395 research outputs found
Treatment of initial parenchymal central nervous system involvement in systemic aggressive B-cell lymphoma
Central nervous system (CNS) involvement in systemic B-cell non-Hodgkin lymphoma (B-NHL) at diagnosis (sysCNS) is rare. We investigated the outcome of 21 patients with sysCNS, most commonly diffuse large B-cell lymphoma, treated with high dose methotrexate (HD-MTX) and R-CHOP. The median number of cycles of HD-MTX and R-CHOP was 4 (range 1â8) and 6 (range 0â8), respectively. Consolidative whole brain radiotherapy (WBRT) was given to 33% (7/21) patients. With a median follow-up of 44 months the 3-year progression free survival (PFS) and overall survival (OS) were 45% (95%CI 34â56%) and 49% (95%CI 38â60%), respectively. Over 90% of patients had an unfavorable international prognostic index score, reflected by treatment-related mortality of 19% (4/21) and relapse-related mortality of 28% (6/21). The outcome of these patients was, however, unexpectedly good when compared to secondary CNS relapses. Prospective studies are needed to define the optimal treatment for patients with sysCNS, but its rarity might be challenging
Nature of bonding and electronic structure in MgB2, a boron intercalation superconductor
Chemical bonding and electronic structure of MgB2, a boron-based newly
discovered superconductor, is studied using self-consistent band structure
techniques. Analysis of the transformation of the band structure for the
hypothetical series of graphite - primitive graphite - primitive graphite-like
boron - intercalated boron, shows that the band structure of MgB2 is
graphite-like, with pi-bands falling deeper than in ordinary graphite. These
bands possess a typically delocalized and metallic, as opposed to covalent,
character. The in-plane sigma-bands retain their 2D covalent character, but
exhibit a metallic hole-type conductivity. The coexistence of 2D covalent
in-plane and 3D metallic-type interlayer conducting bands is a peculiar feature
of MgB2. We analyze the 2D and 3D features of the band structure of MgB2 and
related compounds, and their contributions to conductivity.Comment: 4 pages in revtex, 3 figures in 4 separate EPS file
Probing the isovector transition strength of the low-lying nuclear excitations induced by inverse kinematics proton scattering
A compact approach based on the folding model is suggested for the
determination of the isoscalar and isovector transition strengths of the
low-lying () excitations induced by inelastic proton
scattering measured with exotic beams. Our analysis of the recently measured
inelastic O+p scattering data at and 43 MeV/nucleon
has given for the first time an accurate estimate of the isoscalar
and isovector deformation parameters (which cannot be determined from
the (p,p') data alone by standard methods) for 2 and excited
states in O. Quite strong isovector mixing was found in the 2
inelastic O+p scattering channel, where the strength of the isovector
form factor (prototype of the Lane potential) corresponds to a
value almost 3 times larger than and a ratio of nuclear transition
matrix elements .Comment: 5 pages, 3 figure
Analytical Evaluation of Hierarchical Planning Systems
Hierarchical planning systems have become popular for multilevel decision problems. After reviewing the concept of hierarchical planning and citing some examples, the authors describe a method for analytic evaluation of a hierarchical planning system. They show that multilevel decision problems can be nicely modeled as multistage stochastic programs. Then any hierarchical planning system can be measured against the yardstick of optimality in this stochastic program. They demonstrate this approach on a hierarchical system that can be shown to be asymptotically optimal for a job shop design/scheduling problem
Electronic and optical spectra in a diluted magnetic semiconductor multilayer
The effects of random distribution of magnetic impurities with concentration
in a semiconductor alloy multilayer at a paramagnetic temperature are
investigated by means of coherent potential approximation and tight-binding
model. The change in the electronic states and the optical absorption spectrum
with is calculated for weak and strong exchange interactions between
carrier spins and localized spin moments on magnetic ions. We find that the
density of states and optical absorption are strongly layer-dependent due to
the quantum size effects. The electronic and optical spectra are broadened due
to the spin fluctuations of magnetic ions and in the case of strong exchange
interaction, an energy gap appears in both spectra. Furthermore, the interior
layers show higher contribution in the optical absorption of the system. The
results can be helpful for magneto-optical devices at a paramagnetic
temperature.Comment: 7 pages, 5 figure
Universal flow diagram for the magnetoconductance in disordered GaAs layers
The temperature driven flow lines of the diagonal and Hall magnetoconductance
data (G_{xx},G_{xy}) are studied in heavily Si-doped, disordered GaAs layers
with different thicknesses. The flow lines are quantitatively well described by
a recent universal scaling theory developed for the case of duality symmetry.
The separatrix G_{xy}=1 (in units e^2/h) separates an insulating state from a
spin-degenerate quantum Hall effect (QHE) state. The merging into the insulator
or the QHE state at low temperatures happens along a semicircle separatrix
G_{xx}^2+(G_{xy}-1)^2=1 which is divided by an unstable fixed point at
(G_{xx},G_{xy})=(1,1).Comment: 10 pages, 5 figures, submitted to Phys. Rev. Let
Search for varying constants of nature from astronomical observation of molecules
The status of searches for possible variation in the constants of nature from
astronomical observation of molecules is reviewed, focusing on the
dimensionless constant representing the proton-electron mass ratio
. The optical detection of H and CO molecules with large
ground-based telescopes (as the ESO-VLT and the Keck telescopes), as well as
the detection of H with the Cosmic Origins Spectrograph aboard the Hubble
Space Telescope is discussed in the context of varying constants, and in
connection to different theoretical scenarios. Radio astronomy provides an
alternative search strategy bearing the advantage that molecules as NH
(ammonia) and CHOH (methanol) can be used, which are much more sensitive to
a varying than diatomic molecules. Current constraints are
for redshift , corresponding to
look-back times of 10-12.5 Gyrs, and for
, corresponding to half the age of the Universe (both at 3
statistical significance). Existing bottlenecks and prospects for future
improvement with novel instrumentation are discussed.Comment: Contribution to Workshop "High Performance Clocks in Space" at the
International Space Science Institute, Bern 201
Mode-division-multiplexed 3x112-Gb/s DP-QPSK transmission over 80-km few-mode fiber with inline MM-EDFA and blind DSP
We show transmission of a 3x112-Gb/s DP-QPSK mode-multiplexed signal up to 80km, without and with multi-mode EDFA, using blind 6x6 MIMO digital signal processing. We show that the OSNR-penalty induced by mode-mixing in the multi-mode EDFA is negligible
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in âs = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fbâ1 of protonâproton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
- âŠ