1,786 research outputs found

    Kickin\u27 Sand and Tellin\u27 Lies

    Get PDF
    This document is the script of the two-act play, Kickin’ Sand and Tellin’ Lies, by Jackson B. Miller and Christopher Forrer. The Linfield College Theatre Program presented the world premieres of the play in November 2012 in McMinnville, Oregon and in Pacific City, Oregon. The play was created as part of the Launching through the Surf: The Dory Fleet of Pacific City project, which focuses on the historical and contemporary role of dory fishers and dories in the life of the coastal village of Pacific City, Oregon. Inspired by stories from the project, Kickin’ Sand and Tellin’ Lies is a fictional work. Inquiries concerning the professional or amateur rights to produce Kickin’ Sand and Tellin’ Lies, or any part thereof, should be addressed to Jackson B. Miller ([email protected]) or the Department of Theatre and Communication Arts, Linfield College, 900 SE Baker St., McMinnville, OR 97128 (503-883-2802).https://digitalcommons.linfield.edu/dory_kstl_play/1002/thumbnail.jp

    Analysis Of The Relationship Between Economic Cycle Swings And Adoption Rate Models Of Financial Innovation Diffusion

    Get PDF
    The United States financial crisis, starting with the credit boom of 2007 and ending with the failure of Lehman Brothers in September 2008, has led to a loss of confidence in the United States financial system.  The Financial Crisis Inquiry Commission indicated that the financial crisis affected over 26 million Americans.  Many scholars have attributed the crisis to financial innovations, such as mortgage backed securities, adjustable rate mortgages and no-income verified loans, as key innovations that led to the market collapse.  Financial innovations have had both positive and negative impacts on the financial industry.  Providing a framework that describes the relationship between economic cycle swings and adoption rates of innovative financial instruments can provide greater stability and predictability in financial innovation diffusion, which can lead to more stable returns for shareholders and enhance the public interest through a healthy, innovative and more stable financial industry.  An abbreviated evidence-based systematic review was completed on financial innovations that led to the financial crisis of 2007. The research suggests that there is an equilibrium period of time that financial organizations can adopt innovation to avoid unintended consequences like the recent financial crisis.  Providing a framework of adoption time can demonstrate where financial innovations can be absorbed to provide the organization with the ability to financially innovate during pro and counter cyclical economic periods. Through an understanding of the timing of financial innovations as they occur in economic cycles, managers of financial organizations can choose the adoption period of time more carefully which could have averted the financial crisis that affected millions of Americans

    Diversity in neutrophil biology : from simple foot soldiers to versatile commanders of immunity in infectious diseases

    Get PDF
    Pathogen clearance in infectious diseases strongly depends on a fine-tuned interplay between innate and adaptive immunity. Undoubtedly, neutrophils as first line defense against invading pathogens play a major role to recognize, phagocytose and kill the invaders. However, the diverse role of neutrophils under inflammatory conditions in infectious diseases has been largely ignored so far. In my PhD thesis, I addressed the implications of the versatile neutrophil functions in immunity encountering pathogenic microorganisms that cause infectious diseases. In particular, experimental approaches with human neutrophils from healthy individuals and from patients suffering from various infectious diseases and immunological disorders, respectively, were combined with a mouse model of Salmonella infection with the help of techniques such as flow cytometry, reverse transcription- polymerase chain reaction (RT-PCR) and proteomics to reveal the so far underestimated diversity in neutrophil function. We showed that “simple foot soldier” neutrophils are important for host defense against bacterial and fungal pathogens. With the help of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and myeloperoxidase (MPO), neutrophils are able to produce large amounts of reactive oxygen species (ROS) that are important for pathogen destruction. We could show that neutrophils from patients receiving allogeneic hematopoietic stem cell transplantations (HSCT) have significantly impaired ROS production against Candida (C.) albicans and Aspergillus (A.) fumigatus. However, ROS can also cause detrimental damage in host tissues. We showed that MPO, one of the key enzymes in ROS production, has a protective role in the host by scavenging diffusible hydrogen peroxide (H2O2) at the Salmonella surface and converting it into highly reactive hypochlorite (HOCl) within a short reach. This sophisticated mechanism of MPO- to confine potential harmful molecules to the pathogen microenvironment- leads to both effective pathogen destruction and minimal collateral host tissue damage. Neutrophils as “versatile commanders” are unambiguously involved in the pathogenesis of sepsis, the dysregulated host response to infection. We could observe that neutrophils and monocytes accumulate neutral lipids during Salmonella infection and change their lipid metabolic program in sepsis comparable to atherosclerosis. Moreover, we identified a subset of antigen-presenting cell (APC)-like neutrophils with major histocompatibility complex (MHC) class II molecule expression, which could be induced under inflammatory conditions. The inflammatory environment triggers highly specific signaling pathways in neutrophils that orchestrate intracellular protein phosphorylation cascades, finally leading to the formation of the MHC class II enhanceosome.   We could show that the MHC class II enhanceosome is responsible for the subsequent MHC class II expression on neutrophils and that targeting Janus kinase (JAK) 1/2 could be a promising therapeutic approach in sepsis to reach homeostasis. Overall, these data show that the immunological function of neutrophils in sepsis is highly versatile and goes far beyond simple pathogen destruction. Together, these data show that infectious disease control implies a specialized, but versatile immune system with diverse neutrophil functionality

    Water and Wastewater Utility Affordability The Cape Coral Florida Experience

    Get PDF
    This study describes the trials and tribulations of a growing city involved in maintaining utility rates at an affordable level while completing a one billion dollar utility expansion. Emphasis is on the political and financial issues faced by management. This research deals exclusively with utility rate issues within the City of Cape Coral Florida during rapid growth and utility expansion. The analysis alludes to issues with affordability when the expansion is stopped, but bonds for a new water plant must be paid

    Control of Phytophthora infestans in organic potato production

    Get PDF
    Phytophthora infestans, the cause of late blight, is the most devastating pathogen in potatoes world-wide. To replace copper fungicides in organic potato production, we examined preparations based on plant extracts, micro-organisms, and other natural compounds for their effect on late blight in field trials as well as in vitro and in vivo. Most of this work we realised as participants of the EU project Blight-MOP. The majority of the preparations effectively inhibited P. infestans in vitro or in vivo on tomato plants. However, under field conditions and with applications once a week, commercial and experimental copper-free preparations failed to sufficiently control late blight. In contrast, copper fungicides applied according to the decision support system Bio-PhytoPRE or in regular intervals consistently reduced foliar blight and prevented significant yield losses. Results from an in vitro test and from a detached leaf test indicate that a main cause of the failure of copper-free preparations could be low stability towards rain or dew

    \u3cem\u3eKickin’ Sand and Tellin’ Lies\u3c/em\u3e: Writing a Play

    Get PDF
    This work is part of the student-faculty collaborative research project Launching through the Surf: The Dory Fleet of Pacific City. This facet of the project, which began in the summer of 2011 and continued through the fall of 2012, aimed to collect and preserve the oral histories of the Dory Fleet of Pacific City, Oregon. The team interviewed dory fishers and their families in order to learn about their experiences as commercial and recreational fisherman. Drawing inspiration from the oral history stories and artifacts compiled through the project, the Linfield College Department of Theatre and Communication Arts created an original, fictional theatrical production in November 2012. This presentation focuses on the creative process the playwrights, Dr. Jackson Miller and Chris Forrer, engaged in to compile material from the oral histories, write, and edit the theatrical script that culminated in the multimedia production entitled Kickin\u27 Sand and Tellin\u27 Lies

    Toward an improved understanding of the Southern Ocean's biological pump: phytoplankton group-specific contributions to nitrogen and carbon cycling across the Subantarctic Indian Ocean

    Get PDF
    Iron (and silicate) (co-)limitation of phytoplankton is considered a primary cause of the Southern Ocean's inefficient biological pump. However, the role of phytoplankton community structure and response to nutrient cycling remains poorly understood. In a mass balance sense, phytoplankton consumption of new nitrogen (N; e.g., allochthonous nitrate) is proportional to net carbon (C) export, while growth fueled by recycled N (e.g., ammonium) yields no net C flux. The N isotope ratio (δ15N) of surface biomass has long been used as an integrative tracer of new versus regenerated uptake. This approach is rendered more accurate by coupling either fluorescence-activated cell sorting (FACS; of nano- and picophytoplankton; 0.4-20 μm) or microscopy (for microphytoplankton; >20 um) with groupspecific δ15N measurements. Samples were collected for the analysis of nutrients and nitrate-, FACS-, and microscopy-δ15N on a mid-summer transect of the Subantarctic Indian basin during the 2016/17 Antarctic Circumnavigation Expedition (ACE) cruise. The data show that all phytoplankton populations preferentially utilize nitrate (≥55%) across the Indian Sector of the Subantarctic, potentially driving higher C export potential than previously estimated. Indeed, near the Subantarctic islands, 72% of microand >80% of nano- and picophytoplankton growth is supported by nitrate. This is likely due to the partial alleviation of phytoplankton iron and silicate stress, largely as a result of bathymetric upwelling, which constitutes a manifestation of the island mass effect. C export potential is lower in the open ocean region away from the islands where iron stress has been shown to be higher; here, nitrate supports >55% of micro- and picophytoplankton and 7 to 79% of nanophytoplankton growth. In terms of relative abundance (RA), the open Subantarctic is dominated by picoeukaryotes (64%), although there exists a large disconnect between relative abundance and potential contribution to C export. The three largest surface-ocean phytoplankton populations included in this study – microphytoplankton, cryptophytes, and nanoeukaryotes – each contribute ~30% to the total C export potential across the Subantarctic Indian sector while picophytoplankton contribute ~5%. Thus, as has been concluded previously, the larger phytoplankton size classes are disproportionately important drivers of the Subantarctic biological pump. Other interesting ecological findings include diatom-dominated microphytoplankton populations apparently fueled by a significant fraction of regenerated N, even in areas of iron supply, and Synechococcus relying near-exclusively on new N, in contrast to subtropical observations. Additionally, the abundance of Synechococcus appears to be controlled by the availability of iron across the Subantarctic, with silicate and temperature playing a supporting role

    Ingenieurschule HTL Chur in neuem Haus und mit neuem Ziel

    Get PDF

    Development of Multisector Alliances (MSAs): Organization and Leadership. ACES Working Papers, 2012

    Get PDF
    The research team reviewed numerous several multi- sectoral entities and identified nine GGNs that became the subject of our case studies. The research team conducted semi-structured interviews with executives and staff from each of these GNNs and prepared a profile, including a description of the unique evolution of the organization, goals and objectives, organizational structure and governance arrangements for each GGN. The following list provides an overview of the nine GGNs profiled: 1. Every Woman Every Child is an unprecedented global effort that mobilizes and amplifies action by governments, multilaterals, the private sector, research centers, academia and civil society to address life-threatening health challenges facing women and children globally. 2. HERproject catalyzes global partnerships and local Networks to improve female workers’ general and reproductive health in eight emerging economies. 3. R4 Rural Resilience Initiative is a cutting-edge, strategic, large-scale partnership between the public and private sectors to innovate and develop better tools to help the world’s most vulnerable people build resilient livelihoods. 4. Extractive Industry Transparency Initiative is a coalition of governments, companies, civil society groups, investors and international organizations that aims to improve transparency and accountability in the extractives sector. 5. Global Network for Neglected Tropical Diseases works with international partners at the highest level of government, business and society to break down the logistical and financial barriers to delivering existing treatments for the seven most common neglected tropical diseases. 6. Global Alliance for Improved Nutrition is an alliance that supports public-private partnerships to increase access to the missing nutrients in diets necessary for people, communities and economies to be stronger and healthier. 7. Inter-Agency Network For Education in Emergencies is a global Network of individuals and representatives from NGOs, United Nations and donor agencies, governments, academic institutions, schools and affected populations working to ensure all persons have the right to a quality and safe education in emergencies and post- crisis recovery. 8. mHealth Alliance works with diverse partners to advance mobile-based or mobile-enhanced solutions that deliver health through research, advocacy, support for the development of interoperable solutions and sustainable deployment models. 9. The Rainforest Alliance is a global non-profit that focuses on environmental conservation and sustainable development and works through collaborative partnerships with various stakeholders

    The Long Term Affects Of Data Management On The Economic Welfare Of A City Government

    Get PDF
    This research examines management processes that lead to the omission of $2.3 million in betterment fees in the City of Cape Coral (City).  It concentrates on management processes, data problems, and personnel issues that contributed and resulted in developing properties completing the Planned Development Process (PDP) without checks from critical areas in the financial system.  This research analyzes how betterment fees, often called Contribution in Aid of Construction (CIAC), were designed, collected, and managed.  This case study also outlines key measurement processes neglected by the City and demonstrates how management corrected the issue of lost revenue through errant billing by analysis and reengineering of the system. Despite hours of public debate and input from concerned citizens, this issue has continued for approximately 10 years.  A 2004 betterment list is substantially increased and contains some properties listed on the original 1996 list.   The issue is still as controversial as ever and efforts to address it seem to be ignored or minimized.
    • …
    corecore