Thomas Mapfumo and the polularization of Shona Mbira

The music of Thomas Mapfumo is frequently described as a pop adaptation of traditional mbira music, the ancient ceremonial performance art of the Shona people of Zimbabwe. While this is an oversimplification of Mapfumo’s varied repertoire, mbira is an important, perhaps the most important, aspect of the artist’s work. My book, Lion Songs: Thomas Mapfumo and the Music That Made Zimbabwe (2015) interweaves Zimbabwean history with the biography and music of this under-recognized African innovator, composer, and bandleader.1 This article, adapted from the Lion Songs manuscript, attempts to clarify Thomas’s role first in helping to revive the status of mbira music in his own country, and then in developing an audience for it internationally

Patriotic history and the politicisation of memory: manipulation of popular music to re-invent the liberation struggle in Zimbabwe

This paper investigates how the music nationalism promulgated by the ZANU-PF regime's former Minister of Information and Publicity, Jonathan Moyo, appropriated history and culture in its relentless effort to convince the citizenry that the on-going crisis in Zimbabwe is a continuation of the liberation struggle. It documents how Moyo's propagandised ‘patriotic history’ was written into song lyrics and used in frequently televised propaganda videos and CD/cassette releases to create a music nationalism that appropriated the music of the 1970s Second Chimurenga struggle, then performed to resist colonial oppression, and used it as propaganda intended to maintain the current oppressive regime's grip on political power. It argues that the appropriation of indigenous song/dance forms and the ‘chimurenga music’ of the liberation war has failed to achieve unification of the nation; and that rather, the propaganda's manipulation of memory has offended the Shona cultural aesthetic that requires songwriters to speak the truth of their experience in their music

Introduction to Guitar Ethnographies: Performance, Technology and Material Culture.

Entangled in global cultural flows, but also held in place locally, empowered and agential, musical instruments resonate with social significance. The guitar is, perhaps, the example par excellence, yet it has received little attention within ethnomusicology. This Introduction sets out the theoretical and methodological framework informing the four case studies of the guitar that follow, and provides a relevant literature review. Based largely on deep immersive ethnography and prolonged study in the field, we have been especially influenced by publications in the areas of the ethnography of musical performance, material culture studies, organology, the anthropology of globalisation, and studies of the role of audio technologies in the production of music cultures. Each one of the articles represents a first for the study of the guitar. In two cases, local professional guitarists have a hand in writing the articles. Therefore, this Introduction and the articles that follow include semi-autobiographical detail as we take our guitars with us into ‘the field’ and further into the ever-broadening terrain covered by ethnomusicological studies. The case studies demonstrate the value of the authors' performance skills and knowledge of the instrument and its manufacture in providing an entrée into often-challenging and close-knit guitar worlds (e.g., workshops, retail outlets, backstage meet and greets, and recording studios). Yet local questions about the guitar often demand a larger context of study; for instance, in relation to processes of globalisation, nationalism and ethnicity, the location of the instrument within a wider web of sound technologies, the international trade in musical instruments and natural resources, and hybrid designs and performance techniques

Adopting novel ecosystems as suitable rehabilitation alternatives for former mine sites

The nature and extent of environmental disturbance associated with mining commonly entails completely new and challenging combinations of climate, lithology and landform. Consequently, the outcomes of ecological processes associated with the recovery or restoration of ecosystems cannot be predicted reliably from previously known associations between their physical and biological components. For radically disturbed sites, we propose that it is not practicable to aim for the restoration of historical ecosystems. However, hybrid (reversibly different) or novel (irreversibly different) ecosystems comprising new combinations of physical and biological components, including both native and non-native species, could provide levels of stability and functionality acceptable to all stakeholders and within feasible management regimes. We propose that limiting physical conditions of the landscape can be identified and managed, and that alternative species combinations for introduction to these new landscapes may be considered with cautious optimism

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-inducible expression of a battery of genes encoding key components of the glutathione-based and thioredoxin-based anti-oxidant systems, as well as aldo-keto reductase, glutathione S-transferase, and NAD(P)H:quinone oxi-doreductase-1 drug-metabolizing isoenzymes along with multidrug-resistance-associated efflux pumps. It therefore plays a pivotal role in both intrinsic resistance and cellular adaptation to reactive oxygen species (ROS) and xenobiotics. Activation of Nrf2 can, however, serve as a double-edged sword because some of the genes it induces may contribute to chemical carcinogenesis by promoting futile redox cycling of polycyclic aromatic hydrocarbon metabolites or confer resistance to chemotherapeutic drugs by increasing the expression of efflux pumps, suggesting its cytoprotective effects will vary in a context-specific fashion. In addition to cytoprotection, Nrf2 also controls genes involved in intermediary metabolism, positively regulating those involved in NADPH generation, purine biosynthesis, and the β-oxidation of fatty acids, while suppressing those involved in lipogenesis and gluconeogenesis. Nrf2 is subject to regulation at multiple levels. Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRL(Keap1). Thus modification of Cys residues in Keap1 blocks CRL(Keap1) activity, allowing newly translated Nrf2 to accumulate rapidly and induce its target genes. The ability of Keap1 to repress Nrf2 can be attenuated by p62/sequestosome-1 in a mechanistic target of rapamycin complex 1 (mTORC1)-depen-dent manner, thereby allowing refeeding after fasting to increase Nrf2-target gene expression. In parallel with repression by Keap1, Nrf2 is also repressed by β-transducin repeat-containing protein (β-TrCP), present in the Skp1–cullin-1–F-box protein (SCF) ubiquitin ligase complex SCF(β-TrCP). The ability of SCF(β-TrCP) to suppress Nrf2 activity is itself enhanced by prior phosphorylation of the transcription factor by glycogen synthase kinase-3 (GSK-3) through formation of a DSGIS-containing phosphodegron. However, formation of the phosphodegron in Nrf2 by GSK-3 is inhibited by stimuli that activate protein kinase B (PKB)/Akt. In particular, PKB/Akt activity can be increased by phosphoinositide 3-kinase and mTORC2, thereby providing an explanation of why antioxidant-responsive element-driven genes are induced by growth factors and nutrients. Thus Nrf2 activity is tightly controlled via CRL(Keap1) and SCF(β-TrCP) by oxidative stress and energy-based signals, allowing it to mediate adaptive responses that restore redox homeostasis and modulate intermediary metabolism. Based on the fact that Nrf2 influences multiple biochemical pathways in both positive and negative ways, it is likely its dose–response curve, in terms of susceptibility to certain degenerative disease, is U-shaped. Specifically, too little Nrf2 activity will lead to loss of cytoprotection, diminished antioxidant capacity, and lowered β-oxidation of fatty acids, while conversely also exhibiting heightened sensitivity to ROS-based signaling that involves receptor tyrosine kinases and apoptosis signal-regulating kinase-1. By contrast, too much Nrf2 activity disturbs the homeostatic balance in favor of reduction, and so may have deleterious consequences including overproduction of reduced glutathione and NADPH, the blunting of ROS-based signal transduction, epithelial cell hyperplasia, and failure of certain cell types to differentiate correctly. We discuss the basis of a putative U-shaped Nrf2 dose–response curve in terms of potentially competing processes relevant to different stages of tumorigenesis