85 research outputs found
Patients with suspected acute coronary syndrome in a university hospital emergency department: an observational study
- Author
- A Chandra
- AB Storrow
- Attila Frigyesi
- BG Abbott
- BJ O'Neil
- BW Karlson
- BW Karlson
- E Braunwald
- E Van der Does
- FI Investigators
- FM Fesmire
- FM Fesmire
- G Quin
- GV Heller
- Hans-Jörgen Nilsson
- HP Selker
- JH Pope
- JH Pope
- K Wilkinson
- L Goldman
- LK Newby
- MA Gomez
- MC Kontos
- MC Kontos
- ME Farkouh
- Ole Torffvit
- P Giovas
- RJ Zalenski
- RJ Zalenski
- RL Jesse
- RR Roberts
- S Goodacre
- SM Ng
- SW Goodacre
- TH Lee
- TH Lee
- Ulf Ekelund
- Publication venue
- BioMed Central
- Publication date
- 01/01/2002
- Field of study
BACKGROUND: It is widely considered that improved diagnostics in suspected acute coronary syndrome (ACS) are needed. To help clarify the current situation and the improvement potential, we analyzed characteristics, disposition and outcome among patients with suspected ACS at a university hospital emergency department (ED). METHODS: 157 consecutive patients with symptoms of ACS were included at the ED during 10 days. Risk of ACS was estimated in the ED for each patient based on history, physical examination and ECG by assigning them to one of four risk categories; I (obvious myocardial infarction, MI), II (strong suspicion of ACS), III (vague suspicion of ACS), and IV (no suspicion of ACS). RESULTS: 4, 17, 29 and 50% of the patients were allocated to risk categories I-IV respectively. 74 patients (47%) were hospitalized but only 19 (26%) had ACS as the discharge diagnose. In risk categories I-IV, ACS rates were 100, 37, 12 and 0%, respectively. Of those admitted without ACS, at least 37% could probably, given perfect ED diagnostics, have been immediately discharged. 83 patients were discharged from the ED, and among them there were no hospitalizations for ACS or cardiac mortality at 6 months. Only about three patients per 24 h were considered eligible for a potential ED chest pain unit. CONCLUSIONS: Almost 75% of the patients hospitalized with suspected ACS did not have it, and some 40% of these patients could probably, given perfect immediate diagnostics, have been managed as outpatients. The potential for diagnostic improvement in the ED seems large
Treatments for people who use anabolic androgenic steroids: a scoping review.
- Author
- A Bjornebekk
- A Flores
- A Hardt
- A Kimergard
- A Stanley
- A Tarashande Foumani
- A. Kimergard
- AA Marcacuzco Quinto
- AA Samaha
- AAN Maini
- AJ Giannini
- AM Alaraj
- AM Elsharkawy
- Andreas Kimergård
- Association AP
- AV Christiansen
- B Edvardsson
- B Jacka
- BE Turvey
- BJ Freeman
- BM Hymel
- C Ahlgrim
- C Bickelman
- C Li
- C Marquis
- C Mewis
- CH Wade
- CJ Jennings
- CS Cornford
- D Sagoe
- D Sagoe
- DA Malone
- DA Malone
- Department of Health
- DG Franey
- DH Lau
- DK Menon
- DR Goldstein
- E Begley
- E Merino Garcia
- E Sonmez
- E Tüzel
- E van Breda
- E Ýlhan
- EF Daher
- EJ Ip
- EJ Ip
- EJ Ip
- EJ Ip
- EJ Ip
- EJ Ip
- F Tennant
- FC Diaz
- FC Pampel
- G Bates
- G Bolding
- G Bolding
- G Erturan
- G Hanley Santos
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Kanayama
- G Papazisis
- GA Christou
- Geoff Bates
- Geoff Bates
- GL de Souza
- GP Laroche
- GS Ferenchick
- GV Gill
- H Arksey
- H Pope
- HG David
- HG Pope
- HG Pope
- HG Pope
- HG Pope Jr
- HG Pope Jr
- HI Awai
- I Pirola
- J Ampuero
- J Copeland
- J Hoberman
- J Iversen
- J Joseph
- J McVeigh
- J McVeigh
- J McVeigh
- J Ment
- J Nasr
- JD Rich
- JGY Luc
- Jim McVeigh
- JJ Cohen
- JJ Patil
- Joseph Tay Wee Teck
- JP Corcoran
- JP Jarow
- JP Stannard
- JR Shiber
- JTW Teck
- JW Moor
- K Stergiopoulos
- Katinka Van de Ven
- KB Kashkin
- KJ Brower
- KJ Brower
- KJ Brower
- KJ Brower
- L Rohman
- L Socas
- LR Hays
- LT Westlye
- M Bispo
- M Boks
- M Dunn
- M Evans-Brown
- M Evans-Brown
- M Falkenberg
- M Gahr
- M KramhØFt
- M Labib
- M Salinas
- M Sánchez-Osorio
- M Thevis
- M Thevis
- M Underwood
- M Underwood
- M. Y. Z. Youssef
- Marie-Claire Van Hout
- MC Van Hout
- MJ Geraci
- MJ Huie
- MR Gazvani
- MS Nieminen
- NA Evans
- NICE
- NM Martin
- NS Ding
- O Friedman
- P Garg
- P Gorayski
- P Korkia
- P Leopardi
- P Solbach
- PJ Turek
- PJ Winwood
- PM Stepien
- Public Health England
- PV Krishnan
- R Adamson
- R Brennan
- R Glass
- R Ranjan
- R Rowe
- R Ulrich
- R Zahnow
- R Zahnow
- R. M. Shamloul
- RD Santamarina
- RI Holt
- RJ Auchus
- RM Duffy
- RP Santos
- RS Tan
- RS Tan
- RY Liow
- S Allnutt
- S Arver
- S Colburn
- S Grant
- S Griffiths
- S Ray
- S Unai
- SJ Midgley
- T Kesler
- T Visuri
- U Farkash
- V Singh
- VD Hope
- VD Hope
- VD Hope
- VD Hope
- W Rashid
- Y Güneþ
- Y Shimada
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: A growing body of evidence suggests that anabolic androgenic steroids (AAS) are used globally by a diverse population with varying motivations. Evidence has increased greatly in recent years to support understanding of this form of substance use and the associated health harms, but there remains little evidence regarding interventions to support cessation and treat the consequences of use. In this scoping review, we identify and describe what is known about interventions that aim to support and achieve cessation of AAS, and treat and prevent associated health problems. METHODS: A comprehensive search strategy was developed in four bibliographic databases, supported by an iterative citation searching process to identify eligible studies. Studies of any psychological or medical treatment interventions delivered in response to non-prescribed use of AAS or an associated harm in any setting were eligible. RESULTS: In total, 109 eligible studies were identified, which included case reports representing a diverse range of disciplines and sources. Studies predominantly focussed on treatments for harms associated with AAS use, with scant evidence on interventions to support cessation of AAS use or responding to dependence. The types of conditions requiring treatment included psychiatric, neuroendocrine, hepatic, kidney, cardiovascular, musculoskeletal and infectious. There was limited evidence of engagement with users or delivery of psychosocial interventions as part of treatment for any condition, and of harm reduction interventions initiated alongside, or following, treatment. Findings were limited throughout by the case report study designs and limited information was provided. CONCLUSION: This scoping review indicates that while a range of case reports describe treatments provided to AAS users, there is scarce evidence on treating dependence, managing withdrawal, or initiating behaviour change in users in any settings. Evidence is urgently required to support the development of effective services for users and of evidence-based guidance and interventions to respond to users in a range of healthcare settings. More consistent reporting in articles of whether engagement or assessment relating to AAS was initiated, and publication within broader health- or drug-related journals, will support development of the evidence base
Expanding the diversity of mycobacteriophages: Insights into genome architecture and evolution
- Author
- Agustin B
- Al-Atrache Z
- Alcoser TA
- Alexander LM
- Alfano MB
- Alford ST
- Amy NE
- Anderson AG
- Anderson MD
- Ang AAS
- Barber AJ
- Barker LP
- Barrett JM
- Barshop WD
- Bauerle CM
- Bayles IM
- Belfield KL
- Best AA
- Bowman CA
- Boyer CA
- Bradley KW
- Bradley VA
- Broadway LN
- Budwal K
- Busby KN
- Campbell AM
- Campbell IW
- Carey A
- Caruso SM
- Chew RD
- Cockburn CL
- Cohen LB
- Corajod JM
- Cresawn SG
- Davis KR
- Deng L
- Denver DR
- Dixon BR
- Ekram S
- Elgin SCR
- Engelsen AE
- English BEV
- Erb ML
- Estrada C
- Filliger LZ
- Findley AM
- Forbes L
- Forsyth MH
- Fox TM
- Fritz MJ
- Garcia R
- George ZD
- Georges AE
- Gissendanner CR
- Goff S
- Goldstein R
- Gordon KC
- Green RD
- Guerra SL
- Guiney-Olsen KR
- Guiza BG
- Haghighat L
- Hagopian GV
- Harmon CJ
- Harmson JS
- Hartzog GA
- Harvey SE
- He KJ
- He S
- Healy KE
- Higinbotham ER
- Hildebrandt EN
- Ho JH
- Hogan GM
- Hohenstein VG
- Holz NA
- Huang VJ
- Hufford EL
- Hynes PM
- Jackson AS
- Jacobs-Sera D
- Jansen EC
- Jarvik J
- Jasinto PG
- Jordan TC
- Kasza T
- Katelyn MA
- Kelsey JS
- Kerrigan LA
- Khaw D
- Kim J
- Knutter JZ
- Ko CC
- Larkin GV
- Laroche JR
- Latif A
- Manuel A
- Peebles CL
- Pope WH
- Russel DA
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 07/02/2011
- Field of study
Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists. © 2011 Hatfull et al
A Novel Approach to Determining Violence Risk in Schizophrenia: Developing a Stepped Strategy in 13,806 Discharged Patients
- Author
- AI Green
- AR Hariri
- AS Glas
- C Webster
- CD Webster
- D Watts
- DA Andrews
- DA Andrews
- DC Murrie
- DJ Pilowsky
- DP Farrington
- DR Cox
- E Pedhazur
- E Walsh
- E Walsh
- G Jones
- G Sjöstedt
- G Szmukler
- GV Kass
- H Honest
- HG Pope
- HJ Steadman
- HL Stuart
- HU Wittchen
- J Monahan
- J Reutfors
- JA Hanley
- JA Swets
- Jay P. Singh
- JF Mills
- JL Viljoen
- JO Roaldset
- JP Singh
- JP Singh
- JP Singh
- JW Swanson
- K Dean
- K Hawton
- L Dolmén
- L Hansson
- L Wootton
- Leonardo Fontenelle
- M Cannon
- M Soyka
- M Soyka
- Martin Grann
- MM Large
- MM Large
- MS Swartz
- N Breslow
- Niklas Långström
- P Lindqvist
- P Räsänen
- PA Brennan
- Paul Lichtenstein
- PF Buckley
- PM Bossuyt
- PR Blair
- R Khiroya
- RA Smith
- RK Hanson
- RP Archer
- S Bjørkly
- S Fazel
- S Fazel
- S Fazel
- S Gupta
- S Saha
- Seena Fazel
- SM Harman
- T Taiminen
- VL Quinsey
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Clinical guidelines recommend that violence risk be assessed in schizophrenia. Current approaches are resource-intensive as they employ detailed clinical assessments of dangerousness for most patients. An alternative approach would be to first screen out patients at very low risk of future violence prior to more costly and time-consuming assessments. In order to implement such a stepped strategy, we developed a simple tool to screen out individuals with schizophrenia at very low risk of violent offending. We merged high quality Swedish national registers containing information on psychiatric diagnoses, socio-demographic factors, and violent crime. A cohort of 13,806 individuals with hospital discharge diagnoses of schizophrenia was identified and followed for up to 33 years for violent crime. Cox regression was used to determine risk factors for violent crime and construct the screening tool, the predictive validity of which was measured using four outcome statistics. The instrument was calibrated on 6,903 participants and cross-validated using three independent replication samples of 2,301 participants each. Regression analyses resulted in a tool composed of five items: male sex, previous criminal conviction, young age at assessment, comorbid alcohol abuse, and comorbid drug abuse. At 5 years after discharge, the instrument had a negative predictive value of 0.99 (95% CI = 0.98–0.99), meaning that very few individuals who the tool screened out (n = 2,359 out of original sample of 6,903) were subsequently convicted of a violent offence. Screening out patients who are at very low risk of violence prior to more detailed clinical assessment may assist the risk assessment process in schizophrenia
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berti S
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Bodi Peris V
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Breedveld RW
- Brennan JM
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Camprubi Potau M
- Camsari A
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carroll PA
- Cartasegna LR
- Carter L
- Caruso OC
- Cassimjee S
- Castadot M
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chambilla JMC
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez V-CER
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chiang C-E
- Chizhov P
- Chopda M
- Chopra VK
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Civeira Murillo F
- Claeys M
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
- Clifton S
- Coching RM
- Codutti OR
- Cohen S
- Collins N
- Colombo HR
- Colquhoun D
- Commerford PJ
- Concha YMR
- Conrad G
- Constantine G
- Constantinescu MCA
- Convens C
- Cools F
- Corbett C
- Cornel JH
- Correa Flores RM
- Cosavalente LAC
- Cosin Sales J
- Costa F
- Coste P
- Cottin Y
- Coufal Z
- Coverdale SGM
- Cristian G
- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
- Dai K
- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
- De Wolf L
- Delarche N
- Deloatch S
- Demirtas M
- Denham D
- Devarapalli SK
- DeVore AD
- Diamantis S
- Diaz Fernandez JF
- Diaz A
- Diaz R
- Dickey S
- Dilic M
- Dimkovic S
- Dimov BI
- Dincic DV
- Ding C
- Dion D
- Dodic S
- Dombrowski K
- Doncovska S
- Dong S
- Dong Y
- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drzewiecka A
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
- Duronto EA
- Dzupina A
- Dzyak G
- Eagerton D
- Eapen Z
- East C
- Eaton C
- Ebrahim IO
- Edelberg JM
- Edes I
- Egorova L
- Eisenberg S
- Ekanayaka R
- El Shahawy M
- El-Ahdab F
- Elias M
- Eliaschewitz FG
- Elliott J
- Endsley P
- Eppinger A
- Erglis A
- Erglis A
- Ersanli M
- Fadlallah H
- Faes D
- Faggiano P
- Fairlamb J
- Fajardo Campos P
- Falukozy J
- Fang C-Y
- Fang W
- Fanghanel Salmon G
- Farhat N
- Farrar M
- Fausto Ovando SR
- Fazekas F
- Fazlibegovic E
- Feitosa GS
- Fell D
- Feng Y
- Fernandes Manenti ERF
- Fernandez Portales J
- Fernandez AM
- Fernandez M
- Fernando N
- Ferrari E
- Ferratini M
- Ferrolino A
- Filardi PP
- Fischer S
- Fishberg R
- Fisher D
- Fisher N
- Fisher R
- Florenzano F
- Flores E
- Flores REO
- Fong P
- Forgosh L
- Foster M
- Foster R
- Francis A
- Franek E
- Fras Z
- French WJ
- Friedman D
- Frost L
- Fu G
- Fuchs S
- Fuentes Jimenez F
- Fujii K
- Fujimoto K
- Fujinaga H
- Fulop P
- Fulwani MC
- Furukawa Y
- Galski T
- Galvani M
- Gapon L
- Garcia Brasca DF
- Garcia Castillo A
- Garcia Duran RO
- Garcia Lledo JA
- Garcia-Dorado D
- Gardner G
- Garrahy PJ
- Garrido M
- Garza Ruiz JA
- Gavish D
- Ge J
- Gelormini J
- Gerber J
- Gerber R
- Ghitis A
- Ghlonti R
- Gibson P
- Gielen S
- Giesler G
- Gil-Extremera B
- Gilbert JM
- Gillespie E
- Gilmore R
- Gimple L
- Giordano JA
- Giorgeto FE
- Gislason G
- Giuliano ME
- Gniot J
- Goch A
- Goloborodko B
- Gomez Vilamajo OA
- Gonsorcik J
- Gonzales RJV
- Gonzalez Diaz B
- Gonzalez Salas LG
- Gonzalez-Juanatey C
- Gonzalez-Juanatey JR
- Goodman SG
- Goodman SG
- Gordeev I
- Gordienko A
- Gorny J
- Gosselin G
- Gosselink ATM
- Gotcheva NN
- Gotcheva NN
- Govinda RA
- Goyal NK
- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
- Groutars RGEJ
- Guardigli G
- Guerrero De Leon M
- Guha S
- Gullestad L
- Guneri S
- Guneri S
- Guo Y
- Gurevich V
- Gusi Tragant G
- Guzman PN
- Haddad T
- Hagstrom E
- Hagstrom E
- Hahalis PIG
- Halabi M
- Halcox J
- Hald F
- Haldis T
- Hall J
- Halvorsen S
- Hameed A
- Haniffa R
- Hanotin C
- Hansen O
- Haraguchi T
- Harding S
- Harkut P
- Harrington RA
- Harris B
- Harris B
- Hart H
- Hata Y
- Hattler B
- Hedman A
- Heidenreich L
- Heinc P
- Heitzer T
- Hemetsberger R
- Henderson D
- Henkin Y
- Herath JI
- Herazo AS
- Hermans K
- Hermans WRM
- Hernandez HAA
- Herrman JPR
- Hersbach FMRJ
- Hess CN
- Higashikata T
- Higuera JD
- Hii CLS
- Hirayama A
- Hirooka K
- Hlatky MA
- Hoag G
- Hodes Z
- Hoffer E
- Hoffman D
- Hong T
- Hoogslag PAM
- Hoppe U
- Horak D
- Horowitz J
- Horvath I
- Horwitz P
- Hove JD
- Hrabar AD
- Hranai M
- Hsieh I-C
- Huang L
- Huang S
- Huang T-Y
- Huang W
- Huber K
- Huidobro L
- Huikuri H
- Hunter J
- Hurtig U
- Hussein O
- Huynh T
- Hwang J-J
- II TC
- III DG
- III KG
- Ilic S
- Ilieva-Pandeva KA
- Ince C
- Iniguez A
- Investigators ODYSSEYOUTCOMES
- Iqbal SMR
- Irimpen A
- Istratoaie O
- Ito K
- Ivanov IG
- Ivanova R
- Ivanovic N
- Iyengar SS
- Izzo M
- Jacoby D
- Jafar Z
- Jaffrani N
- Jain D
- Janik M
- Janosik D
- Jaramillo N
- Jatin FGM
- Jaworska K
- Jayawardena J
- Jensen SA
- Jensen SA
- Jeong MH
- Jeppesen J
- Jeserich M
- Jiang W
- Jintapakorn W
- Johansen PB
- Jonas M
- Jones WS
- Jordan JD
- Jortveit J
- Joshi AB
- Joshi P
- Jovin I
- Jr CE
- Jr HW
- Jr LC
- Jr MJ
- Jr PW
- Jr RW
- Jr SJ
- Jr SJF
- Jr WD
- Jujjuru S
- Jukema JW
- Juonala M
- Jure HO
- Jurgaitiene R
- Kadr H
- Kaewsuwanna P
- Kahali D
- Kaikkonen K
- Kaiser S
- Kalashetti S
- Kalil R
- Kamensky G
- Kamiya H
- Kandasamy B
- Kapin T
- Kaplan R
- Kapp IE
- Karalis I
- Karlsberg R
- Karna S
- Karpenko O
- Karpenko Y
- Karpov Y
- Karpov Y
- Kartalis A
- Kasim S
- Katona A
- Katsuda Y
- Katz A
- Kaucak V
- Kavaliauskiene R
- Kawasaki T
- Ke Y
- Keating F
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- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Search for light top squark pair production in final states with leptons and b -jets with the ATLAS detector in s=7 TeV proton-proton collisions
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- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Ybeles Smit GV
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/01/2012
- Field of study
The results of a search for pair production of light top squarks are presented, using 4.7 fb^-1 of sqrt(s) = 7 TeV proton-proton collisions collected with the ATLAS detector at the Large Hadron Collider. This search targets top squarks with masses similar to, or lighter than, the top quark mass. Final states containing exclusively one or two leptons (e, mu), large missing transverse momentum, light-jets and b-jets are used to reconstruct the top squark pair system. Global mass scale variables are used to separate the signal from a large ttbar background. No excess over the Standard Model expectations is found. The results are interpreted in the framework of the Minimal Supersymmetric Standard Model, assuming the top squark decays exclusively to a chargino and a b-quark. Light top squarks with masses between 123-167 GeV are excluded for neutralino masses around 55 GeV
Second-Generation Antipsychotics and Neuroleptic Malignant Syndrome: Systematic Review and Case Report Analysis
- Author
- A Shalev
- A Shalev
- A Yacoub
- AA Monte
- AA Sokoro
- AL Lewis
- American Psychiatric Association
- Argentina Guaglianone
- B Green
- B Margetić
- B Mishra
- C Han
- C Mantas
- CK Chang
- D Berardi
- D Berardi
- D Kato
- D Sierra-Biddle
- D Steele
- D Tarsy
- DK Farver
- E Abay
- EC Atbasoglu
- F Uguz
- G Gambassi
- G Grunder
- G Perrault
- GA Filice
- Gianluca Serafini
- GV Bakken
- H Ball
- H Verdoux
- HG Pope Jr
- HG Pope Jr
- HJ Assion
- HS Duggal
- J Ananth
- J Ananth
- J Gerlach
- J Horacek
- J Leibold
- J Leon de
- J Nielsen
- JH Friedman
- JH Tsai
- JJ Sico
- JL Karagianis
- JL Levenson
- JN Trollor
- JN Trollor
- JR Strawn
- K Marlowe
- L Ghio
- M Amore
- M Amore
- M Nakamura
- Marco Innamorati
- Mario Amore
- Martino Belvederi Murri
- Matteo Respino
- Maurizio Pompili
- MC Borovicka
- MC Tu
- ME Ozen
- Michele Bugliani
- MM Woodbury
- MS Arnaout
- MW Jann
- N Chakraborty
- N Licup
- NS Gray
- P Angelopoulos
- P Sachdev
- Pietro Calcagno
- PJ Perry
- PN Biswasl
- PS Sachdev
- RB Nayak
- RE Nielsen
- RG Murty
- RJ Gurrera
- RJ Gurrera
- RJ Gurrera
- S Mieno
- S Natesan
- S Ochi
- SC Stanfield
- SG Sugden
- SM Stahl
- SN Caroff
- SN Caroff
- T Gallarda
- TC Randolph
- TM Adityanjee
- V Johnson
- V Peritogiannis
- VR Velamoor
- WC Hsu
- Y Chen
- Y Odagaki
- Y Ohno
- YP Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities
- Author
- A Antinori
- A Kamal
- A Morris
- AM Stranahan
- AV Albright
- BA Navia
- BB Gelman
- BT Lang
- C Benedict
- C Benedict
- C Karl
- C Lois
- C Lois
- C Mueller
- C Zhang
- CA Hughes
- CM Cooper-Kuhn
- CS Graham
- D Hu
- D Johnston
- D Vergote
- David R. Marks
- DC Wu
- DE Hornung
- DE Sellmeyer
- DE Vance
- Dennis L. Kolson
- DP Kotler
- DR Marks
- DS Dhanda
- E Mariani
- ER Anderson
- EY Lee
- F Gardoni
- F Gardoni
- F Gonzalez-Scarano
- FH Gage
- G Gegelashvili
- G Rammes
- G Schifitto
- GJ Francis
- GM Zucco
- GU Hoglinger
- GV Desir
- H Dou
- H Hardy
- H Houzen
- H Misonou
- H Murakoshi
- HJ Westervelt
- HS Chen
- J Altman
- J Altman
- J Kelleher-Andersson
- J Raber
- J Razani
- J Takacs
- J Xu
- J Zheng
- JC Brüning
- JC McArthur
- JC Tu
- JD Glass
- JJ Rodriguez
- JL Trejo
- JL Trejo
- JM Brenchley
- K Herrup
- K Jin
- K Ritola
- K Xiong
- Kathryn A. Lindl
- Kelly L. Jordan-Sciutto
- KL Arvin
- KL Jordan-Sciutto
- KL Jordan-Sciutto
- L Bosch Van Den
- L Plum
- L Pulliam
- LA Ryan
- LM Metz
- LP Reagan
- LR Hanson
- LR Hanson
- M Chen
- M Colovic
- M Kam
- M Kaul
- M Perez-Martin
- M Perez-Martin
- M Pope
- M Sheng
- M Sheng
- M Sheng
- MA Aberg
- MA Aberg
- MA Reger
- MA Reger
- MA Reger
- MC Zink
- MF Anderson
- MH Donovan
- MJ Carper
- MJ Ferris
- N Sacktor
- N Sacktor
- N Sacktor
- N Wakabayashi
- NJ Haughey
- NQ Liu
- O Paulsen
- O Tschritter
- P Ancuta
- P Portegies
- P Taupin
- PN Tariot
- PS Eriksson
- Q Chen
- RG Thorne
- RG Thorne
- RG Thorne
- RG Thorne
- RJ Ellis
- RJ Lichtenwalner
- RJ Vandenberg
- RM Grant
- RO Sanchez Mejia
- RS Klein
- RW Price
- S Grinspoon
- S Safrin
- S Visentin
- SA Barber
- SA Lipton
- SC Follstaedt
- SG Birnbaum
- SK Grinspoon
- T Tikka
- TL Walker
- TM Ross
- TM Ross
- TM Tikka
- V Galvan
- V Pencea
- W Kern
- WJ Zhang
- X Lu
- Y Du
- Y Kanai
- Y Li
- Y Neye
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
- Arif I
- Armaganijan L
- Aroney C
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Aylward P
- Aylward PE
- Aylward PE
- Azizad MM
- Badreddine E
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barraud P
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Bejuit R
- Bekkouche M
- Belhassane A
- Beltran P
- Benbernou F
- Bencic ML
- Benecke JLA
- Benedicto A
- Bengrait N
- Bengus CM
- Benov HO
- Berdan L
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berthou C
- Berti S
- Bezault M
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bouancheau C
- Bougon N
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Bravo Mannucci JE
- Breedveld RW
- Bregeault M-F
- Bregeault M-F
- Brennan JM
- Brigui I
- Brocklehurst M
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Butters J
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Calderon Ticona JR
- Camacho Cosavalente LA
- Camp A
- Camprubi Potau M
- Camsari A
- Car S
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carrion Chambilla JM
- Carroll PA
- Cartasegna LR
- Carter L
- Caruso OC
- Cassimjee S
- Castadot M
- Castillo Leon RP
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
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- Chane M
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- Chaudhary S
- Chavez Ayala CA
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chizhov P
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- Chopra VK
- Chotnoparatpat P
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Cianciarulo J
- Cioranu RS
- Citron B
- Civeira Murillo F
- Claeys M
- Claxton E
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
- Clifton S
- Coca Payeras A
- Coching RM
- Codutti OR
- Cohen S
- Collins N
- Colombo HR
- Colquhoun D
- Coman I
- Commerford PJ
- Conrad G
- Constantine G
- Constantinescu MCA
- Convens C
- Cools F
- Corbett C
- Cornel JH
- Correa Flores RM
- Correa Flores RM
- Cosin Sales J
- Costa F
- Costamagna O
- Coste P
- Cotruta R
- Cottin Y
- Coufal Z
- Coulange A
- Coverdale SGM
- Cristian G
- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
- Dai K
- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
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- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Leon ERR
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- De Santos MON
- De Silva HA
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- Dincic DV
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- Dodic S
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- Domokos S
- Doncovska S
- Dong S
- Dong Y
- Dorobantu M
- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drouet E
- Drzewiecka A
- Dubois-Gache H
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
- Duran ROG
- Durand Velasquez JR
- Duronto EA
- Dzupina A
- Dzyak G
- Eagerton D
- Eapen Z
- East C
- Eaton C
- Ebrahim IO
- Edelberg JM
- Edelberg JM
- Edes I
- Egorova L
- Egydio F
- Eisenberg S
- Ekanayaka R
- El Shahawy M
- El-Ahdab F
- Elias M
- Elias N
- Eliaschewitz FG
- Elliott J
- Endsley P
- Eppinger A
- Erglis A
- Ersanli M
- Escudier JM
- Etienne A
- Fadlallah H
- Faes D
- Faggiano P
- Fairlamb J
- Fajardo Campos P
- Falukozy J
- Fan Z
- Fang C-Y
- Fang W
- Fanghanel Salmon G
- Farhat N
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- Faustino D
- Fazekas F
- Fazlibegovic E
- Feitosa GS
- Fell D
- Feng Y
- Fernandes Manenti ERF
- Fernandez Portales J
- Fernandez M
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- Ferrolino A
- Filardi PP
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- Fong P
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- Hoppe U
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- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
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- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aenia T
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Aivković L
- Akdogan T
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
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- Alviggi MG
- Amako K
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- Åkesson TPA
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
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