The ‘Dark Power’ of Instagram: Prospects and Threats for Tourism Organisations

The key to understand and analyse the dynamic relationship between territories, organisations and tourists is currently undergoing significant changes. Due to both their endogenous and exogenous factors, territories should be read as complex adaptive systems (CAS), i.e. systems structurally composed of different sub-systems which interact with each other and help to improve the central systems thanks to the interconnections established among themselves. Thus, in this scenario, territories evolve into potential tourism destinations if these changes make them particularly attractive and capable of setting a profitable dialogue with new emerging tourists profiles. As a matter of fact, contexts and in which these actors communicate between each other nowadays are unconventional and ‘bottom-up oriented’: social media represent the main source for territories and organisation of tourist experience to receive feedback. Nevertheless, the established relationship is not always qualitatively relevant nor reliable. Therefore, by utilising both a data and content analysis approach, the authors will analyse users’ reactions to Instagram posts by destinations to evaluate their engagement process and their emerging profile

3D survey technologies: Investigations on accuracy and usability in archaeology. The case study of the new "Municipio" underground station in Naples

Advanced 3D survey technologies, such as Digital Photogrammetry (imaged based) and Laser Scanner, are nowadays widely used in Cultural Heritage and Archaeological fields. The present paper describes the investigations realized by the Laboratory Hesutech of the Polytechnic of Milan in cooperation with the Superintendence Archaeology Campania in order to examine the potentiality of Image Based Modeling (IBM) systems applied to the archaeological field for advanced documentation purposes. Besides the 3D model production workflow in an uncommon excavation environment, a special consideration about the reached accuracy will be discussed. In the first part of the research, a comparison between photogrammetric camera parameters obtained with IBM systems and the ones provided with the calibration certificate by the manufacturer of the camera is performed. In the second part of the research, the operational phases of the application of such advanced 3D survey technologies are shown. The test field is the archaeological excavation area for the construction of the new "Municipio" underground station in Naples. Due to its position in one of the historical area of the city, its construction coexists with the archaeological excavations and it is strictly tied to their evolution. In such conditions, the need to reduce as much as possible the time to build the public infrastructure is a very relevant feature together with the ability to produce accurate documentation of what is considered archaeologically important

Anti-DFS70 antibodies detected by specific methods in patients with thrombosis or recurrent pregnancy loss: no evidence of an association

A dense fine speckled pattern (DFS) caused by antibodies to the DFS70 kDa nuclear protein is a relatively common finding while testing for anti-nuclear antibodies (ANA) by indirect immunofluorescence (IIF) on HEp-2 cells. However, despite many efforts and numerous studies, the clinical significance of anti-DFS70 antibodies is still unknown as they can be found in patients with various disorders and even in healthy subjects. In this study we aimed at verifying whether these antibodies are associated with thrombotic events or with unexplained recurrent pregnancy loss (RPL). We studied 443 patients with venous or arterial thrombosis or RPL and 244 controls by IIF on HEp-2 cells and by a DFS70-specific chemiluminescent immunoassay (CIA). The DFS pattern was observed in IIF in 31/443 (7.0%) patients and in 6/244 (2.5%) controls (p\u2009=\u20090.01) while anti-DFS70 specific antibodies were detected by CIA in 11 (2.5%) patients and in one (0.4%) control (p\u2009=\u20090.06). Positive samples, either by IIF or by CIA, were then assayed by a second DFS70-specific line-immunoassay (LIA) method: 83.3% of the CIA positive samples were confirmed DFS70 positive versus only 29.7% of the IIF positive samples. These findings show that IIF overestimates anti-DFS70 antibody frequency and that results obtained by specific CIA and LIA assays do not indicate that venous or arterial thrombosis or RPL are linked to a higher prevalence of anti-DFS70 antibodies

Effects of Different Up-Dosing Regimens for Hymenoptera Venom Immunotherapy on Serum CTLA-4 and IL-10

BACKGROUND: Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is involved in the activation pathways of T lymphocytes. It has been shown that the circulating form of CTLA-4 is elevated in patients with hymenoptera allergy and can be down regulated by immunotherapy. OBJECTIVE: to assess the effects on CTLA-4 of venom immunotherapy, given with different induction protocols: conventional (6 weeks), rush (3 days) or ultra rush (1 day). METHODS: Sera from patients with hymenoptera allergy were collected at baseline and at the end of the induction phase. CTLA-4 and IL-10 were assayed in the same samples. A subset of patients were assayed also after 12 months of VIT maintenance. RESULTS: Ninety-four patients were studied. Of them, 50 underwent the conventional induction, 20 the rush and 24 the ultra-rush. Soluble CTLA-4 was detectable in all patients at baseline, and significantly decreased at the end of the induction, irrespective of its duration. Of note, a significant decrease of sCTLA-4 could be seen already at 24 hours. In parallel, IL-10 significantly increased at the end of the induction. At 12 months, sCTLA-4 remained low, whereas IL-10 returned to the baseline values. CONCLUSIONS: Serum CTLA4 is an early marker of the immunological effects of venom immunotherapy, and its changes persist after one year of maintenance treatment

From Boatyard to Museum: 3D laser scanning and digital modelling of the Qatar Museums watercraft collection, Doha, Qatar

This is the final version of the article. Available from Wiley via the DOI in this record.This article presents the results of a project to 3D laser scan and digitally model 14 watercraft from the Qatar Museums collection, comprising a range of regional vessels: most had not been surveyed previously. The project used the resulting point clouds generated 2D naval lines and orthographic records of the vessels in their current condition, and photorealistic 3D digital models for gallery display. This case study provides illustrative examples of the intermediate stages and final outputs. It assesses the pros and cons of 3D laser scanning as a survey technology for nautical scholars in terms of the time, cost, and skillset, as well as logistical considerations. It also compares the accuracy of traditional hand survey methods.We wish to thank QM for enabling and funding this research (Grant number SL-05894)