Strengthening Somalia’s Systems Smartly: A Country Systems Risk Benefit Analysis

Somalia’s donors are unambiguous: statebuilding is a key, if not the key, goal of their development assistance. This paper examines donors’ decision-making about the use of country systems (UCS), an internationally recognized tool for statebuilding, exploring both the perceived and actual risks and benefits associated with it. UCS refers to a variety of ways in which international partners can engage with national counterparts to deliver aid ranging from alignment with national priorities to direct implementation by government. While using country systems comes with risks, so do alternative delivery modalities. Considering the risks and benefits both of UCS and its alternatives side-by-side may help in achieving a mix of delivery modalities that better serves donors’ and government’s shared statebuilding objectives

Flight to Safety: COVID-Induced Changes in the Intensity of Status Quo Preference and Voting Behavior

The relationship between anxiety and investor behavior is well known enough to warrant its own aphorism: a “flight to safety.” We posit that anxiety alters the intensity of voters’ preference for the status quo, inducing a political flight to safety toward establishment candidates. Leveraging the outbreak of the novel coronavirus during the Democratic primary election of 2020, we identify a causal effect of the outbreak on voting, with Biden benefiting between 7 and 15 percentage points at Sanders’s expense. A survey experiment in which participants exposed to an anxiety-inducing prompt choose the less disruptive hypothetical candidate provides further evidence of our theorized flight to safety among US-based respondents. Evidence from 2020 French municipal and US House primary elections suggests a COVID-induced flight to safety generalizes to benefit mainstream candidates across a variety of settings. Our findings suggest an as-yet underappreciated preference for “safe” candidates in times of anxiety

An agenda for the study of Public Administration in Developing Countries

Developing nations demand a different scholarly approach in the field of public administration. We advance an agenda for research that stands on four pillars. First, in the absence of easily accessible data scholars of developing world public administration must assemble it for themselves. Second, building and testing theory plays a paramount role because researchers face limited information. Third, in developing countries, multi‐national and non‐governmental organizations are often crucial and must be considered in studying public administration. Fourth, given the novelties and ambiguities researchers face, qualitative information must be integrated throughout the research process. Our article—and the articles in this volume—constitute a call for developing country research to contribute to the study of public administration writ large, informing our understanding of both developing and developed states.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162699/2/gove12520_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162699/1/gove12520.pd

Increased Concentration of Polyvalent Phospholipids in the Adsorption Domain of a Charged Protein

We studied the adsorption of a charged protein onto an oppositely charged membrane, composed of mobile phospholipids of differing valence, using a statistical-thermodynamical approach. A two-block model was employed, one block corresponding to the protein-affected region on the membrane, referred to as the adsorption domain, and the other to the unaffected remainder of the membrane. We calculated the protein-induced lipid rearrangement in the adsorption domain as arising from the interplay between the electrostatic interactions in the system and the mixing entropy of the lipids. Equating the electrochemical potentials of the lipids in the two blocks yields an expression for the relations among the various lipid fractions in the adsorption domain, indicating a sensitive dependence of lipid fraction on valence. This expression is a result of the two-block picture but does not depend on further details of the protein-membrane interaction. We subsequently calculated the lipid fractions themselves using the Poisson-Boltzmann theory. We examined the dependence of lipid enrichment, i.e., the ratio between the lipid fractions inside and outside the adsorption domain, on various parameters such as ionic strength and lipid valence. Maximum enrichment was found for lipid valence of about (-3) to (-4) in physiological conditions. Our results are in qualitative agreement with recent experimental studies on the interactions between peptides having a domain of basic residues and membranes containing a small fraction of the polyvalent phosphatidylinositol 4,5-bisphosphate (PIP2). This study provides theoretical support for the suggestion that proteins adsorbed onto membranes through a cluster of basic residues may sequester PIP2 and other polyvalent lipids.Comment: 25 pages, 12 figure

Piezo-phototronic effect on quantum well terahertz photodetector for continuously modulating wavelength

Piezo-phototronic effect is unique for effectively controlling semiconductor and photonic properties by strain-induced piezoelectric field. In this work, we theoretically explore piezo-phototronic effect on intersubband optical absorption of wurtzite-structured AlGaN/GaN quantum well by self-consistently solving eight-band kp Hamiltonian and Poisson equations. Intersubband transition is associated with the transition of two electronic states so it has longer wavelength due to lower transition energy. Strain can also effectively increase absorption wavelength in Al0.15Ga0.85N/GaN/Al0.05Ga0.95N quantum well by quantum Stark effect. For Al0.1Ga0.9N/GaN/Al0.05Ga0.95N quantum well, absorption wavelength decreases with increasing strain. Quantum efficiency can be sensitively controlled by strain. This study not only provides the theory models of piezo-phototronics of intersubband transition, but also offers the method for continuously controlling terahertz application by piezo-phototronic effect

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by PICALM genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one PICALM variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that PICALM variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly