138 research outputs found
The Ethnomedicine of the Haya people of Bugabo ward, Kagera Region, north western Tanzania
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
\ud
The Kagera region, in north western Tanzania, is endowed with a strong culture of traditional medicine that is well supported by a rich diversity of medicinal plants. However, most of the plants in this region have not been documented nor evaluated for safety and efficacy. As an initiative in that direction, this study documented the knowledge on medicinal plant use by traditional healers of Bugabo Ward in Bukoba District. Key informants were selected with the help of local government officials and information on their knowledge and use of plants for therapeutic purposes was gathered using a semi-structured interview format. In this study 94 plant species representing 84 genera and 43 families were found to be commonly used in the treatment of a variety of human ailments. The family Asteraceae had the highest number of species being used as traditional medicines. The study revealed that Malaria is treated using the highest number of different medicinal species (30), followed by skin conditions (19), maternal illnesses and sexually transmitted diseases (14), respiratory diseases (11) and yellow fever, Herpes simplex and peptic ulcers (10). Majority of the species are used to treat less than five different diseases/conditions each and leaves were the most commonly used part, comprising 40% of all the reports on use of plant parts. Trees comprised the most dominant growth form among all plants used for medicinal purposes in the study area. Bugabo Ward has a rich repository of medicinal plants and this reinforces the need for an extensive and comprehensive documentation of medicinal plants in the area and a concomitant evaluation of their biological activity as a basis for developing future medicines.\u
Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome
- Author
- A Lopez
- A Nohria
- A Ratcliff
- AM Dondorp
- Bert K. Lopansri
- BK Lopansri
- Catherine Jones
- CE Jones
- Christabelle J. Darcy
- CJ Lowenstein
- Daniel A. Lampah
- David S. Celermajer
- DE McClintock
- Donald L. Granger
- Emiliana Tjitra
- Enny Kenangalem
- F Hinder
- FE Lovegrove
- G Minigo
- GD Turner
- GP Maguire
- J Hibbs
- J Leiper
- J. Brice Weinberg
- James W. Kazura
- JT Kielstein
- JT Kielstein
- M Jallow
- M Karyana
- MC Richir
- MC Richir
- ME Molyneux
- MJ O'Dwyer
- MW Vaughn
- N Day
- Nicholas M. Anstey
- NM Anstey
- NP Day
- P Bulau
- P Vallance
- P Vallance
- Q Fan
- R De Caterina
- Retno Gitawati
- Ric N. Price
- RJ Nijveldt
- RJ Nijveldt
- RW Snow
- S Anthony
- SJ Brett
- Stephen B. Duffull
- T Teerlink
- Tsin W. Yeo
- TW Yeo
- TW Yeo
- TW Yeo
- TW Yeo
- WR Taylor
- Yvette R. McNeil
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adverse outcomes in malaria is unknown. In adults with and without falciparum malaria, we tested the hypotheses that plasma ADMA would be: 1) increased in proportion to disease severity, 2) associated with impaired vascular and pulmonary NO bioavailability and 3) independently associated with increased mortality. We assessed plasma dimethylarginines, exhaled NO concentrations and endothelial function in 49 patients with SM, 78 with moderately severe malaria (MSM) and 19 healthy controls (HC). Repeat ADMA and endothelial function measurements were performed in patients with SM. Multivariable regression was used to assess the effect of ADMA on mortality and NO bioavailability. Plasma ADMA was increased in SM patients (0.85 Β΅M; 95% CI 0.74β0.96) compared to those with MSM (0.54 Β΅M; 95%CI 0.5β0.56) and HCs (0.64 Β΅M; 95%CI 0.58β0.70; p<0.001). ADMA was an independent predictor of mortality in SM patients with each micromolar elevation increasing the odds of death 18 fold (95% CI 2.0β181; pβ=β0.01). ADMA was independently associated with decreased exhaled NO (rsβ=ββ0.31) and endothelial function (rsβ=ββ0.32) in all malaria patients, and with reduced exhaled NO (rsβ=ββ0.72) in those with SM. ADMA is increased in SM and associated with decreased vascular and pulmonary NO bioavailability. Inhibition of NOS by ADMA may contribute to increased mortality in severe malaria
A multidisciplinary, multifactorial intervention program reduces postoperative falls and injuries after femoral neck fracture
- Author
- A Jonsson
- B. BorssΓ©n
- B. Olofsson
- C Colon-Emeric
- D Oliver
- DA Lawlor
- DG Altman
- E Jensen
- ER Marcantonio
- ES Siris
- FE Shaw
- H Luukinen
- H Myers
- IP Donald
- J Davison
- J Jensen
- J Jensen
- J Sheikh
- JT Chang
- K Kallin
- K Pils
- L Nyberg
- L. Nyberg
- M Stenvall
- M Vassallo
- M. LundstrΓΆm
- M. Stenvall
- MC Robertson
- ME Tinetti
- ME Tinetti
- MF Folstein
- NE Mayo
- O Johnell
- O Sletvold
- O. Svensson
- P Halfon
- R Tideiksaar
- S Sadigh
- T Gluck
- TP Haines
- U Sonn
- U. Englund
- Y Gustafson
- Y Gustafson
- Y. Gustafson
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2006
- Field of study
INTRODUCTION: This study evaluates whether a postoperative multidisciplinary, intervention program, including systematic assessment and treatment of fall risk factors, active prevention, detection, and treatment of postoperative complications, could reduce inpatient falls and fall-related injuries after a femoral neck fracture. METHODS: A randomized, controlled trial at the orthopedic and geriatric departments at UmeΓ₯ University Hospital, Sweden, included 199 patients with femoral neck fracture, aged ββ₯70Β years. RESULTS: Twelve patients fell 18 times in the intervention group compared with 26 patients suffering 60 falls in the control group. Only one patient with dementia fell in the intervention group compared with 11 in the control group. The crude postoperative fall incidence rate was 6.29/1,000Β days in the intervention group vs 16.28/1,000Β days in the control group. The incidence rate ratio was 0.38 [95% confidence interval (CI): 0.20βββ0.76, pβ=β0.006] for the total sample and 0.07 (95% CI: 0.01β0.57, p=0.013) among patients with dementia. There were no new fractures in the intervention group but four in the control group. CONCLUSION: A team applying comprehensive geriatric assessment and rehabilitation, including prevention, detection, and treatment of fall risk factors, can successfully prevent inpatient falls and injuries, even in patients with dementia
Observation of associated near-side and away-side long-range correlations in βsNN=5.02ββTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro GuimarΓ£es da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
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- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
- Berry T
- Bertella C
- Bertin A
- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bittner B
- Black CW
- Black JE
- Black KM
- Blair RE
- Blanchard JB
- Blazek T
- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boddy CR
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- Boek J
- Boek TT
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- Bogdanchikov A
- Bogouch A
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- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bomben M
- Bona M
- Boonekamp M
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borri M
- Borroni S
- Bortfeldt J
- Bortolotto V
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- Boscherini D
- Bosman M
- Boterenbrood H
- Bouchami J
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- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boutouil S
- Boveia A
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- Boyko IR
- Bozovic-Jelisavcic I
- Bracinik J
- Branchini P
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- Brau JE
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- Brelier B
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- Bristow TM
- Britton D
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- Bruckman de Renstrom PA
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- Bruneliere R
- Brunet S
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- Bruschi M
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- Buat Q
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- Buchholz P
- Buckingham RM
- Buckley AG
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- Budagov IA
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- Bugge L
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- Burckhart H
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- Buszello CP
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- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
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- Cabrera UrbΓ‘n S
- Caforio D
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- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
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- Calvet D
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- Capeans Garrido MD
- Caprini I
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- Castillo Gimenez V
- Castro NF
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- Catastini P
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- Cetin SA
- Chafaq A
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- Chalupkova I
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- Chapman JD
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- Charlton DG
- Chavda V
- Chavez Barajas CA
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- Chekulaev SV
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- Christidi IA
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- Coniavitis E
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- Dearnaley WJ
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- Delemontex T
- Deliyergiyev M
- Dell'acqua A
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- Delmastro M
- Delsart PA
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- Demers S
- Demichev M
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deviveiros PO
- Dewhurst A
- Dewilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
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- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
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- Di Simone A
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- Diaz MA
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- Dietrich J
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- Dingfelder J
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- Doan TK
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- Dobos D
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- Dodd J
- Doglioni C
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- Etienvre AI
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- Facini GJ
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- Ferreira de Lima DE
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- Fiedler F
- FilipΔiΔ A
- Filthaut F
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- Fiolhais MC
- Fiorini L
- Firan A
- Fischer J
- Fisher MJ
- Fitzgerald EA
- Flechl M
- Fleck I
- Fleischmann P
- Fleischmann S
- Fletcher G
- Fletcher GT
- Flick T
- Floderus A
- Flores Castillo LR
- Florez Bustos AC
- Flowerdew MJ
- Fonseca Martin T
- Formica A
- Forti A
- Fortin D
- Fournier D
- Fowler AJ
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- Francavilla P
- Franchini M
- Franchino S
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- Frank T
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- Franz S
- Fraternali M
- Fratina S
- French ST
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- Froidevaux D
- Frost JA
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- Fullana Torregrosa E
- Fulsom BG
- Fuster J
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- Gadfort T
- Gadomski S
- Gagliardi G
- Gagnon P
- Galea C
- Galhardo B
- Gallas EJ
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- Gallop BJ
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- Gan KK
- Gandrajula RP
- Gao YS
- Gaponenko A
- Garay Walls FM
- Garberson F
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- GarcΓa Navarro JE
- GarcΓa C
- Gardner RW
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- Garonne V
- Gatti C
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- Gaur B
- Gauthier L
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- Gavrilenko IL
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- Gazis EN
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- Gellerstedt K
- Gemme C
- Gemmell A
- Genest MH
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- George S
- Gerbaudo D
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- Gershon A
- Geweniger C
- Ghazlane H
- Ghodbane N
- Giacobbe B
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- Giangiobbe V
- Gianotti F
- Gibbard B
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- Gillam TP
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- Gillman AR
- Gingrich DM
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- Gonzalez-Sevilla S
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- Gonçalo R
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- Gordon HA
- Gorelov I
- Gorfine G
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- Yen AL
- Yilmaz M
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- Yorita K
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- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- ZeniΕ‘ T
- Zerwas D
- Zevi Della Porta G
- Zhang D
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhu CG
- Zhu H
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- ZivkoviΔ L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ΞΟ) and pseudorapidity (ΞΞ·) are measured in βsNN=5.02ββTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ββΞΌb-1 of data as a function of transverse momentum (pT) and the transverse energy (Ξ£ETPb) summed over 3.1<Ξ·<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|ΞΞ·|<5) βnear-sideβ (ΞΟβΌ0) correlation that grows rapidly with increasing Ξ£ETPb. A long-range βaway-sideβ (ΞΟβΌΟ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small Ξ£ETPb, is found to match the near-side correlation in magnitude, shape (in ΞΞ· and ΞΟ) and Ξ£ETPb dependence. The resultant ΞΟ correlation is approximately symmetric about Ο/2, and is consistent with a dominant cosβ‘2ΞΟ modulation for all Ξ£ETPb ranges and particle pT
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Abajyan T
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- Abdallah J
- Abdelalim AA
- Abdinov O
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- Allwood-Spiers SE
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- Wooden G
- Wosiek BK
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- Woudstra MJ
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- Yilmaz M
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- Yoshihara K
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- Zanzi D
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- Zeitnitz C
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- Zenin O
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- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ο lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ο, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan Ξ² in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Khalek SA
- Abdelalim AA
- Abdinov O
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- Yilmaz M
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- Zerwas D
- della Porta GZ
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
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- Zimmermann S
- Ziolkowski M
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- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fbβ1 of sβ=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan Ξ² < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at sβ=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
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- Yanush S
- Yao L
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- Yilmaz M
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- Yoshihara K
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- Youssef S
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- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
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- Zerwas D
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- Zhemchugov A
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- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Zβ² gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/Ξ³ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fbβ1 in the e + e β channel and 5.0 fbβ1 in the ΞΌ + ΞΌ βchannel. A Z β² boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Zβ² Models
The Toronto prehospital hypertonic resuscitation-head injury and multi organ dysfunction trial (TOPHR HIT) - Methods and data collection tools
- Author
- A Benton
- A Rey
- Alex Kiss
- Andrew J Baker
- Anna Trompeo
- AT Beck
- B Jennett
- B Simma
- Brian Schwartz
- C Golden
- CE Wade
- D Delis
- D Wechsler
- D Wechsler
- Donald T Stuss
- DT Stuss
- DT Stuss
- DT Wong
- E Kaplan
- FL Ferreira
- FQ Gao
- GA Lancaster
- J Cuschieri
- JC Marshall
- JT Wilson
- K Hall
- KL Mattox
- LA Dade
- Laurie J Morrison
- LE Pelinka
- M Freedman
- M Lawrence
- M Lezack
- M Rappaport
- M Thiel
- MC Morganti-Kossmann
- Merita Simitciu
- N Kovacevic
- PaB Safar
- PJ Basser
- PM Walker
- R Heaton
- RH Swartz
- RH Swartz
- RM Roumen
- Russell MacDonald
- Sandra E Black
- Sandro B Rizoli
- SB Rizoli
- SB Rizoli
- SB Rizoli
- SB Rizoli
- SG Soriano
- Shawn G Rhind
- TA Dodds
- TH Ward
- TM Rudkin
- TS Tan
- Tyrone Perreira
- U Kreimeier
- WA Knaus
- WD Gouvier
- WF Dick
- WH Loomis
- Publication venue
- BioMed Central
- Publication date
- 01/11/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Clinical trials evaluating the use of hypertonic saline in the treatment of hypovolemia and head trauma suggest no survival superiority over normal saline; however subgroup analyses suggest there may be a reduction in the inflammatory response and multiorgan failure which may lead to better survival and enhanced neurocognitive function. We describe a feasibility study of randomizing head injured patients to hypertonic saline and dextran vs. normal saline administration in the out of hospital setting.</p> <p>Methods/Design</p> <p>This feasibility study employs a randomized, placebo-controlled design evaluating normal saline compared with a single dose of 250 ml of 7.5% hypertonic saline in 6% dextran 70 in the management of traumatic brain injuries. The primary feasibility endpoints of the trial were: 1) baseline survival rates for the treatment and control group to aid in the design of a definitive multicentre trial, 2) randomization compliance rate, 3) ease of protocol implementation in the out-of-hospital setting, and 4) adverse event rate of HSD infusion.</p> <p>The secondary objectives include measuring the effect of HSD in modulating the immuno-inflammatory response to severe head injury and its effect on modulating the release of neuro-biomarkers into serum; evaluating the role of serum neuro-biomarkers in predicting patient outcome and clinical response to HSD intervention; evaluating effects of HSD on brain atrophy post-injury and neurocognitive and neuropsychological outcomes.</p> <p>Discussion</p> <p>We anticipate three aspects of the trial will present challenges to trial success; ethical demands associated with a waiver of consent trial, challenging follow up and comprehensive accurate timely data collection of patient identifiers and clinical or laboratory values. In addition all the data collection tools had to be derived de novo as none existed in the literature.</p> <p>Trial registration number</p> <p>NCT00878631</p
Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers
- Author
- A Trkola
- AJ Hessell
- AN Cline
- Ann J. Hessell
- BD Walker
- BR Mothe
- CN Scanlan
- DA Calarese
- DA Calarese
- David I. Watkins
- DD Richman
- Dennis R. Burton
- DH Barouch
- Donald N. Forthal
- DR Casimiro
- EJ Soilleux
- Eva G. Rakasz
- G Zanetti
- Gary Landucci
- J Lue
- J Su
- JM Binley
- JM Binley
- JM Harouse
- JM Harouse
- JR Mascola
- JR Mascola
- JT Loffredo
- KH Roux
- KH Roux
- Lars Hangartner
- LJ Yant
- M Kaizu
- M Li
- MC Gauduin
- MI Johnston
- Michael Farzan
- P Poignard
- P Roben
- PA Kozlowski
- PA Marx
- Pascal Poignard
- PL Moore
- PW Hong
- PW Parren
- PW Parren
- PW Parren
- QJ Sattentau
- R Pal
- R Shibata
- RC Tan
- RS Veazey
- RW Sanders
- S Wolbank
- SK Wang
- TB Geijtenbeek
- TC Friedrich
- TW Baba
- Wayne C. Koff
- Y Nishimura
- Y Yasutomi
- ZQ Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Developing an immunogen that elicits broadly neutralizing antibodies (bNAbs) is an elusive but important goal of HIV vaccine research, especially after the recent failure of the leading T cell based HIV vaccine in human efficacy trials. Even if such an immunogen can be developed, most animal model studies indicate that high serum neutralizing concentrations of bNAbs are required to provide significant benefit in typical protection experiments. One possible exception is provided by the anti-glycan bNAb 2G12, which has been reported to protect macaques against CXCR4-using SHIV challenge at relatively low serum neutralizing titers. Here, we investigated the ability of 2G12 administered intravenously (i.v.) to protect against vaginal challenge of rhesus macaques with the CCR5-using SHIVSF162P3. The results show that, at 2G12 serum neutralizing titers of the order of 1βΆ1 (IC90), 3/5 antibody-treated animals were protected with sterilizing immunity, i.e. no detectable virus replication following challenge; one animal showed a delayed and lowered primary viremia and the other animal showed a course of infection similar to 4 control animals. This result contrasts strongly with the typically high titers observed for protection by other neutralizing antibodies, including the bNAb b12. We compared b12 and 2G12 for characteristics that might explain the differences in protective ability relative to neutralizing activity. We found no evidence to suggest that 2G12 transudation to the vaginal surface was significantly superior to b12. We also observed that the ability of 2G12 to inhibit virus replication in target cells through antibody-mediated effector cell activity in vitro was equivalent or inferior to b12. The results raise the possibility that some epitopes on HIV may be better vaccine targets than others and support targeting the glycan shield of the envelope
Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila
- Author
- A Sureau
- AL Saltzman
- BM Cali
- BP Lewis
- CR Alonso
- D Gatfield
- D Hattori
- DM Bates
- Dmitri A. Petrov
- Donald C. Rio
- E Hornstein
- E Nagy
- Elisa Izaurralde
- Fabian L. Gallusser
- G Goshima
- GK Smyth
- H Le Hir
- I Behm-Ansmant
- J Rehwinkel
- J Rehwinkel
- J Vilardell
- JA Calarco
- Jan Rehwinkel
- JT Mendell
- JZ Ni
- K Lange
- Kasper Daniel Hansen
- LF Lareau
- LF Lareau
- Liana F. Lareau
- LM McIntyre
- LR Bell
- M Blanchette
- M Blanchette
- M Cuccurese
- M Gabut
- M Kozak
- M Kozak
- M Suyama
- Marco Blanchette
- MC Wollerton
- ME Ritchie
- MJ Ruiz-Echevarria
- MP Somma
- MR Culbertson
- MT Hyvonen
- NJ McGlincy
- O Isken
- O Rossbach
- O Shai
- Q Pan
- Qi Meng
- RC Gentleman
- Richard E. Green
- S Barberan-Soler
- S Carbon
- S Sayani
- S Zhang
- Sandrine Dudoit
- Steven E. Brenner
- T Hothorn
- TL Bailey
- V Stolc
- WG Fairbrother
- YK Kim
- YK Kim
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Alternative mRNA splicing adds a layer of regulation to the expression of thousands of genes in Drosophila melanogaster. Not all alternative splicing results in functional protein; it can also yield mRNA isoforms with premature stop codons that are degraded by the nonsense-mediated mRNA decay (NMD) pathway. This coupling of alternative splicing and NMD provides a mechanism for gene regulation that is highly conserved in mammals. NMD is also active in Drosophila, but its effect on the repertoire of alternative splice forms has been unknown, as has the mechanism by which it recognizes targets. Here, we have employed a custom splicing-sensitive microarray to globally measure the effect of alternative mRNA processing and NMD on Drosophila gene expression. We have developed a new algorithm to infer the expression change of each mRNA isoform of a gene based on the microarray measurements. This method is of general utility for interpreting splicing-sensitive microarrays and high-throughput sequence data. Using this approach, we have identified a high-confidence set of 45 genes where NMD has a differential effect on distinct alternative isoforms, including numerous RNAβbinding and ribosomal proteins. Coupled alternative splicing and NMD decrease expression of these genes, which may in turn have a downstream effect on expression of other genes. The NMDβaffected genes are enriched for roles in translation and mitosis, perhaps underlying the previously observed role of NMD factors in cell cycle progression. Our results have general implications for understanding the NMD mechanism in fly. Most notably, we found that the NMDβtarget mRNAs had significantly longer 3β² untranslated regions (UTRs) than the nontarget isoforms of the same genes, supporting a role for 3β² UTR length in the recognition of NMD targets in fly
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