69 research outputs found
Criteria and tools for determining drainage divide stability
© 2018 Elsevier B.V. Watersheds are the fundamental organizing units in landscapes and thus the controls on drainage divide location and mobility are an essential facet of landscape evolution. Additionally, many common topographic analyses fundamentally assume that river network topology and divide locations are largely static, allowing channel profile form to be interpreted in terms of spatio-temporal patterns of rock uplift rate relative to base level, climate, or rock properties. Recently however, it has been suggested that drainage divides are more mobile than previously thought and that divide mobility, and resulting changes in drainage area, could potentially confound interpretations of river profiles. Ultimately, reliable metrics are needed to diagnose the mobility of divides as part of routine landscape analyses. One such recently proposed metric is cross-divide contrasts in χ a proxy for steady-state channel elevation, but cross-divide contrasts in a number of topographic metrics show promise. Here we use a series of landscape evolution simulations in which we induce divide mobility under different conditions to test the utility of a suite of topographic metrics of divide mobility and for comparison with natural examples in the eastern Greater Caucasus Mountains, the Kars Volcanic Plateau, and the western San Bernadino Mountains. Specifically, we test cross-divide contrasts in mean gradient, mean local relief, channel bed elevation, and χ all measured at, or averaged upstream of, a reference drainage area. Our results highlight that cross-divide contrasts in χ only faithfully reflect current divide mobility when uplift, rock erodibility, climate, and catchment outlet elevation are uniform across both river networks on either side of the divide, otherwise a χ-anomaly only indicates a possible future divide instability. The other metrics appear to be more reliable representations of current divide motion, but in natural landscapes, only cross-divide contrasts in mean gradient and local relief appear to consistently provide useful information. Multiple divide metrics should be considered simultaneously and across-divide values of all metrics examined quantitatively as visual assessment is not sufficiently reliable in many cases. We provide a series of Matlab tools built using TopoToolbox to facilitate routine analysis
Relict basin closure and crustal shortening budgets during continental collision: An example from Caucasus sediment provenance
Comparison of plate convergence with the timing and magnitude of upper crustal shortening in collisional orogens indicates both shortening deficits (200–1700 km) and significant (10–40%) plate deceleration during collision, the cause(s) for which remains debated. The Greater Caucasus Mountains, which result from postcollisional Cenozoic closure of a relict Mesozoic back‐arc basin on the northern margin of the Arabia‐Eurasia collision zone, help reconcile these debates. Here we use U‐Pb detrital zircon provenance data and the regional geology of the Caucasus to investigate the width of the now‐consumed Mesozoic back‐arc basin and its closure history. The provenance data record distinct southern and northern provenance domains that persisted until at least the Miocene. Maximum basin width was likely ~350–400 km. We propose that closure of the back‐arc basin initiated at ~35 Ma, coincident with initial (soft) Arabia‐Eurasia collision along the Bitlis‐Zagros suture, eventually leading to ~5 Ma (hard) collision between the Lesser Caucasus arc and the Scythian platform to form the Greater Caucasus Mountains. Final basin closure triggered deceleration of plate convergence and tectonic reorganization throughout the collision. Postcollisional subduction of such small (102–103 km wide) relict ocean basins can account for both shortening deficits and delays in plate deceleration by accommodating convergence via subduction/underthrusting, although such shortening is easily missed if it occurs along structures hidden within flysch/slate belts. Relict basin closure is likely typical in continental collisions in which the colliding margins are either irregularly shaped or rimmed by extensive back‐arc basins and fringing arcs, such as those in the modern South Pacific.Key PointsU‐Pb provenance indicates Greater Caucasus formed by postcollisional Cenozoic closure of a Mesozoic back arc basin likely ~350–400 km widePostcollisional subduction/underthrusting of such relict basins helps account for shortening deficits and delayed plate decelerationPlate convergence should not be expected to balance upper crustal shortening or the length of subducted slab following collisionPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135981/1/tect20504.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135981/2/tect20504_am.pd
Towards the possibility to combine LOFAR and GNSS measurements to sense ionospheric irregularities
Inhomogeneities within the ionospheric plasma density affect trans-ionospheric radio signals, causing radio wave scintillation in the amplitude and phase of the signals. The amount of scintillation induced by ionospheric irregularities typically decreases with the radio wave frequency. As the ionosphere affects a variety of technological systems (e.g., civil aviation, financial operations) as well as low-frequency radio astronomy observations, it is important to detect and monitor iono-
spheric effects with higher accuracy than currently available. Here, a novel methodology for the detection and characterization of ionospheric irregularities is established on the basis of LOFAR scintillation measurements at VHF that takes into account of the lack of ergodicity in the intensity fluctuations induced by scintillation. The methodology estimates the S 4 scintillation index originating from irregularities with spatial scales in the inertial sub-range of electron density fluctuations in the ionosphere. The methodology is illustrated by means of observations that were collected through the Polish LOFAR stations located in Bałdy, Borówiec and Łazy: its validation was carried out by comparing LOFAR VHF scintillation observations with independent GNSS observations that were collected through a high-rate receiver located near the LOFAR station in Bałdy as well as through geodetic receivers from the Polish ASG-EUPOS network. Two case stud-
ies are presented: 31 March 2017 and 28 September 2017. The comparison between LOFAR S4 observations and independent ionospheric measurements of both scintillation and rate of change of TEC from GNSS reveals that the sensitivity of LOFAR and GNSS to ionospheric structures is different as a consequence of the frequency dependency of radio wave scintillation. Furthermore, it can be noticed that observations of LOFAR VHF scintillation can be utilised to detect plasma
structures forming in the mid-latitude ionosphere, including electron density gradients occurring over spatial scales that are not necessarily detected through traditional GNSS measurements: the detection of all spatial scales is important for a correct monitoring and modelling of ionospheric processes. Hence, the different sensitivity of LOFAR to ionospheric structures, in addition to traditional GNSS ionospheric measurements, allows to expand the knowledge of ionospheric processes
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Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization of mice with pneumococci confers CD4+ T cell–dependent, antibody- and serotype-independent protection against colonization. Here we show that this immunity, rather than preventing initiation of carriage, accelerates clearance over several days, accompanied by neutrophilic infiltration of the nasopharyngeal mucosa. Adoptive transfer of immune CD4+ T cells was sufficient to confer immunity to naïve RAG1−/− mice. A critical role of interleukin (IL)-17A was demonstrated: mice lacking interferon-γ or IL-4 were protected, but not mice lacking IL-17A receptor or mice with neutrophil depletion. In vitro expression of IL-17A in response to pneumococci was assayed: lymphoid tissue from vaccinated mice expressed significantly more IL-17A than controls, and IL-17A expression from peripheral blood samples from immunized mice predicted protection in vivo. IL-17A was elicited by pneumococcal stimulation of tonsillar cells of children or adult blood but not cord blood. IL-17A increased pneumococcal killing by human neutrophils both in the absence and in the presence of antibodies and complement. We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines
Properties of Graphene: A Theoretical Perspective
In this review, we provide an in-depth description of the physics of
monolayer and bilayer graphene from a theorist's perspective. We discuss the
physical properties of graphene in an external magnetic field, reflecting the
chiral nature of the quasiparticles near the Dirac point with a Landau level at
zero energy. We address the unique integer quantum Hall effects, the role of
electron correlations, and the recent observation of the fractional quantum
Hall effect in the monolayer graphene. The quantum Hall effect in bilayer
graphene is fundamentally different from that of a monolayer, reflecting the
unique band structure of this system. The theory of transport in the absence of
an external magnetic field is discussed in detail, along with the role of
disorder studied in various theoretical models. We highlight the differences
and similarities between monolayer and bilayer graphene, and focus on
thermodynamic properties such as the compressibility, the plasmon spectra, the
weak localization correction, quantum Hall effect, and optical properties.
Confinement of electrons in graphene is nontrivial due to Klein tunneling. We
review various theoretical and experimental studies of quantum confined
structures made from graphene. The band structure of graphene nanoribbons and
the role of the sublattice symmetry, edge geometry and the size of the
nanoribbon on the electronic and magnetic properties are very active areas of
research, and a detailed review of these topics is presented. Also, the effects
of substrate interactions, adsorbed atoms, lattice defects and doping on the
band structure of finite-sized graphene systems are discussed. We also include
a brief description of graphane -- gapped material obtained from graphene by
attaching hydrogen atoms to each carbon atom in the lattice.Comment: 189 pages. submitted in Advances in Physic
Tamoxifen for the treatment of myeloproliferative neoplasms: a phase II clinical trial and exploratory analysis
Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Phase-II, multicenter, single-arm clinical trial assessed tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2V617F, CALRins5 or CALRdel52 peripheral blood allele burden ≥20% (EudraCT 2015-005497-38). 38 patients were recruited over 112w and 32 completed 24w-treatment. The study’s A’herns success criteria were met as the primary outcome ( ≥ 50% reduction in mutant allele burden at 24w) was observed in 3/38 patients. Secondary outcomes included ≥25% reduction at 24w (5/38), ≥50% reduction at 12w (0/38), thrombotic events (2/38), toxicities, hematological response, proportion of patients in each IWG-MRT response category and ELN response criteria. As exploratory outcomes, baseline analysis of HSPC transcriptome segregates responders and non-responders, suggesting a predictive signature. In responder HSPCs, longitudinal analysis shows high baseline expression of JAK-STAT signaling and oxidative phosphorylation genes, which are downregulated by tamoxifen. We further demonstrate in preclinical studies that in JAK2V617F+ cells, 4-hydroxytamoxifen inhibits mitochondrial complex-I, activates integrated stress response and decreases pathogenic JAK2-signaling. These results warrant further investigation of tamoxifen in MPN, with careful consideration of thrombotic risk
Absence of Ca2+-Induced Mitochondrial Permeability Transition but Presence of Bongkrekate-Sensitive Nucleotide Exchange in C. crangon and P. serratus
Mitochondria from the embryos of brine shrimp (Artemia franciscana) do not undergo Ca2+-induced permeability transition in the presence of a profound Ca2+ uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-insensitive mitochondrial adenine nucleotide exchange, prompting the conjecture that refractoriness to bongkrekate and absence of Ca2+-induced permeability transition are somehow related phenomena. Here we report that mitochondria isolated from two other crustaceans, brown shrimp (Crangon crangon) and common prawn (Palaemon serratus) exhibited bongkrekate-sensitive mitochondrial adenine nucleotide transport, but lacked a Ca2+-induced permeability transition. Ca2+ uptake capacity was robust in the absence of adenine nucleotides in both crustaceans, unaffected by either bongkrekate or cyclosporin A. Transmission electron microscopy images of Ca2+-loaded mitochondria showed needle-like formations of electron-dense material strikingly similar to those observed in mitochondria from the hepatopancreas of blue crab (Callinectes sapidus) and the embryos of Artemia franciscana. Alignment analysis of the partial coding sequences of the adenine nucleotide translocase (ANT) expressed in Crangon crangon and Palaemon serratus versus the complete sequence expressed in Artemia franciscana reappraised the possibility of the 208-214 amino acid region for conferring sensitivity to bongkrekate. However, our findings suggest that the ability to undergo Ca2+-induced mitochondrial permeability transition and the sensitivity of adenine nucleotide translocase to bongkrekate are not necessarily related phenomena
Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization of mice with pneumococci confers CD4+ T cell–dependent, antibody- and serotype-independent protection against colonization. Here we show that this immunity, rather than preventing initiation of carriage, accelerates clearance over several days, accompanied by neutrophilic infiltration of the nasopharyngeal mucosa. Adoptive transfer of immune CD4+ T cells was sufficient to confer immunity to naïve RAG1−/− mice. A critical role of interleukin (IL)-17A was demonstrated: mice lacking interferon-γ or IL-4 were protected, but not mice lacking IL-17A receptor or mice with neutrophil depletion. In vitro expression of IL-17A in response to pneumococci was assayed: lymphoid tissue from vaccinated mice expressed significantly more IL-17A than controls, and IL-17A expression from peripheral blood samples from immunized mice predicted protection in vivo. IL-17A was elicited by pneumococcal stimulation of tonsillar cells of children or adult blood but not cord blood. IL-17A increased pneumococcal killing by human neutrophils both in the absence and in the presence of antibodies and complement. We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines
Measurement of dijet cross-sections in pp collisions at 7 TeV centre-of-mass energy using the ATLAS detector
Double-differential dijet cross-sections measured in pp collisions at the LHC with a 7 TeV centre-of-mass energy are presented as functions of dijet mass and half the rapidity separation of the two highest-pT jets. These measurements are obtained using data corresponding to an integrated luminosity of 4.5 fb−¹, recorded by the ATLAS detector in 2011. The data are corrected for detector effects so that cross-sections are presented at the particle level. Cross-sections are measured up to 5 TeV dijet mass using jets reconstructed with the anti-kt algorithm for values of the jet radius parameter of 0.4 and 0.6. The cross-sections are compared with next-to-leading-order perturbative QCD calculations by NLOJet++ corrected to account for non-perturbative effects. Comparisons with POWHEG predictions, using a next-to-leading-order matrix element calculation interfaced to a parton-shower Monte Carlo simulation, are also shown. Electroweak effects are accounted for in both cases. The quantitative comparison of data and theoretical predictions obtained using various parameterizations of the parton distribution functions is performed using a frequentist method. In general, good agreement with data is observed for the NLOJet++ theoretical predictions when using the CT10, NNPDF2.1 and MSTW 2008 PDF sets. Disagreement is observed when using the ABM11 and HERAPDF1.5 PDF sets for some ranges of dijet mass and half the rapidity separation. An example setting a lower limit on the compositeness scale for a model of contact interactions is presented, showing that the unfolded results can be used to constrain contributions to dijet production beyond that predicted by the Standard Model
Measurement of the inclusive jet cross-section in proton-proton collisions at √s=7 TeV using 4.5 fb−1 of data with the ATLAS detector
The inclusive jet cross-section is measured in proton-proton collisions at a centre-of-mass energy of 7 TeV using a data set corresponding to an integrated luminosity of 4.5 fb−1 collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-kt algorithm with radius parameter values of 0.4 and 0.6. The double-differential cross-sections are presented as a function of the jet transverse momentum and the jet rapidity, covering jet transverse momenta from 100 GeV to 2 TeV. Next-to-leading-order QCD calculations corrected for non-perturbative effects and electroweak effects, as well as Monte Carlo simulations with next-to-leading-order matrix elements interfaced to parton showering, are compared to the measured cross-sections. A quantitative comparison of the measured cross-sections to the QCD calculations using several sets of parton distribution functions is performed
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