432 research outputs found
SalmoNet, an integrated network of ten Salmonella enterica strains reveals common and distinct pathways to host adaptation
- Author
- A Chatr-Aryamontri
- A Karimpour-Fard
- A Kreimer
- A Mazé
- A Medina-Rivera
- A Medina-Rivera
- A Rytkönen
- A Takaya
- AD González
- AJ Wolfe
- AM Tomljenovic-Berube
- AR Wattam
- AS Rolig
- C Shou
- C Smith
- CD Ellermeier
- CH Chiu
- D Fazekas
- D Szklarczyk
- D Walthers
- DA Rodionov
- DB Huang
- DM Fitzgerald
- DM Mills
- E Gonçalves
- E Haghjoo
- E Portales-Casamar
- EC Butcher
- EG Wilkins
- EJ Klemm
- ELL Sonnhammer
- F Gorga
- F Mao
- F Ronquist
- F Sievers
- FM Sánchez-Vargas
- FR DeRubertis
- GBD.
- H Chen
- H Yu
- HJ Chae
- I Thiele
- J Kaur
- J Parkhill
- J Pogliano
- J Song
- JE Galán
- JRJ Haycocks
- JS Kim
- JS McKinney
- JW Wilson
- K Zakikhany
- KD MacKenzie
- LCM Antunes
- LD Hernandez
- LD Tilley
- M Herzberg
- M Kanehisa
- M Lara-Tejero
- M Thomas-Chollier
- MA Bakowski
- MA Wynosky-Dolfi
- MJ Mann
- N Juty
- N Shen
- O Steele-Mortimer
- OL Griffith
- P Kurupati
- PL Chen
- PS Novichkov
- Q Xu
- R Caspi
- R García-Contreras
- R Hegde
- R Mosca
- RE Timme
- RJ Arsenault
- RR Chaudhuri
- RS Wang
- S Aleksic
- S Gama-Castro
- S Orchard
- S Schleker
- S Zhang
- SE Majowicz
- SE Winter
- SH Hong
- SL Abbott
- SS Singh
- SV Rajagopala
- T Berg
- T Dandekar
- T Koo
- T Korcsmáros
- The UniProt Consortium.
- TL Raivio
- U Bodenhofer
- VK Sharma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or extra-intestinal. Genome-wide comparisons revealed that extra-intestinal strains are closer relatives of gastro-intestinal strains than to each other indicating a parallel evolution of this trait. Given the complexity of the differences, a systems-level comparison could reveal key mechanisms enabling extra-intestinal serovars to cause systemic infections. Accordingly, in this work, we introduce a unique resource, SalmoNet, which combines manual curation, high-throughput data and computational predictions to provide an integrated network for Salmonella at the metabolic, transcriptional regulatory and protein-protein interaction levels. SalmoNet provides the networks separately for five gastro-intestinal and five extra-intestinal strains. As a multi-layered, multi-strain database containing experimental data, SalmoNet is the first dedicated network resource for Salmonella. It comprehensively contains interactions between proteins encoded in Salmonella pathogenicity islands, as well as regulatory mechanisms of metabolic processes with the option to zoom-in and analyze the interactions at specific loci in more detail. Application of SalmoNet is not limited to strain comparisons as it also provides a Salmonella resource for biochemical network modeling, host-pathogen interaction studies, drug discovery, experimental validation of novel interactions, uncovering new pathological mechanisms from emergent properties and epidemiological studies. SalmoNet is available at http://salmonet.org
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
- Ajetunmobi Oo
- Aker M
- Akyol Oo
- Al Dorzi Hm
- Al Jabbary As
- Albaiceta Gm
- Albarrak Mm
- Albiero D
- Alda Rs
- Alejandro Rv
- Alexander P
- Algaba Á
- Aliaga Fa
- Alisasis Au
- Allan Rm
- Allue Rm
- Almekhlafi G
- Alonso Jg
- Altaf W
- Alvarez Am
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen Fh
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli Mm
- Antônio Acp
- Aoki N
- Appelberg H
- Arabi Y
- Arabi Ym
- Arabi Ym
- Araujo Am
- Arizmendi A
- Arnal Jm
- Artiga Mjd
- Artigas A
- Ascoli A
- Au Sm
- Avila Le
- Azad R
- Azevedo Lc
- Baboi L
- Badie Jc
- Bailey Im
- Bailey Mb
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed Vm
- Barberet G
- Baron Rm
- Baronia Ak
- Barratt-Due A
- Barros Fm
- Barros Nc
- Batra H
- Battle Ce
- Bauer Pr
- Beck E
- Beck O
- Bedreag Oh
- Beegle Sh
- Beitler Jr
- Bellani G
- Bellani Giacomo
- Beloncle F
- Benslama A
- Beraldo Do
- Berkelmans F
- Besset Sl
- Bettini Lr
- Beuret P
- Bezzi Mg
- Bhardwaj Vk
- Bhowmick K
- Biehler J
- Bihari S
- Biondi Rs
- Biscione Rr
- Bisso Mc
- Black Cs
- Blakeman Tc
- Blanco J
- Bolon S
- Borello Sa
- Borotto Ee
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw Mj
- Boyd O
- Boyle Andrew J.
- Bramall J
- Braschi A
- Braschi A
- Brazzi L
- Breen Dm
- Briquet A
- Brito Va
- Brizuela M
- Broman Lm
- Brown Sm
- Browne Ts
- Bruhn Scar
- Brunettini B
- Bruns Mm
- Buensuseso Ja
- Bugedo G
- Buise Mp
- Bulpa Pa
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw Aj
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet Lp
- Careless Jp
- Carpentier D
- Carreño Ng
- Carteaux G
- Casalena P
- Casement J
- Castro Ag
- Castro S
- Catorze Nt
- Cazorla-Barranquero Fg
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato Vi
- Cervantes Mr
- Cesar Ps
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau Sk
- Chelly J
- Chen K
- Chena A
- Cheng Mp
- Chiche Jd
- Chouchene I
- Choudry S
- Christiansen A
- Cimic N
- Cinnella G
- Cirone R
- Citalán Je
- Claraco-Vega Lm
- Clarkson K
- Clarkson Kp
- Claverias L
- Cohen Je
- Cole Jm
- Collins Dv
- Collyer T
- Colombo R
- Combaux Dm
- Combes A
- Constantin Jm
- Conti S
- Cooper R
- Coppadoro A
- Corneci De
- Cortegiani A
- Cortez Ca
- Coxo Cm
- Cracchiolo An
- Cranshaw Jh
- Crapelli G
- Crouch Dr
- Crouch Dr
- Crova Pj
- Csabi P
- Curley G
- Curto Eg
- Daldin J
- Dangers L
- Daniel F.
- Danin Pe
- Daubin C
- Daviaud F
- Davies Kg
- Dawson H
- De Cima-Iglesias S
- De Gordoa Lo
- De Haro C
- De Pablo R
- de Prost N
- Dean Mn
- Deane Adam M.
- Declercq Pm
- Dector D
- Dector Dm
- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman Ss
- Di Tomasso Nn
- Di Yd
- Diaz-Rodriguez E
- Dive Am
- Dixit Sb
- do Vale Fernandes A
- Dolva Ms
- Donnelly A
- Dowling At
- Doyen D
- Dres M
- Dreyer Kr
- Dreyer Kr
- Dunne Es
- Dupont H
- Duranteau J
- Dwyer R
- Démpaire G
- Ebeid A
- Elatrous S
- Elisabet Gm
- Elkhayari M
- Ellis He
- Elmasri M
- Erbabacan E
- Eriksson Ke
- Estenssoro E
- Esteve F
- Estilita Jm
- Estrella Cr
- Ezzouine H
- Fan E
- Fartoukh M
- Faruq Mo
- Farías Pa
- Fawkes Da
- Ferguson A
- Ferguson Nd
- Fernandez Am
- Fernandez Ro
- Fierro Jm
- Floris L
- Follin A
- Fontenele Dc
- Formenti P
- Forteza C
- Fossali T
- Foti G
- Franco N
- Francois Gm
- França Ag
- Frati E
- Frendl G
- Frigyik Ad
- Fusari M
- Futami S
- Gally J
- Ganesan D
- Gao Y
- Gao Yn
- Garcia Ph
- Gazenkampf Aa
- Gelée B
- George Fg
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin Nk
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher Ec
- Gomaa D
- Gomaa D
- Gomersall C
- Gomes Rm
- Gomez Pe
- Gomez-Flores Ss
- Gonzalez Dr
- Gonzalez M
- González Rojas Ma
- González Rm
- González-Salamanca Á
- Gonçalves Ch
- Goodson Jc
- Gordo F
- Gosselin Rj
- Goubaux B
- Graziani R
- Grelon F
- Griffin Ro
- Grigoriev E
- Grijalba Cq
- Grissom Ck
- Gritsan Ai
- Grubissich N
- Gueret Rm
- Gurjar M
- Guttormsen Ab
- Guérin C
- Gómez Pra
- Hacking Dj
- Haddad Y
- Hadfield D
- Hagan Sj
- Han H
- Han Y
- Hang Ay
- Hanlon Gc
- Harasawa T
- Harrois A
- Hashemian Sm
- Hashemian Sm
- Hashida T
- He Z
- Hedlund L
- Heidari F
- Heines Sj
- Helleberg J
- Henderson G
- Herbrecht Je
- Hermosa C
- Hessell Rj
- Heunks Lm
- Heunks Lm
- Higashijima U
- Hirata A
- Holzgraefe B
- Honda H
- Honrubia T
- Hopf Hf
- Hopkins P
- Hormis Ap
- Hou Pc
- Hou Sk
- Hua Mx
- Huang Qq
- Huang Xb
- Huerta Fp
- Huff Ng
- Humphreys Sk
- Hunt A
- Hurtado J
- Hurtado J
- Hurtado J
- Hutchison Ra
- Hutton Pj
- Ibañez-Santacruz M
- Ichikado K
- Ilutovich S
- Imai H
- Imma Vp
- Imperio Mc
- Inskip Dm
- Ioannou N
- Iotti Ga
- Irvine Da
- Ismail D
- Ismail M
- Ito F
- Izawa M
- Jaafar Rf
- Jakubowska K
- Jamaati H
- Jarquin-Badiola Yd
- Jassal M
- Javeed A
- JhaMatthew Thomas Rr
- Jiang L
- Jibaja M
- Jimenez Ag
- Jochmans S
- Jog Sa
- John Trinder T
- Jovanovic B
- Judy C
- Jurado Mt
- Kadaba V
- Kajtor I
- Kakar V
- Kalaitzis E
- Kalkoff M
- Kamel G
- Kameyama Y
- Kamoun S
- Kander T
- Kannan Sg
- Kashif W
- Kashiwa Y
- Kedelv H
- Kennedy B
- Khebbeb S
- Kheir F
- Kheir Fm
- Kimura H
- Kiourtzieva Ev
- Kitch Bt
- Klasen F
- Knapman Km
- Knoll J
- Knowles S
- Koh Y
- Kol Mr
- Kong J
- Koyama K
- Kraßler J
- Krstevski A
- Kulkarni S
- Kumar A
- Kurahashi K
- Kusumoto K
- Laake Jh
- Laake Jh
- Labarca Ef
- Laffey J
- Laffey John G.
- Lamb Kd
- Lanspa Mj
- Larsson A
- Larsson N
- Le Moal C
- Lebbinck H
- Lee J
- Lee J
- Lee J
- Leemann-Refondini C
- Lemiale V
- Lemus Js
- Leon Yoshido Hh
- Li B
- Li Q
- Li Qj
- Li W
- Li X
- Li Xl
- Li Y
- Li Yy
- Li-Xin Z
- Liew Ky
- Ling Ll
- Liu H
- Liu J
- Liu Jl
- Liu L
- Llano M
- Llinares Moya Dd
- Lohner R
- Loiacono Fa
- Lombardo A
- Lopez-Delgado Jc
- Lora Fs
- Lora P
- Lorente Ja
- Losada Ep
- Lovazzano P
- Lu W
- Lu Y
- Luis Pse
- Luo X
- Lynch Jm
- López-Messa Jb
- Maazouzi W
- Macfadyen R
- Macfie Cc
- Madotto Fabiana
- Maeyama Hn
- Maghrabi Ka
- Magret M
- Mahto Hl
- Mancebo J
- Manoharan V
- Marcos Dp
- Marcu A
- Marin J
- Marin Mc
- Martinez Ft
- Martinho Am
- Marum Sm
- Massa Ev
- Mataloun S
- Matamis D
- Matsumoto S
- Mattei A
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- Mcarthur C
- Mcauley
- Mcauley D
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- Mccalman Kh
- Mckechnie S
- Mckee R
- Mckenna Te
- Mcleod A
- Mcnamee L
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- Meaney Ea
- Meco Bc
- Mehta S
- Mejia Fjf
- Mellis C
- Memon M
- Mercat A
- Mesar T
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- Messias Am
- Messika J
- Meybohm P
- Michel P
- Millar Rt
- Miller Jj
- Miller Rr
- Mirabella L
- Mizuguchi I
- Mochizuki K
- Mohr Nm
- Mojoli F
- Mojoli F
- Moles Si
- Molin A
- Montanha Gm
- Monteiro Jm
- Montero La
- Montes Oscanoa Fa
- Monti G
- Montini Lm
- Moock M
- Morin Ak
- Mortaza S
- Morton A
- Mouloudi Ek
- Mukkera Sr
- Mustafa Gm
- Muthuchellappan R
- Máca J
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- Namih M
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- Nasu M
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- Navarra L
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- O'Muircheartaigh Ac
- Occhipinti G
- Oetting Tw
- Ogino Y
- Oikonomou Ma
- Okane Sc
- Okuda N
- Oldroyd Mg
- Olga Mf
- Oliveira Bs
- Oneill O
- Ortiz Ca
- Osman Em
- Oss P
- Ouanes I
- Ourailogloy V
- Owens Rl
- Ozcelik M
- Palaniswamy V
- Palma Dm
- Palmese S
- Palo Je
- Panarello G
- Papanikolaou Mn
- Papavasilopoulou Tg
- Papazian L
- Papurica M
- Para Lh
- Parhar K
- Parotto M
- Pasanting-Lim Rab
- Patjanasoontorn B
- Patroniti N
- Pattarino Pti
- Pecci E
- Pellegrini Ca
- Pelletier N
- Pellicer Am
- Penuelas O
- Pereira Cs
- Perez Cp
- Perez Mp
- Persson L
- Pesenti Antonio
- Pg Hj Ismail Dmab
- Pham T
- Pham T
- Pham Tài
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- Philippe M
- Piacentini Ea
- Pillai S
- Pintado Mc
- Piquilloud L
- Piquilloud L
- Piras C
- Pittini G
- Plotnikow Ga
- Poblano M
- Poli Mm
- Pota V
- Pozo Nc
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- Pronovost A
- Protti A
- Qin B
- Qin J
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- Qiu H
- Raaijmakers M
- Rabboni F
- Rafael Si
- Raimondi F
- Raj As
- Ramakrishnan N
- Ramesh Vj
- Ramirez-Alfaro Cm
- Ramirez-Gutierrez A
- Rampinelli Am
- Ranero Jl
- Raponi F
- Recio Nn
- Reschreiter H
- Reske Aw
- Reuter D
- Reynolds C
- Rhayakar Rv
- Rialp G
- Richecoeur Jr
- Ricome S
- Rigaud Jp
- Rigshopitalet
- Rinia M
- Rios F
- Riss Kc
- Rittayamai N
- Roberts Bl
- Robine A
- Robles Jb
- Roche-Campo F
- Rodgers Hj
- Rodriguez Ll
- Rodriguez R
- Rosa Ji
- Roser Tp
- Rossi A
- Roux D
- Rugonfalvi S
- Ruiz Sr
- Ruiz-Aguilar Al
- Rylander Cc
- Ryosuke S
- Sabelnikovs O
- Sable Sd
- Saenz Mg
- Saez Aa
- Sagar Sv
- Saito K
- Saito S
- Salahuddin N
- Salas Je
- Sales Vm
- Samkaoui N
- Sanchez Rj
- Sanchez-Hurtado La
- Sanchez-Medina Jr
- Sandesc D
- Santoli Fl
- Santos C
- Sauvadet Ep
- Savioli M
- Scafetti S
- Schiavone V
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- Schiöler F
- Schlichting Ab
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- Sivashanmugavel M
- Sjøbø Bå
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- Souissi Ab
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- Srinivasa L
- Stamou Ee
- Staudinger T
- Stephenson L
- Stewart R
- Stigler W
- Strauch U
- Sula H
- Sun R
- Surbatovic M
- Suzuki H
- Symmonds S
- Synclair J
- Szakmany T
- Sánchez Rm
- Sánchez-Ballesteros J
- Søreide E
- Tabhan E
- Tabhan Ee
- Tainter C
- Takaba A
- Takada T
- Takagi S
- Tallet Alfonso Aa
- Tan Bc
- Tanaka H
- Tang R
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- Tarantino F
- Temprano S
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- Thibault S
- Thompson B. Taylor
- Thompson Mm
- Tibblin Ao
- Tinnirello A
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- Todeschini M
- Tomescu Dr
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- Toth-Tarsoly P
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- Trinidad Oa
- Tulaimat A
- Twohey L
- Uchiyama A
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- Ueno K
- Umbrello M
- Unnikrishnan R
- Uppalapati A
- Van Haren F
- Van Wezel Hm
- Vargas Mp
- Vascotto Er
- Vasquez Dn
- Vega Ld
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez Aj
- Villamagua Bg
- Villar V
- Virgilio Cg
- Vitale Mn
- Volta Ca
- Wang C
- Wang Hx
- Wang Sh
- Wang W
- Warren J
- Watanabe E
- Watt P
- Welters Id
- Wenham T
- Wessbergh J
- Whitehead C
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- Woods Pw
- Wrathall Dw
- Wrigge H
- Wu Yq
- Xin-Hua Q
- Xu Y
- Yamaguchi O
- Yamaji Y
- Yao Q
- Ye Zl
- Yeatts Dj
- Yu R
- Yu T
- Yu W
- Yumha Js
- Yuste Lj
- Zacharas Ga
- Zacharowski Kd
- Zani G
- Zantua Ks
- Zazu A
- Zeggwagh Aa
- Zeggwagh Aa
- Zein So
- Zender Ho
- Zhai Z
- Zhang F
- Zhang Xy
- Zhao H
- Zhao J
- Zhao Xy
- Zheng R
- Zhou Fc
- Zhou S
- Zhu Bh
- Zhu Wh
- Zogheib Eh
- Ñamendys-Silva Sa
- Ünal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antônio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
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- Uchiyama A
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- Unnikrishnan R
- Uppalapati A
- van Haren F
- van Haren F.
- Van Wezel HM
- Vargas MP
- Vascotto ER
- Vasquez DN
- Vega LD
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez AJ
- Villamagua BG
- Villar V
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- Virgilio CG
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- Wrathall DW
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- Wrigge H.
- Wu YQ
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- Yuste LJ
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- Zeggwagh AA
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- Zhu BH
- Zhu WH
- Zogheib EH
- Ñamendys-Silva SA
- Ünal N
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antônio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
- Casement J
- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato VI
- Cervantes MR
- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
- Chena A
- Cheng MP
- Chiche JD
- Chile SC
- Chouchene I
- Choudry S
- Cimic N
- Cinnella G
- Cirone R
- Citalán JE
- Claraco-Vega LM
- Clarkson K
- Clarkson KP
- Claverias L
- Cohen JE
- Cole JM
- Collins DV
- Collyer T
- Colombo R
- Combaux DM
- Combes A
- Conti S
- Cooper R
- Coppadoro A
- Corneci DE
- Cortegiani A
- Cortez CA
- Coxo CM
- Cracchiolo AN
- Cranshaw JH
- Crapelli G
- Crouch DR
- Crova PJ
- Csabi P
- Curley G
- Curto EG
- Daldin J
- Dangers L
- Danin PE
- Daubin C
- Daviaud F
- Davies KG
- Dawson H
- de Cima-Iglesias S
- de Gordoa LO
- de Haro C
- de Pablo R
- de Prost N
- Dean MN
- Declercq PM
- Dector D
- Dector DM
- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman SS
- Di Tomasso NN
- Di YD
- Diaz-Rodriguez E
- Dive AM
- Dixit SB
- do Vale Fernandes A
- Dolva MS
- Donnelly A
- Dowling AT
- Doyen D
- Dres M
- Dreyer KR
- Dunne ES
- Dupont H
- Duranteau J
- Dwyer R
- Démpair G
- Ebeid A
- Elatrous S
- Elisabet GM
- Elkhayari M
- Ellis HE
- Elmasri M
- Erbabacan E
- Eriksson KE
- Esteban A
- Estenssoro E
- Esteve F
- Estilita JM
- Estrella CR
- Ezzouine H
- Fan E
- Fartoukh M
- Farías PA
- Fawkes DA
- Ferguson A
- Ferguson ND
- Fernandez AM
- Fernandez RO
- Fierro JM
- Floris L
- Fontenele DC
- Formenti P
- Forteza C
- Fossali T
- Foti G
- Franco N
- Francois GM
- França AG
- Frati E
- Frendl G
- Frigyik AD
- Fusari M
- Futami S
- Gally J
- Ganesan D
- Gao Y
- Gao YN
- Garcia PH
- Gattinoni L
- Gazenkampf AA
- Gelée B
- General H
- George FG
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin NK
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher EC
- Gomaa D
- Gomaa D
- Gomes RM
- Gomez PE
- Gomez-Flores SS
- Gonzalez DR
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Descriptive Epidemiology in Mexican children with cancer under an open national public health insurance program
- Author
- Alberto Olaya-Vargas
- Cecilia Correa-Gonzalez
- Censo Poblacional de la República Mexicana
- E Steliarova–Foucher
- Eduardo Altamirano-Alvarez
- ET Petridou
- F Perera
- Fernando Sánchez-Zubieta
- FM Knaul
- Francisco Pantoja-Guillen
- G Calaminus
- I Magrath
- IJ Pan
- J Ferlay
- Jaime Shalkow-Klincovstein
- JS Chang
- L Chatenoud
- Liliana Velasco-Hidalgo
- M Greaves
- M Valcke
- Marco R Aguilar-Ortiz
- Marta Zapata-Tarrés
- MP Curado
- N Howlader
- OG Dantés
- P Farmer
- Protocolos Técnicos Cáncer en Niños
- R Perez-Cuevas
- R Rivera-Luna
- R Sullivan
- RC Ribeiro
- RC Ribeiro
- RE Goldsby
- Roberto Rivera-Luna
- Rocio Cárdenas-Cardós
- S Gupta
- SC Howard
- SC Howard
- SC Hsu
- SJ Kellie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the Pseudorapidity and Centrality Dependence of the Transverse Energy Density in Pb-Pb Collisions at √sNN=2.76 TeV
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- Yilmaz Y
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- Yumiceva F
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The transverse energy (E-T) in Pb-Pb collisions at 2.76 TeV nucleon-nucleon center-of-mass energy (root s(NN)) has been measured over a broad range of pseudorapidity (eta) and collision centrality by using the CMS detector at the LHC. The transverse energy density per unit pseudorapidity (dE(T)/d eta) increases faster with collision energy than the charged particle multiplicity. This implies that the mean energy per particle is increasing with collision energy. At all pseudorapidities, the transverse energy per participating nucleon increases with the centrality of the collision. The ratio of transverse energy per unit pseudorapidity in peripheral to central collisions varies significantly as the pseudorapidity increases from eta = 0 to vertical bar eta vertical bar = 5.0. For the 5% most central collisions, the energy density per unit volume is estimated to be about 14 GeV/fm(3) at a time of 1 fm/c after the collision. This is about 100 times larger than normal nuclear matter density and a factor of 2.6 times higher than the energy density reported at root s(NN) = 200 GeV at the Relativistic Heavy Ion Collider
Measurement of the differential cross section for isolated prompt photon production in pp collisions at 7 TeV
- Author
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- Yilmaz Y
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- Yun JC
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- Zumerle G
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
A measurement of the differential cross section for the inclusive production of isolated prompt photons in proton-proton collisions at a center-of-mass energy of 7 TeV is presented. The data sample corresponds to an integrated luminosity of 36 pb(-1) recorded by the CMS detector at the LHC. The measurement covers the pseudorapidity range vertical bar eta vertical bar < 2.5 and the transverse energy range 25 < E-T < 400 GeV, corresponding to the kinematic region 0.007 < x(T) < 0.114. Photon candidates are identified with two complementary methods, one based on photon conversions in the silicon tracker and the other on isolated energy deposits in the electromagnetic calorimeter. The measured cross section is presented as a function of E-T in four pseudorapidity regions. The next-to-leading-order perturbative QCD calculations are consistent with the measured cross section
Observation of a New Excited Beauty Strange Baryon Decaying to Ξb- π+π-
- Author
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- Yusli MN
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Ξb-π+π- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Ξb- is reconstructed via its decays to J/ψΞ- and J/ψΛK-. A narrow resonance, labeled Ξb(6100)-, is observed at a Ξb-π+π- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Ξb-) MeV, where the last uncertainty reflects the precision of the Ξb- baryon mass. The upper limit on the Ξb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Ξb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Ξc baryon states, the new Ξb(6100)- resonance and its decay sequence are consistent with the orbitally excited Ξb- baryon, with spin and parity quantum numbers JP=3/2-
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
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- Álvarez Fernández A
- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of τ Leptons in pp collisions at sqrt[s]=13 TeV
- Author
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- Aarup Petersen H
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- Trembath-Reichert S
- Trevisani N
- Tricomi A
- Trocino D
- Trocsanyi ZL
- Tropea P
- Troshin S
- Tsamalaidze Z
- Tsatsos A
- Tsipolitis G
- Tsirou A
- Tully C
- Tumasyan A
- Tuo S
- Tuominen E
- Tuominiemi J
- Turini N
- Turkcapar S
- Tuuva T
- Tuve C
- Tytgat M
- Tyurin N
- Tziaferi E
- Uchida K
- Ujvari B
- Ulmer KA
- Ulrich R
- Uniyal R
- Uplegger L
- Urda Gómez L
- Uribe Estrada C
- Usai E
- Uvarov L
- Uzunian A
- Vaandering EW
- Vagnerini A
- Vai I
- Valencia Palomo L
- Valsecchi D
- Valuev V
- Van De Klundert M
- Van Der Linden J
- Van Doninck W
- Van Hove P
- Van Mechelen P
- Van Mulders P
- Van Onsem GP
- Van Putte S
- Van Remortel N
- Vanden Bemden M
- Vander Donckt M
- Vander Velde C
- Vanlaer P
- Varela J
- Varelas N
- Vargas Hernandez AM
- Vartak A
- Vats D
- Vazquez Valencia F
- Vazzoler F
- Veckalns V
- Veelken C
- Velasco M
- Velkovska J
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- Venditti R
- Venturi A
- Verdini PG
- Veres GI
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- Veszpremi V
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- Vlimant JR
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- Von Cube RF
- Vorobyev A
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- Voytishin N
- Vámi TÁ
- Wadud MA
- Wagner SR
- Walkingshaw Pass K
- Wallny R
- Walsh R
- Waltenberger W
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- Wamorkar T
- Wan Abdullah WAT
- Wanczyk J
- Wang B
- Wang C
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- Wezenbeek L
- Whitbeck A
- White R
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- Wickramarathna DDC
- Wiedenbeck S
- Wieland S
- Wiens L
- Wightman A
- Williams A
- Williams J
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer BL
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf R
- Wolfe E
- Wong K
- Wong WY
- Wood D
- Wozniak KA
- Wozniewski S
- Wright D
- Wu HY
- Wu Z
- Wuchterl S
- Wulz C-E
- Wunsch S
- Wyslouch B
- Würthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang S
- Yang S
- Yang UK
- Yang YC
- Yao Y
- Yarar H
- Yates BR
- Yazgan E
- Ye Z
- Yetkin EA
- Yi K
- Yigitbasi E
- Yohay R
- Yoo HD
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu GB
- Yu I
- Yu PR
- Yu SS
- Yuan L
- Yuan S
- Yuldashev BS
- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the τ lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two τ leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
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