Estudios actuales de literatura comparada. Teorías de la literatura y diálogos interdisciplinarios

Estos dos volúmenes constituyen una contribución al desarrollo de la comparatística que se realiza, principalmente, desde América Latina. El primer volumen está organizado en tres partes y consta de 22 artículos, mientras que el segundo reúne 24 capítulos.UCR::Vicerrectoría de Docencia::Artes y Letras::Facultad de Letras::Escuela de Filología, Lingüística y LiteraturaUCR::Vicerrectoría de Docencia::Ciencias Básicas::Sistema de Educación General::Escuela de Estudios GeneralesUCR::Vicerrectoría de Investigación::Sistema de Estudios de Posgrado::Artes y Letras::Maestría Académica en Literatura FrancesaUCR::Vicerrectoría de Investigación::Sistema de Estudios de Posgrado::Artes y Letras::Maestría Académica en Literatura LatinoamericanaUCR::Vicerrectoría de Docencia::Artes y Letras::Facultad de Letras::Escuela de Lenguas Moderna

Guía Mexicana para el Diagnóstico y el Tratamiento de la Urticaria

La urticaria es una enfermedad que padece una quinta parte de la población en algún momento de su vida. Las guías inter- nacionales recientes han propuesto unos cambios de fondo en su diagnóstico y tratamiento, por lo que había la necesidad de crear una guía nacional y multidisciplinaria, con base amplia en los gremios de especialistas y médicos de primer contacto en México. ABSTRACT Urticaria is a disease that a fifth of the population shall suffer once in a lifetime. Recent clinical guidelines have proposed some fundamental changes in the diagnosis and treatment of urticaria, making the development of a national, multidisciplinary guideline, with wide acceptability among different professional groups –both specialists and primary health care workers–, necessary in Mexico

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Statistical metadata in knowledge discovery

Metadata representsthe semantic schema of the data collected over the years by an organization in order to apply the business intelligence approach. However, the metadata normally collected are not enough to facilitate knowledge discovery processes because they are conceived, primarily, for the interoperability between information systems. Research undertaken in this study confirmed the need to enrich data warehousing systems with structured meaningful metadata in order to increase the productivity and efficacy of any investigation, including data management and future business analytics. This need led us to adopt and extend the concept of “statistical metadata”. Thus, our proposed conceptual model of statistical metadata not only considers recognized standards, but also represents other additional properties. This means that our conceptual model allows increased levels of detail about the data and quality of the semanticcontents.Los metadatos representan el esquema semántico de los datos recolectados a lo largo de los años por una organización para aplicar el enfoque de inteligencia de negocios. Sin embargo, los metadatos normalmente recopilados no son suficientes para facilitar los procesos de descubrimiento de conocimiento porque están concebidos, principalmente, para la interoperabilidad entre sistemas de información. La investigación realizada en este estudio confirmó la necesidad de enriquecer los sistemas de almacenamiento de datos con metadatos significativos y estructurados con el fin de aumentar la productividad y la eficacia de cualquier investigación, incluida la gestión de datos y la analítica futura del negocio. Esta necesidad nos llevó a adoptar y ampliar el concepto de "metadatos estadísticos". Por lo tanto, nuestro modelo conceptual propuesto de metadatos estadísticos no sólo considera estándares reconocidos, sino que también representa otras propiedades adicionales. Esto significa que nuestro modelo conceptual permite mayores niveles de detalle sobre los datos y la calidad de los contenidos semánticos

Psicología del desarrollo para docentes

Presenta un manual de ayuda en la formación de docentes cuyo ámbito de responsabilidad se sitúa dentro de los títulos de grado de educación infantil, primaria y educación social, para colaborar en el entrenamiento de competencias generales y específicas que hagan posible una labor educativa responsable. Al final de cada capítulo se expone el estudio de casos o situaciones para resolver problemas, finalmente incluye un glosario de términos de ayuda en la comprensión de los conceptos incluidos.MadridBiblioteca del Ministerio de Educación y Formación Profesional; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]

Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes

Introduction: A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country remain open. Methods: A literature review was completed aimed to provide estimates for DIAD pathogenic variants in the LatAm population. The search strategies were established using a combination of standardized terms for DIAD and LatAm. Results: Twenty-four DIAD pathogenic variants have been reported in LatAm countries. Our combined dataset included 3583 individuals at risk; countries with highest DIAD frequencies were Colombia (n = 1905), Puerto Rico (n = 672), and Mexico (n = 463), usually attributable to founder effects. We found relatively few reports with extensive documentation on biomarker profiles and disease progression. Discussion: Future DIAD studies will be required in LatAm, albeit with a more systematic approach to include fluid biomarker and imaging studies. Regional efforts are under way to extend the DIAD observational studies and clinical trials to Latin America.Fil: Llibre Guerra, Jorge J.. Washington University in St. Louis; Estados UnidosFil: Li, Yan. Washington University in St. Louis; Estados UnidosFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chrem Mendez, Patricio Alexis. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Surace, Ezequiel Ignacio. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Llibre Rodriguez, Juan J.. Universidad de La Habana; CubaFil: Sosa, Ana Luisa. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Aláez Verson, Carmen. Instituto Nacional de Medicina Genómica; MéxicoFil: Longoria, Erika Mariana. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Tellez, Alberto. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Carrillo Sánchez, Karol. Instituto Nacional de Medicina Genómica; MéxicoFil: Flores Lagunes, Luis Leonardo. Instituto Nacional de Medicina Genómica; MéxicoFil: Sánchez, Victor. Universidade de Sao Paulo; BrasilFil: Takada, Leonel Tadao. General Hospital of Fortaleza; BrasilFil: Nitrini, Ricardo. General Hospital of Fortaleza; BrasilFil: Ferreira Frota, Norberto Anizio. Grupo de Neurociencias de Antioquia; ColombiaFil: Benevides Lima, Joyce. Grupo de Neurociencias de Antioquia; ColombiaFil: Lopera, Francisco. Universidad de Puerto Rico; Puerto RicoFil: Ramírez, Laura. Universidad de Puerto Rico; Puerto RicoFil: Jiménez Velázquez, Ivonne. Universidad Nacional Pedro Henríquez Ureña; República DominicanaFil: Schenk, Christian. Universidad Nacional Pedro Henríquez Ureña; República DominicanaFil: Acosta, Daisy. Universidad de Chile.; Chile. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Behrens, María Isabel. Washington University in St. Louis; Estados UnidosFil: Doering, Michelle. Washington University in St. Louis; Estados UnidosFil: Ziegemeier, Ellen. Washington University in St. Louis; Estados UnidosFil: Morris, John C.. Washington University in St. Louis; Estados UnidosFil: McDade, Eric. Washington University in St. Louis; Estados UnidosFil: Bateman, Randall J.. Washington University in St. Louis; Estados Unido

Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease

International audiencePurpose: Pittsburgh Compound-B (11C-PiB) and 18F-florbetapir are amyloid-β (Aβ) positron emission tomography (PET) radiotracers that have been used as endpoints in Alzheimer's disease (AD) clinical trials to evaluate the efficacy of anti-Aβ monoclonal antibodies. However, comparing drug effects between and within trials may become complicated if different Aβ radiotracers were used. To study the consequences of using different Aβ radiotracers to measure Aβ clearance, we performed a head-to-head comparison of 11C-PiB and 18F-florbetapir in a Phase 2/3 clinical trial of anti-Aβ monoclonal antibodies.Methods: Sixty-six mutation-positive participants enrolled in the gantenerumab and placebo arms of the first Dominantly Inherited Alzheimer Network Trials Unit clinical trial (DIAN-TU-001) underwent both 11C-PiB and 18F-florbetapir PET imaging at baseline and during at least one follow-up visit. For each PET scan, regional standardized uptake value ratios (SUVRs), regional Centiloids, a global cortical SUVR, and a global cortical Centiloid value were calculated. Longitudinal changes in SUVRs and Centiloids were estimated using linear mixed models. Differences in longitudinal change between PET radiotracers and between drug arms were estimated using paired and Welch two sample t-tests, respectively. Simulated clinical trials were conducted to evaluate the consequences of some research sites using 11C-PiB while other sites use 18F-florbetapir for Aβ PET imaging.Results: In the placebo arm, the absolute rate of longitudinal change measured by global cortical 11C-PiB SUVRs did not differ from that of global cortical 18F-florbetapir SUVRs. In the gantenerumab arm, global cortical 11C-PiB SUVRs decreased more rapidly than global cortical 18F-florbetapir SUVRs. Drug effects were statistically significant across both Aβ radiotracers. In contrast, the rates of longitudinal change measured in global cortical Centiloids did not differ between Aβ radiotracers in either the placebo or gantenerumab arms, and drug effects remained statistically significant. Regional analyses largely recapitulated these global cortical analyses. Across simulated clinical trials, type I error was higher in trials where both Aβ radiotracers were used versus trials where only one Aβ radiotracer was used. Power was lower in trials where 18F-florbetapir was primarily used versus trials where 11C-PiB was primarily used.Conclusion: Gantenerumab treatment induces longitudinal changes in Aβ PET, and the absolute rates of these longitudinal changes differ significantly between Aβ radiotracers. These differences were not seen in the placebo arm, suggesting that Aβ-clearing treatments may pose unique challenges when attempting to compare longitudinal results across different Aβ radiotracers. Our results suggest converting Aβ PET SUVR measurements to Centiloids (both globally and regionally) can harmonize these differences without losing sensitivity to drug effects. Nonetheless, until consensus is achieved on how to harmonize drug effects across radiotracers, and since using multiple radiotracers in the same trial may increase type I error, multisite studies should consider potential variability due to different radiotracers when interpreting Aβ PET biomarker data and, if feasible, use a single radiotracer for the best results