoization') leads to lower turnout among these groups

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.info:eu-repo/semantics/publishedVersio