Panorámica de la distribución de azafrán en el mercado urbano de Zaragoza

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El vídeo y la tele: desde el despacho a la calle

Junta de Andalucía HUM21

Application of molecular topology to the prediction of the phenoloxidase inhibition by a group of benzaldehyde thiosemicarbazone and their derivatives

A topological-mathematical model has been arranged to search for new derivatives of benzaldehyde thiosemicarbazone and related compounds acting as phenoloxidase inhibitors. By using multilinear regression analysis a function with two descriptors, 1χv, 4χpv and r2 = 0,940 was capable to predict adequately the IC50 for each compound.After carrying out a virtual screening based upon such a model, new structures potentially active against the enzyme are proposed

Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3

Spinocerebellar ataxia type-3 (SCA-3) is the most prevalent autosomal dominant inherited ataxia. We recently found that the endocannabinoid system is altered in the post-mortem cerebellum of SCA-3 patients, and similar results were also found in the cerebellar and brainstem nuclei of a SCA-3 transgenic mouse model. Given that the neuropathology of SCA-3 is not restricted to these two brain regions but rather, it is also evident in other structures (e.g., the basal ganglia), we studied the possible changes to endocannabinoid signaling in the striatum of these transgenic mice. SCA-3 mutant mice suffer defects in motor coordination, balance and they have an abnormal gait, reflecting a cerebellar/brainstem neuropathology. However, they also show dystonia-like behavior (limb clasping) that may be related to the malfunction/deterioration of specific neurons in the striatum. Indeed, we found a loss of striatal projecting neurons in SCA-3 mutant mice, accompanied by a reduction in glial glutamate transporters that could potentially aggravate excitotoxic damage. In terms of endocannabinoid signaling, no changes in CB2 receptors were evident, yet an important reduction in CB1 receptors was detected by qPCR and immunostaining. The reduction in CB1 receptors was presumed to occur in striatal afferent and efferent neurons, also potentially aggravating excitotoxicity. We also measured the endocannabinoid lipids in the striatum and despite a marked increase in the FAAH enzyme in this area, no overall changes in these lipids were found. Collectively, these studies confirm that the striatal endocannabinoid system is altered in SCA-3 mutant mice, adding to the equivalent changes found in other strongly affected CNS structures in this type of ataxia (i.e.: the cerebellum and brainstem). These data open the way to search for drugs that might correct these changes.Funding: This study has been supported: (i) by MICINN (SAF2009-11847 and SAF2015-68580-C2-1-R), CIBERNED (CB06/05/0089) and “Fundación Eugenio Rodríguez Pascual”, to JFR; (ii) by the Research and Education Component of the Advancing a Healthier Wisconsin Endowment at the Medical College of Wisconsin, to CJH; and (iii) by Fundação para a Ciência e Tecnologia through the project POCI-01-0145-FEDER-016818 (PTDC/NEU-NMC/3648/2014) and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), to PM. Carmen Rodríguez-Cueto was a predoctoral fellow supported by FPI Program-Ministry of Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersio

Evaluación geológica - minera del ANAP Jalaoca

El Instituto Geológico Minero y Metalúrgico por medio de la Dirección de Recursos Mineros Energéticos y el Programa de Metalogenia, en el marco del proyecto GE 28: “Prospección de ANAPs” realizó la evaluación Geológico Minero del ANAP Jalaoca. El ANAP Jalaoca está ubicada en la región Apurímac, comprendiendo parte de las provincias de Aymaraes y Antabamba, 30 Km al SE del poblado de Chalhuanca. Tiene un área de 6,400 has y se encuentra a una altura promedio de 4500 msnm. Las propiedades particulares que rodean al ANAP Jalaoca pertenecen a Consorcio Minero Horizonte, Buenaventura, Minera Meridian Peru, Sumitomo Metal Minig, SPCC, Super Strong Mining y Minera Suroeste. Hacia el N y NE del ANAP se encuentran importantes proyectos mineros como Los Chancas, Antilla y Utupara, hacia el S y SE los proyectos de Trapiche y Antabamba (Lahuani). En el ANAP Jalaoca se han reconocido cuatro zonas de interés (targets), que según su importancia económica son: Pucasalla (1048 has), Llamoja (1877 has), Huarajo (100 has) y Mesaorco (369 has). La geología está representada por una secuencia de areniscas, lutitas y calizas de la Formación Socosani del Jurásico medio, cortada por intrusivos del Eoceno – Oligoceno del Batolito Andahuaylas – Yauri formados por la granodiorita pre-mineral, cuarzo-monzonita intermineral tempranas, cuarzo-monzodioritas intermineral tardías, pórfido cuarzo-monzodiorítico tardimineral y pórfidos dacíticos post-mineral. Estas secuencias están cubiertas en discordancia angular por rocas andesíticas del Grupo Tacaza del Oligoceno-Mioceno. El magmatismo, la alteración hidrotermal y la mineralización han sido controladas por tres sistemas estructurales que tienen un azimut de: (1) 120-135°, (2) 070-080°y (3) 010°. Estos sistemas se relacionan con la falla Mollebamba de extensión regional, la cual tiene una orientación NO-SE. Las alteraciones hidrotermales reconocidas son de tipo skarn, potásica, silicificación, fílica, propilítica y argilización. La mineralización se encuentra diseminada y en venillas y consiste de calcopirita en el skarn, y de bornita, calcopirita, pirita, pirrotita, molibdenita y especularita en la areniscas silicificadas; pirita y calcopirita en la zona potásica; molibdenita en vetas de cuarzo. Estas características, sumadas con las anomalías geofísicas muestran un depósito tipo pórfido-skarn Cu-Au en Pucasalla y un depósito tipo pórfido Cu-Mo en Llamoja. A partir de los resultados geoquímicos de sedimentos de quebrada se definieron 13 elementos anómalos: As, Au, Ca, Cd, Cu, Co, Hg, Mo, Na, Pb, Ni, Sb y Zn, los cuales ayudaron a definir los targets en el ANAP Jalaoca. En los trabajos de campo, además del cartografiado geológico y de alteración-mineralización, se recolectaron 455 muestras, de las cuales 49 fueron de sedimentos de quebrada y 333 de esquirlas de roca. A las muestras de campo se agregaron 73 muestras para control de calidad (blancos, estándares, duplicados) y se analizaron por ensayo al fuego de 50g para el Au, vapor en frío para el Hg e ICP-EOS para 32 elementos trazas. Los targets de Pucasalla, Llamoja, Huarajo y Mesaorco presentaron anomalías geoquímicas de rocas en Cu (> 50ppm), Mo (> 10ppm), Au (> 10 ppb), Pb (> 20 ppm) y Zn (> 50 ppm). Las anomalías mayores que las moderadas de Cu-Mo-Au tienen un área efectiva de 0.16 a 1 Km2 y están ubicadas en Pucasalla y Llamoja respectivamente. Estas anomalías permitieron definir las zonas donde se realizaron los trabajos de prospección geofísica. Se realizaron trabajos de prospección geofísica de polarización inducida (IP), resistividad y magnetometría en los cuatro targets, donde se determinaron anomalías de cargabilidad mayores que 28 mV/V, de resistividad menores que 200 Ohmxm y las magnéticas fueron mayores que 24500 nT. Estas anomalías fueron encontradas en Pucasalla, que correspondieron a 3 anomalías de cargabilidad, 2 de resistividad y 2 magnéticas. En Llamoja sólo se encontraron anomalías débiles de cargabilidad ( 50 ppm), Pb (> 20 ppm), Ag (> 10 ppm) y Cu (> 50 ppm) relacionadas con las de cargabilidad, resistividad y magnetometría. Por tal motivo se considera como primera prioridad para perforar. El área prospectiva de Llamoja sería una segunda opción para perforar y confirmar la continuidad de la mineralización en profundidad. Las anomalías de cargabilidad en estos targets muestran una profundidad de la mineralización hasta 500 m. Se puede concluir que el ANAP Jalaoca presenta dos tipos de depósitos tipo pórfido-skarn Cu-Au en Pucasalla y tipo pórfido Cu-Mo en Llamoja. A pesar que las anomalías de molibdeno en el centro de Llamoja puedan mostrar las raíces de un sistema porfirítico, también es probable que las anomalías puedan corresponder a óxidos de molibdeno, ya que en superficie no se ha encontrado mineralización de molibdenita diseminada ni en vetillas

Participation in biocultural diversity conservation : insights from five Amazonian examples

Unidad de excelencia María de Maeztu CEX2019-000940-MThe past three decades have seen the emergence of myriads of initiatives focused on conserving, revitalizing, and maintaining Indigenous and Local Knowledge (ILK) as part of biocultural approaches to conservation. However, the extent to which these efforts have been participatory has been often overlooked. In this chapter, we focus on five prominent ILK conservation initiatives in the Amazon Basin to examine the participation of Indigenous Peoples and Local Communities (IPLCs) in ILK conservation. Our review illustrates several examples of ILK conservation initiatives offering substantial opportunities for meaningful IPLC participation over the long term. Overall, our case studies suggest that the development of robust and inclusive decision-making processes is essential to optimize IPLC participation in ILK conservation, thereby increasing the legitimacy of these initiatives. Our review is not an exhaustive account of the breadth and depth of all initiatives promoting participatory biocultural conservation in this region, but it illustrates that there are many strategies that can help foster IPLC engagement and lead the participatory turn in biocultural conservation

Role of age and comorbidities in mortality of patients with infective endocarditis

Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015. Patients were stratified into three age groups:<65 years, 65 to 80 years, and = 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 = 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients =80 years who underwent surgery were significantly lower compared with other age groups (14.3%, 65 years; 20.5%, 65-79 years; 31.3%, =80 years). In-hospital mortality was lower in the <65-year group (20.3%, <65 years;30.1%, 65-79 years;34.7%, =80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%, =80 years; p = 0.003).Independent predictors of mortality were age = 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI = 3 (HR:1.62; 95% CI:1.39–1.88), and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared, the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. Conclusion: There were no differences in the clinical presentation of IE between the groups. Age = 80 years, high comorbidity (measured by CCI), and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

The European Solar Telescope

The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l'Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems

Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air (R) App

Background In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom-medication scores obtained concurrently. Methods All consecutive MASK-air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self-assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom-medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra-individual response variability (IRV) index was calculated. Results A strong correlation was observed between VAS work and other VAS. The highest levels for correlation with VAS work and variance explained in VAS work were found with VAS global, followed by VAS nose, eye and asthma. In comparison with VAS global, the mCSMS and MASK control score showed a lower correlation with VAS work. Results are unlikely to be explained by a low quality of data arising from repeated VAS measures. Conclusions VAS work correlates with other outcomes (VAS global, nose, eye and asthma) but less well with a symptom-medication score. VAS work should be considered as a potentially useful AR outcome in intervention studies.Peer reviewe