Infection control, genetic assessment of drug resistance and drug susceptibility testing in the current management of multidrug/extensively-resistant tuberculosis (M/XDR-TB) in Europe: A tuberculosis network European Trialsgroup (TBNET) study

Aim Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. Methods TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing. Results 68/105 responses gave valid information and were from countries within the WHO European Region. Inpatient beds matched demand, but single rooms with negative pressure were only available in low incidence countries; ultraviolet decontamination was used in 5 sites, all with >10 patients with M/XDR-TB per year. Molecular tests for mutations associated with rifampicin resistance were widely available (88%), even in lower income and especially in high incidence countries. Molecular tests for other first line and second line drugs were less accessible (76 and 52% respectively). A third of physicians considered that drug susceptibility results were delayed by > 2 months. Conclusion Infection control for inpatients with M/XDR-TB remains a problem in high incidence countries. Rifampicin resistance is readily detected, but tests to plan regimens tailored to the drug susceptibilities of the strain of Mycobacterium tuberculosis are significantly delayed, allowing for further drug resistance to develop

Planck pre-launch status : The Planck-LFI programme

Peer reviewe

Euclid: Forecasts from the void-lensing cross-correlation

The Euclid space telescope will survey a large dataset of cosmic voids traced by dense samples of galaxies. In this work we estimate its expected performance when exploiting angular photometric void clustering, galaxy weak lensing, and their cross-correlation. To this aim, we implemented a Fisher matrix approach tailored for voids from the Euclid photometric dataset and we present the first forecasts on cosmological parameters that include the void-lensing correlation. We examined two different probe settings, pessimistic and optimistic, both for void clustering and galaxy lensing. We carried out forecast analyses in four model cosmologies, accounting for a varying total neutrino mass, Mν, and a dynamical dark energy (DE) equation of state, w(z), described by the popular Chevallier-Polarski-Linder parametrization. We find that void clustering constraints on h and Ωb are competitive with galaxy lensing alone, while errors on ns decrease thanks to the orthogonality of the two probes in the 2D-projected parameter space. We also note that, as a whole, with respect to assuming the two probes as independent, the inclusion of the void-lensing cross-correlation signal improves parameter constraints by 10 − 15%, and enhances the joint void clustering and galaxy lensing figure of merit (FoM) by 10% and 25%, in the pessimistic and optimistic scenarios, respectively. Finally, when further combining with the spectroscopic galaxy clustering, assumed as an independent probe, we find that, in the most competitive case, the FoM increases by a factor of 4 with respect to the combination of weak lensing and spectroscopic galaxy clustering taken as independent probes. The forecasts presented in this work show that photometric void clustering and its cross-correlation with galaxy lensing deserve to be exploited in the data analysis of the Euclid galaxy survey and promise to improve its constraining power, especially on h, Ωb, the neutrino mass, and the DE evolution

Euclid preparation: XXII. Selection of Quiescent Galaxies from Mock Photometry using Machine Learning

The Euclid Space Telescope will provide deep imaging at optical and near-infrared wavelengths, along with slitless near-infrared spectroscopy, across ~15,000 sq deg of the sky. Euclid is expected to detect ~12 billion astronomical sources, facilitating new insights into cosmology, galaxy evolution, and various other topics. To optimally exploit the expected very large data set, there is the need to develop appropriate methods and software. Here we present a novel machine-learning based methodology for selection of quiescent galaxies using broad-band Euclid I_E, Y_E, J_E, H_E photometry, in combination with multiwavelength photometry from other surveys. The ARIADNE pipeline uses meta-learning to fuse decision-tree ensembles, nearest-neighbours, and deep-learning methods into a single classifier that yields significantly higher accuracy than any of the individual learning methods separately. The pipeline has `sparsity-awareness', so that missing photometry values are still informative for the classification. Our pipeline derives photometric redshifts for galaxies selected as quiescent, aided by the `pseudo-labelling' semi-supervised method. After application of the outlier filter, our pipeline achieves a normalized mean absolute deviation of ~< 0.03 and a fraction of catastrophic outliers of ~< 0.02 when measured against the COSMOS2015 photometric redshifts. We apply our classification pipeline to mock galaxy photometry catalogues corresponding to three main scenarios: (i) Euclid Deep Survey with ancillary ugriz, WISE, and radio data; (ii) Euclid Wide Survey with ancillary ugriz, WISE, and radio data; (iii) Euclid Wide Survey only. Our classification pipeline outperforms UVJ selection, in addition to the Euclid I_E-Y_E, J_E-H_E and u-I_E,I_E-J_E colour-colour methods, with improvements in completeness and the F1-score of up to a factor of 2. (Abridged)Comment: 37 pages (including appendices), 26 figures; accepted for publication in Astronomy & Astrophysic

A search for neutrino emission from the Fermi bubbles with the ANTARES telescope

Analysis of the Fermi-LAT data has revealed two extended structures above and below the Galactic Centre emitting gamma rays with a hard spectrum, the so-called Fermi bubbles. Hadronic models attempting to explain the origin of the Fermi bubbles predict the emission of high-energy neutrinos and gamma rays with similar fluxes. The ANTARES detector, a neutrino telescope located in the Mediterranean Sea, has a good visibility to the Fermi bubble regions. Using data collected from 2008 to 2011 no statistically significant excess of events is observed and therefore upper limits on the neutrino flux in TeV range from the Fermi bubbles are derived for various assumed energy cutoffs of the source

The positioning system of the ANTARES Neutrino Telescope

The ANTARES neutrino telescope, located 40km off the coast of Toulon in the Mediterranean Sea at a mooring depth of about 2475m, consists of twelve detection lines equipped typically with 25 storeys. Every storey carries three optical modules that detect Cherenkov light induced by charged secondary particles (typically muons) coming from neutrino interactions. As these lines are flexible structures fixed to the sea bed and held taut by a buoy, sea currents cause the lines to move and the storeys to rotate. The knowledge of the position of the optical modules with a precision better than 10cm is essential for a good reconstruction of particle tracks. In this paper the ANTARES positioning system is described. It consists of an acoustic positioning system, for distance triangulation, and a compass-tiltmeter system, for the measurement of the orientation and inclination of the storeys. Necessary corrections are discussed and the results of the detector alignment procedure are described

Euclid preparation: XVI. Exploring the ultra-low surface brightness Universe with Euclid /VIS

Context. While Euclid is an ESA mission specifically designed to investigate the nature of dark energy and dark matter, the planned unprecedented combination of survey area (∼15â 000 deg2), spatial resolution, low sky-background, and depth also make Euclid an excellent space observatory for the study of the low surface brightness Universe. Scientific exploitation of the extended low surface brightness structures requires dedicated calibration procedures that are yet to be tested. Aims. We investigate the capabilities of Euclid to detect extended low surface brightness structure by identifying and quantifying sky-background sources and stray-light contamination. We test the feasibility of generating sky flat-fields to reduce large-scale residual gradients in order to reveal the extended emission of galaxies observed in the Euclid survey. Methods. We simulated a realistic set of Euclid/VIS observations, taking into account both instrumental and astronomical sources of contamination, including cosmic rays, stray-light, zodiacal light, interstellar medium, and the cosmic infrared background, while simulating the effects of background sources in the field of view. Results. We demonstrate that a combination of calibration lamps, sky flats, and self-calibration would enable recovery of emission at a limiting surface brightness magnitude of μlim = 29.5-0.27+0.08 mag arcsec-2 (3σ, 10â ×â 10 arcsec2) in the Wide Survey, and it would reach regions deeper by 2 mag in the Deep Surveys. Conclusions.Euclid/VIS has the potential to be an excellent low surface brightness observatory. Covering the gap between pixel-To-pixel calibration lamp flats and self-calibration observations for large scales, the application of sky flat-fielding will enhance the sensitivity of the VIS detector at scales larger than 1″, up to the size of the field of view, enabling Euclid to detect extended surface brightness structures below μlimâ =â 31 mag arcsec-2 and beyond

Time calibration of the ANTARES neutrino telescope

The ANTARES deep-sea neutrino telescope comprises a three-dimensional array of photomultipliers to detect the Cherenkov light induced by upgoing relativistic charged particles originating from neutrino interactions in the vicinity of the detector. The large scattering length of light in the deep sea facilitates an angular resolution of a few tenths of a degree for neutrino energies exceeding 10 TeV. In order to achieve this optimal performance, the time calibration procedures should ensure a relative time calibration between the photomultipliers at the level of similar to 1 ns. The methods developed to attain this level of precision are described

Decreased Numbers of Blood Dendritic Cells and Defective Function of Regulatory T Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

BACKGROUND: Dendritic cells (DC) and regulatory cells (Treg) play pivotal roles in controlling both normal and autoimmune adaptive immune responses. DC are the main antigen-presenting cells to T cells, and they also control Treg functions. In this study, we examined the frequency and phenotype of DC subsets, and the frequency and function of Treg from patients with ANCA-associated vasculitis (AAV). METHODOLOGY/PRINCIPAL FINDINGS: Blood samples from 19 untreated patients with AAV during flares and before any immunosuppressive treatment were analyzed, along with 15 AAV patients in remission and 18 age-matched healthy controls. DC and Treg numbers, and phenotypes were assessed by flow cytometry, and in vitro suppressive function of Treg was determined by co-culture assay. When compared to healthy volunteers, absolute numbers of conventional and plasmacytoid DC were decreased in AAV patients. During the acute phase this decrease was significantly more pronounced and was associated with an increased DC expression of CD62L. Absolute numbers of Treg (CD4(+)CD25(high)CD127(low/-) Tcells) were moderately decreased in patients. FOXP3 and CD39 were expressed at similar levels on Treg from patients as compared to controls. The suppressive function of Treg from AAV patients was dramatically decreased as compared to controls, and this defect was more pronounced during flares than remission. This Treg functional deficiency occurred in the absence of obvious Th17 deviation. CONCLUSION: In conclusion, these data show that AAV flares are associated with both a decrease number and altered phenotype of circulating DC and point to a role for Treg functional deficiency in the pathogenesis of AAV

Probing invisible neutrino decay with KM3NeT-ORCA

In the era of precision measurements of the neutrino oscillation parameters, upcoming neutrino experiments will also be sensitive to physics beyond the Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A three-flavour neutrino oscillation scenario, where the third neutrino mass state $\nu_3$ decays into an invisible state, e.g. a sterile neutrino, is considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino decays with $1/\alpha_3=\tau_3/m_3 < 180$~$\mathrm{ps/eV}$ at $90\%$ confidence level, assuming true normal ordering. Finally, the impact of neutrino decay on the precision of KM3NeT/ORCA measurements for $\theta_{23}$, $\Delta m^2_{31}$ and mass ordering have been studied. No significant effect of neutrino decay on the sensitivity to these measurements has been found.Comment: 27 pages, 14 figures, bibliography updated, typos correcte