757 research outputs found
A high resolution scintillating fiber tracker with SiPM readout for the PEBS experiment
Using thin scintillating fibers with Silicon Photomultiplier (SiPM) readout a
mo dular high-resolution charged-particle tracking detector has been designed.
The fiber modules consist of 2 x 5 layers of 128 round multiclad scintillating
fiber s of 0.250mm diameter. The fibers are read out by four SiPM arrays (8mm x
1mm) e ach on either end of the module.Comment: 6 pages, 5 figures, presented at the ICATPP 1
Silicon photomultiplier arrays - a novel photon detector for a high resolution tracker produced at FBK-irst, Italy
A silicon photomultiplier (SiPM) array has been developed at FBK-irst having
32 channels and a dimension of 8.0 x 1.1 mm^2. Each 250 um wide channel is
subdivided into 5 x 22 rectangularly arranged pixels. These sensors are
developed to read out a modular high resolution scintillating fiber tracker.
Key properties like breakdown voltage, gain and photon detection efficiency
(PDE) are found to be homogeneous over all 32 channels of an SiPM array. This
could make scintillating fiber trackers with SiPM array readout a promising
alternative to available tracker technologies, if noise properties and the PDE
are improved
A High-resolution Scintillating Fiber Tracker With Silicon Photomultiplier Array Readout
We present prototype modules for a tracking detector consisting of multiple
layers of 0.25 mm diameter scintillating fibers that are read out by linear
arrays of silicon photomultipliers. The module production process is described
and measurements of the key properties for both the fibers and the readout
devices are shown. Five modules have been subjected to a 12 GeV/c proton/pion
testbeam at CERN. A spatial resolution of 0.05 mm and light yields exceeding 20
detected photons per minimum ionizing particle have been achieved, at a
tracking efficiency of more than 98.5%. Possible techniques for further
improvement of the spatial resolution are discussed.Comment: 31 pages, 27 figures, pre-print version of an article published in
Nuclear Instruments and Methods in Physics Research Section A, Vol. 62
A Scintillating Fiber Tracker With SiPM Readout
We present a prototype for the first tracking detector consisting of 250
micron thin scintillating fibers and silicon photomultiplier (SiPM) arrays. The
detector has a modular design, each module consists of a mechanical support
structure of 10mm Rohacell foam between two 100 micron thin carbon fiber skins.
Five layers of scintillating fibers are glued to both top and bottom of the
support structure. SiPM arrays with a channel pitch of 250 micron are placed in
front of the fibers. We show the results of the first module prototype using
multiclad fibers of types Bicron BCF-20 and Kuraray SCSF-81M that were read out
by novel 32-channel SiPM arrays from FBK-irst/INFN Perugia as well as
32-channel SiPM arrays produced by Hamamatsu. A spatial resolution of 88 micron
+/- 6 micron at an average yield of 10 detected photons per minimal ionizig
particle has been achieved.Comment: 5 pages, 7 figures, submitted as proceedings to the 11th Topical
Seminar on Innovative Particle and Radiation Detectors (IPRD08
An in-vitro screening assay for the detection of inhibitors of proinflammatory cytokine synthesis: a useful tool for the development of new antiarthritic and disease modifying drugs
AbstractObjective This work targets the development of a new tool to help develop new anticytokine drugs that prevent or reduce the progression of arthritic diseases. The specific aim of our study was to establish a fast and reliable in vitro screening assay of cytokine synthesis inhibitors (TNFα, IL-1ÎČ) which shows better correlation with enzyme assays than previously reported in vitro assays. The test system should be able to detect p38-MAP kinase inhibitors.Material and methods Human peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll density gradient centrifugation from human EDTA-potassium whole blood. Cells were adjusted at 1Ă106 cells/ml. PBMCs were stimulated with lipopolysaccharide (LPS; E. coli serotype 026:B6: 1ÎŒg/ml) in the presence of test compound (10â5â10â8M) for 4h at 37°C in a 5% CO2-incubator. Induced TNFα and IL-1ÎČ protein were measured by ELISA.Results The following are representative examples of inhibitors which effect cytokine synthesis. Corticoid Dexamethasone inhibits IL-1ÎČ and TNFα synthesis at IC50 of 38nM and 25nM, respectively. ERK1/ERK2 inhibitor U0126 effects cytokine synthesis at IC50 of 0.34ÎŒM for IL-1ÎČ production and 0.26ÎŒM for TNFα synthesis.p38-MAP kinase inhibitor SB 203580 inhibits IL-1ÎČ- and TNF-α-synthesis (IC50sof 0.052ÎŒM and 0.46ÎŒM) in the same degree as p38-MAP kinase activity (IC50: 0.34ÎŒM). Same results could be shown for SB 210313, which had same efficacy on IL-1ÎČ and TNFα biosynthesis (IC50's: 1.88ÎŒM and 1.01ÎŒM) and on p38-MAP kinase (IC50: 6.85ÎŒM). Also for SB 202190 this correlation in inhibition of IL-1ÎČ and TNFα synthesis (IC50's: 0.055ÎŒM and 1.01ÎŒM) and p38-MAP kinase inhibition (IC50: 0.088ÎŒM) could be shown.Conclusion This study shows the screening assay using PBMCs stimulated with LPS for IL-1ÎČ and TNFα synthesis is a reliable test system for the quantification of the effectiveness of new drugs modulating IL-1ÎČ and TNFα synthesis which is mainly mediated by p38-MAP Kinase. These assay allows fast detection of IL-1ÎČ and TNFα synthesis inhibitors with different modes of action, including p38-MAP kinase inhibitors. The results obtained with our in-vitro screening assay show good correlation with results from enzyme assays. Copyright 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved
Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art research on noncoding RNAs (ncRNAs) as biomarkers in regulatory toxicology and as analytical and therapeutic agents. There was agreement that ncRNA expression profiling data requires careful evaluation to determine the utility of specific ncRNAs as biomarkers. To advance the use of ncRNA in regulatory toxicology, the following research priorities were identified: (1) Conduct comprehensive literature reviews to identify possibly suitable ncRNAs and areas of toxicology where ncRNA expression profiling could address prevailing scientific deficiencies. (2) Develop consensus on how to conduct ncRNA expression profiling in a toxicological context. (3) Conduct experimental projects, including, e.g., rat (90-day) oral toxicity studies, to evaluate the toxicological relevance of the expression profiles of selected ncRNAs. Thereby, physiological ncRNA expression profiles should be established, including the biological variability of healthy individuals. To substantiate the relevance of key ncRNAs for cell homeostasis or pathogenesis, molecular events should be dose-dependently linked with substance-induced apical effects. Applying a holistic approach, knowledge on ncRNAs, 'omics and epigenetics technologies should be integrated into adverse outcome pathways to improve the understanding of the functional roles of ncRNAs within a regulatory context
Bose-Einstein correlations of same-sign charged pions in the forward region in pp collisions at âs=7 TeV
Bose-Einstein correlations of same-sign charged pions, produced in protonproton collisions at a 7 TeV centre-of-mass energy, are studied using a data sample collected
by the LHCb experiment. The signature for Bose-Einstein correlations is observed in the
form of an enhancement of pairs of like-sign charged pions with small four-momentum
difference squared. The charged-particle multiplicity dependence of the Bose-Einstein correlation parameters describing the correlation strength and the size of the emitting source
is investigated, determining both the correlation radius and the chaoticity parameter. The
measured correlation radius is found to increase as a function of increasing charged-particle
multiplicity, while the chaoticity parameter is seen to decreas
Study of charmonium production in b -hadron decays and first evidence for the decay Bs0
Using decays to Ï-meson pairs, the inclusive production of charmonium states in b-hadron decays is studied with pp collision data corresponding to an integrated luminosity of 3.0 fbâ1, collected by the LHCb experiment at centre-of-mass energies of 7 and 8 TeV. Denoting byBC ⥠B(b â C X) Ă B(C â ÏÏ) the inclusive branching fraction of a b hadron to a charmonium state C that decays into a pair of Ï mesons, ratios RC1C2 ⥠BC1 /BC2 are determined as RÏc0ηc(1S) = 0.147 ± 0.023 ± 0.011, RÏc1ηc(1S) =0.073 ± 0.016 ± 0.006, RÏc2ηc(1S) = 0.081 ± 0.013 ± 0.005,RÏc1 Ïc0 = 0.50 ± 0.11 ± 0.01, RÏc2 Ïc0 = 0.56 ± 0.10 ± 0.01and Rηc(2S)ηc(1S) = 0.040 ± 0.011 ± 0.004. Here and below the first uncertainties are statistical and the second systematic.Upper limits at 90% confidence level for the inclusive production of X(3872), X(3915) and Ïc2(2P) states are obtained as RX(3872)Ïc1 < 0.34, RX(3915)Ïc0 < 0.12 andRÏc2(2P)Ïc2 < 0.16. Differential cross-sections as a function of transverse momentum are measured for the ηc(1S) andÏc states. The branching fraction of the decay B0s â ÏÏÏ is measured for the first time, B(B0s â ÏÏÏ) = (2.15±0.54±0.28±0.21B)Ă10â6. Here the third uncertainty is due to the branching fraction of the decay B0s â ÏÏ, which is used for normalization. No evidence for intermediate resonances is seen. A preferentially transverse Ï polarization is observed.The measurements allow the determination of the ratio of the branching fractions for the ηc(1S) decays to ÏÏ and p p asB(ηc(1S)â ÏÏ)/B(ηc(1S)â p p) = 1.79 ± 0.14 ± 0.32
Study of J /Ï production in Jets
The production of J/Ï mesons in jets is studied in the forward region of proton-proton collisions using data collected with the LHCb detector at a center-of-mass energy of 13 TeV. The fraction of the jet transverse momentum carried by the J/Ï meson, z(J/Ï)âĄpT(J/Ï)/pT(jet), is measured using jets with pT(jet)>20 GeV in the pseudorapidity range 2.5<η(jet)<4.0. The observed z(J/Ï)distribution for J/Ï mesons produced in b-hadron decays is consistent with expectations. However, the results for prompt J/Ï production do not agree with predictions based on fixed-order nonrelativistic QCD. This is the first measurement of the pT fraction carried by prompt J/Ï mesons in jets at any experiment
Observation of an Excited Bc+ State
Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+Ï+Ï- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bcâ(2S31)+ state reconstructed without the low-energy photon from the Bcâ(1S31)+âBc+Îł decay following Bcâ(2S31)+âBcâ(1S31)+Ï+Ï-. A second state is seen with a global (local) statistical significance of 2.2Ï (3.2Ï) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date
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