170 research outputs found
Hvad er ledelse af brugerinddragelse? En gennemgang af mål og tre individuelle brugerinddragelsesmodeller
- Publication venue
- Medicinsk Antropologisk Forum/Afdeling for Antropologi og Etnografi, Aarhus Universitet
- Publication date
- 01/08/2015
- Field of study
Brugerinddragelse i det danske sundhedsvæsen står højt på den politiske dagsorden, men det er stadig en udfordring at implementere visionen i klinisk praksis. Ledelse af brugerinddragelse bliver aktuelt udpeget som en central nøgle til at føre visionen ud i livet. Samtidig er der kun relativt lidt forskning om ledelse af brugerinddragelse i sundhedsvæsenet og på det empiriske plan er det uklart, hvad det er lederne skal implementere. Artiklen identificerer syv forskellige italesatte mål med brugerinddragelse, hvoraf nogle potentielt kan være i konflikt med hinanden. Herudover peges der på, at brugerinddragelse skal implementeres i en verden, hvor der allerede er en række andre mål tilstede. En central ledelsesudfordring er derfor, at nogle af målene med brugerinddragelse forudsætter nye måder at organisere ikke bare arbejdet og kompetencer på, men også relationer til patienter og pårørende. En væsentlig opgave i ledelse af brugerinddragelse vil derfor være at fremme en gentænkning af de etablerede roller og identiteter i sundhedsvæsenet. Artiklen opstiller tre forskellige inddragelsesmodeller, der hver organiserer relationer mellem sundhedsprofessionelle og sundhedsvæsenets brugere på forskellige måder.Artiklen bygger dels på en gennemgang af dansk og international litteratur og policy dokumenter, dels på en empirisk best practice undersøgelse af ledelse af brugerinddragelse, som i perioden 2012-2013 blev gennemført på tre danske hospitalsafdelinger
Implementing Integrated Care – Lessons from the Odense Integrated Care Trial
- Publication venue
- 'Ubiquity Press, Ltd.'
- Publication date
- 01/10/2018
- Field of study
Introduction: Creating coordination and concerted action between sectors of modern healthcare is an inherent challenge, and decision makers in search for solutions tend replicate new models across countries and settings. An example of this is the translation of the North West London integrated care pilot into a large-scale trial that took place in the Danish Municipality of Odense from 2013–2016. This article highlights the findings from our evaluation of the ill-fated project and discusses lessons learned. Methods: We examined implementation and short-term outcome in a multi-method evaluation based on qualitative interviews, direct observation, electronic surveys and quantitative analysis of change in service use and costs, using patient level data and a matched control group. Results and discussion: Despite an ambitious setup, ample financing, a shared governance structure and a well-functioning project organisation, implementation failed at the clinical level. Also, service use and costs for included patients increased significantly, without yielding the intended results. Primary explanations relate to an overly optimistic timeframe and a failure to take professionals’ wishes, daily practices and values into account. The results underline the importance of basing future attempts at integrated care on thorough studies of the perception of actual needs and timing, including rigorous pilot testing on a smaller scale, before attempting large-scale implementation
Sygeplejerskernes veje på arbejdsmarkedet:En kvantitativ og kvalitativ undersøgelse af sygeplejerskernes arbejdsmarked og fastholdelse.
- Publication venue
- 'Ali Nihat Gokyigit Egitim, Saglik, Kultur, Sanat ve Dogal Varliklari Koruma Vakfi (ANG Vakfi)'
- Publication date
- 01/01/2009
- Field of study
Measurement properties of UCLA Activity Scale for hip and knee arthroplasty patients and translation and cultural adaptation into Danish
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Background and purpose — The UCLA Activity Scale (UCLA) is a questionnaire assessing physical activity level from 1 (low) to 10 (high) in patients undergoing hip or knee arthroplasty (HA/KA). After translation and cultural adaptation, we evaluated the measurement properties of the Danish UCLA. Patients and methods — After dual panel translation, cognitive interviews were performed among 55 HA/KA patients. An orthopedic surgeon and a physiotherapist estimated UCLA scores for 80 KA patients based on short interviews. Measurement properties were evaluated in 130 HA and 134 KA patients preoperatively and 1-year postoperatively. Results — To suit Danish patients of today, several adaptations were required. Prior to interviews, 4 patients were excluded, and 11 misinterpreted the answer options. Examiners rated the remaining 65 patients (mean age 67 years) 0.2–1.6 UCLA levels lower than patients themselves. The 130 HA and 134 KA patients (mean age 71/68 years) changed from 4.3 (SD 1.9)/4.5 (1.8) preoperatively to 6.6 (1.8)/6.2 (1.0) at 1-year follow-up. 103 (79%) HA and 89 (66%) KA patients reported increased activity. Effect sizes were large (1.2/0.96). Knee patients reaching minimal important change (MIC, ≥ 8 Oxford Knee Score points) had higher 1-year UCLA scores than patients not reaching MIC. Interpretation — Original scale development was undocumented. Content validity was questionable, and there was discrepancy between patient and examiner estimates. UCLA appears valuable for measuring change in self-reported physical activity on a group level. 4 out of 5 HA patients and 2 out of 3 KA patients were more physically active 1 year after joint replacement surgery
Biosynthesis of acurin A and B in Aspergillus aculeatus
- Author
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
- Author
- Abecasis Gonçalo R.
- Absher Devin
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes Themistocles L.
- Aulchenko Yurii S.
- Baas Annette F.
- Badger Stephen A.
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Bandinelli Stefania
- Barbalic Maja
- Barnes Timothy A.
- Barroso Inês
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda J.
- Berger Klaus
- Berglund Göran
- Bergman Richard N.
- Bingham Sheila A.
- Bis Joshua C.
- Blagieva Roza
- Blair Ross D.
- Blankenberg Stefan
- Blankensteijn Jan D.
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bots Michiel L.
- Bown Matthew J.
- Bradley Declan T.
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul R.
- Burtt Noël P.
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Chambers John C.
- Charpentier Guillaume
- Chen Li
- Child Anne H.
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Clough Rachel E.
- Cockerill Gillian
- Codd Veryan
- Coin Lachlan
- Connell John M.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Crawford Gabriel J.
- Daly Mark J.
- Davies Robert W.
- de Faire Ulf
- de Graaf Jacqueline
- de Jong Paul E.
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- Devaney Joseph M.
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex S. F.
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Sarah
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eriksson Per
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Felix Stephan B.
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Marcus
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forouhi Nita G.
- Fox Caroline S.
- Franco-Cereceda Anders
- Franklin Christopher S.
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gloyn Anna L.
- Goel Anuj
- Golledge Jonathan
- Goodall Alison H.
- Grallert Harald
- Grarup Niels
- Green Todd
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick E.
- Groop Leif
- Groves Christopher J.
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gut Ivo G.
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hadley David
- Hafez Hany
- Hall Alistair S.
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen Torben
- Harrison Seamus C.
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Hazen Stanley L.
- Heath Simon C.
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Hide Winston A.
- Hill Andrew A.
- Hitman Graham A.
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Horne Benjamin D.
- Hu Frank B.
- Hua Zhao Jing
- Hughes Anne E.
- Humphries Steve E.
- Hunt Sarah E.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne U.
- Jarvelin Marjo-Riitta
- Johnson Anne
- Johnson Paul R. V.
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jørgensen Torben
- Kaiser Michael A.
- Kao Wen H. L.
- Kaplan Lee M.
- Kastelein John J. P.
- Kathiresan Sekar
- Khaw Kay-Tee
- Kiemeney Lambertus A.
- Klopp Norman
- Knowles Joshua W.
- Kolovou Genovefa
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward G.
- Lambrechts Diether
- Langenberg Claudia
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David R.
- Li Mingyao
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia M.
- Lindholt Jes S.
- Loley Christina
- Loos Ruth J. F.
- Lorbeer Roberto
- Lotery Andrew J.
- Lourdes Sampietro M.
- Luan Jian'an
- Luben Robert N.
- Lucas Gavin
- Lyssenko Valeriya
- Mannucci Pier M.
- Maouche Seraya
- Mark Lathrop G.
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson Stefan E.
- Matthijs Boekholdt S.
- Matullo Giuseppe
- McArdle Wendy L.
- McCarroll Steve A.
- McCarthy Mark I.
- McCulloch Laura J.
- McKeown Pascal P.
- McNoe Les A.
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Merriman Tony R.
- Midthjell Kristian
- Mohlke Karen L.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Munroe Patricia B.
- Musunuru Kiran
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Naik Dilip K.
- Najjar Samer S.
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen J.
- Newton-Cheh Christopher
- Nilsson Peter
- Norman Paul E.
- Numans Mattijs E.
- Nöthen Markus M.
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Olivieri Oliviero
- Onland-Moret N. Charlotte
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem H.
- Owen Katharine R.
- Palmen Jutta
- Palmer Colin N. A.
- Panico Salvatore
- Pankow James S.
- Papadakis Konstantinos
- Patel Riyaz S.
- Patterson Chris C.
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Peltonen Leena
- Perola Markus
- Perry John R. B.
- Peters Annette
- Petersen Ann-Kristin
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet T.
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rallidis Loukianos S.
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Reffelmann Thorsten
- Refstrup Mette
- Reilly Muredach P.
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Samani Nilesh J.
- Sampson Michael J.
- Sandhu Manjinder S.
- Sanna Serena
- Saxena Richa
- Sayers Robert D.
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schäfer Arne
- Scott D Julian A.
- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V.
- Shields Beverley M.
- Shrader Peter
- Sigurdsson Gunnar
- Sijbrands Eric
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith Alberto
- Smith Andrew J.
- Smith Tamara B.
- Snieder Harold
- Snoep Jaapjan D.
- Sohrabi Soroush
- Song Kijoung
- Soranzo Nicole
- Sparsø Thomas
- Spector Tim D.
- Spertus John A.
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdottir Valgerdur
- Stewart Alexandre F. R.
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Stringham Heather M.
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy J.
- Sylvius Nicolas
- Syvänen Ann-Christine
- Tanaka Toshiko
- Teijink Joep A. W.
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John R.
- Thompson Matthew M.
- Thomson Ian A.
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin D.
- Tognoni Giovanni
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Uda Manuela
- Uiterwaal Cuno S.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Valle Timo T.
- van Bockxmeer Frank M.
- van Dam Rob M.
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Rij Andre
- van Rij Andre M.
- van Vliet-Ostaptchouk Jana V.
- Vasudevan Thodur M.
- Vicky Phillips L.
- Vineis Paolo
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wain Louise V.
- Walker Mark
- Wallace Chris
- Waltham Matthew
- Wareham Nicholas J.
- Watanabe Richard M.
- Waterworth Dawn M.
- Watkins Hugh
- Webster John
- Weedon Michael N.
- Welch Ryan P.
- Wells George A.
- Wichmann H-Erich
- Wijmenga Cisca
- Wild John B.
- Wild Philipp S.
- Willenborg Christina
- Willer Cristen J.
- William Rayner N.
- Williams Frances M.
- Wilson Tang W. H.
- Wilson James F.
- Witteman Jaqueline C. M.
- Wouter Jukema J.
- Wright Benjamin J.
- Wu Guanming
- Ye Shu
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler Andreas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
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- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
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- Olivieri Oliviero
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- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
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- Bolton Judith A Hoffman
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- Bouchard Claude
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- Brennan Eoin P
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- Brody Jennifer
- Broekmans Frank J
- Broer Linda
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- Brown Morris J
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- Burnier Michel
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- Chen Wei
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- Cheng Iona
- Cheng Sulin
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- Cho Yoon Shin
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- Willenborg Christina
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- Wilsgaard Tom
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- Wilson Sarah
- Wilson Scott G
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- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
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- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
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- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen J Von
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FL Lucio
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 08/03/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
- …