286 research outputs found
Protective effect of Arque-Ajeeb on acute experimental diarrhoea in rats
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/07/2004
- Field of study
BACKGROUND: Diarrhoea is a major health problem for children worldwide, accounting for 5–8 million deaths each year. Arque-Ajeeb (AA) is a compound formulation of Unani medicine. It is reputed for its beneficial effects in the treatment of diarrhoea and cholera, but the claim of its efficacy is yet to be tested. Therefore the present study has been planned to investigate the real efficacy of this drug in rats. METHODS: The effect of Arque-Ajeeb was investigated for antidiarrhoeal activity against charcoal-induced gut transit, serotonin-induced diarrhoea and PGE(2)-induced small intestine enteropooling in rats. The control, standard and test groups of experimental animals were administered with normal saline (p.o.), diphenoxylate hydrochloride (5 mg/kg, p.o.) and Arque-Ajeeb (0.07 ml and 0.14 ml/kg, p.o.) respectively except the control group of PGE(2)-induced small intestine enteropooling which received only 5% ethanol in normal saline (i.p.). Charcoal (10 ml/kg, p.o.) and serotonin (600 μg/kg, i.p.) were administered after 30 min, while PGE(2 )(100 μg/kg, p.o.) was administered immediately afterwards. The distance traveled by charcoal in small intestine was measured after 15 and 30 min of charcoal administration, diarrhoea was observed every 30-min for six hour after serotonin administration and the volume of intestinal fluid was measured after 30 min of PGE(2 )administration. RESULTS: Arque-Ajeeb (0.07 ml and 0.14 ml/kg) significantly inhibited the frequency of defaecation and decreased the propulsion of charcoal meal through the gastrointestinal tract, reduced the wetness of faecal droppings in serotonin-induced diarrhoea and also reduced the PGE(2)-induced small intestine enteropooling. CONCLUSION: Arque-Ajeeb may have potential to reduce the diarrhoea in rats. Thus the drug may prove to be an alternate remedy in diarrhoea
Prevalence of Clostridium difficile colonization among healthcare workers
- Author
- AL Bull
- C Burnham
- Centers for Disease Control and Prevention
- CR Clabots
- D Van der Waaij
- Daniel R Knight
- Douglas Stupart
- E Ozaki
- E Van Nood
- Elise K Davey
- H Kato
- J Swindells
- James Pollard
- L Arfons
- L Kyne
- LC McDonald
- LJ Brandt
- Louise Parry
- LV McFarland
- M Hell
- Masoomeh Khajehnoori
- MH Samore
- MJ Richards
- MM Riggs
- N Deborah Friedman
- PL Russo
- R Viscidi
- RA Bowman
- RA Bowman
- S Johnson
- S Johnson
- SA Villano
- SH Cohen
- SM Carroll
- SP Borriello
- Thomas V Riley
- TV Riley
- U Jabbar
- VG Loo
- Y Carmelli
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
BackgroundClostridium difficile infection (CDI) has increased to epidemic proportions in recent years. The carriage of C. difficile among healthy adults and hospital inpatients has been established. We sought to determine whether C. difficile colonization exists among healthcare workers (HCWs) in our setting.MethodsA point prevalence study of stool colonization with C. difficile among doctors, nurses and allied health staff at a large regional teaching hospital in Geelong, Victoria. All participants completed a short questionnaire and all stool specimens were tested by Techlab® C.diff Quik Check enzyme immunoassay followed by enrichment culture.ResultsAmong 128 healthcare workers, 77% were female, of mean age 43 years, and the majority were nursing staff (73%). Nineteen HCWs (15%) reported diarrhoea, and 12 (9%) had taken antibiotics in the previous six weeks. Over 40% of participants reported having contact with a patient with known or suspected CDI in the 6 weeks before the stool was collected. C. difficile was not isolated from the stool of any participants.ConclusionAlthough HCWs are at risk of asymptomatic carriage and could act as a reservoir for transmission in the hospital environment, with the use of a screening test and culture we were unable to identify C. difficile in the stool of our participants in a non-outbreak setting. This may reflect potential colonization resistance of the gut microbiota, or the success of infection prevention strategies at our institution.<br /
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
- Author
- Adeniran JF
- Alphonse PJ
- Boyd RF
- Cepko CL
- Chan Y
- Chan YK
- Chiang JJ
- Chu CJ
- Church GM
- Copland DA
- Costa Verdera H
- Dick AD
- Gao G
- Graveline AR
- Inciong RGCO
- Jabbar MH
- Kaplan HJ
- Krause TB
- Letizia AJ
- Lim ET
- Liu T
- McCall MA
- Mingozzi F
- Muhuri M
- Neidermyer WJ
- Pezone M
- Robinson-McCarthy LR
- Sahu B
- Sanchez M
- Sethi M
- Slain JM
- Tai PWL
- Tam JM
- Vernet A
- Vihtelic TS
- Wang MK
- Wang SK
- Wang W
- Xiao R
- Xie J
- Xue Y
- Publication venue
- Publication date
- 10/02/2021
- Field of study
Nucleic acids are used in many therapeutic modalities, including gene therapy, but their ability to trigger host immune responses in vivo can lead to decreased safety and efficacy. In the case of adeno-associated viral (AAV) vectors, studies have shown that the genome of the vector activates Toll-like receptor 9 (TLR9), a pattern recognition receptor that senses foreign DNA. Here, we engineered AAV vectors to be intrinsically less immunogenic by incorporating short DNA oligonucleotides that antagonize TLR9 activation directly into the vector genome. The engineered vectors elicited markedly reduced innate immune and T cell responses and enhanced gene expression in clinically relevant mouse and pig models across different tissues, including liver, muscle, and retina. Subretinal administration of higher-dose AAV in pigs resulted in photoreceptor pathology with microglia and T cell infiltration. These adverse findings were avoided in the contralateral eyes of the same animals that were injected with the engineered vectors. However, intravitreal injection of higher-dose AAV in macaques, a more immunogenic route of administration, showed that the engineered vector delayed but did not prevent clinical uveitis, suggesting that other immune factors in addition to TLR9 may contribute to intraocular inflammation in this model. Our results demonstrate that linking specific immunomodulatory noncoding sequences to much longer therapeutic nucleic acids can “cloak” the vector from inducing unwanted immune responses in multiple, but not all, models. This “coupled immunomodulation” strategy may widen the therapeutic window for AAV therapies as well as other DNA-based gene transfer methods
Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong
- Author
- A Goorhuis
- AC Clements
- AJ Hedges
- B Aronsson
- C Yip
- CA Muto
- CA Muto
- CR Clabots
- D Paredes-Sabja
- D Wolff
- DW Hecht
- E. Y. F. Tse
- ER Dubberke
- F Barbut
- FA Zar
- G. K. H. Siu
- H. Tse
- I Joost
- J Dzink
- J Pépin
- J Pépin
- J Wu
- J. F. W. Chan
- J. L. Y. Tsang
- J. W. M. Tai
- JA Linder
- JE Coia
- K. K. W. To
- K. Y. Yuen
- L Fenner
- L Kyne
- LC McDonald
- LV McFarland
- M Merrigan
- M Miller
- M Warny
- M Warny
- ME McCusker
- MH Samore
- MH Wilcox
- MJ Alfa
- MT Oughton
- O. T. C. Lam
- P Bidet
- P Spigaglia
- P Verity
- P. L. Ho
- R Gaynes
- R Viscidi
- S Borgmann
- S Johnson
- S Persson
- S Underwood
- SL Stubbs
- T Akerlund
- T Akerlund
- U Jabbar
- V. C. C. Cheng
- VC Cheng
- VC Cheng
- VC Cheng
- VC Cheng
- VG Loo
- W. C. Yam
- WC Yam
- WN Fawley
- WN Fawley
- WN Fawley
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
We identified a predominant clone of Clostridium difficile PCR ribotype 002, which was associated with an increased sporulation frequency. In 2009, 3,528 stool samples from 2,440 patients were tested for toxigenic C. difficile in a healthcare region in Hong Kong. A total of 345 toxigenic strains from 307 (13.3%) patients were found. Ribotype 002 was the predominant ribotype, which constituted 35 samples from 29 (9.4%) patients. The mean sporulation frequency of ribotype 002 was 20.2%, which was significantly higher than that of the 56 randomly selected ribotypes other than 002 as concurrent controls (3.7%, p < 0.001). Patients carrying toxigenic ribotype 002 were more frequently admitted from an elderly home (p = 0.01) and received more β-lactam antibiotics in the preceding 3 months compared with the controls (p = 0.04) . The identification of toxigenic ribotype 002 in 2009 was temporally related to a significant increase in both the incidence of toxigenic C. difficile from 0.53 to 0.95 per 1,000 admissions (p < 0.001) and the rate of positive detection from 4.17% to 6.28% (p < 0.001) between period 1 (2004–2008) and period 2 (2009). This finding should alert both the physician and the infection control team to the establishment of and possible outbreaks by ribotype 002 in our hospitals, as in the case of ribotype 027
EZH2 Depletion Blocks the Proliferation of Colon Cancer Cells
- Author
- A Sgambato
- A Sparmann
- AL Jackson
- Angela Holzer
- AP Bracken
- AV Ougolkov
- Axel Benner
- BD Parsons
- Bettina Fussbroich
- BF Liebersbach
- C Chen
- C Cullmann
- C Lu
- CG Kleer
- CG Wang
- CJ Sneeringer
- D Holland
- DF Dukers
- E Ezhkova
- E Martinez-Garcia
- F Takeshita
- Felix Hoppe-Seyler
- G Nikoloski
- G Schneider
- GK Smyth
- GS Winkler
- Holger Sültmann
- I Crnkovic-Mertens
- IM Chu
- J Ferlay
- J Tan
- JA Simon
- JD Pereira
- JW Tukey
- K Butz
- K Butz
- K Mimori
- Karin Hoppe-Seyler
- KJ Livak
- L Peng
- LL Kodach
- LM Kamminga
- Maria Fälth
- MH Fox
- Moray Campbell
- N Wagener
- Nina Wagener
- O Fluge
- P Chomczynski
- P Wang
- Q Du
- R Palmqvist
- RD Morin
- RD Petty
- RS Tuma
- S Varambally
- SA Jabbar
- Stephan Macher-Goeppinger
- T Ernst
- T Fujita
- T Sudo
- W Fiskus
- Y Benjamini
- Y Wei
- ZL Wu
- ZY Rao
- Publication venue
- Public Library of Science
- Publication date
- 13/07/2011
- Field of study
The Enhancer of Zeste 2 (EZH2) protein has been reported to stimulate cell growth in some cancers and is therefore considered to represent an interesting new target for therapeutic intervention. Here, we investigated a possible role of EZH2 for the growth control of colon cancer cells. RNA interference (RNAi)-mediated intracellular EZH2 depletion led to cell cycle arrest of colon carcinoma cells at the G1/S transition. This was associated with a reduction of cell numbers upon transient transfection of synthetic EZH2-targeting siRNAs and with inhibition of their colony formation capacity upon stable expression of vector-borne siRNAs. We furthermore tested whether EZH2 may repress the growth-inhibitory p27 gene, as reported for pancreatic cancer. However, expression analyses of colon cancer cell lines and colon cancer biopsies did not reveal a consistent correlation between EZH2 and p27 levels. Moreover, EZH2 depletion did not re-induce p27 expression in colon cancer cells, indicating that p27 repression by EZH2 may be cell- or tissue-specific. Whole genome transcriptome analyses identified cellular genes affected by EZH2 depletion in colon cancer cell lines. They included several cancer-associated genes linked to cellular proliferation or invasion, such as Dag1, MageD1, SDC1, Timp2, and Tob1. In conclusion, our results demonstrate that EZH2 depletion blocks the growth of colon cancer cells. These findings might provide benefits for the treatment of colon cancer
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
- Carreiro De Freitas AV
- Castro Mollo M
- Cengiz Y
- Cengiz Y
- Ceriani C
- Chachulski W
- Chambers A
- Chan E
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
- Chiu SMY
- Choi J
- Chong BFHK
- Chong CL
- Chong HY
- Chowdhury A
- Chun A
- Chun T
- Chung S
- Cirocchi R
- Clark DJ
- Clark T
- Clement KD
- Clements JM
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Cocker DM
- Collaborative G
- Colombani J-F
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Coomber R
- Corro-Diaz Gonzalez S
- Costa-Maia J
- Court E
- Cragg J
- Cross K
- Cruz H
- Cucumazzo S
- Currow C
- D'aguzan N
- D'amours SK
- D'cruz R
- D'Souza R
- Da Silva LA
- Dabessa D
- Dablouk M
- Dablouk MO
- Dal Canto M
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daqeeq A
- Dar M
- Darweesh M
- Das A
- Das K
- Das S
- Davenport R
- Davies J
- Dawnay G
- Dawoud H
- De Bono P
- De Sousa AV
- Dean R
- Deckelbaum DL
- Decker E
- Deichsel F
- Dempster E
- Deputy M
- Dervenis C
- Despotidis V
- Desta S
- Devadasar GH
- Dharamshi HA
- Di Franco F
- Di Saverio S
- Diab A
- Diaconescu I-B
- Dias S
- Diaz-Zorrilla C
- Dickfos M
- Dickson L
- Dindyal S
- Domini E
- Donoghue D
- dos Santos DV
- Doughan S
- Doughty J
- Drake TM
- Driscoll A
- Du Plessis D
- Dubois A
- Duffy L
- Dwydar A
- Ebdewi H
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eisner L
- El Ashal G
- El Deen KN
- El Gendy A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Hamouly AS
- El-Kashef H
- El-Ma'doul AS
- El-Rabaa S
- El-Shahat NS
- El-Sheemy H
- Elabdin HZ
- Elashmawy M
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbatahgy A
- Elbermawy M
- Eldamaty L
- Elebute O
- Elena G
- Elfeki H
- Elfil M
- Elfouly N
- Elfouly Y
- Elgebaly A
- Elgendy FI
- Elhendawy AOA
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkhadrawi M
- Elkholy A
- Elkolaly SS
- Elkorashy AM
- Elmelegy R
- Elnemr AE
- Elsawahly DME
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elshaer K
- Elshaer M
- Elshafay AE
- Elshanwany S
- Elsheikh S
- Elsherbiny AS
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Escobar EG
- Estupinian S
- Etchill E
- Etman M
- Eysa A
- Eyssartier E
- Faccincani R
- Fadel A
- Fahiem A
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fakher R
- Farah A
- Faraz A
- Farhad M
- Farinella E
- Farooq T
- Farquharson A
- Fattah AA
- Faturoti O
- Faure A
- Fautz T
- Fawzy A
- Felipe CO
- Fergusson S
- Fergusson SJ
- Fermani C
- Fernandez-Bueno F
- Fievet L
- Findlay-Cooper K
- Firdouse M
- Fitzgerald JEF
- Forno W
- Fouad A
- Fouad D
- Fowler AJ
- Fozard T
- Frade F
- Fraga GP
- Francois-Coridon H
- Freitas AV
- Frisk B
- Fujii F
- Furqan MM
- Gadhvi V
- Gaignard E
- Galloway S
- Gamaly E
- Garaycochea O
- Garcia Florez LJ
- Garcia Torres CP
- Garland A
- Gash K
- Gasteratos K
- Gemeah M
- Gemenetzis G
- George R
- Germanos S
- Gerosa A
- Ghandora N
- Ghanem E
- Ghanem S
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Giacci L
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giuliani S
- Giuriato TF
- Glasbey JC
- Glover TE
- Gobin N
- Goh CC
- Gohar ME-SAM
- Gokani S
- Golding D
- Gomaa A
- Gomah M
- Gonzales Stuva JP
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Graffeille V
- Graffieille V
- Grandinetti PP
- Grant A
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Green N
- Griffiths E
- Griffiths M
- Grossart C
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Gumar M
- Gunnarsson U
- Guo W
- Gustafsson U
- Gyanchandani N
- Habeeb MA
- Habeebullah A
- Hache-Marliere M
- Hafez AT
- Hafez M
- Hafiz S
- Hagar A
- Haines S
- Hakim H
- Hall N
- Hall NJ
- Hall TF
- Hallam S
- Hamad MGM
- Hamasaki J
- Hammad A
- Hammad AM
- Hampton M
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanrahan M
- Hantour U
- Harbord P
- Haroun A
- Harper E
- Harrison EM
- Harrison N
- Harrison P
- Harrison R
- Hasan A
- Hasheminia A
- Hashish A
- Hashish M
- Hassan A
- Hassan A
- Hassan A
- Hassan M
- Hassan S
- Hassan Z
- Hassanain M
- Havemann I
- Hawkins W
- Heath J
- Heffernan D
- Hegazy Y
- Hemeda D
- Hemingway D
- Hemmila M
- Henderson L
- Herrera Puma CM
- Herrera N
- Herrera-Matta J
- Hervieux E
- Hettiarachchi TS
- Hewage K
- Heywood EG
- Highcock S
- Hinojosa C
- Hjertberg M
- Ho CW
- Ho W
- Ho WC
- Hogea M
- Holton P
- Hoogakker E
- Horobjowsky A
- Hosein S-P
- Hosh M
- Hossaini S
- Houlden C
- Howells L
- Howie EE
- Huaman E
- Humm G
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Hutch W
- Huwait A
- Ibraheem HI
- Ibrahem AA
- Ibrahim I
- Ibrahim MH
- Ibrahim Y
- Idris SAI
- Iftikhar Z
- Ingabire JDLCA
- Iordache F-M
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
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- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √s=8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT>120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between EmissT>150 GeV and EmissT>700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
- Author
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- Abdallah J
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Measurement of the W±Z boson pair-production cross section in pp collisions at √s=13TeV with the ATLAS detector
- Author
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- Aad G
- Abbott B
- Abdallah J
- Abdinov O
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- Winklmeier F
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- Worm SD
- Wosiek BK
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- Yao W-M
- Yap YC
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- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
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- Yu J
- Yu J
- Yu JM
- Yuan L
- Yuen SPY
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang R
- Zhang X
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- Netherlands
- Publication date
- 01/01/2016
- Field of study
published_or_final_versio
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlas Collaboration
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
- Bajic M
- Bakalis C
- Baker OK
- Bakker PJ
- Bakshi Gupta D
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barlow N
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães Da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batlamous S
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
- Bellos P
- Belotskiy K
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Besjes GJ
- Bessidskaia Bylund O
- Bessner M
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Biswal JP
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blunier D
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt A
- Brandt G
- Brandt O
- Braren F
- Bratzler U
- Brau B
- Brau JE
- Breaden Madden WD
- Brendlinger K
- Brennan AJ
- Brenner L
- Brenner R
- Bressler S
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brost E
- Broughton JH
- Bruckman De Renstrom PA
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Brunt BH
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
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- Wermes N
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- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- White R
- Whiteson D
- Whitmore BW
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wiglesworth C
- Wiik-Fuchs LAM
- Wildauer A
- Wilk F
- Wilkens HG
- Wilkins LJ
- Williams HH
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- Wilson JA
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolter MW
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- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
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- Wyatt TR
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- Yabsley B
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- Yajima K
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- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki T
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- Yan Z
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- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
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- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yorita K
- Yoshihara K
- Young C
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- Yu J
- Yu J
- Yue X
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeitnitz C
- Zeißner SV
- Zemaityte G
- Zeng JC
- Zeng Q
- Zenin O
- Zerwas D
- Zgubič M
- Zhang D
- Zhang DF
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
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