Roosting Habitat Use by Sandhill Cranes and Waterfowl on the North and South Platte Rivers in Nebraska

Migration ecology and habitat use of spring migrating birds using the Central Platte River is a well-explored topic, yet less is known about use of the North and South Platte rivers (NSPR) in western Nebraska. The efficiency and effectiveness of conservation efforts in the NSPR could be greatly improved with access to information about where and when birds roost and landscape prioritization tools. We used aerial surveys to determine population distribution and migration phenology of sandhill cranes Antigone canadensis, Canada geese Branta canadensis, and ducks using the NSPR for roosting during the mid-February to mid-April spring migration. We used these data and geospatial information to identify important river reaches for these species and habitat covariates that discriminate between those used at lower and higher densities. We found that sandhill cranes and waterfowl generally roosted in different segments of the NSPR and, subsequently, different factors were associated with high densities. Sandhill crane density was positively correlated with distance from obstructions greater than 1 m high and negatively correlated with area of unvegetated sandbar within 1 km. Density of Canada geese and ducks was high in segments positively associated with wetland and sand pit habitats. Human disturbance variables such as roads and bridges in this rural region had little effect on identification of roosting areas used by high densities of all groups. On the basis of our results, habitat conservation efforts that specifically target sandhill cranes will not have similar positive effects on waterfowl use and distribution in the NSPR. Our identification of the most important river segments should allow managers to better target land acquisition or management resources to areas that will have the greatest effect on either waterfowl or sandhill cranes during spring migration

Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence

<p>Abstract</p> <p>Background</p> <p>Treatment options for overactive bladder (OAB) with urinary urge incontinence (UUI) refractory to oral antimuscarinics include: botulinum toxin type A (BoNTA), sacral neuromodulation (SNM), and augmentation cystoplasty (AC). A standard treatment success metric that can be used in both clinical and economic evaluations of the above interventions has not emerged. Our objective was to conduct a literature review and synthesis of published measures of treatment success for OAB with UUI interventions and to identify a treatment success outcome.</p> <p>Methods</p> <p>We performed a literature review of primary studies that used a definition of treatment success in the OAB with UUI population receiving BoNTA, SNM, or AC. The recommended success outcome was compared to generic and disease-specific health-related quality-of-life (HRQoL) measures using data from a BoNTA treatment study of neurogenic incontinent patients.</p> <p>Results</p> <p>Across all interventions, success outcomes included: complete continence (n = 23, 44%), ≥ 50% improvement in incontinence episodes (n = 16, 31%), and subjective improvement (n = 13, 25%). We recommend the OAB with UUI treatment success outcome of ≥ 50% improvement in incontinence episodes from baseline. Using data from a neurogenic BoNTA treatment study, the average change in the Incontinence Quality of Life questionnaire was 8.8 (95% CI: -4.7, 22.3) higher for those that succeeded (N = 25) versus those that failed (N = 26). The average change in the SF-6D preference score was 0.07 (95% CI: 0.02, 0.12) higher for those that succeeded versus those that failed.</p> <p>Conclusion</p> <p>A treatment success definition that encompasses the many components of underlying OAB with UUI symptoms is currently not practical as a consequence of difficulties in measuring urgency. The treatment success outcome of ≥ 50% improvement in incontinence episodes was associated with a clinically meaningful improvement in disease-specific HRQoL for those with neurogenic OAB with UUI. The recommended success definition is less restrictive than a measure such as complete continence but includes patients who are satisfied with treatment and experience meaningful improvement in symptoms. A standardized measure of treatment success will be useful in clinical and health economic applications.</p

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements