Retinal Microvascular Abnormalities in Depression

Retinal microvascular abnormalities in depression Depressive disorder is a debilitating and most common mental disorder. According to the World Health Organization, approximately 280 million people worldwide suffered from depression in 2019. Studies seeking to identify biomarkers for depressive disorder diagnosis and treatment have not yet found any one candidate which achieves a sufficient sensitivity and specificity. The aim of the study was to find a possible association between retinal microvascular abnormality and major depression in a non-geriatric study population. The participants with major depression were hospitalised at the University Hospital in Hradec Kralove, Department of Psychiatry. Retinal images were obtained using a stationary Fundus camera FF450 by Zeiss and a hand-held camera by oDocs. Fifty patients (men N = 18, women N = 32) aged 16 to 55 (men's average age 33.7±9.9 years, women's average age 37.9±11.5 years) were compared with fifty mentally healthy subjects (men N = 28, women N = 22) aged 18 to 61 (men's average age 35.3±9.2 years, women's average age 36.6±10.6 years) in a cross- sectional design. The patients were diagnosed with a single depressive episode (N = 26) or a recurrent depressive disorder (N = 24) according to the ICD-10 classification. Our results confirmed...Souhrn Depresivní porucha je vysilující a nejčastěji se vyskytující duševní porucha. Dle Světové zdravotnické organizace v roce 2019 celosvětově depresí trpělo přibližně 280 milionů obyvatel. Vědecké studie usilující o identifikaci biomarkerů pro diagnostiku a léčbu depresivní poruchy dosud nenalezly žádný biomarker, který by dosáhl dostatečné senzitivity a specificity. Cílem studie bylo najít možnou souvislost mezi retinální mikrovaskulární patalogií a depresívní poruchou u negeriatrické populace. Nemocní s depresí byli hospitalizováni na Psychiatrické klinice Fakultní nemocnice Hradec Králové. Snímky sítnice byly získány pomocí stacionární kamery Fundus FF450 od Zeiss a přenosné kamery od oDocs. Celkem se studie zúčastnilo padesát pacientů s depresivní poruchou (muži N = 18, ženy N = 32) ve věku 16 až 55 let (průměrný věk mužů 33,7±9,9 let, průměrný věk žen 37,9±11,5 let), kteří byli srovnáni s padesáti duševně zdravými jedinci (muži N = 28, ženy N = 22) ve věku 18 až 61 let (průměrný věk mužů 35,3±9,2 let, průměrný věk žen 36,6±10,6 let). U pacientů byla diagnostikována depresivní epizoda (N = 26) nebo rekurentní depresivní porucha (N = 24) podle klasifikace MKN-10. Výsledky potvrdily statisticky významné mikrovaskulární změny na sítnici oka u pacientů s depresivní poruchou ve srovnání s kontrolní...Psychiatrická klinikaDepartment of PsychiatryFaculty of Medicine in Hradec KrálovéLékařská fakulta v Hradci Králov

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements