A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry

abstract Daptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no "green" analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 µg mL-1. A Student's t-test demonstrated that the proposed method was comparable to an HPLC method previously validated. Thus, the validated spectrophotometric method could quantify daptomycin in a powder form for injectable solutions, while being an economical, rapid, and "green" alternative for routine analysis in quality control

Operational precise irrigation for cotton cultivation through the coupling of meteorological and crop growth models.

In this paper, we tested the operational capacity of an interoperable model coupling system for the irrigation scheduling (IMCIS) at an experimental cotton (Gossypium hirsutum L.) field in Northern Greece. IMCIS comprises a meteorological model (TAPM), downscaled at field level, and a water-driven cultivation tool (AquaCrop), to optimize irrigation and enhance crop growth and yield. Both models were evaluated through on-site observations of meteorological variables, soil moisture levels and canopy cover progress. Based on irrigation management (deficit, precise and farmer’s practice) and method (drip and sprinkler), the field was divided into six sub-plots. Prognostic meteorological model results exhibited satisfactory agreement in most parameters affecting ETo, simulating adequately the soil water balance. Precipitation events were fairly predicted, although rainfall depths needed further adjustment. Soil water content levels computed by the crop growth model followed the trend of soil humidity measurements, while the canopy cover patterns and the seed cotton yield were well predicted, especially at the drip irrigated plots. Overall, the system exhibited robustness and good predicting ability for crop water needs, based on local evapotranspiration forecasts and crop phenological stages. The comparison of yield and irrigation levels at all sub-plots revealed that drip irrigation under IMCIS guidance could achieve the same yield levels as traditional farmer’s practice, utilizing approximately 32% less water, thus raising water productivity up to 0.96 kg/m3.N/

Kreislaufstillstand unter besonderen Umständen: Elektrolytstörungen, Vergiftungen, Ertrinken, Unter-kühlung, Hitzekrankheit, Asthma, Anaphylaxie, Herzchirurgie, Trauma, Schwangerschaft, Stromunfall

Soar J, Perkins GD, Abbas G, et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution. Resuscitation. 2010;81(10):1400-1433