32 research outputs found
Molecular characterization of occult hepatitis B virus infection in patients with end-stage liver disease in Colombia.
- Author
- A Duque-Jaramillo
- A Fernandez-Medarde
- A Marzano
- AT Hall
- B Abedi-Ardekani
- B Seigneres
- C Brechot
- C Gerstenkorn
- CH Huang
- CK Cheung
- CS Coffin
- D di Filippo Villa
- D Rios
- DA Gouas
- DK Wong
- E Michailidis
- E Tabor
- EA Santos
- F Birnbaum
- F Cortes-Mancera
- F Zoulim
- Fabian Cortes-Mancera
- FV Chisari
- G Raimondo
- G Raimondo
- G Raimondo
- G Squadrito
- G Zhong
- GB Zeng
- GC Kimbi
- GM Barros Junior
- GY Minuk
- H Bautista
- H Bautista-Amorocho
- H Kim
- H Kim
- HL Chan
- HL Zhu
- I Baginski
- I Cacciola
- I Pult
- IC Ramirez
- Isabelle Chemin
- J Arroyave
- J Kock
- J Lucifora
- J Samal
- J Torresi
- JH Ireland
- JH Kao
- JI Tsui
- Juan Carlos Restrepo-Gutierrez
- Julio Cesar Rendon
- K Koike
- K Shetty
- K Tamura
- KQ Hu
- L Belloni
- L Menendez-Arias
- M Beltran
- M Bottecchia
- M Devesa
- M Di Stefano
- M Hofer
- M Krajden
- M Levrero
- M Minami
- M Nassal
- M Nunez
- Maria-Cristina Navas
- MI Allen
- MV Alvarado Mora
- MV Alvarado Mora
- N Coppola
- N Freitas
- N Mahboobi
- NF Ma
- NK Tonks
- O Chazouilleres
- P Deny
- P Paterlini
- P Paterlini
- P Polo
- P Toniutto
- P Vivekanandan
- Q Dong
- R Kannangai
- R Lozano
- R Mazzolla
- RA Ponde
- RC Dickson
- RS Alencar
- S Frietze
- S Gunther
- S Jammeh
- S Ocana
- S Parekh
- S Schaefer
- S Takada
- S Tong
- SA Gujar
- Sergio Hoyos
- SI Strasser
- SJ Muñoz
- SM Wakil
- T Pollicino
- TC Ferrari
- TJ Liang
- TM De Feo
- V Ghisetti
- V Kumar
- WA Rios-Ocampo
- WK Sung
- X Hu
- Y Fang
- Y Murakami
- Y Niu
- Y Zhong
- YS Lee
- YZ Castellanos
- Z Han
- Z Zhang
- Z Zhang
- ZH Zhang
- ZK Hassan
- ZM Huang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
ABSTARCT: Hepatitis B virus (HBV) occult infection (OBI) is a risk factor to be taken into account in transfusion, hemodialysis and organ transplantation. The aim of this study was to identify and characterize at the molecular level OBI cases in patients with end-stage liver disease.
METHODS:
Sixty-six liver samples were obtained from patients with diagnosis of end-stage liver disease submitted to liver transplantation in Medellin (North West, Colombia). Samples obtained from patients who were negative for the surface antigen of HBV (n = 50) were tested for viral DNA detection by nested PCR for ORFs S, C, and X and confirmed by Southern-Blot. OBI cases were analyzed by sequencing the viral genome to determine the genotype and mutations; additionally, viral genome integration events were examined by the Alu-PCR technique.
RESULTS:
In five cases out of 50 patients (10%) the criteria for OBI was confirmed. HBV genotype F (subgenotypes F1 and F3), genotype A and genotype D were characterized in liver samples. Three integration events in chromosomes 5q14.1, 16p13 and 20q12 affecting Receptor-type tyrosine-protein phosphatase T, Ras Protein Specific Guanine Nucleotide Releasing Factor 2, and the zinc finger 263 genes were identified in two OBI cases. Sequence analysis of the viral genome of the 5 OBI cases showed several punctual missense and nonsense mutations affecting ORFs S, P, Core and X.
CONCLUSIONS:
This is the first characterization of OBI in patients with end-stage liver disease in Colombia. The OBI cases were identified in patients with HCV infection or cryptogenic cirrhosis. The integration events (5q14.1, 16p13 and 20q12) described in this study have not been previously reported. Further studies are required to validate the role of mutations and integration events in OBI pathogenesis
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
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- Ahmed MA
- Ajai OT
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- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
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- Dogar S
- Doheim MF
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36â39) and median bodyweight at presentation was 2·8 kg (2·3â3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; pâ€0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88â4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59â2·79], p<0·0001), sepsis at presentation (1·20 [1·04â1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4â5 vs ASA 1â2, 1·82 [1·40â2·35], p<0·0001; ASA 3 vs ASA 1â2, 1·58, [1·30â1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02â1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41â2·71], p=0·0001; parenteral nutrition 1·35, [1·05â1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47â0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50â0·86], p=0·0024) or percutaneous central line (0·69 [0·48â1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
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- Zuolo D
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- Ălvarez FernĂĄndez A
- Ăsterberg K
- Ăzçelik Ă
- Ć irokĂœ J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
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- Abbiendi G
- Abbrescia M
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
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- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
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Search for low-mass dilepton resonances in Higgs boson decays to four-lepton final states in protonâproton collisions at âs=13TeV
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- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Data Availability: This manuscript has no associated data or the data will not be deposited. [Authorsâ comment: For CMS Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2).]Copyright © CERN for the benefit of the CMS collaboration 2022. A search for low-mass dilepton resonances in Higgs boson decays is conducted in the four-lepton final state. The decay is assumed to proceed via a pair of beyond the standard model particles, or one such particle and a Z boson. The search uses protonâproton collision data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 137fbâ1, at a center-of-mass energy sâ=13TeV. No significant deviation from the standard model expectation is observed. Upper limits at 95% confidence level are set on model-independent Higgs boson decay branching fractions. Additionally, limits on dark photon and axion-like particle production, based on two specific models, are reported.SCOAP3
Search for dark matter produced in association with a leptonically decaying Z boson in protonâproton collisions at sâ=13TeV
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- Zghiche A
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- Zorbilmez C
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- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/12/2020
- Field of study
A search for dark matter particles is performed using events with a Z boson candidate and large missing transverse momentum. The analysis is based on protonâproton collision data at a center-of-mass energy of 13TeV, collected by the CMS experiment at the LHC in 2016â2018, corresponding to an integrated luminosity of 137fbâ1. The search uses the decay channels Zâee and ZâΌΌ. No significant excess of events is observed over the background expected from the standard model. Limits are set on dark matter particle production in the context of simplified models with vector, axial-vector, scalar, and pseudoscalar mediators, as well as on a two-Higgs-doublet model with an additional pseudoscalar mediator. In addition, limits are provided for spin-dependent and spin-independent scattering cross sections and are compared to those from direct-detection experiments. The results are also interpreted in the context of models of invisible Higgs boson decays, unparticles, and large extra dimensions.SCOAP
Measurements of pp â ZZ production cross sections and constraints on anomalous triple gauge couplings at â = 13 TeV
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/12/2020
- Field of study
© 2021 The CMS Collaboration. The production of Z boson pairs in protonâproton (pp) collisions, pp â (Z/â)(Z/â) â 2â2ââČ, where â,ââČ = e or ÎŒ, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The data sample corresponds to an integrated luminosity of 137fbâ1, collected during 2016â2018. The ZZ production cross section, tot(pp â ZZ) = 17.4 ± 0.3 (stat) ± 0.5 (syst) ± 0.4 (Theo) ± 0.3 (lumi) pb, measured for events with two pairs of opposite-sign, same-flavor leptons produced in the mass region 60 < â+ââ < 120 GeV is consistent with standard model predictions. Differential cross sections are also measured and agree with theoretical predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ couplings.SCOAP
Plasmon-Enhanced Surface Photovoltage of ZnO/Ag Nanogratings
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Hybrid perovskite light emitting diodes under intense electrical excitation
- Author
- A Walsh
- BR Sutherland
- C Eames
- C Wehrenfennig
- DW DeQuilettes
- EL Unger
- F Deschler
- G Li
- G Xing
- GAH Wetzelaer
- GY Kim
- H Cho
- H Yu
- HJ Snaith
- IH Campbell
- J Beilsten-Edmands
- J Cho
- JM Azpiroz
- L Zhao
- Larry A. Coldren
- ME Ziffer
- NC Giebink
- NC Giebink
- OA Jaramillo-Quintero
- RL Milot
- S Meloni
- SA Veldhuis
- SD Stranks
- W Tress
- W Zou
- X Shi
- Y Jia
- Y Jia
- Y Setoguchi
- Z Xiao
- ZK Tan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study