69 research outputs found

    Managing marine socio-ecological systems: picturing the future

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    What do you get when a lawyer, a modeller, an economist, a social scientist and an ecologist talk about the ocean? Besides an interesting conversation, it is likely there will be some consideration of how to solve many of the problems facing marine ecosystems around the world. That is precisely what the MSEAS 2016 symposium on understanding marine socio-ecological systems aimed to do. From 30 May to 3 June in Brest, France, the symposium gathered over 230 participants from around the world and from multiple disciplines to discuss the challenge of explicitly considering the human component in producing synoptic assessments of marine social-ecological systems. The symposium fostered dynamic debates on the inter-disciplinary collaborations needed to support management of ongoing and anticipated growth in multiple ocean uses, with particular consideration of the triple bottom line of ecological, economic and social sustainability. Building on the illustrations produced by a professional cartoonist during the meeting, this graphic novel summarizes the key challenges ahead in understanding marine socio-ecological systems and draws a path for future research endeavours in this domain

    Simulating MADMAX in 3D: Requirements for Dielectric Axion Haloscopes

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    We present 3D calculations for dielectric haloscopes such as the currently envisioned MADMAX experiment. For ideal systems with perfectly flat, parallel and isotropic dielectric disks of finite diameter, we find that a geometrical form factor reduces the emitted power by up to 30%30\,\% compared to earlier 1D calculations. We derive the emitted beam shape, which is important for antenna design. We show that realistic dark matter axion velocities of 103c10^{-3} c and inhomogeneities of the external magnetic field at the scale of 10%10\,\% have negligible impact on the sensitivity of MADMAX. We investigate design requirements for which the emitted power changes by less than 20%20\,\% for a benchmark boost factor with a bandwidth of 50MHz50\,{\rm MHz} at 22GHz22\,{\rm GHz}, corresponding to an axion mass of 90μeV90\,\mu{\rm eV}. We find that the maximum allowed disk tilt is 100μm100\,\mu{\rm m} divided by the disk diameter, the required disk planarity is 20μm20\,\mu{\rm m} (min-to-max) or better, and the maximum allowed surface roughness is 100μm100\,\mu{\rm m} (min-to-max). We show how using tiled dielectric disks glued together from multiple smaller patches can affect the beam shape and antenna coupling

    Simulating MADMAX in 3D: requirements for dielectric axion haloscopes

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    International audienceWe present 3D calculations for dielectric haloscopes such as the currently envisioned MADMAX experiment. For ideal systems with perfectly flat, parallel and isotropic dielectric disks of finite diameter, we find that a geometrical form factor reduces the emitted power by up to 30 % compared to earlier 1D calculations. We derive the emitted beam shape, which is important for antenna design. We show that realistic dark matter axion velocities of 10-3 c and inhomogeneities of the external magnetic field at the scale of 10 % have negligible impact on the sensitivity of MADMAX. We investigate design requirements for which the emitted power changes by less than 20 % for a benchmark boost factor with a bandwidth of 50 MHz at 22 GHz, corresponding to an axion mass of 90 μ eV. We find that the maximum allowed disk tilt is 100 μ m divided by the disk diameter, the required disk planarity is 20 μ m (min-to-max) or better, and the maximum allowed surface roughness is 100 μ m (min-to-max). We show how using tiled dielectric disks glued together from multiple smaller patches can affect the beam shape and antenna coupling

    Measurement of charged particle spectra in minimum-bias events from proton-proton collisions at root s =13 TeV

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    Pseudorapidity, transverse momentum, and multiplicity distributions are measured in the pseudorapidity range vertical bar eta vertical bar 0.5 GeV in proton-proton collisions at a center-of-mass energy of root s = 13 TeV. Measurements are presented in three different event categories. The most inclusive of the categories corresponds to an inelastic pp data set, while the other two categories are exclusive subsets of the inelastic sample that are either enhanced or depleted in single diffractive dissociation events. The measurements are compared to predictions from Monte Carlo event generators used to describe high-energy hadronic interactions in collider and cosmic-ray physics.Peer reviewe

    The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases.

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    Some isolates of Yersinia pseudotuberculosis produce the cytotoxic necrotizing factor (CNFY), but the functional consequences of this toxin for host-pathogen interactions during the infection are unknown. In the present study we show that CNFY has a strong influence on virulence. We demonstrate that the CNFY toxin is thermo-regulated and highly expressed in all colonized lymphatic tissues and organs of orally infected mice. Most strikingly, we found that a cnfY knock-out variant of a naturally toxin-expressing Y. pseudotuberculosis isolate is strongly impaired in its ability to disseminate into the mesenteric lymph nodes, liver and spleen, and has fully lost its lethality. The CNFY toxin contributes significantly to the induction of acute inflammatory responses and to the formation of necrotic areas in infected tissues. The analysis of the host immune response demonstrated that presence of CNFY leads to a strong reduction of professional phagocytes and natural killer cells in particular in the spleen, whereas loss of the toxin allows efficient tissue infiltration of these immune cells and rapid killing of the pathogen. Addition of purified CNFY triggers formation of actin-rich membrane ruffles and filopodia, which correlates with the activation of the Rho GTPases, RhoA, Rac1 and Cdc42. The analysis of type III effector delivery into epithelial and immune cells in vitro and during the course of the infection further demonstrated that CNFY enhances the Yop translocation process and supports a role for the toxin in the suppression of the antibacterial host response. In summary, we highlight the importance of CNFY for pathogenicity by showing that this toxin modulates inflammatory responses, protects the bacteria from attacks of innate immune effectors and enhances the severity of a Yersinia infection

    Climate change 2022: impacts, adaptation and vulnerability

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    The Working Group II contribution to the IPCC Sixth Assessment Report assesses the impacts of climate change, looking at ecosystems, biodiversity, and human communities at global and regional levels. It also reviews vulnerabilities and the capacities and limits of the natural world and human societies to adapt to climate change
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