Contrasting stress fields on correlating margins of the South Atlantic

The “passiveness” of passive continental margins across the globe is currently under debate since several studies have shown that these margins may experience a variety of stress states and undergo significant vertical movement post-breakup. Of special interest is the South Atlantic, because the bounding continents have very different recent geological histories, with Africa experiencing continental rifting whereas South America is influenced by subduction on the Pacific side. It is not clear to what extent the Atlantic continental margins are subject to the same stresses and vertical motions as the main continents. To address this problem, we performed a paleostress analysis of two originally adjacent areas, i.e. NW Namibia and SE/S Brazil. Both areas are covered by the ~ 133-Ma-old Paraná-Etendeka extrusives that were emplaced shortly before or during the onset of the Atlantic rifting. Thus, the volcanics serve as a time marker for syn- or post-rift deformation. Collected fault slip data in the volcanics reveal remarkable differences between the two correlating areas. NW Namibia was dominated by extension in ENE-WSW and SW-NE directions, and by minor strike-slip movement with NW-SE directed compression. SE/S Brazil was mostly affected by strike-slip faulting, with compression oriented E-W and SW-NE. Similar fault systems appear widespread across SE Brazil and may be the combined result of flexural margin bending and the Nazca plate subduction. The results of NW Namibia differ from known compressional stress tensors in western South Africa, post-dating 90 Ma. The south-western African continental margin may thus have experienced a spatially variable stress history. Our results show that the tectonic evolution of the continental margins of the South Atlantic is not passive and that both margins vary significantly in structural style and stress fields, indicating that variable plate boundary forces play a major role in margin evolution

Cenozoic-Recent tectonics and uplift in the Greater Caucasus: a perspective from Azerbaijan

The Greater Caucasus is Europe's highest mountain belt and results from the inversion of the Greater Caucasus back-arc-type basin due to the collision of Arabia and Eurasia. The orogenic processes that led to the present mountain chain started in the Early Cenozoic, accelerated during the Plio-Pleistocene, and are still active as shown from present GPS studies and earthquake distribution. The Greater Caucasus is a doubly verging fold-and-thrust belt, with a pro- and a retro wedge actively propagating into the foreland sedimentary basin of the Kura to the south and the Terek to the north, respectively. Based on tectonic geomorphology – active and abandoned thrust fronts – the mountain range can be subdivided into several zones with different uplift amounts and rates with very heterogeneous strain partitioning. The central part of the mountain range – defined by the Main Caucasus Thrust to the south and backthrusts to the north – forms a triangular-shape zone showing the highest uplift and fastest rates, and is due to thrusting over a steep tectonic ramp system at depth. The meridional orogenic in front of the Greater Caucasus in Azerbaijan lies at the foothills of the Lesser Caucasus, to the south of the Kura foreland basin

Автоматизация учета и анализа проведения ремонтных работ в котельном цехе ООО "ЮТЭЦ"

В статье представлена разработка информационной системы для автоматизации учета и анализа проведения ремонтных работ в котельном цехе ООО «ЮТЭЦ». Для разработки информационной системы выбрана платформа «1С: Предприятие». Показаны созданные в системе основные объекты: справочники, документы, отчеты.The article presents the development of an information system for the automation of accounting and analysis of repair work in the boiler room. For the development of the information system, the 1C: Enterprise platform was chosen. The main objects created in the system are shown: directories, documents, reports

Safety and Efficacy of Itraconazole Compared to Amphotericin B as Empirical Antifungal Therapy for Neutropenic Fever in Patients with Haematological Malignancy

Safety, tolerability and efficacy of itraconazole and amphotericin B (AMB) were compared for empirical antifungal treatment of febrile neutropenic cancer patients. Patients and Methods: In an open, randomised study, 162 patients with at least 72 h of antimicrobial treatment received either intravenous followed by oral itraconazole suspension or intravenous AMB for a maximum of 28 days. Permanent discontinuation of study medication due to any adverse event was the primary safety parameter. Efficacy parameters included response and success rate for both treatment groups. Results: Significantly fewer itraconazole patients discontinued treatment due to any adverse event (22.2 vs. 56.8% AMB; p < 0.0001). The main reason for discontinuation was a rise in serum creatinine (1.2% itraconazole vs. 23.5% AMB). Renal toxicity was significantly higher and more drug-related adverse events occurred in the AMB group. Intention-to-treat (ITT) analysis showed favourable efficacy for itraconazole: response and success rate were both significantly higher than for AMB (61.7 vs. 42% and 70.4 vs. 49.3%, both p < 0.0001). Treatment failure was markedly reduced in itraconazole patients (25.9 vs. 43.2%), largely due to the better tolerability. Conclusions: Itraconazole was tolerated significantly better than conventional AMB and also showed advantages regarding efficacy. This study confirms the role of itraconazole as a useful and safe agent in empirical antifungal therapy of febrile neutropenic cancer patients.Hintergrund: Es wurden die Sicherheit, Verträglichkeit und Wirksamkeit von Itraconazol und Amphotericin B (AMB) in der antimykotischen Therapie der persistierend febrilen Neutropenie verglichen. Patienten und Methoden: In einer offenen, randomisierten Studie erhielten 162 Patienten mit mindestens 72-stündiger antibiotischer Therapie entweder Itraconazol (erst intravenös, dann oral) oder AMB (intravenös) für maximal 28 Tage. Primärer Sicherheitsparameter war die dauerhafte Unterbrechung der Studienmedikation aufgrund von Nebenwirkungen. Die Wirksamkeitsparameter umfassten die Ansprech- und Erfolgsrate für beide Behandlungsgruppen. Ergebnisse: Signifikant weniger Itraconazol-Patienten brachen die Behandlung wegen Nebenwirkungen ab (22,2 vs. 56,8% AMB; p < 0,0001). Hauptursache für Studienabbrüche war der Anstieg des Serum-Kreatinin-Spiegels (1,2% Itraconazol vs. 23,5% AMB). Nephrotoxische und weitere Nebenwirkungen traten im AMB-Studienarm signifikant häufiger auf. Intention-to-Treat (ITT)-Analysen zeigten eine bessere Wirksamkeit von Itraconazol: Ansprech- und Erfolgsrate waren signifikant höher als unter AMB (61,7 vs. 42% und 70,4 vs. 49,3%, beide p < 0,0001). Behandlungsversagen trat bei Itraconazol-Patienten merklich weniger auf (25,9 vs. 43,2%). Schlussfolgerungen: Die Verträglichkeit von Itraconazol war signifikant höher als beim herkömmlichen AMB. Itraconazol zeigte ebenfalls Vorteile in der Wirksamkeit. Diese Studie bestätigt die Rolle von Itraconazol als sinnvolles und sicheres Medikament in der empirischen antimykotischen Therapie von fiebrigen neutropenischen Tumorpatienten.Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich

Cosmic rays from Galactic pulsars

We calculate energy spectra and mass composition of cosmic rays accelerated by the galactic population of pulsars during their radio and gamma-ray phase. Several models proposed for the distribution of the initial parameters of the galactic pulsar population are considered. The best description of the observed cosmic ray spectrum and mass composition between 10^15 eV and 10^18 eV is obtained for the model B of Lorimer et al. (1993) in which the logs of initial pulsar periods and surface magnetic fields are given by the Gaussian distributions with the average values of log P[ms] = 2.6 and log B[G] = 12.3, respectively.Comment: 10 pages, 4 figures, A&A accepte

On the knee in the energy spectrum of cosmic rays

The knee in the all-particle energy spectrum is scrutinized with a phenomenological model, named poly-gonato model, linking results from direct and indirect measurements. For this purpose, recent results from direct and indirect measurements of cosmic rays in the energy range from 10 GeV up to 1 EeV are examined. The energy spectra of individual elements, as obtained by direct observations, are extrapolated to high energies using power laws and compared to all-particle spectra from air shower measurements. A cut-off for each element proportional to its charge Z is assumed. The model describes the knee in the all-particle energy spectrum as a result of subsequent cut-offs for individual elements, starting with the proton component at 4.5 PeV, and the second change of the spectral index around 0.4 EeV as due to the end of stable elements (Z=92). The mass composition, extrapolated from direct measurements to high energies, using the poly-gonato model, is compatible with results from air shower experiments measuring the electromagnetic, muonic, and hadronic components. But it disagrees with the mass composition derived from X_max measurements using Cerenkov and fluorescence light detectors.Comment: 30 pages, 21 figures, 9 tables, accepted by Astroparticle Physic

Multiple thermochronometers applied to the quantitative analysis of compressive systems: The southern sub-Andean fold and thrust belt of Bolivia: From source rock to trap

The evolution of fold and thrust belts requires time data restrictions to determine the rates related to the interaction of surface and subsurface processes and to quantify the time relationship between the components of the petroleum system: reservoir, seal, source rock and trap. The sub-Andean fold-and-thrust belt in the Bolivian territory in general, and the regional transect that links the structures of Curuyuqui-Carohuaicho-Tatarenda-Borebigua-Charagua and Mandeyapecua in particular, constitutes a complex multi-variable system in which the definition of time-Temperature (t-T) trajectories has led to new suitable structural and stratigraphic conclusions. The integration of multiple thermochronological-geochronological systems (Apatite Fission Track, Apatite (U-Th-Sm)/He and UPb SHRIMP on zircon) and the existing surface and subsurface geological constraints made it possible to develop a chrono-kinematic characterization of fault-related anticlines, defining their formation chronology, structural growth rate and link between them in the study area. Furthermore, it was also possible to perform a quantitative analysis of the subsidence-burial and exhumation-erosion phenomena that occurred from the deposition of Silurian-Devonian source rocks to the present time, providing relevant determinations to the modeling of the Oil & Gas system.Fil: Hernandez, Juan I.. Geomap S.a.; ArgentinaFil: Hernández, Roberto M.. Geomap S.a.; ArgentinaFil: Dalenz Farjat, Alejandra. Geomap S.a.; ArgentinaFil: Cristallini, Ernesto Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología. Laboratorio de Modelado Geológico; ArgentinaFil: Alvarez, Luis A.. Geomap S.a.; ArgentinaFil: Dellmans, Luis M.. Geomap S.a.; ArgentinaFil: Costilla, Marcos Roberto. Geomap S.a.; ArgentinaFil: Alvarez, Andres F.. Geomap S.a.; ArgentinaFil: Becchio, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Bordese, Sofia. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Arzadún, Guadalupe. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guibaldo, Cristina. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Glasmacher, Ulrich A.. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Tomezzoli, Renata Nela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Stockli, Daniel F.. University of Texas; Estados UnidosFil: Fuentes, Facundo. YPF - Tecnología; ArgentinaFil: Soria Galvarro, Jaime. YPF - Tecnología; ArgentinaFil: Rosales, Adolfo. YPF - Tecnología; ArgentinaFil: Dzelalija, Francisco. YPF - Tecnología; ArgentinaFil: Haring, Claudio. YPF - Tecnología; Argentin

Measurements of the Cosmic Ray Composition with Air Shower Experiments

In this paper we review air shower data related to the mass composition of cosmic rays above 10$^{15}$ eV. After explaining the basic relations between air shower observables and the primary mass and energy of cosmic rays, we present different approaches and results of composition studies with surface detectors. Furthermore, we discuss measurements of the longitudinal development of air showers from non-imaging Cherenkov detectors and fluorescence telescopes. The interpretation of these experimental results in terms of primary mass is highly susceptible to the theoretical uncertainties of hadronic interactions in air showers. We nevertheless attempt to calculate the logarithmic mass from the data using different hadronic interaction models and to study its energy dependence from 10$^{15}$ to 10$^{20}$ eV.Comment: 21 pages, invited review accepted for publication in Astroparticle Physics, Topical Issue on Cosmic Ray

KASCADE measurements of energy spectra for elemental groups of cosmic rays: Results and open problems

A composition analysis of KASCADE air shower data is performed by means of unfolding the two-dimensional frequency spectrum of electron and muon numbers. Aim of the analysis is the determination of energy spectra for elemental groups representing the chemical composition of primary cosmic rays. Since such an analysis depends crucially on simulations of air showers the two different hadronic interaction models QGSJet and SIBYLL are used for their generation. The resulting primary energy spectra show that the knee in the all particle spectrum is due to a steepening of the spectra of light elements but, also, that neither of the two simulation sets is able to describe the measured data consistently over the whole energy range with discrepancies appearing in different energy regions.Comment: 39 pages, accepted for publication in Astropart. Phy

Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients

BACKGROUND: Neutropenic enterocolitis is a life-threatening complication most frequently occurring after intensive chemotherapy in acute leukaemias. Gramnegative bacteria constitute the most important group of causative pathogens. Fungi have also been reported, but their practical relevance remains unclear. The guidelines do not address concrete treatment recommendations for fungal neutropenic enterocolitis. METHODS: Here, we conducted a metaanalysis to answer the questions: What are frequency and mortality of fungal neutropenic enterocolitis? Do frequencies and microbiological distribution of causative fungi support empirical antimycotic therapy? Do reported results of antimycotic therapy in documented fungal neutropenic enterocolitis help with the selection of appropriate drugs? Following a systematic search, we extracted and summarised all detail data from the complete literature. RESULTS: Among 186 articles describing patients with neutropenic enterocolitis, we found 29 reports describing 53 patients with causative fungal pathogens. We found no randomised controlled trial, no good quality cohort study and no good quality case control study on the role of antifungal treatment. The pooled frequency of fungal neutropenic enterocolitis was 6.2% calculated from all 860 reported patients and 3.4% calculated from selected representative studies only. In 94% of the patients, Candida spp. were involved. The pooled mortality rate was 81.8%. Most authors did not report or perform antifungal therapy. CONCLUSION: In patients with neutropenic enterocolitis, fungal pathogens play a relevant, but secondary role compared to bacteria. Evidence concerning therapy is very poor, but epidemiological data from this study may provide helpful clues to select empiric antifungal therapy in neutropenic enterocolitis