120 research outputs found
Aptamer-based therapeutics and their potential in radiopharmaceutical design
- Publication venue
- Publication date
- 01/09/2007
- Field of study
Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications. These range from inhibition of receptors and enzymes to the identification of small molecules in sensor applications, and from the development of targeted therapeutic to the design of novel diagnostic and imaging agents. Furthermore, aptamers have been designed for targets that cover a wide range of diseases, from HIV to tropical diseases, cancer and inflammation. Their easy development and flexibility of use and manipulation, offers further potential. In this paper we review their selection and consider some of the recent applications of aptamers in the design of radiopharmaceuticals for the targeted radiotherapy and medical imaging of disease
The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density
- Author
- A Bolzer
- A Ono
- AM Boutanaev
- B Dutrillaux
- BA Boggs
- C Federico
- C Federico
- C Federico
- C Federico
- C Federico
- Catia Daniela Cantarella
- CM Clemson
- Concetta Federico
- D Zink
- E Lukasova
- ED Andrulis
- EV Volpi
- G Bernardi
- G DâOnofrio
- H Tanabe
- H Tanabe
- HA Foster
- I Solovei
- IHGSC (International Human Genome Sequencing Consortium)
- J Ferreira
- J Strouboulis
- J Zhou
- JA Croft
- JJ Roix
- JM Bridger
- K Kupper
- KE Brown
- L Andreozzi
- M Cockell
- M Costantini
- M Neusser
- N Gilbert
- N Sadoni
- NV Petrova
- Patrizia Di Mare
- PS Masny
- S Boyle
- S DâAntoni
- S Saccone
- S Saccone
- S Saccone
- S Saccone
- Sabrina Tosi
- Salvatore Saccone
- SW Scherer
- T Cremer
- TS Furey
- U Francke
- WA Bickmore
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/04/2008
- Field of study
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer-Verlag 2008.In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of each chromosome. However, chromosomes are very heterogeneous in size and base composition, and can contain both very gene-dense and very gene-poor regions. Thus, a precise analysis of chromosome organisation in the nuclei should consider also the distribution of DNA belonging to the chromosomal bands in each chromosome. To improve our understanding of the chromatin organisation, we localised chromosome 7 DNA regions, endowed with different gene densities, in the nuclei of human lymphocytes. Our results showed that this chromosome in cell nuclei is arranged radially with the gene-dense/GC-richest regions exposed towards the nuclear interior and the gene-poorest/GC-poorest ones located at the nuclear periphery. Moreover, we found that chromatin fibres from the 7p22.3 and the 7q22.1 bands are not confined to the territory of the bulk of this chromosome, protruding towards the inner part of the nucleus. Overall, our work demonstrates the radial arrangement of the territory of chromosome 7 in the lymphocyte nucleus and confirms that human genes occupy specific radial positions, presumably to enhance intra- and inter-chromosomal interaction among loci displaying a similar expression pattern, and/or similar replication timing
Metrics for GO based protein semantic similarity: a systematic evaluation
- Author
- A Schlicker
- A Valencia
- André O Falcão
- AntĂłnio EN Ferreira
- C Pesquita
- C Wu
- Catia Pesquita
- D Devos
- D Devos
- D Faria
- D Lin
- Daniel Faria
- E Camon
- EB Camon
- F Azuaje
- F Azuaje
- F Couto
- F Couto
- FM Couto
- Francisco M Couto
- Gentleman
- Hugo Bastos
- J Chabalier
- J Jiang
- J Tuikkala
- JL Sevilla
- L Stein
- P Lord
- P Lord
- P Resnik
- PH Lee
- RM Othman
- RM Riensche
- S Cao
- T Joshi
- X Guo
- X Wu
- Y Tao
- Z Lei
- ZH Duan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Several semantic similarity measures have been applied to gene products annotated with Gene Ontology terms, providing a basis for their functional comparison. However, it is still unclear which is the best approach to semantic similarity in this context, since there is no conclusive evaluation of the various measures. Another issue, is whether electronic annotations should or not be used in semantic similarity calculations.</p> <p>Results</p> <p>We conducted a systematic evaluation of GO-based semantic similarity measures using the relationship with sequence similarity as a means to quantify their performance, and assessed the influence of electronic annotations by testing the measures in the presence and absence of these annotations. We verified that the relationship between semantic and sequence similarity is not linear, but can be well approximated by a rescaled Normal cumulative distribution function. Given that the majority of the semantic similarity measures capture an identical behaviour, but differ in resolution, we used the latter as the main criterion of evaluation.</p> <p>Conclusions</p> <p>This work has provided a basis for the comparison of several semantic similarity measures, and can aid researchers in choosing the most adequate measure for their work. We have found that the hybrid <it>simGIC</it> was the measure with the best overall performance, followed by Resnik's measure using a best-match average combination approach. We have also found that the average and maximum combination approaches are problematic since both are inherently influenced by the number of terms being combined. We suspect that there may be a direct influence of data circularity in the behaviour of the results including electronic annotations, as a result of functional inference from sequence similarity.</p
Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV
- Author
- Adam Jaroslav
- Adam Jaroslav
- AdamovĂĄ Dagmar
- AdamovĂĄ Dagmar
- Aggarwal Madan Mohan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agnello Michelangelo
- Agrawal Neelima
- Agrawal Neelima
- Ahammed Zubayer
- Ahammed Zubayer
- Ahn Sang Un
- Ahn Sang Un
- Aiola Salvatore
- Aiola Salvatore
- Akindinov Alexander
- Akindinov Alexander
- Alam Sk Noor
- Alam Sk Noor
- Aleksandrov Dmitry
- Aleksandrov Dmitry
- Alessandro Bruno
- Alessandro Bruno
- Alexandre Didier
- Alexandre Didier
- Alfaro Molina Jose Ruben
- Alfaro Molina Jose Ruben
- Alici Andrea
- Alici Andrea
- Alkin Anton
- Alkin Anton
- Almaraz J.R.M.
- Almaraz J.R.M.
- Alme Johan
- Alme Johan
- Alt Torsten
- Alt Torsten
- Altinpinar Sedat
- Altinpinar Sedat
- Altsybeev Igor
- Altsybeev Igor
- Andrei Cristian
- Andrei Cristian
- Andronic Anton
- Andronic Anton
- Anguelov Venelin
- Anguelov Venelin
- Anielski Jonas
- Anielski Jonas
- Antinori Federico
- Antinori Federico
- AntiÄiÄ Tome
- AntiÄiÄ Tome
- Antonioli Pietro
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Aphecetche Laurent Bernard
- AppelshÀuser Harald
- AppelshÀuser Harald
- Arcelli Silvia
- Arcelli Silvia
- Arnaldi Roberta
- Arnaldi Roberta
- Arnold Oliver Werner
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arsene Ionut Cristian
- Arslandok Mesut
- Arslandok Mesut
- Audurier Benjamin
- Audurier Benjamin
- Augustinus Andre
- Augustinus Andre
- Averbeck Ralf Peter
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Azmi Mohd Danish
- BadalĂ Angela
- BadalĂ Angela
- Baek Yong Wook
- Baek Yong Wook
- Bagnasco Stefano
- Bagnasco Stefano
- Bailhache Raphaëlle
- Bailhache Raphaëlle
- Bala Remu
- Bala Remu
- Baldisseri Alberto
- Baldisseri Alberto
- Baral Rama Chandra
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbano Anastasia Maria
- Barbera Roberto
- Barbera Roberto
- Barile Francesco
- Barile Francesco
- Barnaföldi Gergely Gåbor
- Barnaföldi Gergely Gåbor
- Barnby Lee Stuart
- Barnby Lee Stuart
- Barret Valerie
- Barret Valerie
- Bartalini Paolo
- Bartalini Paolo
- Barth Klaus
- Barth Klaus
- Bartke Jerzy
- Bartke Jerzy
- Bartsch Esther
- Bartsch Esther
- Basile Maurizio
- Basile Maurizio
- Bastid Nicole
- Bastid Nicole
- Basu Sumit
- Basu Sumit
- Bathen Bastian
- Bathen Bastian
- Batigne Guillaume
- Batigne Guillaume
- Batista Camejo Arianna
- Batista Camejo Arianna
- Batyunya Boris
- Batyunya Boris
- Bearden Ian Gardner
- Bearden Ian Gardner
- Beck Hans
- Beck Hans
- Bedda Cristina
- Bedda Cristina
- Behera Nirbhay Kumar
- Behera Nirbhay Kumar
- Belikov Iouri
- Belikov Iouri
- Bellini Francesca
- Bellini Francesca
- Bello Martinez Hector
- Bello Martinez Hector
- Bellwied Rene
- Bellwied Rene
- Belmont Ron
- Belmont Ron
- Belmont-Moreno Ernesto
- Belmont-Moreno Ernesto
- Belyaev Vladimir
- Belyaev Vladimir
- Bencédi Gyula
- Bencédi Gyula
- BeolĂš Stefania
- BeolĂš Stefania
- Berceanu Ionela
- Berceanu Ionela
- Bercuci Alexandru
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berdnikov Yaroslav
- Bertens Redmer Alexander
- Bertens Redmer Alexander
- Berzano Dario
- Berzano Dario
- Berényi Dåniel
- Berényi Dåniel
- Betev Latchezar
- Betev Latchezar
- Bhasin Anju
- Bhasin Anju
- Bhat Inayat Rasool
- Bhat Inayat Rasool
- Bhati Ashok Kumar
- Bhati Ashok Kumar
- Bhattacharjee Buddhadeb
- Bhattacharjee Buddhadeb
- Bhom Jihyun
- Bhom Jihyun
- Bianchi Livio
- Bianchi Livio
- Bianchi Nicola
- Bianchi Nicola
- Bianchin Chiara
- Bianchin Chiara
- BielÄĂk Jaroslav
- BielÄĂk Jaroslav
- BielÄĂkovĂĄ Jana
- BielÄĂkovĂĄ Jana
- Bilandzic Ante
- Bilandzic Ante
- Biswas Rathijit
- Biswas Rathijit
- Biswas Saikat
- Biswas Saikat
- Bjelogrlic Sandro
- Bjelogrlic Sandro
- Blair Justin Thomas
- Blair Justin Thomas
- Blau Dmitry S.
- Blau Dmitry S.
- Blume Christoph
- Blume Christoph
- Bock Friederike
- Bock Friederike
- Bogdanov Alexey A.
- Bogdanov Alexey A.
- BoldizsĂĄr LĂĄszlĂł
- BoldizsĂĄr LĂĄszlĂł
- Bombara Marek
- Bombara Marek
- Book Julian
- Book Julian
- Borel Hervé
- Borel Hervé
- Borissov Alexander
- Borissov Alexander
- Borri Marcello
- Borri Marcello
- BossĂș Francesco
- BossĂș Francesco
- Botta Elena
- Botta Elena
- Bourjau Christian
- Bourjau Christian
- Braun-Munzinger Peter
- Braun-Munzinger Peter
- Bregant Marco
- Bregant Marco
- Breitner Timo
- Breitner Timo
- Broker Theo Alexander
- Broker Theo Alexander
- Browning Tyler Allen
- Browning Tyler Allen
- Broz Michal
- Broz Michal
- Bruna Elena
- Bruna Elena
- Bruno Giuseppe Eugenio
- Bruno Giuseppe Eugenio
- BrĂŒcken Erik Jens
- BrĂŒcken Erik Jens
- Budnikov Dmitry
- Budnikov Dmitry
- Bufalino Stefania
- Bufalino Stefania
- BunÄiÄ Predrag
- BunÄiÄ Predrag
- Busch Oliver
- Busch Oliver
- Buthelezi Edith Zinhle
- Buthelezi Edith Zinhle
- Butt Jamila Bashir
- Butt Jamila Bashir
- Buxton Jesse Thomas
- Buxton Jesse Thomas
- BĂ€tzing Paul Christoph
- BĂ€tzing Paul Christoph
- Böttger Stefan
- Böttger Stefan
- BĂžggild Hans
- BĂžggild Hans
- BĂŒsching Henner
- BĂŒsching Henner
- Cabanillas Noris Juan Carlos
- Cabanillas Noris Juan Carlos
- Caffarri Davide
- Caffarri Davide
- Cai Xiao
- Cai Xiao
- Caines Helen Louise
- Caines Helen Louise
- Calero Diaz Liliet
- Calero Diaz Liliet
- Caliva Alberto
- Caliva Alberto
- Calvo Villar Ernesto
- Calvo Villar Ernesto
- Camerini Paolo
- Camerini Paolo
- Carena Francesco
- Carena Francesco
- Carena Wisla
- Carena Wisla
- Carnesecchi Francesca
- Carnesecchi Francesca
- Castillo Castellanos Javier Ernesto
- Castillo Castellanos Javier Ernesto
- Castro Andrew John
- Castro Andrew John
- Casula Ester Anna Rita
- Casula Ester Anna Rita
- Ceballos Sanchez Cesar
- Ceballos Sanchez Cesar
- Cerello Piergiorgio
- Cerello Piergiorgio
- Cerkala Jakub
- Cerkala Jakub
- Chang B.
- Chang B.
- Chapeland Sylvain
- Chapeland Sylvain
- Chartier Marielle
- Chartier Marielle
- Charvet Jean-Luc Fernand
- Charvet Jean-Luc Fernand
- Chattopadhyay S.
- Chattopadhyay S.
- Chattopadhyay S.
- Chattopadhyay S.
- Chelnokov Volodymyr
- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Chibante Barroso Vasco Miguel
- Chinellato David Dobrigkeit
- Chinellato David Dobrigkeit
- Cho Soyeon
- Cho Soyeon
- Chochula Peter
- Chochula Peter
- Choi Kyungeon
- Choi Kyungeon
- Chojnacki Marek
- Chojnacki Marek
- Choudhury Subikash
- Choudhury Subikash
- Christakoglou Panagiotis
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christensen Christian Holm
- Christiansen Peter L.
- Christiansen Peter L.
- Chujo Tatsuya
- Chujo Tatsuya
- Chung Suh-Urk
- Chung Suh-Urk
- CicalĂČ Corrado
- CicalĂČ Corrado
- Cifarelli Luisa
- Cifarelli Luisa
- Cindolo Federico
- Cindolo Federico
- Cleymans Jean Willy Andre
- Cleymans Jean Willy Andre
- Colamaria Fabio Filippo
- Colamaria Fabio Filippo
- Colella Domenico
- Colella Domenico
- Collu Alberto
- Collu Alberto
- Colocci Manuel
- Colocci Manuel
- Conesa Balbastre Gustavo
- Conesa Balbastre Gustavo
- Conesa del Valle Zaida
- Conesa del Valle Zaida
- Connors Megan Elizabeth
- Connors Megan Elizabeth
- Conti Camila de
- Conti Camila de
- Contreras Nuno Jesus Guillermo
- Contreras Nuno Jesus Guillermo
- Cormier Thomas Michael
- Cormier Thomas Michael
- Corrales Morales Yasser
- Corrales Morales Yasser
- Correia Zanoli Henrique Jose
- Correia Zanoli Henrique Jose
- Cortese Pietro
- Cortese Pietro
- Cortés Maldonado Ismael
- Cortés Maldonado Ismael
- Cosentino Mauro Rogerio
- Cosentino Mauro Rogerio
- Costa Filippo
- Costa Filippo
- Crochet Philippe
- Crochet Philippe
- Cruz Albino Rigoberto
- Cruz Albino Rigoberto
- Cuautle Flores Eleazar
- Cuautle Flores Eleazar
- Cunqueiro Mendez Leticia
- Cunqueiro Mendez Leticia
- Cuveland Jan de
- Cuveland Jan de
- Dahms Torsten
- Dahms Torsten
- Dainese Andrea
- Dainese Andrea
- Danu Andrea
- Danu Andrea
- Das Debasish
- Das Debasish
- Das Indranil
- Das Indranil
- Das Supriya
- Das Supriya
- Dash Ajay Kumar
- Dash Ajay Kumar
- Dash Sadhana
- Dash Sadhana
- De Caro Annalisa
- De Caro Annalisa
- De Cataldo Giacinto
- De Cataldo Giacinto
- De Falco Alessandro
- De Falco Alessandro
- De Gruttola Daniele
- De Gruttola Daniele
- De Marco Nora
- De Marco Nora
- De Pasquale Salvatore
- De Pasquale Salvatore
- De Sudipan
- De Sudipan
- Deisting Alexander
- Deisting Alexander
- Deloff Andrzej
- Deloff Andrzej
- Deplano Caterina
- Deplano Caterina
- Dhankher Preeti
- Dhankher Preeti
- Di Bari Domenico
- Di Bari Domenico
- Di Mauro Antonio
- Di Mauro Antonio
- Di Nezza Pasquale
- Di Nezza Pasquale
- Diaz Corchero Miguel Angel
- Diaz Corchero Miguel Angel
- Dietel Thomas
- Dietel Thomas
- Dillenseger Pascal
- Dillenseger Pascal
- DiviĂ Roberto
- DiviĂ Roberto
- Djuvsland Ăystein
- Djuvsland Ăystein
- Dobrin Alexandru Florin
- Dobrin Alexandru Florin
- Domenicis Gimenez Diogenes
- Domenicis Gimenez Diogenes
- Dordic Olja
- Dordic Olja
- Drozhzhova Tatiana
- Drozhzhova Tatiana
- Dubey Anand Kumar
- Dubey Anand Kumar
- Dubla Andrea
- Dubla Andrea
- Ducroux Laurent
- Ducroux Laurent
- Dupieux Pascal
- Dupieux Pascal
- DĂ©nes Ervin Sandor
- DĂ©nes Ervin Sandor
- Dönigus Benjamin
- Dönigus Benjamin
- Ehlers Raymond James
- Ehlers Raymond James
- Elia Domenico
- Elia Domenico
- Engel Heiko
- Engel Heiko
- Epple Eliane
- Epple Eliane
- Erazmus Barbara Ewa
- Erazmus Barbara Ewa
- Erdemir I.
- Erdemir I.
- Erhardt Filip
- Erhardt Filip
- Espagnon Bruno
- Espagnon Bruno
- Estienne Magali Danielle
- Estienne Magali Danielle
- Esumi ShinIchi
- Esumi ShinIchi
- Eum Jongsik
- Eum Jongsik
- Evans David
- Evans David
- Evdokimov Sergey
- Evdokimov Sergey
- Eyyubova Gyulnara
- Eyyubova Gyulnara
- Fabbietti Laura
- Fabbietti Laura
- Fabris Daniela
- Fabris Daniela
- Faivre Julien
- Faivre Julien
- Fantoni Alessandra
- Fantoni Alessandra
- Fasel Markus
- Fasel Markus
- Feldkamp Linus
- Feldkamp Linus
- Feliciello Alessandro
- Feliciello Alessandro
- Feofilov Grigori A.
- Feofilov Grigori A.
- Ferencei Jozef
- Ferencei Jozef
- FernĂĄndez TĂ©llez Arturo
- FernĂĄndez TĂ©llez Arturo
- Ferretti Alessandro
- Ferretti Alessandro
- Festanti Andrea
- Festanti Andrea
- Feuillard Victor Jose Gaston
- Feuillard Victor Jose Gaston
- Figiel Jan
- Figiel Jan
- Figueredo Marcel Araujo Silva
- Figueredo Marcel Araujo Silva
- Filchagin Sergey
- Filchagin Sergey
- Filho Elienos Pereira de Oliveira
- Filho Elienos Pereira de Oliveira
- Finogeev Dmitry
- Finogeev Dmitry
- Fionda Fiorella Maria Celeste
- Fionda Fiorella Maria Celeste
- Fiore Enrichetta Maria
- Fiore Enrichetta Maria
- Fleck Martin Gabriel
- Fleck Martin Gabriel
- Floris Michele
- Floris Michele
- Foertsch Siegfried Valentin
- Foertsch Siegfried Valentin
- Foka Panagiota
- Foka Panagiota
- Fokin Sergey
- Fokin Sergey
- Fragiacomo Enrico
- Fragiacomo Enrico
- Francescon Andrea
- Francescon Andrea
- Frankenfeld Ulrich
- Frankenfeld Ulrich
- Fuchs Ulrich
- Fuchs Ulrich
- Furget Christophe
- Furget Christophe
- Furs Artur
- Furs Artur
- Fusco Girard Mario
- Fusco Girard Mario
- GaardhĂžje Jens JĂžrgen
- GaardhĂžje Jens JĂžrgen
- Gagliardi Martino
- Gagliardi Martino
- Gago Medina Alberto MartĂn
- Gago Medina Alberto MartĂn
- Gallio Mauro
- Gallio Mauro
- Gangadharan Dhevan Raja
- Gangadharan Dhevan Raja
- Ganoti Paraskevi
- Ganoti Paraskevi
- Gao C.
- Gao C.
- Garabatos Chilo
- Garabatos Chilo
- Garcia-Solis Edmundo Javier
- Garcia-Solis Edmundo Javier
- GarcĂa MartĂnez GinĂ©s
- GarcĂa MartĂnez GinĂ©s
- Gargiulo Corrado
- Gargiulo Corrado
- Gasik Piotr
- Gasik Piotr
- Gauger Erin Frances
- Gauger Erin Frances
- Germain Marie
- Germain Marie
- Gheata Andrei George
- Gheata Andrei George
- Gheata Mihaela
- Gheata Mihaela
- Ghosh Premomoy
- Ghosh Premomoy
- Ghosh Sanjay Kumar
- Ghosh Sanjay Kumar
- Gianotti Paola
- Gianotti Paola
- Giubellino Paolo
- Giubellino Paolo
- Giubilato Piero
- Giubilato Piero
- GlÀssel Peter
- GlÀssel Peter
- Godoy Denise Aparecida Moreira de
- Godoy Denise Aparecida Moreira de
- Gonzalez Ferreiro Elena
- Gonzalez Ferreiro Elena
- Gonzalez Victor
- Gonzalez Victor
- GonzĂĄlez Zamora Pedro
- GonzĂĄlez Zamora Pedro
- Gorbunov Sergey
- Gorbunov Sergey
- Gotovac Sven
- Gotovac Sven
- Grabski Varlen
- Grabski Varlen
- Grachov O.A.
- Grachov O.A.
- Graczykowski Ćukasz Kamil
- Graczykowski Ćukasz Kamil
- Graham Katie Leanne
- Graham Katie Leanne
- Grelli Alessandro
- Grelli Alessandro
- Grigoras Alina Gabriela
- Grigoras Alina Gabriela
- GrigoraÈ Costin
- GrigoraÈ Costin
- Grigoriev Vladislav A.
- Grigoriev Vladislav A.
- Grigoryan Ara
- Grigoryan Ara
- Grigoryan Smbat
- Grigoryan Smbat
- Grinyov Boris V.
- Grinyov Boris V.
- Grion Nevio
- Grion Nevio
- Gronefeld Julius Maximilian
- Gronefeld Julius Maximilian
- Grossiord Jean-Yves
- Grossiord Jean-Yves
- Grosso Raffaele
- Grosso Raffaele
- GroĂe-Oetringhaus Jan Fiete
- GroĂe-Oetringhaus Jan Fiete
- Guber Fedor
- Guber Fedor
- Guernane Rachid
- Guernane Rachid
- Guerzoni Barbara
- Guerzoni Barbara
- Gulbrandsen Kristjan Herlache
- Gulbrandsen Kristjan Herlache
- Gunji Taku
- Gunji Taku
- Gupta Anik
- Gupta Anik
- Gupta Ramni
- Gupta Ramni
- GĂłmez Coral Diego Mauricio
- GĂłmez Coral Diego Mauricio
- GĂłmez RamĂrez AndrĂ©s
- GĂłmez RamĂrez AndrĂ©s
- Görlich Lidia Maria
- Görlich Lidia Maria
- GĆadysz-DziaduĆ Ewa
- GĆadysz-DziaduĆ Ewa
- Haake RĂŒdiger
- Haake RĂŒdiger
- Haaland Ăystein Senneset
- Haaland Ăystein Senneset
- Hadjidakis Cynthia Marie
- Hadjidakis Cynthia Marie
- Haiduc Maria
- Haiduc Maria
- Haller Barthélémy von
- Haller Barthélémy von
- Hamagaki Hideki
- Hamagaki Hideki
- Hamar Gergö
- Hamar Gergö
- Harris John W.
- Harris John W.
- Harton Austin Vincent
- Harton Austin Vincent
- Hatzifotiadou Despina
- Hatzifotiadou Despina
- Hayashi Shinichi
- Hayashi Shinichi
- Heckel Stefan Thomas
- Heckel Stefan Thomas
- Heide Markus
- Heide Markus
- Helstrup HĂ„vard
- Helstrup HĂ„vard
- Herghelegiu Andrei Ionut
- Herghelegiu Andrei Ionut
- Herrera Corral Gerardo Antonio
- Herrera Corral Gerardo Antonio
- Hess Benjamin Andreas
- Hess Benjamin Andreas
- Hetland Kristin Fanebust
- Hetland Kristin Fanebust
- Hillemanns Hartmut
- Hillemanns Hartmut
- Hippolyte Boris
- Hippolyte Boris
- Hoorne Jacobus Willem van
- Hoorne Jacobus Willem van
- Hosokawa Ritsuya
- Hosokawa Ritsuya
- Hristov Peter
- Hristov Peter
- Huang M.
- Huang M.
- Humanic Thomas J.
- Humanic Thomas J.
- Hussain Nur
- Hussain Nur
- Hussain Tahir
- Hussain Tahir
- Hutter Dirk
- Hutter Dirk
- Hwang D.S.
- Hwang D.S.
- Ilkaev Radiy
- Ilkaev Radiy
- Inaba Motoi
- Inaba Motoi
- Ippolitov Mikhail
- Ippolitov Mikhail
- Irfan M.
- Irfan M.
- Ivanov Marian
- Ivanov Marian
- Ivanov V.
- Ivanov V.
- Izucheev Vladimir
- Izucheev Vladimir
- Jacobs Peter Martin
- Jacobs Peter Martin
- Jadhav Manoj Bhanudas
- Jadhav Manoj Bhanudas
- Jadlovska Slavka
- Jadlovska Slavka
- Jadlovsky Jan
- Jadlovsky Jan
- Jahnke Cristiane
- Jahnke Cristiane
- Jakubowska Monika Joanna
- Jakubowska Monika Joanna
- Jang Haeng Jin
- Jang Haeng Jin
- Janik Malgorzata Anna
- Janik Malgorzata Anna
- Jayarathna Pahula Hewage Sandun Yasassri
- Jayarathna Pahula Hewage Sandun Yasassri
- Jena Chitrasen
- Jena Chitrasen
- Jena Satyajit
- Jena Satyajit
- JimĂ©nez Bustamante RaĂșl Tonatiuh
- JimĂ©nez Bustamante RaĂșl Tonatiuh
- Jones Peter Graham
- Jones Peter Graham
- Jung H.
- Jung H.
- Jusko Anton
- Jusko Anton
- Kalinak Peter
- Kalinak Peter
- Kalweit Alexander Philipp
- Kalweit Alexander Philipp
- Kamin Jason Adrian
- Kamin Jason Adrian
- Kang Ju Hwan
- Kang Ju Hwan
- Kaplin Vladimir
- Kaplin Vladimir
- Kar Somnath
- Kar Somnath
- Karasu Uysal Ayben
- Karasu Uysal Ayben
- Karavichev Oleg V.
- Karavichev Oleg V.
- Karavicheva Tatiana L.
- Karavicheva Tatiana L.
- Karayan Lilit
- Karayan Lilit
- Karpechev Evgeny
- Karpechev Evgeny
- Kebschull Udo
- Kebschull Udo
- Keidel Ralf
- Keidel Ralf
- Keijdener Darius Laurens D.
- Keijdener Darius Laurens D.
- Keil Markus
- Keil Markus
- Khan P.
- Khan P.
- Khan Shuaib Ahmad
- Khan Shuaib Ahmad
- Khanzadeev Alexei
- Khanzadeev Alexei
- Kharlov Yury
- Kharlov Yury
- Kileng Bjarte
- Kileng Bjarte
- Kim D.
- Kim D.
- Kim D.J.
- Kim D.J.
- Kim D.W.
- Kim D.W.
- Kim H.
- Kim H.
- Kim J.S.
- Kim J.S.
- Kim M.
- Kim M.
- Kim M.
- Kim M.
- Kim S.
- Kim S.
- Kim T.
- Kim T.
- Kirsch Stefan
- Kirsch Stefan
- Kisel Ivan
- Kisel Ivan
- Kiselev Sergej N.
- Kiselev Sergej N.
- Kisiel Adam Ryszard
- Kisiel Adam Ryszard
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- Kiss Gabor
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- Klay Jennifer Lynn
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- Klein Carsten
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- Klein Jochen
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- Klewin Sebastian
- Klewin Sebastian
- Kluge Alexander
- Kluge Alexander
- Knichel Michael Linus
- Knichel Michael Linus
- Knospe Anders Garritt
- Knospe Anders Garritt
- Kobayashi Taiyo
- Kobayashi Taiyo
- Kobdaj Chinorat
- Kobdaj Chinorat
- Kollegger Thorsten
- Kollegger Thorsten
- Kolojvari Anatoly
- Kolojvari Anatoly
- Kondratiev Valery P.
- Kondratiev Valery P.
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- Kondratyeva Natalia
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- Kondratyuk Evgeny
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- Konevskikh Artem
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- Kouzinopoulos Charalampos
- Kouzinopoulos Charalampos
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- Kovalenko Vladimir
- Kowalski Marek
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- Koyithatta Meethaleveedu Greeshma
- Koyithatta Meethaleveedu Greeshma
- KravÄĂĄkovĂĄ Adela
- KravÄĂĄkovĂĄ Adela
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- Krivda Marian
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- Krizek Filip
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- Kryshen Evgeny
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- Krzewicki Mikolaj
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- KrĂĄlik Ivan
- Kubera Andrew Michael
- Kubera Andrew Michael
- Kuhn Christian Claude
- Kuhn Christian Claude
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- Kuijer Paulus Gerardus
- Kumar Ajay
- Kumar Ajay
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- Kumar Jitendra
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- Kumar Lokesh
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- Kumar Shyam
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- Kurepin Alexander
- Kurepin Alexander
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- Kurepin Alexey B.
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- Kweon Min Jung
- Kweon Min Jung
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- Lee Graham Richard
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- Lee S.
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- Leeuwen Marco van
- Lehas Fatiha
- Lehas Fatiha
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- Lemmon Roy Crawford
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- Lenti Vito
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- LeĂłn MonzĂłn Ildefonso
- LeĂłn Vargas H.
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- Li S.
- Li S.
- Li X.
- Li X.
- Lien JÞrgen André
- Lien JÞrgen André
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- Lietava Roman
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- Lindal Svein
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- Lippmann Christian
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- Lisa Michael A.
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- Ljunggren Hans Martin
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- Lodato Davide Francesco
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- Lowe Andrew John
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- LĂ©vai PĂ©ter
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- LĂłpez Torres Ernesto
- LĂłpez Torres Ernesto
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- LĂŒttig Philipp
- LĂŒttig Philipp
- Maarel Jasper van der
- Maarel Jasper van der
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- Mager Magnus
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- Malaev Mikhail
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- Mayer Christoph
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- Pandey Ashutosh Kumar
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- Sielewicz Krzysztof Marek
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- Smirnov N.
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- Snellings Raimond
- Snellman Tomas Wilhelm
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- Song J.
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- Song M.
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- Song Z.
- Soramel Francesca
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- Szymanski Maciej Pawel
- Szymanski Maciej Pawel
- SĂžgaard C.
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- Zhigareva Natalia
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- ZĂĄvada Petr
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- Ć umbera Michal
- Ć ĂĄndor Ladislav
- Ć ĂĄndor Ladislav
- Publication venue
- Publication date
- 14/09/2015
- Field of study
Peer reviewe
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- AgnĂšs Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de JesĂșs Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Ć uput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali KaÄnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana AlĂcia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sånchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana MarĂa De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell FernĂĄndez
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas StĂŒbner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
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- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
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- Javier Bogarin
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- Ji Li
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- Jing Fu
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- Jing Li
- Jing Li
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- Jo Jones
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- Joaquin Aguirre
- Joerg C Schefold
- Joerg C Schefold
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- Juan P Romero-Gonzalez
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- Stephen M Pastores
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- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ăgoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ăngela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam ViĆĄnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- AkdaÄ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo MartĂn
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas MarĂa Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini MatĂas
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- Baker Helen
- Baker Nerilee
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- Balbay Abidin Oner
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- Banwarie Preveen
- Bao Guijun
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- Barnes Christopher
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- Baronia Arvind
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- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
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- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
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- Elatrous Souheil
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- Elhadi Ahmed
- Elhadi Muhammed
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- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
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- Enamorado Judy
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- Eng Timothy
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- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- VukoviÄ Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
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- Wang Haiyan
- Wang Jing
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- Wang Shuo
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- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
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- Wu Xiaojun
- Wu Xiaoying
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- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz Ä°smail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias JesĂșs Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman AvĆar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ăgoston Zsuzsann
- Ă kerman Eva
- Ăelik Jale Bengi
- Ăamendys-Silva Silvio A.
- Ăzcan Beysim
- Ăzserezli BoÄaç
- ĂnlĂŒ Nurdan
- Äuljak Hemena
- ĆentĂŒrk Evren
- Ć uput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam ViĆĄnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- AkdaÄ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
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- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
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- Yao Yanlan
- Yao Zhiru
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- Ye Mei
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- Yeon-Joo Lee
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- Yilmaz Hakan
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- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias JesĂșs Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman AvĆar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ăgoston Zsuzsann
- Ă kerman Eva
- Ăelik Jale Bengi
- Ăamendys-Silva Silvio A.
- Ăzcan Beysim
- Ăzserezli BoÄaç
- ĂnlĂŒ Nurdan
- Äuljak Hemena
- ĆentĂŒrk Evren
- Ć uput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
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- Publication venue
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Targeted radiopharmaceuticals offer the possibility of improved tumor imaging and radiotherapy, with reduced side effects. A variety of monoclonal antibodies and antibody fragments have previously been successfully radiolabeled and used in diagnostic imaging and targeted radiotherapy of cancer. Many such antibodies have been shown to recognize the well-characterized MUC1 tumor marker and have recently been in clinical trials. Furthermore, a number of chelators have been synthesized and are currently used as radiopharmaceuticals for imaging and therapy. We now report the synthesis of a novel, cyclen-based ligand with a sulfur-containing arm that offers increased stability of the ligand-metal complex. We have coupled this ligand with previously selected aptamers to the MUC1 tumor marker to generate a novel targeted radiopharmaceutical with improved properties. We have tested the complex against known, commercially available chelators such as MAG3 in model breast cancer systems. To improve the pharmacokinetic properties of the aptamer-based targeted radiopharmaceutical, we have generated multi-aptamer complexes around a central chelator. Such multi-aptamer complexes have increased retention of the complex in circulation, without affecting the lack of immunogenicity of the complex or altering its superior tumor penetration properties
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- 'Springer Science and Business Media LLC'
- Publication date
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P-glycoprotein (P-gp, ABCB1) overexpression is, currently, one of the most important multidrug resistance (MDR) mechanisms in tumor cells. Thus, modulating drug efflux by P-gp has become one of the most promising approaches to overcome MDR in cancer. Yet, more insights on the molecular basis of drug specificity and efflux-related signal transmission mechanism between the transmembrane domains (TMDs) and the nucleotide binding domains (NBDs) are needed to develop molecules with higher selectivity and efficacy. Starting from a murine P-gp crystallographic structure at the inward-facing conformation (PDB ID: 4Q9H), we evaluated the structural quality of the herein generated human P-gp homology model. This initial human P-gp model, in the presence of the "linker" and inserted in a suitable lipid bilayer, was refined through molecular dynamics simulations and thoroughly validated. The best human P-gp model was further used to study the effect of four single-point mutations located at the TMDs, experimentally related with changes in substrate specificity and drug-stimulated ATPase activity. Remarkably, each P-gp mutation is able to induce transmembrane alpha-helices (TMHs) repacking, affecting the drug-binding pocket volume and the drug-binding sites properties (e.g. volume, shape and polarity) finally compromising drug binding at the substrate binding sites. Furthermore, intracellular coupling helices (ICH) also play an important role since changes in the TMHs rearrangement are shown to have an impact in residue interactions at the ICH-NBD interfaces, suggesting that identified TMHs repacking affect TMD-NBD contacts and interfere with signal transmission from the TMDs to the NBDs
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- Author
- Publication venue
- 'MDPI AG'
- Publication date
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- Field of study
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