Rachel Caldwell in a Sophomore Recital

This is the program for the sophomore voice recital of Rachel Caldwell, accompanied by Janet Frank on the piano. The recital was held on March 13, 1998, in the McBeth Recital Hall of the Mabee Fine Arts Center

Amy Kathryn Cobb in a Junior Recital

This is the program for the junior voice recital for Amy Kathryn Cobb, accompanied by Janet Franks on the piano. The recital was held on March 11, 1994, in the Mabee Fine Arts Center\u27s Recital Hall

Dana Campbell in a Sophomore Recital

This is the sophomore voice recital of Dana Campbell, accompanied by Janet Franks on the piano and assisted by Barry McVinney on the flute. The recital was held on March 18, 1994, in the Recital Hall of the Mabee Fine Arts Center

Alan Malone and Krista Brown in a Senior Voice Recital

This is the program for the voice recital of Alan Malone, tenor, accompanied by Janet Franks on the piano, and Krista Brown, mezzo-soprano, accompanied by Pamela Dennis on the piano. The recital was held on April 28, 1994, in Mabee Fine Arts Center\u27s Recital Hall

Governing for ecosystem health and human wellbeing

Governance arrangements and processes influence access to and benefits from ecosystem services, and therefore the potential for ecosystem services to alleviate poverty. Governance also then influences the health of ecosystems. This chapter learns from decades of governance-related research to identify how to make ecosystem governance more effectively ‘pro-poor’. It is informed by a systematic mapping of literature related to governance of ecosystem services and renewable natural resources for improved wellbeing and poverty alleviation, expert interviews and a workshop with government and non-government actors across a range of sectors from both North and South. The chapter is organised around the concept of trade-offs, considering first ecosystem-focused approaches, then rights-based approaches and lastly, participatory approaches to governance. The chapter further addresses the relevance of scale and multiple administrative levels (multi-level governance) and the importance of informal, or socially embedded, institutions. The chapter concludes that there is no single governance approach that can definitively deliver on improved ecosystem health and human wellbeing, that trade-offs are inevitable and governance is therefore an inherently political process

Chronicles of Oklahoma

Article describes the journey and works of James Otto Lewis, an official artist who joined the commissioners of the Bureau of Indian Affairs to councils and treaty signings and documented the events. His collection of portraits of tribe chiefs is included

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

INTRODUCTION: METHODS: We screened 19 clinical respiratory RESULTS: The respiratory CONCLUSION: Altogether, these findings show that phagocytosis is a primary determinant of pulmonary clearance of clinica

The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides

The drug efflux pump P-glycoprotein (P-gp) (ABCB1) confers multidrug resistance, a major cause of failure in the chemotherapy of tumours, exacerbated by a shortage of potent and selective inhibitors. A high throughput assay using purified P-gp to screen and characterise potential inhibitors would greatly accelerate their development. However, long-term stability of purified reconstituted ABCB1 can only be reliably achieved with storage at -80 °C. For example, at 20 °C, the activity of ABCB1 was abrogated with a half-life of <1 day. The aim of this investigation was to stabilise purified, reconstituted ABCB1 to enable storage at higher temperatures and thereby enable design of a high throughput assay system. The ABCB1 purification procedure was optimised to allow successful freeze drying by substitution of glycerol with the disaccharides trehalose or maltose. Addition of disaccharides resulted in ATPase activity being retained immediately following lyophilisation with no significant difference between the two disaccharides. However, during storage trehalose preserved ATPase activity for several months regardless of the temperature (e.g. 60% retention at 150 days), whereas ATPase activity in maltose purified P-gp was affected by both storage time and temperature. The data provide an effective mechanism for the production of resilient purified, reconstituted ABCB1

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms