FDZ Annual Report 2008

"Following the exceedingly positive response to our Annual Report 2007, you now have the Annual Report 2008 of the Research Data Centre (FDZ) of the Federal Employment Agency at the Institute for Employment Research in this FDZ Methodenreport. Like last year, the FDZ Annual Report 2008 is not a glossy brochure full of photos but summarises the main events of the past 12 months in a few pages. The Annual Report 2008 is mainly based on key figures which the FDZ made available to the German Council for Social and Economic Data for their evaluation in 2009. The Annual Report also serves to provide transparency for our users, who after all justify the existence of the FDZ. The Report is divided into the following chapters: 'General function', 'Basic information', 'The service-oriented FDZ', 'The international FDZ' and, as an apt conclusion, 'Research at the FDZ'." (Author's abstract, IAB-Doku) ((en)) Additional Information Here you can find the German version of the report.Forschungsdatenzentrum - Bericht, Bundesagentur für Arbeit, IAB, amtliche Statistik, Datenzugang, Datenschutz, Arbeitsmarkt- und Berufsforschung, IAB-Beschäftigtenstichprobe, IAB-Betriebspanel, IAB-Betriebs-Historik-Panel, IAB-Linked-Employer-Employee-Datensatz, Integrierte Erwerbsbiografien, Datenaufbereitung, Datenausgabe, BA-Beschäftigtenpanel, Befragung, IAB-Querschnittsbefragung, IAB-Haushaltspanel, IAB-kombinierte Firmendaten, IAB-Weiterbildungspanel

Follow-up of Bernese Mountain dogs and other dogs with serologically diagnosed Borrelia burgdorferi infection: What happens to seropositive animals?

<p>Abstract</p> <p>Background</p> <p>Data on the long-term outcome of <it>B. burgdorferi </it>infections in adult dogs are sparse. The aim of the present study was to investigate whether Bernese Mountain dogs with serological evidence of natural <it>B. burgdorferi </it>infection more often develop signs such as lameness, azotemia or proteinuria during a follow-up period of 2.5 to 3.0 years. Seropositive Bernese Mountain dogs were compared to seronegative Bernese Mountain dogs and to seropositive and seronegative control dogs of other breeds.</p> <p>Dogs included in a previous study on the prevalence of antibodies against <it>B. burgdorferi </it>in Bernese Mountain dogs were re-evaluated. Antibodies against <it>B. burgdorferi </it>were determined using an ELISA with a whole-cell sonicate as antigen and results were confirmed using a Western blot assay.</p> <p>Results</p> <p>Fifty-three Bernese Mountain dogs and 30 control dogs were re-evaluated. Re-evaluation was performed between 2.5 and 3.0 years (median 2.7 years) after the first assessment.</p> <p>The age of the dogs at the second evaluation ranged from 3 to 11 years (median 6 years). There were no significant differences with regard to poor general condition or lameness between the first and the second evaluation.</p> <p>At the first evaluation 22 (42%) of the Bernese Mountain dogs and 11 (37%) of the control dogs were considered positive for antibodies against <it>B. burgdorferi</it>. At the second evaluation 25 (47%) of the Bernese Mountain dogs and 12 (40%) of the control dogs were considered positive; 69% of the dogs showed the same serological result at both examinations and 31% were seroconverted or seroreverted. During the first examination, azotemia was diagnosed in 6 Bernese Mountain dogs and during the second examination in 11 Bernese Mountain dogs. No control dogs had azotemia in this study. In seropositive dogs there was no increase in lameness or signs of renal disease over time.</p> <p>Conclusion</p> <p>It may be concluded that antibodies against <it>B. burgdorferi </it>determined by whole cell ELISA and confirmed by Western blot were neither associated with the development of lameness nor with signs of renal disease like azotemia or proteinuria in dogs observed over a period of 2.5 to 3.0 years.</p

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

While chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform. Several studies have demonstrated that disruption of CD19 genes and transcripts can lead to disease relapse after initial response; however, few other tumor-intrinsic drivers of CAR T cell failure have been reported. Here we identify expression of the Golgi-resident intramembrane protease Signal peptide peptidase-like 3 (SPPL3) in malignant B cells as a potent regulator of resistance to CAR therapy. Loss of SPPL3 results in hyperglycosylation of CD19, an alteration that directly inhibits CAR T cell effector function and suppresses anti-tumor cytotoxicity. Alternatively, over-expression of SPPL3 drives loss of CD19 protein, also enabling resistance. In this pre-clinical model these findings identify post-translational modification of CD19 as a mechanism of antigen escape from CAR T cell therapy

Coronavirus-Pandemie: Wirksame Regeln für Herbst und Winter aufstellen : 6. Ad-hoc-Stellungnahme - 23. September 2020

Wirksame Regeln für Herbst und Winter zur Bekämpfung der Pandemie: Schutzmaßnahmen konsequent einhalten, schnell und gezielt testen, Quarantäne- und Isolationszeiten verkürzen, verantwortungsvolles Handeln erleichtern, soziale und psychische Folgen abmildern

Kinder und Jugendliche in der Coronavirus-Pandemie: psychosoziale und edukative Herausforderungen und Chancen : 8. Ad-hoc-Stellungsnahme - 21. Juni 2021

Die Coronavirus-Pandemie hat für Kinder und Jugendliche vielfältige Auswirkungen auf deren Bildung, soziale Interaktion, sozioemotionale Entwicklung, körperliche Aktivität sowie auf das psychische Wohlbefinden. Viele Betroffene werden in der Lage sein, die Auswirkungen zu überwinden. Manche dagegen werden mittel- und wahrscheinlich auch langfristig von den erlittenen Defiziten begleitet. Um diesen zu begegnen, empfiehlt die Nationale Akademie der Wissenschaften Leopoldina in der Ad-hoc-Stellungnahme „Kinder und Jugendliche in der Coronavirus-Pandemie: psychosoziale und edukative Herausforderungen und Chancen“ den Auf- und Ausbau von Unterstützungs- und Bildungsstrukturen. Diese sollten die derzeit bestehenden Ungleichheiten in Bildungs- und Entwicklungschancen nachhaltig adressieren und nicht nur pandemiebedingte Nachteile ausgleichen, sondern die Situation im Vergleich zum Status Quo vor der Pandemie verbessern

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries