Clima organizacional y satisfacción laboral del personal de la sede central del Gobierno Regional de Lima, 2021.

Objetivo: Determinar de qué manera el clima organizacional se relaciona con la satisfacción laboral del personal de la Sede Central del Gobierno Regional de Lima, 2021. Métodos: La presente investigación es de tipo básica, nivel es correlacional, diseño no experimental, enfoque cuantitativo. La población es de 147 trabajadores, muestra de 107 trabajadores. Resultados: Respecto al clima organizacional, con respecto a si considera que el líder genera confianza y admiración al personal el 45.8% manifestó estar totalmente en desacuerdo y en desacuerdo; respecto a si considera que la comunicación que le brinda a los usuarios es de fácil entendimiento el 45.8% manifestó estar totalmente en desacuerdo y en desacuerdo; respecto a si considera que las tareas que se desarrollan en la institución son eficientes el 54.2% manifestó estar totalmente en desacuerdo y en desacuerdo. Respecto a la satisfacción laboral, respecto a en tu puesto de trabajo, te dan la autonomía para tomar decisiones el 43.9% manifestó estar totalmente en desacuerdo y en desacuerdo; respecto a si siente que tus trabajos valoran el esfuerzo que realizas el 38.3% manifestó estar totalmente en desacuerdo y en desacuerdo; respecto a si se sientes satisfecho con el salario que percibes el 44.9% manifestó estar totalmente en desacuerdo y en desacuerdo. Conclusión: el clima organizacional se relaciona significativamente con la satisfacción laboral del personal de la Sede Central del Gobierno Regional de Lima, 2021; de acuerdo a los resultados obtenidos en la prueba de Rho de Spearman el valor de 0.578 correspondiendo a un grado positivo moderado y con un nivel de significancia del p = 0.00 siendo menor al 0.05

EL CAPITAL HUMANO EN LA GESTIÓN DE CALIDAD EN LOS PRODUCTOS DE LA HACIENDA CACHIGAGA - HUÁNUCO 2019

Esta investigación tuvo por objetivo saber cómo influye el Capital humano en la Gestión de calidad en los productos de la Hacienda Cachigaga Huánuco 2019, esta investigación es del tipo aplicada, el enfoque cuantitativo, alcance descriptivo correlacional porque se está considerando 2 variables, método deductivo y diseño no experimental de corte transversal - correlacional; donde la variable independiente es el Capital Humano, y la variable dependiente es Gestión de calidad. La población está conformada por todos los trabajadores dentro de la Hacienda Cachigaga N=20, distribuidos de la siguiente forma: Ws en producción 5, Ws en campo 2, Ws en maquinaria 1, Ws con los animales 2, W en almacén 2, W en ventas 2, W en distribución 1, Ingeniero Agrónomo 1, Gerente 1, Subgerente 1, Administrador 1, Contador 1; y por los clientes mensuales a la tienda de la Hacienda Cachigaga N=4500, tomando como muestra los clientes diarios n=150 ; dando un total de encuestados de 170 personas. Para constatar la hipótesis utilizamos un programa llamado SPSS versión 22, con la prueba de PEARSON y obtuvimos que la correlación positiva moderada, fue de 0.552 y el valor de significancia es 0.000, en tal sentido se acepta la Hipótesis alternativa (Hi) y se rechaza la hipótesis nula (Ho); podemos decir que el capital humano influye significativamente en la Gestión de calidad en los productos de la Hacienda Cachigaga Huánuco 2019, con una correlación positiva moderada de un 75 % con un nivel de confianza del 96%.Tesi

Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia.

BackgroundPlasmodium knowlesi and Plasmodium cynomolgi are two malaria parasites naturally transmissible between humans and wild macaque through mosquito vectors, while Plasmodium inui can be experimentally transmitted from macaques to humans. One of their major natural hosts, the long-tailed macaque (Macaca fascicularis), is host to two other species of Plasmodium (Plasmodium fieldi and Plasmodium coatneyi) and is widely distributed in Southeast Asia. This study aims to determine the distribution of wild macaques infected with malarial parasites by examining samples derived from seven populations in five countries across Southeast Asia.MethodsPlasmodium knowlesi, P. cynomolgi, P. coatneyi, P. inui and P. fieldi, were detected using nested PCR assays in DNA samples from 276 wild-caught long-tailed macaques. These samples had been derived from macaques captured at seven locations, two each in the Philippines (n = 68) and Indonesia (n = 70), and one each in Cambodia (n = 54), Singapore (n = 40) and Laos (n = 44). The results were compared with previous studies of malaria parasites in long-tailed macaques from other locations in Southeast Asia. Fisher exact test and Chi square test were used to examine the geographic bias of the distribution of Plasmodium species in the macaque populations.ResultsOut of 276 samples tested, 177 were Plasmodium-positive, with P. cynomolgi being the most common and widely distributed among all long-tailed macaque populations (53.3 %) and occurring in all populations examined, followed by P. coatneyi (20.4 %), P. inui (12.3 %), P. fieldi (3.4 %) and P. knowlesi (0.4 %). One P. knowlesi infection was detected in a macaque from Laos, representing the first documented case of P. knowlesi in wildlife in Laos. Chi square test showed three of the five parasites (P. knowlesi, P. coatneyi, P. cynomolgi) with significant bias in prevalence towards macaques from Malaysian Borneo, Cambodia, and Southern Sumatra, respectively.ConclusionsThe prevalence of malaria parasites, including those that are transmissible to humans, varied among all sampled regional populations of long-tailed macaques in Southeast Asia. The new discovery of P. knowlesi infection in Laos, and the high prevalence of P. cynomolgi infections in wild macaques in general, indicate the strong need of public advocacy in related countries

El entorno de aprendizaje favorece la producción de un programa televisivo como logro del taller de televisión de los estudiantes del quinto ciclo de la carrera de Comunicación Audiovisual y Multimedia de un instituto de Lima Metropolitana, durante el periodo académico 2019-I

La presente investigación tiene por objeto determinar si el entorno de aprendizaje, entendido como la integración del proceso metodológico, el ambiente de aprendizaje y las habilidades blandas, contribuye en el logro de aprendizaje del curso Taller de Realización y Producción Televisiva. Los participantes involucrados en esta investigación son estudiantes de ambos sexos, divididos en dos salones que cursan el quinto ciclo de la carrera de Comunicación Audiovisual y Multimedia de un instituto de Lima Metropolitana. La investigación se desarrolló durante el periodo académico 2019-I. La metodología empleada en el desarrollo de la investigación tiene un enfoque cualitativo, es de alcance descriptivo y su diseño es de investigación-acción. Se trabajó sobre dos grupos de estudiantes, denominados A y B, utilizando al grupo A como muestra de análisis, al cual se aplicaron modificaciones al entorno de aprendizaje, y se observó su influencia en la realización del programa televisivo. Se concluyó que las modificaciones en el entorno de aprendizaje, entendido como aportes al proceso metodológico, el uso activo de los ambientes de aprendizaje y el fortalecimiento de habilidades blandas evidenció una mejora sustancial en la realización del programa televisivo como logro de aprendizaje. A raíz de la aplicación de la presente investigación, el instituto hizo suya la estrategia utilizada en la presente investigación para desarrollar su propio producto al que denominó ‘Aula disruptiva y creativa’ que piensa aplicarla a partir del año 2020.The purpose of this research is to determine if the learning environment, understood as the integration of the methodological process, the learning environment and soft skills, contributes to the learning achievement of the Workshop on Television Production. The participants involved in this research are students of both sexes, divided into two classrooms that are in the fifth semester of the Audiovisual and Multimedia Communication degree at an institute in Metropolitan Lima. Said research was developed during the academic period 2019-I. The methodology used in the development of the research was with a qualitative approach, descriptive scope and research-action design. We worked on two groups of students, called A and B, using group A as an analysis sample. Modifications were applied to this learning environment, and its influence was observed in the realization of the television program. It was concluded that the intervention in the learning environment, understood as modifications in the methodological process, the active use of spaces and the strengthening of soft skills evidenced a substantial improvement in the realization of the television program as a learning achievement. Following the application of the present investigation, the institute endorsed the strategy used in the present investigation to develop its own product, named as the ‘Disruptive and creative classroom’ which intends to be applied since 2020.Trabajo de investigaciónCampus Lima Centr

Incidencia y riesgo de caídas en pacientes tratados por neoplasias hematológicas en Unidad Hematología Intensiva

Objetivo: determinar a incidência e a taxa de risco de quedas em pacientes adultos tratados por neoplasias hematológicas na Unidade de Hematologia Intensiva de um hospital de referência. Método: corresponde a um estudo observacional retrospectivo. Foram avaliados 101 pacientes. A ocorrência de quedas foi obtida a partir do registro da unidade e as variáveis preditivas do modelo Hendrich II foram coletadas: sexo, presença de tontura ou vertigem, confusão mental, problemas de eliminação, depressão, uso de benzodiazepínicos, uso de anticonvulsivantes e o teste Get up and Go. Resultados: dois eventos de quedas foram relatados em 101 pacientes (incidência de 1,98% em um período de 1,5 ano). Usando o ponto de corte cinco do Modelo Hendrich II, identificou-se que 30 pacientes (29,7%) apresentaram risco de queda no primeiro dia de hospitalização, 41 (40,6%) ao meio e 38 (37,6%) no momento da alta hospitalar. Conclusões: pacientes tratados por neoplasias hematológicas apresentaram baixa incidência e alto risco de quedas durante a hospitalização.Objetivo: determinar la incidencia y la tasa de riesgo de caídas en pacientes adultos tratados por neoplasias hematológicas en la Unidad de Hematología Intensiva de un hospital de referencia. Método: corresponde a un estudio observacional retrospectivo. Se evaluaron 101 pacientes. La ocurrencia de caídas se obtuvo del registro de la unidad y las variables predictivas del modelo Hendrich II fueron recopiladas: sexo, presencia de mareos o vértigo, confusión mental, problemas de eliminación, depresión, uso de benzodiacepina, uso de anticonvulsionantes y la prueba Get up and Go. Resultados: dos eventos de caídas fueron reportados en 101 pacientes (incidencia de 1,98% en un período de 1,5 años). Utilizando el punto de corte 5 del Modelo Hendrich II, fue identificado que 30 pacientes (29,7%) tenían riesgo de caída al ingreso hospitalario, 41 (40,6%) en la mitad y 38 (37,6%) al egreso hospitalario. Conclusiones: los pacientes tratados por neoplasias hematológicas presentaron una incidencia baja y un alto riesgo de caídas durante la hospitalización.Objective: to determine the incidence and rate of risk of falls in adult patients treated for hematologic malignancies in the Intensive Hematology Unit of a reference hospital. Method: this is a retrospective observational study. A total of 101 patients were evaluated. The occurrence of falls was obtained from records of the unit and the predictive variables of the Hendrich II model were collected, namely: sex, presence of dizziness or vertigo, mental confusion, elimination problems, depression, use of benzodiazepines, use of anticonvulsants, and the Get up and Go test. Results: two fall events were reported in 101 patients (incidence of 1.98% over a 1.5- year period). Based on the cut-off point 5 of the Hendrich II Model, 30 patients (29.7%) were at risk of fall at the moment of hospital admission, 41 (40.6%) in the middle of the hospitalization period, and 38 (37.6%) at the moment of hospital discharge. Conclusions: patients treated for hematological malignancies presented low incidence and high risk of falls during hospitalization

International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia

Funding Information: The Republic of Turkey Ministry of National Education for the PhD studentship. Publisher Copyright: © 2022 The Author(s)Objectives: To develop evidence-based expert recommendations for non-pharmacological treatments for pain, fatigue, sleep problems, and depression in fibromyalgia. Methods: An international, multidisciplinary Delphi exercise was conducted. Authors of EULAR and the Canadian Fibromyalgia Guidelines Group, members of the American Pain Society and clinicians with expertise in fibromyalgia were invited. Participants were asked to select non-pharmacological interventions that could be offered for specific fibromyalgia symptoms and to classify them as either core or adjunctive treatments. An evidence summary was provided to aid the decision making. Items receiving >70% votes were accepted, those receiving <30% votes were rejected and those obtaining 30-70% votes were recirculated for up to two additional rounds. Results: Seventeen experts participated (Europe (n = 10), North America (n = 6), and Israel (n = 1)) in the Delphi exercise and completed all three rounds. Aerobic exercise, education, sleep hygiene and cognitive behavioural therapy were recommended as core treatments for all symptoms. Mind-body exercises were recommended as core interventions for pain, fatigue and sleep problems. Mindfulness was voted core treatment for depression, and adjunctive treatment for other symptoms. Other interventions, namely music, relaxation, hot bath, and local heat were voted as adjunctive treatments, varying between symptoms. Conclusions: This study provided evidence-based expert consensus recommendations on non-pharmacological treatments for fibromyalgia that may be used to individualise treatments in clinical practice targeting the diverse symptoms associated with fibromyalgia.publishersversionepub_ahead_of_prin

Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus

Abstract Mineralocorticoid receptors (MRs), which are activated by mineralocorticoids and glucocorticoids, actively participate in mechanisms that affect the structure and function of blood vessels. Although experimental and clinical evidence shows that vascular damage in diabetes is associated with structural alterations in large and small arteries, the role of MR in this process needs further studies. Thus, we tested the hypothesis that MR, through redox-sensitive mechanisms, plays a role in diabetes-associated vascular remodelling. Male, 12-14-weeks-old db/db mice, a model of type 2 diabetes and their non-diabetic counterpart controls (db/+) were treated with spironolactone (MR antagonist, 50 mg/kg/day) or vehicle for 6 weeks. Spironolactone treatment did not affect blood pressure, fasting glucose levels or weight gain, but increased serum potassium and total cholesterol in both, diabetic and control mice. In addition, spironolactone significantly reduced serum insulin levels, but not aldosterone levels in diabetic mice. Insulin sensitivity, evaluated by the HOMA (homoeostatic model assessment)-index, was improved in spironolactone-treated diabetic mice. Mesenteric resistance arteries from vehicle-treated db/db mice exhibited inward hypertrophic remodelling, increased number of smooth muscle cells and increased vascular stiffness. These structural changes, determined by morphometric analysis and with a myography for pressurized arteries, were prevented by spironolactone treatment. Arteries from vehicle-treated db/db mice also exhibited augmented collagen content, determined by Picrosirius Red staining and Western blotting, increased reactive oxygen species (ROS) generation, determined by dihydroethidium (DHE) fluorescence, as well as increased expression of NAD(P)H oxidases 1 and 4 and increased activity of mitogen-activated protein kinases (MAPKs). Spironolactone treatment prevented all these changes, indicating that MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins

A View from the Past Into our Collective Future: The Oncofertility Consortium Vision Statement

Today, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium. The Oncofertility Consortium is an international, interdisciplinary initiative originally designed to explore the urgent unmet need associated with the reproductive future of cancer survivors. As the strategies for fertility management were invented, developed or applied, the individuals for who the program offered hope, similarly expanded. As a community of practice, Consortium participants share information in an open and rapid manner to addresses the complex health care and quality-of-life issues of cancer, transgender and other patients. To ensure that the organization remains contemporary to the needs of the community, the field designed a fully inclusive mechanism for strategic planning and here present the findings of this process. This interprofessional network of medical specialists, scientists, and scholars in the law, medical ethics, religious studies and other disciplines associated with human interventions, explore the relationships between health, disease, survivorship, treatment, gender and reproductive longevity. The goals are to continually integrate the best science in the service of the needs of patients and build a community of care that is ready for the challenges of the field in the future

SNAPSHOT USA 2019 : a coordinated national camera trap survey of the United States

This article is protected by copyright. All rights reserved.With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August - 24 November of 2019). We sampled wildlife at 1509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the USA. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as well as future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication.Publisher PDFPeer reviewe

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe