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48 research outputs found

Inspiratory muscle recruitment during swallow and a comparison across airway behaviors.

Author: English Allison V
Publication venue: ThinkIR: The University of Louisville\u27s Institutional Repository
Publication date: 01/05/2019
Field of study

During swallow, a negative esophageal pressure is present that, along positive pressure from the tongue, which works to move the bolus through the pharynx into the esophagus. This negative esophageal pressure is thought to be produced via recruitment of chest wall inspiratory muscles (diaphragm and parasternal). This current study aimed to examine respiratory muscle recruitment across behaviors which have known inspiratory muscle activity (eupnea, augmented breath and cough) and compare to swallow. It was hypothesized that there would be no significant difference in amplitude and muscle recruitment over 75 ms between swallow and eupnea, but cough and augmented breath would be significantly larger. Electromyograms (EMG) from the costal diaphragm and parasternal muscles were recorded and analyzed in five freely breathing anesthetized cats. Muscle recruitment was examined by taking both the root mean square over the initial 75 ms (RMS75) of each behavior and the maximum amplitude of muscle activity for the total duration of the behavior. Results found that there was a significant difference for maximum amplitude of muscle activation across all behaviors for the parasternal and for augmented breath and cough for the diaphragm. Muscle recruitment of parasternal was significantly different from swallow for the behavior of eupnea. These results, along with a growing body of evidence, provide credence to the theory that inspiratory muscle activity is part of the swallow central pattern generator. This work could provide needed clinical information for the evaluation of dysphagia in at-risk patients

University of Louisville

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

Author: Abdallah J.
Abdullah R.
Abejuela Z.
Abouglila K.
Abramowitz M.
Abusnana S.
Acosta I.
Agafyina A.
Aggarwal N.
Agra J.
Ahmad N. N. F. N.
Ahmed F.
Aiello J.
Ainsworth P.
Aizenberg D.
Akiyama H.
Akright L.
Akyea-Djamson A.
Al-Karadsheh A.
Alamartine E.
Alappan R.
Albisu J. P.
Ali N.
Ali Z.
Alicic R.
Allison D. C.
Alonso R. D. V.
Alva H.
Alvarisqueta A.
Amodeo C.
Andreeva V.
Angelescu L. M.
Angelova A.
Anghel V.
Antic S.
Aoki H.
Aquitania G.
Arauz-Pacheco C.
Arcos E.
Arenales J. A. S.
Arfeen S.
Arif A.
Aronson R.
Arutchelvam V.
Arvind M.
Asano A.
Atray N.
Avendano J.
Avram R. -I.
Awad A.
Babikova J.
Badat A.
Bajaj H.
Baker J.
Bakris G.
Ballesteros C. G.
Barbarash O.
Barna O.
Barnard M.
Barnhill P.
Baron P. F.
Barranco E.
Barrera C.
Barrios C.
Bartaskova D.
Bartolacci I.
Barton P.
Barysheva O.
Beacom M.
Behara V.
Bellary S.
Belo D.
Belobradkova J.
Bentley-Lewis R.
Benusova O.
Berenguer R.
Berli M. A.
Bermudez L.
Bernardo M.
Bijata-Bronisz R.
Bilyk S. D.
Biscoveanu M.
Bonadonna R.
Bordonava A.
Borges J. L. C.
Borot S.
Botsyurko V.
Bowman-Stroud C.
Brandon D.
Breedt J.
Bregman R.
Brusco O.
Buganova I.
Burst V.
Busch R.
Busegeanu M. -M.
Calcaneo J. P.
Calella P.
Canaan Y.
Canani L. H.
Cannon C. P.
Canonge R. S.
Cantero M. C.
Caringal C.
Cariou B.
Carlo A. D.
Carrillo L. V.
Cartasegna L. R.
Casabella T. S.
Castellanos R. O.
Castellino P.
Castro F. C.
Ceballos R. I. L.
Cepeda A. V.
Cercos E.
Ceriello A.
Cervera L. F. F.
Chacra A. R.
Chae D. -W.
Chang C. -T.
Chavez E. T.
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Cherney D.
Cheung N. W.
Chilito A.
Chiovato L.
Chizhov D.
Cho Y. M.
Chouinard G.
Christensen T.
Christiano C.
Christofides E.
Chuang L. -M.
Chuateco C.
Cianni G. D.
Cif A.
Cohen K.
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Coloma G. C.
Colombo H.
Cometa L. V.
Comia R. S.
Commendatore V.
Conway J.
Cook C.
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Coyne D.
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D'Avila D.
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Tsang V.
Tseluyko V.
Tsujimoto M.
Tu P.
Turatti L. A. A.
Turner W.
Twahirwa M.
Ulla M. R.
Updegrove J.
Urbanaviciene E.
Uriasyev O.
Valdez M.
Valenzuela A.
Valis M.
Vallejos A.
Van Buren P.
Vangel S.
Vannorsdall M.
Varghese F.
Vasas S.
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Velasquez-Mieyer P.
Velichkova E.
Vencio S. A. C.
Vengadasalam P.
Ventrapragada S.
Vera G. O.
Vera M. P.
Veronelli A. M.
Vila M. A. M.
Villarino A.
Villegas I.
Visco V. E.
Vizir V.
Vlasenko M.
Vorobyev S.
Vukotic G.
Vyasam R. C.
Wada T.
Wadud K.
Wahba M.
Wakasugi M.
Wakeling J.
Wakida Y.
Walker R.
Wang G.
Warren M.
Wassermann A.
Watanabe T.
Watson E.
Watson H.
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Weiner D.
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Welker J.
Welsh J.
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Williams M.
Williams S.
Winocour P.
Wong A. C.
Woo V.
Yakov A.
Yamada M.
Yamada S.
Yanagida K.
Yanase T.
Yang J.
Yao C.
Yap Y. E.
Ygpuara M. D. L.
Yin A.
Yoon K. H.
Young S.
Yu X.
Yumita W.
Yupanqui H.
Yusof M. D. C.
Zaidman C. J.
Zalunardo N.
Zanella M. T.
Zaniewski-Singh M.
Zanoli L.
Zaoui P.
Zateyshchikova A.
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Zemek S.
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Publication venue: 'Ovid Technologies (Wolters Kluwer Health)'
Publication date: 01/01/2021
Field of study

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Author: Abdallah J
Abdul Ghani R
Abdul Kadir K
Abdullah R
Abejuela Z
Abouglila K
Abraham O
Abrahamsen I
Abraira Munoz Ld
Abramowitz M
Abusnana S
Accini Mendoza Jl
Acosta I
Agafyina A
Agarwal R
Agarwal Rajiv
Aggarwal N
Agra J
Ahmed F
Ahuad Guerrero Ra
Aiello J
Ainsworth P
Aizenberg D
Akiyama H
Akright L
Akyea-Djamson A
Al-Karadsheh A
Alamartine E
Alappan R
Albisu Jp
Ali N
Ali Z
Alicic R
Allison Dc
Alvarez Garcia P
Alvarisqueta A
Alves da Costa Fa
Amerena J
Amigo A
Amodeo C
Andreeva V
Andreotti Turatti La
Angelescu Lm
Angelova A
Anghel V
Antic S
Aoki H
Aquitania G
Arauz-Pacheco C
Arcos E
Arfeen S
Arif A
Aronson R
Arutchelvam V
Arvind M
Asano A
Asmarats Mercadal L
Atray N
August P
Avendano J
Avram Ri
Awad A
Babikova J
Badat A
Bajaj H
Baker J
Bakris G
Bakris George
Barbarash O
Barna O
Barnard M
Barnhill P
Barranco E
Barrera C
Barrios C
Bartaskova D
Bartolacci I
Barton P
Barysheva O
Beacom M
Behara V
Bellary S
Belo D
Belobradkova J
Bentley-Lewis R
Benusova O
Berenguer R
Berli Ma
Bermudez L
Bernardo M
Bhushan Rs
Bijata-Bronisz R
Bilyk Sd
Bin Shudim Ss
Biscoveanu M
Bompoint Severine
Bonadonna R
Bordonava A
Borot S
Botsyurko V
Bowman-Stroud C
Brandon D
Breedt J
Bregman R
Brenner Barry M
Brenner Bm
Brusco O
Buganova I
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Zanata Petry Tb
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Zaniewski-Singh M.
Zanoli L
Zaoui P
Zateyshchikova A
Zateyshshikov D
Zaviriukha V
Zemek S
Zhang H
Zhang Hong
Zhao M
Zheng H
Zinman B
Zinman Bernard
Zlova T
Zsom M
Zub L
Zykova T
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

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Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

Author: Ab Majid MA
Ab Rahman AS
Ab Rahman R
Abayasinghe C
Abbott T
Abdullah NH
Abdur-Rahman L
Abeloos J
Abernethy C
Abidin UN
Abrunhosa A
Absar M
Adam S
Adams D
Adams G
Adamson M
Adekola O
Adelaja Y
Ademola A
Adenekan A
Adenike O
Adeolu AA
Adetoye A
Adewale B
Adigun T
Adolfsson A
Aflori L
Africander C
Afshari A
Agarwal V
Agodirin O
Aguero Vera M
Aguzzoli C
Ahmad A
Ahmad N
Ahmad T
Ahmad T
Ahmad Y
Ahmed A
Ahmed J
Ai Y
Aignatoaie M
Aimoniotou-Georgiou E
Akanmu O
Akerman N
Akinwale M
Akring I
Al 'Amri K
Al Anizi M
Al hussaini S
Al-Soudaine Y
Aladin H
Alagbe-Briggs O
Alaman Laguarda G
Albaj S
Alcock D
Alcock L
Aldecoa C
Aldecoa C
Aleixo FB
Alexander H
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Alexander-Sefre F
Alherz F
Ali H
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Ali S
Alias A
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Alias RLR
Alit MA
Allen S
Allen SJ
Allison J
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Allsop J
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Alphonsus C
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Chan WKJ
Chan YL
Chande S
Chandler B
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Chandrasekharan S
Chang YH
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Charlalampidoy A
Charles R
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Cheng B
Cheng KH
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Cheong E
Cherian R
Cherrett V
Chetty RR
Chew M
Chhabra A
Chicken D-W
Chilinciuc I
Chin II
Chirkut S
Chisbert Cuenca V
Chlorou D
Choi H-MD
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Christiansen IC
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Christodoulopoulou T
Christofaki M
Christoforidis D
Chronis C
Chu HM
Chu S
Chua P
Chukkambotla S
Chung CKE
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Ciobanu C
Ciobotaru OR
Cirstea E
Clark R
Clarkson A
Clarkson R
Claxton A
Clemmons K
Cloro LM
Clyde A
Cobzaru I
Codita A
Colangelo A
Colangelo C
Colling K
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Comptaer N
Conde C
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Constantin K
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Cope J
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Copotoiu SM
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Cornish J
Correia da Silva RFM
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Costelloe H
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Coulter I
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Coutinho F
Cowton A
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Cozar OI
Craig J
Craven R
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Critchley R
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Cruickshank R
Cruikshanks A
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Cueva A
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Currow H
Czepanski C
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Damant R
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Dave T
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de Araujo DM
De Baerdemaeker L
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de Boer HD
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de Campos Ferreira MF
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De Meyer JN
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de Wet J
Deacon M
Deblaere I
Dedemadi G
Deen T
Deepak S
Deighton K
Deja M
Delgado Garcia DR
Delgado Navarro C
Della Rocca G
Dempsey G
Dempster A
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Denham S
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Despotidis V
Diaconescu C
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Dodsworth K
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Douglas J
Doumos R
Downes C
Doyle D
Dragnea D
Dragoescu NA
Drake M
Drimala M
Drinkwater Z
Drummond L
Du F
Du F
Du X
Duarte C
Dube NZ
Duca A
Dudgeon L
Dudson R
Duenser M
Dumitrascu CO
Dumitrescu A
Dunay A
Dunk N
Durant E
Durodola A
Dursin AN
Durst A
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Dylst D
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Echem R
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Edwards M
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Egan T
Eggleston C
Eichwalder A
Eikman J
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El-Sayed A
Elabib A
Elena G
Elferink-Vonk R
Elgasim M
Ellis J
Ellis K
Elna C
Emma T
Endersby S
Eneje P
Eng K
English D
English R
Epodoi J
Eskildsen KZ
Esteves S
Ethgen S
Evans A
Evans C
Everingham K
Ewe R
Ezekiel E
Ezike H
Fagerlund MJ
Faina L
Falk E
Fan H
Fan L
Fan Y
Fanfani LC
Faponle F
Faria e Maia D
Faria F
Farid N
Farina Z
Farrell H
Farrow M
Fasina O
Fatungase OM
Faulds M
Fei Y
Fellinger P
Feng Y
Fengas L
Fergey L
Ferguson M
Fernandez S
Ferrando C
Filipescu D
Filippopoulos A
Finch A
Fiorentza K
Fischbach N
Flatt J
Fleischer A
Fleisher L
Fleisher LA
Flores Risco S
Flores AAA
Flores K
Flossos A
Foers W
Foglia J
Foley J
Fonck K
Foord D
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Foot J
Ford D
Forget P
Forsans E
Forstner K
Foster R
Foubert L
Fouracres A
Fowler A
Fowler C
Fraga JM
Fragandreas G
Francis D
Franklin J
Franks R
Frantzeskos G
Freeman D
Freeman V
Freethy A
Freitas K
Freschini A
Freschini D
Frewer N
Fritsch G
Frost V
Fu K
Fu S
Fu Y
Fuad A
Fuentes I
Fulton G
Funk B
Funk D
Furrer M
Furtado Paiva AA
Futier E
Gaitanakis S
Gall L
Gallacher P
Gallard S
Gallego L
Gama NS
Gambhir R
Ganter DL
Ganter MT
Gao H
Garcia Del Valle S
Garcia J
Garcia-Saiz I
Gardikou VV
Gardiner M
Garg A
Garg S
Garg S
Garrett E
Gastaldi C
Gatke MR
Gatta A
Gaudin C
Gavril L
Gbolahan O
Ge X
Geddoa B
Geddoa E
Geisen M
Geldenhuys J
Geng W
Georgakakis G
George R
Georgiou G
Georgopoulou E
Gercek Y
Germann R
Geromarkaki E
Ghafar FNIA
Ghignone F
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Ghushe N
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Giannaki C
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Gkioni P
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Glasgow E
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Goad EHA
Goebel U
Goga IE
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Goldberg O
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Gomez Diago L
Gondo P
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Gordon P
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Govindasamy V
Grace A
Gracia E
Gradwohl-Matis I
Granum SN
Graterol J
Gratrix K
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Greaves R
Green GM
Green-Thompson R
Greene M
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Grey B
Griffiths E
Grigoras I
Grigoryev E
Grintescu I
Grishkowez E
Grosu R-M
Grubmueller KG
Gudaca M
Guimaraes M
Guizeline J
Gunn J
Guo B
Guo F
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Guo Z
Guok EC
Gupta A
Gupta JK
Guttenthaler V
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Hack Y
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Halliwell R
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Helen B
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Hernandez CB
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Hills V
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Hitchcock R
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Hodgson RE
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Hove MO
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Iosep GF
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Ishimaru A
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Iurin A
Izquierdo Palomares A
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Januszewska M
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Javier Redondo F
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Katime A
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Katsika E
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Kaunang J
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Knibel MF
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Kochhar A
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Komnos I
Kong C-C
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Kontis E
Koo EGY
Koompirochana V
Koopman-van Gemert A
Korkmaz M
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Kottam L
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Koulouras V
Koutelidakis I
Koutsikou A
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Kozompoli D
Krepil A
Kretov V
Krishnachetty B
Kruse C-H
Krystopchuk A
Kuan PX
Kubitzek C
Kuhn WP
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Kulkarni A
Kulkarni A
Kulkarni R
Kumar P
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kumar VR
Kumara P
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Kurasz C
Kurnia A
Kusel BS
Kushakovsky V
Kwok A
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Lataniotou O
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Liddle A
Liebenberg R
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Lih TAT
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Liljequist VA
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Liu Q
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Lockwood G
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Looi JK
Looseley A
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Lopes M
Lopez del Moral O
Lopez AG
Lopez JCJA
Loumpias C
Lowery T
Lozano A
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Lubach I
Lubnin A
Lueke K
Luisa Garcia-Perez M
Lumsden R
Luna P
Lundsgaard RS
Luo D
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Luz Serrano M
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Madansein R
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Madiba TE
Maenner O
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Maia B
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Makowski A
Makzal Z
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Malgapo EV
Malik R
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Marques Lobo FR
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Martin T
Martinez Ernesto EP
Martins Costa ACM
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Martins I
Martinson V
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Maselli P
Mathers E
Mathney E
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Matos-Puig R
Mattera M
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McLean AL
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Melbourne S
Melissopoulou T
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Meng Q-T
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Meroni R
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Mishra S
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Mitre C
Mo Y
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Mohr O
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Molkov A
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Momeni M
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Murphy JF
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Nascimento V
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Olajumokex T
Olaleye O
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Olonisakin RP
Olsen KS
Olukoju O
Omer O
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Ortega D
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Osinaike BB
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Ourailoglou V
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Oyedepo OO
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Papadopoullos S
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Papageorgiou G
Papailia A
Papaioannou A
Papakonstantinou N
Papapanagiotou I
Papapostolou K
Papavasilopoulou T
Papurica M
Paraforou T
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Parsons T
Pascazio A
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Pascoe R
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Pazmino-Canizares J
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Pender M
Peng ZD
Pentela R
Pereira de Castro GI
Pereira H
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Perez Gonzalez A
Perez Martin F
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Peris R
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Pernu PK
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Publication venue: 'Oxford University Press (OUP)'
Publication date: 01/01/2016
Field of study

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

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Whole-genome sequencing reveals host factors underlying critical COVID-19

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Abdel-Aziz M.
Abdelrazik M.
Abdollahi H.
Abdullah T.
Abecasis G. R.
Abedalthagafi M.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N. S.
Acquilini D.
Adams C.
Adams E. L.
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Adamsara A.
Adanini O.
Adeleye O.
Adra D.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Agasou A.
Agrawal S.
Aguero D.
Ahmad N.
Ahmadi S.
Ahmed A.
Ahmed C.
Akeroyd L.
Akhtar M. N.
Akinkugbe O.
Aksentijevich A.
Al-Afghani H.
Al-Awdah L.
Alaamery M.
Alahmadey Z. Z.
Alaverdian D.
Alavere H.
Albader A.
Albaiceta G. M.
Albakri J. K.
AlBardis H.
Albeladi M.
Albesher N.
Albrich W.
AlDhawi N.
Aldridge J.
Aleagha A. E.
Alexander P.
Alfonso J.
Alghamdi B.
Alghamdi J.
Ali A.
Ali A.
Ali I. A. M.
Ali S.
Aliannejad R.
Aljawini N.
AlJohani S.
Alkwai S.
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Almohammed I.
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Smithson E.
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Stephenson E.
Stephenson L.
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Tracy B.
Trankiem A.
Tranter H.
Trembath R. C.
Tridente A.
Trim F.
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Trotman S.
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Trumper E.
Tsao P.
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Tsuo K.
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Tully R.
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Turki S.
Turley P.
Turnbull A.
Turner K.
Turner L.
Turner P.
Turner V.
Turner-Bone I.
Turney S.
Turtle L.
Tutton R.
Twiss S.
Tyl D.
Tyler A.
Uitterlinden A. G.
Underwood S. J.
Vaghi M.
Vaida M.
Valente S.
Valentine J.
Valentino F.
van Blokland I.
van Heel D. A.
van Koutrik L.
Varghese M.
Vecchia M.
Vedage D.
Veerapen K.
Venkatesh H.
Venn L. D.
Venturelli S.
Vergori A.
Verlander M.
Verma A.
Verma S. S.
Vertue M.
Verula J.
Verzuri A.
Vigurs C.
Villalonga J. M.
Vincent R.
Vincenti A.
Virgilio E.
Vitart V.
Vizcaychipi M. P.
Vochin A.
Voide C.
von Frenckell C.
von Hohenstaufen K. A.
Vonk J. M.
Vulesevic B.
Vuylsteke A.
Wackett T.
Wadams B.
Waddington N.
Wagstaff V.
Wain L. V.
Waite A. A. C.
Wakefield P.
Wakinshaw F.
Waldron J.
Walker D.
Walker R.
Walker S.
Walker S.
Wall A.
Walsh T.
Walters R. K.
Walton O.
Wang B.
Wang J.
Wang X.
Wanying Z.
Ward G.
Ward L.
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Warden S.
Warmerdam R.
Warren D.
Wassall H.
Wasson C.
Watkins C.
Watson E.
Watson G.
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Watters M.
Waugh V.
Weaver J.
Webster A.
Webster D.
Webster K.
Wei S.
Weiss S. T.
Weldon C. H.
Wells C.
Welters I. D.
Weston H.
Whileman A.
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Whiteley S.
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Whitton C.
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Wicks S. J.
Wilby E.
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Wilcox R.
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Williams A. T.
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Williams M.
Williams P.
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Willis C.
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Willson J.
Wilson A.
Wilson D. J.
Wilson J.
Wilson J. F.
Winnard S.
Winter-Goodwin B.
Wolf-Roberts R.
Wolford B.
Wong J.
Wood D.
Wood H. -L.
Wood S.
Wood T.
Woodford C.
Woodruff M.
Woods L.
Woodyatt W.
Woolley A. E.
Worner R.
Worsley L.
Wray G.
Wren L.
Wright D.
Wright J.
Wright M.
Wrobel N.
Wu Y.
Wulandari R.
Wyllie D. H.
Wynter I.
Xavier K.
Xue X.
Yadav A.
Yang J.
Yassen A. M.
Yates B.
Ye C.
Yun N.
Zainy T.
Zak A.
Zaki A.
Zamikula J.
Zanella I.
Zborowski A. C.
Zeberg H.
Zechner M.
Zguro K.
Zhang M.
Zhao J. H.
Zheng C.
Zhou W.
Zitter L.
Zlatopolsky M.
Zollner S.
Zongo O.
Zucchi P.
Zyndorf M.
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2022
Field of study

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

PubliCatt

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Author: Liza
- AP-HP) Bertrand Dousset (H\uf4pital Cochin
- APHP) Anne Thomin (H\uf4pital Trousseau
- ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
/ Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
3 University Hospital) Bridget Egan (Tallaght
4 Lapolla Pierfrancesco
5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
6 G\uf3mez Marcos
\u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
\u2013 Italy) 20089 Rozzano (MI)
\uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
A Aaraj Mahmoud
A Ayeni Funbi
A Bass Gary
A Benson Ruth
A Bozkurt Mehmet
A Breen Kerry
A Breen Kerry
A Breen Kerry
A Callcut Rachael
A Chung Eric
A Coughlin Patrick
A de Gheldere Charles
A De Marchi Joshua
A Elliott Jessie
A Fahey Brian
A Griffiths Ewen
A Griffiths Ewen
A Griffiths Ewen
A Guariglia Claudio
A Hirji Sameer
A Khalefa Mohamed
A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
A Nguyen (Frankfurt University Hospital Truong
A Olson (Duke University Medical Center) Steven
A Raptis Dimitri
A Rollett Rebecca
A Saeed Samerah
A Salama Hiba
A Salamah Abdulrauf
A Schnitzbauer Andreas
A Schnitzbauer Andreas
A Singh Aminder
A Stevens Kent
A Stylianides Nicholas
A Thaha Mohamed
A Vega (12 de Octubre University Hospital) Viviana
A Vivas Alfredo
A Zappa Marco
Abate Emmanuele
Abdalaziz (Gloucestershire Royal Hospital) Hossam
Abdelkarim Mostafa
Abdou Hossam
Aboelkassem-Ibrahim Ahmad
Abuown Ala
Acebes-Garcia Fernando
Acharya Metesh
Adamina Michel
Addae-Boateng Emmanuel
Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
Aftab Raiyyan
AG Moir John
Agarwal Arnav
AH Ibrahim Mohamed
Aitken (Queen Elizabeth University Hospital) Emma
Al-Azzawi Marwa
Al-Embideen Somya
Al-Sukaini Ahmad
Alakaloko Felix
Alam (Heartlands Hospital) Ruhina
Alameer Ehab
Alderson Derek
Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
Aljanadi Firas
Almasri Murad
Alonso Poza (Hospital Universitario del Sureste) Alfredo
Alonso-Ortu\uf1o Paula
Alser Osaid
Alser Osaid
Alser Osaid
Altintoprak (Sakarya University Faculty of Medicine) Fatih
Amalina Che Bakri Nur
Amjad Rabbia
Anania Gabriele
and Westminster Hospital NHS FT and Imperial College London) Chelsea
Andabaka Tatjana
Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
Angelou Dimitrios
Anita Volpe (New York Presbyterian Queens) Stephen Merola
Annamalai Seethalakshmi
Annessi Valerio
Anthoney James
Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
Anwar Sibtain
Aragon-Chamizo Juan
Ardito Antonella
Arigoni Michele
Armao Teodora
Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
Armstrong Lara
Asaad Peter
Ashcroft James
Ashmore Christopher
Asqalan Ahmad
Asti (IRCCS Policlinico San Donato Emanuele
Aubry Emmanuelle
Aytac Erman
Ayuso-Herrera Esther
Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
B Avellana Rocio
B Catton Andrew
B Fonsi Giovanni
B Hing Caroline
B O'Meara Lindsay
B Schaffer Kathryn
B Yousuf (Tobruk Medical Center) Farhat
B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
Baldi Caterina
Baldini Edoardo
Baldo (Ospedale Santa Corona Stefano
Ballabio Michele
Baloyiannis Ioannis
Baltazar Gerard
Bandiera Alessandro
Barlow Emma
Barmasse (Ospedale Regionale Umberto Parini) Roberto
Barmpagianni Christina
Baronio (Policlinico San Pietro) Gianluca
Barra Fabio
Bartholomew's Hospital) St
Bartsch Anne-Marie
Basgaran Amedra
Basha Amr
Bashkirova (North Middlesex University Hospital) Varvara
Bastazza Marco
BB Sullivan (The Royal London Hospital) Tom
Beak Philip
Belcher Elizabeth
Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
Beltr\ue1n de Heredia Juan
Belvedere Angela
Ben\uedtez-Linero Inmaculada
Benjamin Franklin) Campus
Bergeat Damien
Bernasconi Matteo
Bhalla Ashish
Bhangu Aneel
Bianco Federica
Bisagni Pietro
BJ Borgstein Alexander
Blake (Southport and Formby District General Hospital) Iain
Blanco-Colino Ruth
Blazquez-Martin (Hospital Principe De Asturias) Alma
Boal Matthew
Bologna) Ausl
Bonavina Giulia
Bonavina Luigi
Bond-Smith Giles
Booth (Freeman Hospital) Karen
Borges Filipe
Borghi Felice
Borja De Lacy (Hospital Clinic Barcelona) F
Bourke Grainne
Boyle Emily
Brachini Gioia
Brain Jessie
Brar Amanpreet
Breckles Lisa
Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
Brianza) Carate
Brixton Genevieve
Bruzzaniti Placido
Bueser Teofila
Burnside Nathan
C Bosanquet David
C Brown (Manchester University NHS Foundation Trust Benjamin
C De Souza Anthony
C Glasbey James
C Glasbey James
C Hopkins James
C Lauscher Johannes
C McIntyre Robert
C Mckay Siobhan
C Neary Paul
C Nugent III William
C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
C Roslani April
C Tucker Sarah
C Velmahos (Massachusetts General Hospital) George
C Winter Stuart
Caballero Albert
Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
Calcerrada-Alises Enrique
Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
Camarero Enrique
Campagnaro Tommaso
Campanelli Michela
Candiani Massimo
Cannoletta (Royal Brompton Hospital) Marina
Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
Cao Han
Capizzi Vita
Carcano (Ospedale di Circolo Giulio
Carissimi Francesca
Carlini Massimo
Carlos Bernal-Sprekelsen Juan
Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
Carlucci Michele
Carmela Giuffrida Maria
Carmichael Heather
Carrasco Milagros
Carrillo Mariana
Carvello Michele
Casati Massimiliano
Castoro Carlo
Castro Ruiz Carolina
Catalan Vanesa
Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
Cavaleiro Salom\ue9
Cellerino Paola
Center Amsterdam) Cancer
Centinaio (Ospedale Maggiore di Lodi) Giovanna
Cernei Cristina
Cervellera Maurizio
Chakrabortee Sohini
Chamberlain Stephanie
Chan Jeffrey
Chang Grace
Chaudhry Daoud
Chebaro Alexandre
Chen (Jamaica Hospital) David
Chetty Govind
Chia (Royal Derby Hospital) Zoe
Chiappini Ambra
Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
Chidambaram Swathikan
Chiozza Matteo
Cholewa Hanna
Chong (Evelina London Children's Hospital) Clara
Choolani-Bhojwani Ekta
Christian Cotsoglou (ASST Vimercate) Stefano Granieri
Chui Karen
Chung Choyin
Cirillo Bruno
Citterio Davide
Clermidi Pauline
Coccolini Federico
Colletti Gaia
Compagnoni Bruno
Concepci\uf3n-Mart\uedn Vanesa
Confalonieri Marco
Connolly Hannah
Conso Christel
Conti Luigi
Cooper Zara
Corral Javier
Costa Marta
Costanzi Andrea
Cox Daniel
Cozza Valerio
CR Wormald Justin
Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
CS Clough Ethan
Cuming Tamzin
Cuneo)
Curtis Miles
Cuschieri Joseph
D Baron Ryan
D Bosch Karen
D Brown Oliver
D Bueno-Ca\uf1ones Alejandro
D Cato Liam
D Drake Thomas
D Jenkinson Michael
D Jenkinson Michael
D Liyanage Aloka S
D Pinkney Thomas
D Rajgor Amarkumar
D Stewart Grant
D Tebala Giovanni
D'Agruma Michele
D'Andrea Giancarlo
D\uedaz P\ue9rez David
D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
Da Roit Anna
da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
Dare Oliver
Darko Ebenezer
Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
Day Andrew
De Andr\ue9s-Asenjo Beatriz
de Medicina Facultad
De Miguel-Ardevines Maria-Carmen
De Nardi Paola
De Simone Veronica
De Toma Giorgio
Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
Dehart Dustin
Del Giudice Roberto
Delgado-Oliver Eduardo
Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
Denning Max
Desai Anant
Desender (Ghent University Hospital) Liesbeth
Dester (ASST Valcamonica Ospedale di Esine) Sara
Di Candido Francesca
Di Chiara Francesco
Di Franco Gregorio
Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Diaz-Pe\uf1a Patricia
Dieguez Fernandez Beatriz
Dissemination Committee: Michel Adamina Aneel Bhangu.
Dolores Del Toro M
Domodossola
Doussot Alexandre
Duff Sarah
Dunning Joel
Dunstan Matt
Duque-Mallen Victoria
Dziakova Jana
E Canova Michaela
e Carle Hospital Chiara Peluso (Santa Croce
e Carlo ASST Santi Paolo
E Dawson Brett
E Dickson Kathryn
E Hudson Victoria
E Jenny (Johns Hopkins Hospital) Hillary
E Lewis Sophia
E Nita George
e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
E P\ue9rez-S\ue1nchez Luis
E Rice Henry
E Ssentongo Anna
e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
E Xyda Souzana
Edward Fitzgerald J
EF Abbott Tom
EF Abbott Tom
Egan Richard
Egypt: Mohamed El Kassas University of Copenhagen).
El Youzouri Hanan
El-Ali (Queen's Hospital Abess
Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
Elfeki Hossam
Elhadi Muhammed
Eljareh (Aljalaa Hospital) Mohammed
Elkadi Hannah
Elkady Ramy
Elkhafeefi Fatimah
Elmore Ugo
Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
EM Bouhuwaish Ahmad
EM Brathwaite Collin
Emmerson (North Manchester General Hospital) Oliver
Enemosah Ibrahim
English Camilla
English William
Ereidge Simon
Escartin Jorge
Estaire-Gomez Mercedes
EuroSurg
Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
Exley Rebecca
F Bath Michael
F Cunha Miguel
F Cunha Miguel
F Davis Niall
F Ridgway Paul
Fabbri Nicol\uf3
Falco Giuseppe
Familiari Pietro
Fancellu (Cliniche San Pietro Alessandro
Fanjul G\uf3mez Mar\ueda
Farik Shebani
Farr\ue9 Font Roser
Farrell Tony
Fehervari Matyas
Fell Adam
Fern\ue1ndez- Mart\uednez Mar\ueda
Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
Fern\ue1ndez-Mar\uedn Reyes
Fernandez-Camu\uf1as Angel
Ferrara)
Ferrara Francesco
Ferrari Guglielmo
Ferrero Simone
FF Simoes Joana
FF Simoes Joana
Findlay Laura
Fiore Marco
Fiore Marco
Fiori Enrico
FJ Dunne Declan
Flatman Michael
Flindall Ian
Fontana (Vittorio Emanuele Tommaso
Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
Ford Samuel
Forlani Stefano
Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
Francisco de Vitoria Universidad
Francone Elisa
Frattaruolo Colomba
Frio (Institute of Neurological Sciences of Bologna Federico
Frosinone)
G Aoun Salah
G Barranquero Alberto
G Blazer III Dan
G Collins Chris
G Edwards John
G Edwards John
G Morton Dion
G Povey Meical
G Velopulos Catherine
G Wade Ryckie
Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
Gagliano Annalisa
Gagliardi Filippo
Gahunia Sukhpreet
Gala Tanzeela
Galfrascoli Elisa
Galimberti Luca
Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
Gallagher Phoebe
Galleano Raffaele
Gallo Gaetano
Gallo Gaetano
Gallo Gaetano
Galv\ue1n-P\ue9rez Armando
Gamal Amira Ibrahim Sallam
Gammeri Emanuele
Ganau Mario
Garc\ue9s-Garc\ueda Ra\ufal
Garcia Fernandez Andres
Garcia-Conde Delgado Maria
Garulli (Ospedale Infermi di Rimini) Gianluca
Gascon-Ferrer Isabel
Gattolin (Regina Montis Regalis Hospital Andrea
Gaujoux Sebastien
Gentilli Sergio
Georgiades Fanourios
Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
Ghanbari (Homerton University Hospital) Amir
Ghosh Dhruv
Giacometti Marco
Giblin Anna-Victoria
Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
Gim\ue9nez Clara
Giorgakis Emmanouil
Gipponi Manuel
Glen Paul
GlobalPaedSurg GlobalSurg
Goatly Giles
Gobatti (San Carlo Borromeo Hospital Davide
Godbole Chintamani
Gohil Kajal
Gomez-Rosado Juan-Carlos
Gonullu Emre
Gonzalez-De Miguel Melania
Gonzalez-Gonzalez Enrique
Gordini Luca
Gracia Isabel
Gracia-Roche Carlos
Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
Green Susanna
Grivon Manuela
Grove (Department of Colorectal Surgery Thomas
Guaglio Marcello
Guaitoli (Perrino) Eleonora
Guglielmi Alfredo
Guha Soumya
Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
Guti\ue9rrez Samaniego Mar\ueda
H Babu Bheemanakone
H Chowdhury Abeed
H Davidson Giana
H Davidson Giana
H Davidson Giana
H Elfallal Ahmed
H Emile Sameh
H Kirmani Bilal
H Liu Helen
H Murphy Suzanne
H van Ramshorst Gabrielle
H\uf6lzle Frank
Habeeb Amir
Hagger Robert
Hakmi Hazim
Halkias Constantine
Halkias Constantine
Hampton (Rotherham District General Hospital) Matthew
Handa Siddhartha
Haq Iram
Harky (Liverpool Heart and Chest Hospital) Amer
Harries (Morriston Hospital Rhiannon
Harrison Joseph
Hasan Raashad
Hawari Mohammad
Hawkin Paul
Hebblethwaite Bethany
Helier University Hospitals NHS Trust) St
Heritage Emily
Hernandez Garcia Miguel
Hernandez-Juara Pilar
Herrero-Lopez Maria
Hervieux Erik
Heyd Bruno
Higgs Simon
Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
Ho Beatrice
Hogan Aisling
Hospital of Varese University
Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
Hospital) Atakent
Hospital) Wythenshawe
Hossain Tanvir
Houston Roy
Hurt Libor
HV Byrne Matthew
i Pujol) Alba Zarate (Hospital Germans Trias
I Roxo (Brigham and Women's Hospital) Vanessa
I van Berge Henegouwen (Amsterdam UMC Mark
I Alessandro Di Bartolomeo (Policlinico Umberto
Iannone Immacolata
Ibrahim Sherif
Iovino Domenico
Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
Isik Arda
Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
J Abbott Sarah
J Baker Olivia
J Baldwin Alexander
J Beamish Andrew
J Carlos William
J Caruana Edward
J Caruana Edward
J Davies Emma
J Diaz Jose
J Doe Matthew
J Eardley Nicola
J Fern\ue1ndez Antonio
J G\uf3mez D\uedaz Carlos
J Hainsworth Alison
J Hall Bria
J Holme Thomas
J Hutchinson Peter
J Hutchinson Peter
J Kalkwarf Kyle
J Lin Daniel
J Lowery Aoife
J McCluney Simon
J Mehigan Brian
J Mills Sarah
J Pachl (Birmingham Children's Hospital) Max
J Rogers Luke
J Ryan \uc9anna
J Scurrah Rachel
J Shackcloth Michael
J Smart Neil
J Steinkamp Pieter
J Tejero-Pintor Francisco
J Thomas Amy
J Torres Antonio
J Warren Oliver
J Warren Oliver
J Williams Katherine
James RW Hall (Stepping Hill Hospital) Claire Hall
James's Hospital) Conor P Barry (St.
Jamil Tahir
Jayaraju (University Hospital of Wales) Ullas
Jenner Edward
JG Chase Thomas
Jha Shane Lester (James Cook University Hospital) Madan
Jimenez-Higuera Elisa
Jimeno Jaime
JM Dunne Naomi
JM Ferguson Henry
Jo\ue3o Lima Maria
Johnstone Jack
Jones Mark
Jordan: Mahmoud Al-Masri Gela).
JS Wall Joshua
Judkins Nicholas
JW Wilkin Richard
K Abou Chaar Mohamad
K Ambler Graeme
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Brown Allison
K Fusai Giuseppe
K Gill Charn
K Kamarajah Sivesh
K Patel Panna
K Ubhi Harmony
K Weerasinghe Chamindri
K\uf6nigsrainer Alfred
Kalidindi Venugopala
Kamal Mona
Kang Chong
Kara Yasin
Karam Edward
Karim Ahmed
Kashora Florence
KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
Kearney (Beaumont Hospital) David
Khajuria Apoorva
Khan Azam
Khan Umul
Khatri Chetan
Kinross James
Kler Aaron
Klimopoulos (Evangelismos General Hospital) Serafeim
Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
Kolias Angelos
Kolias Angelos
Kontovounisios Christos
Kourdouli (Leicester Royal Infirmary) Amar
Krishnan Emily
Kristinsson Sverrir
Kruijff Schelto
KS Viswanath Yirupaiahgari
Kudsk-Iversen S\uf8ren
Kufeji Dorothy
Kulkarni Rugved
Kurihara Hayato
L Biffl Walter
L Coleman Natasha
L Collins Michelle
L Engel (Temple University Hospital) Jamie
L Fowler Amy
L Garcia Galocha Jose
L Hughes Jane
L J\uf6nsson (Bispebjerg Hospital Maria
L Labib Peter
L Marsh (Scripps Memorial Hospital) Christopher
L McKevitt Kevin
L Osorio Alexander
L Romera Jose
L Serevina Olivia
L Venn Mary
L Venn Mary
L Venn Mary
L Wright Franklin
L Young Alastair
L\ue1zaro Andr\ue9
La Torre Filippo
Laface (Ospedale Vittorio Emanuele III Letizia
Lami Mariam
Landaluce-Olavarria Aitor
Laura Hansen 9
Lawani Ismail
Lawday (Southmead Hospital) Samuel
Lawday Samuel
Le Roy Bertrand
Lecco) Asst
Lecolle Katia
Lederhuber Hans
Lederhuber Hans
Leeds)
Leicester)
Leventoglu Sezai
Li Elizabeth
Li Elizabeth
Li Zoe
Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
Liew Ignatius
Ligure (SV) Pietra
Lima Buarque Igor
Lisi Giorgio
Lizzi Vincenzo
Lo Terence
Lombardia) Regione
Lomiento Daniele
Longhi Marco
Lopez Antonanzas (Hospital Clinico San Carlos Leyre
Losada Ruiz Manuel
Lostis Emilie
Lostoridis Eftychios
Loubani Mahmoud
Lowy- Benoliel Alejandro
Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
luis Blas Laina Juan
Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
Luke Louis
Lunevicius Raimundas
Luraghi Marco
Lye George
M Alrahawy (Menofiya University Hospital) Mahmoud
M Andreani Stefano
M Ashoush Fouad
M Bajomo Oreoluwa
M Blundell Chris
M Cicerchia Pierfranco
M Connolly Tara
M Diez-Alonso Manuel
M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
M Emslie Katy
M Harrison Ewen
M Holbrook Charlotte
M Isolani Simone
M Keatley James
M Leite-Moreira Andr\ue9
M Mithany Reda H
M Mohan Helen
M Mohan Helen
M Monteiro Joana
M Morgom (Tripoli Central Hospital) Marwa
M Muguerza Jose
M Nunes Quentin
M Nygaard Rachel
M Omar Aneel Bhangu Omar
M Philp Matthew
M Pollok Joerg
M Rooney Siobhan
M Sampietro Gianluca
M Sewards Joseph
M Tang Alethea
M Trout Isobel
M Walters (Harborview Medical Center Andrew
MA Kaafarani Haytham
MA Kaafarani Haytham
MA Kaafarani Haytham
Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
Mabrouk Islam
Macchi Alberto
MacDonald Luisa
Machairas (Royal Free Hospital) Nikolaos
Madonini Marco
Madrid)
Madrid)
Magalh\ue3es Maia Mariana
Magne Augestad Knut
Magowan Drew
Maha H Haqqani (Boston Medical Center) Frederick T Drake
Maisonneuve Emeline
Majkowska Agata
Majkowski (Northern General Hospital Lawrence
Mak (Queen Elizabeth Hospital Birmingham) Jason
Malabarba Stefano
Malerba Michele
Maninder Kalkat 7
Mannan Syed
Manson Joanna
Mansuri Ahmer
Mantoglu (Sakarya University Research and Educational Hospital) Baris
Manu Nichola
Manzoni 56 Via
Maqsood Afnan
Marano Alessandra
Marchbank Adrian
Marcos-Santos Pablo
Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
Marqueta De Salas Maria
Marrano Enrico
Mart\uedn-Rom\ue1n Lorena
Mart\uednez P\ue9rez Carolina
Mart\uednez-dePaz Fernando
Martel Lozano Saida
Martin (St Mary's Hospital) Guy
Martin Emmeline
Martin Janet
Martin-Albo Lorena
Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
Martinelli Fabio
Martinez-German Antonio
Martinez-Pinedo Carlos
Martins Ricardo
Marwan Hisham
Marzi Federica
MAS Baig Mirza
Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
Mater Studiorum University of Bologna) Alma
Mathieu (CHU Besan\ue7on) Pierre
Matute-Najarro Maria-Soledad
Maw Andrew
Mazingi Dennis
Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
McCanny (Antrim Area Hospital) Andrew
McKenzie Katherine
McLarty (Northumbria NHS Hospital Trust) Nicola
McPherson Iain
Medina Esther
Mediratta Saniya
Medone Marzia
Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
Mele Simone
Melero-Cort\ue9s Lidia
Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
Mendon\ue7a Ata\uedde Gomes Gustavo
Mendoza-Moreno Fernando
Meneghini Simona
Merate
Mercante Giuseppe
Merdrignac (Rennes University Hospital) Aude
Metallidis Symeon
Michel (Pinderfields Hospital) Martin
Migliore Marco
Milan)
Milan)
Milan)
Miller Douglas
Minaya- Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Mingoli Andrea
Minto Gary
Mirabella Antonello
Misra Nikhil
Mitrasinovic Stefan
Miu Victor
Moawad (Royal Victoria Hospital) Nader
Mochet Sylvie
Modabber Ali
Mohammad Adam
Mohan Midhun
Moliner-S\ue1nchez Carmen
Mondov\uec)
Mongelli Francesco
Monteleone (Ospedale San Leopoldo Mandic Michela
Montuori Mauro
Moore Rachel
Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
Morales Dieter
Morales Xavier
Morelli Luca
Morelli Lucia
Morgan Richard
Morris Chris
Mortini Pietro
Mosca Angelo
Moszkowicz David
Moszkowicz David
Motter Dema
Moug Susan
Mukherjee Samrat
Munoz Rivas Ana
Murcia)
N Bence Matthew
N Hopkinson David
N Mashbari Hassan
N Mashbari Hassan
N Mashbari Hassan
N Naumann David
N Rao Jagan
N Townshend David
N\ufa\uf1ez Jordi
Najdy Manhal
Nakas (Glenfield Hospital Apostolos
Namazov Ilgar
Naredla Pradyumna
Nasef Emmhamed
Nassa Heeam
Nath Rahul
Navarro-S\ue1nchez Antonio
Nazarian (Bupa Cromwell Hospital) Scarlet
Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
Negri Giampiero
Nehra Deepika
Neil-Dwyer Jason
Nepogodiev Dmitri
Nepogodiev Dmitri
Nepogodiev Dmitri
Neri Jacopo
Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
Newton (Manchester Royal Infirmary) Katy
Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
Niquen Milagros
Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
Nogueiro Jorge
Nogues Pevidal (Royo Villanova) Ana
Novara)
Ntirenganya Faustin
Nugent Michael
O Ademuyiwa Adesoji
O Kavanagh Dara
O Larkin John
Oca\uf1a Juan
of Amsterdam University
of Ferrara) University
of Insubria University
of Milan) University
of Surgeons in Training (ASiT) Association
of Surgery) Department
of Washington) University
Okafor Barbara U.
Okechukwu Valentine
Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
Oliveira Ana
OM Abdalla Mutwakil
Omar M Omar
OO Ayorinde John
Osagie-Clouard (Epsom &amp
Osman (Walsall Manor Hospital) Khabab
Ottolina Jessica
Ourieff (Mount Sinai Hospital) Jared
Outani Oumaima
Oyewole Bankole
P Arnaud Alexis
P Arnaud Alexis
P Arnaud Alexis
P Baker Markus
P Belgaumkar Ajay
P Boddy Alexander
P Duffy (Nottingham City Hospital) John
P Evans Jonathan
P Hazelton Joshua
P Jones Andrew
P Jones Robert
P Joyce Doireann
P Kisiel Aaron
P Pezzuto Anna
P Singh Rabindra
P\ue9rez-Gonz\ue1lez Marta
P\ue9rez-Saborido Baltasar
Pacheco-Sanchez David
Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
Pai (Hammersmith Hospital) Madhava
Paiella Salvatore
Paisley (Brighton and Sussex NHS Trust Samuel
Palermo)
Palini Gianmarco
Palmeri Matteo
Parente Alessandro
Parlanti Daniele
Parmar Chetan
Pascual Angela
Pata Francesco
Pata Francesco
Patel Mahul
Pathak Abhijit
Patil Sangram
Pattyn Piet
Peckham- Cooper Adam
Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
Pedrazzani Corrado
Pellino Gianluca
Pereira Andr\ue9
Pereira-Neves Ant\uf3nio
Perez-Diaz Md
Perivoliotis (General University Hospital of Larissa) Konstantinos
Perkins Clare
Perotto (CHU Saint Etienne) Ornella
Perra Teresa
Petrone Patrizio
Phenix George
Piacenza)
Picazo Sara
Picon-Rodriguez Rafael
Piloni Martina
Pingarr\uf3n-Mart\uedn Lorena
Pinotti Enrico
Pizzini Paolo
PM de Vries Jean-Paul
Pockney Peter
Podolsky Dina
Poggioli Gilberto
Pompili Cecilia
Pontari Michael
Porcu Alberto
Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
Potter (Royal Bournemouth Hospital) Ryan
Price Claire
Prita Daliya 8
Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
PTSurg ItSURG
Pujol-Muncunill Roger
Puppo Andrea
Q Mehdi (University of Texas Medical Branch) Mohammad
Quante Markus
Quintana-Villamandos Bego\uf1a
Qureshi Ali
R Burke Joshua
R Davidson Brian
R Dixon Jan
R Fretwell Kenneth
R Gujjuri Rohan
R Gujjuri Rohan
R Kowal Mikolaj
R O\u2019Neill John
R Sarma Diwakar
R Spalding Duncan
R Springford Laurie
Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
Radenkovic Dejan
Rahman Saad (Medway Maritime Hospital) Abdel
Rakvin Ivan
Ramallo-Sol\ueds Irene
Ramcharan Sean
Ramos Diego
Ramos-Bonilla Antonio
Ramos-De la Medina Antonio
Ramzi Joussi
Rathinam Sridhar
Rausa Emanuele
Ravaioli Matteo
Ravindran Sharanya
Raymond (Royal Lancaster Infirmary) Thomas
Razik Aisha
Redfern (Furness General Hospital) Jennifer
Reguera-Rosal Julio
Rey-Biel Juan
Rey-Valcarcel Cristina
RG Sheel Andrea
Ribolla Marta
Richards Tomos
Richmond (University of Maryland Medical Center) Michael
Righini (Ospedale del Delta Erminio
Rio-Gomez Javier
Riuniti Villa Sofia-Cervello Ospedali
Riyat Harjoat
Rizvi Sana
Roberts Keith
Roberts Matthew
Robertson (University Hospitals Coventry and Warwickshire) Stuart
Robertson (University of Arkansas for Medical Sciences) Ronald
Robin-Valle Alvaro
Rochon Melissa
Rojo Mikel
Rolli Luigi
Romano Silvio
Rome)
Romford)
Ross Elizabeth
Ross Howard
Rottoli Matteo
Royal Hospital) Princess
Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
Ruiz- Grande Fernando
Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
Ruzzenente Andrea
Ryska Ondrej
S Abdelaal (Alexandria Main University Hospital) Ahmed
S Al Maadany Faraj
S Faria Carlos
S Hammond John
S Hossain Fahad
S Jeyaretna Deva
S Jones Conor
S Khan (Queen Alexandra Hospital) Jim
S Moura Francisco
S Ng-Kamstra Joshua
S Sica Giuseppe
S Tamimy Muhammad
S Wadley Martin
S\ue1nchez- Arteaga Alejandro
SA Taher Ahmed
Saez Carlos
Sahnan Kapil
Sahni Arun
Salim Ali
Salvia Roberto
Sammarco Giuseppe
Sampaio-Alves Mafalda
San Miguel-Mendez Carlos
Sanchez del Pueblo Cristina
Sanchez-Fuentes Maria-Nieves
Sanchez-Pelaez Daniel
Sanchez-Perez Coral
Sanchez-Rubio Maria
Sancho-Muriel Jorge
Sanchon Fructuoso Lorena
Sanders Julie
Santero-Ramirez Maria-Pilar
Santora Thomas
Santoro Antonio
Santos Irene
Sapienza Paolo
Sartarelli (Sant\u2019Orsola Hospital Lodovico
Sarveswaran Janahan
Sasia Diego
Sassari) A. O. U.
Saudemont Alain
Saudi-Moro Sef
Saxena Dolly
Saxena Shobhit
Sayasneh Ahmad
Scalabre Aurelien
Schache Andrew
Schiavina Riccardo
Schineis (Charit\ue9 University Medicine Christian
Schreckenbach Teresa
Scorza Antonella
Scott Lucy
Seegert (ProMedica Toledo Hospital) Sara
Seguin-Givelet Agathe
Senent-Boza Ana
Serrano Gonz\ue1lez Javier
Sette Laghi Asst
Seymour Keith
Shabana Amanda
Shah (The Whittington Hospital) Sujay
Shah Jigar
Shah Karishma
Shah Preena
Shakir Taner
Shalaby (Mansoura University Hospital) Mostafa
Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
Shaw Richard
Sheffield)
Shehata Sameh
Shelley Hwang E.
Shen Ban Vin
Shenfine Amy
Sheridan Kelda
Sherief Ahmed
Sherif Mohamed
Shinkwin Michael
Shu Sebastian
Siaw-Acheampong Kwabena
Sileri (San Raffaele Scientific Institute Pierpaolo
Singh Abhinav
Singh Shailendra
Sinha Sanjay
Siragusa (Policlinico Tor Vergata Hospital Leandro
Sivaprakasam Rajesh
Sivayoganathan Sriharan
SJ Ledesma Frances
Smillie Robert
Smith (Countess of Chester Hospital) Claire
Smith Andrew
Smith Christopher
Sochorova (Royal Liverpool University Hospital) Dana
Society of Coloproctology (ESCP) European
Society of Colorectal Surgery (SICCR) Italian
Soggiu Fiammetta
Sohrabi (St Bartholomew's Hospital) Catrin
Sohrabi (Whipps Cross University Hospital) Catrin
Sohrabi Catrin
Solari (Royal Gwent Hospital) Francesca
Solli Piergiorgio
Soreide Kjetil
Soto Montesinos Cristina
SpainSurg
Spinelli Antonino
Spinelli Antonino
Spoletini (Sant'Eugenio Hospital) Domenico
Spriano Giuseppe
Sravanam Sanskrithi
Ssentongo (Pennsylvania State University) Paddy
Stanger Sophie
Stavroulias Dionisios
Steel (Sunderland Royal Hospital) Ben
Stella Marco
Stewart Robbie
Stringer Sally
Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
Sulen Nina
Sundar Sudha
Sundhu (Aintree University Hospital) Matthew
Surgical Research Collaborative (ISRC) Irish
Suri (University of California Davis Health Avni
Swansea)
Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
Syed Arooj
Szatmary Peter
T Colonna Emily
T Enjuto Diego
T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
TA Neely David
Tabiri Stephen
Tadross Daniel
Taglietti Lucio
Tansey (Princess Alexandra Hospital) Rosamond
Tartaglia Dario
Tawheed (Endemic Medicine Department Ahmed
Tayeh Salim
Testa Valentina
Tewari Nilanjana
Thoenissen Philipp
Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
Thrush Jessica
Tierney Sean
Tiwari Abhinav
Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
Toledo Enrique
Tonini Valeria
Torkington Jared
Torzilli Guido
Totty Joshua
Tousidonis Manuel
Townend Philip
Townsend Catherine
Trompeter (St George's Hospital) Alex
Trotta Francesco
Truant St\ue9phanie
Trujillo-D\uedaz Jeancarlos
Tsoulfas George
Tsoulfas Georgios
Turco Celia
Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
Turrado- Rodriguez Victor
Turri Giulia
Tustin (Cumberland Infirmary) Harry
Tyler Jayne
Tzedakis Stylianos
Tzovaras George
Ullah Ramzan
Unit\ue0 Sanitaria Locale di Ferrara Azienda
United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
University Hospitals NHS Trust) Nottingham
University of Rome) Sapienza
University) Goethe
University) Helwan
Urban (University of Colorado Hospital) Shane
Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
Usai Antonella
V Bhavaraju Avi
V Comini Lara
V Feo Carlo
V Marino Marco
V Shaw Abigail
V\ue1zquez- Fern\ue1ndez Andrea
Vaccarella (Azienda Ospedaliera Gianpaolo
Valdes- Hernandez Javier
Valsecchi Luca
Vashisht Rajiv
VCO) Asl
Venkatesan (Glan Clwyd Hospital) Gowtham
Vera-Mansilla Cristina
Vergari (Ospedali Riuniti di Ancona) Roberto
Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
Vidya Raghavan
Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
Vijay Vardhini
Vimalachandran Dale
Vimalachandran Dale
Violante Tommaso
Vovola Fernanda
Vulliamy Paul
W Endorf (Hennepin Healthcare) Frederick
W Etchill Eric
W L\uf6ffler Markus
W L\uf6ffler Markus
Wall Rosemary
Wallwork Kate
Ward Alex
Warwick (University Hospital Southampton) David
Waseem Saima
Weaver Helen
Wells Fiona
Wen Jiaxin
West Raha
Whitehall Emma
Wild Laura
Wilkins Alex
Williams Gethin
Williams Matthew
Winnand (University Hospital Aachen) Philipp
Wong (Addenbrooke's Hospital) Ken
Worku (Queen\u2019s Medical Centre Dawit
Wright Naomi
WS Ho (Leeds Teaching Hospitals NHS Trust Michael
WT Ngu Albert
y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
Y Oo (Department of Cardiothoracic Surgery Aung
y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
Y van der Plas Willemijn
Yalamanchili Seema
Yershov (South Warwickshire NHS Foundation Trust) Danylo
Young Richard
Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
Yurttas Can
Zadegan Frederic
Zafar (Northwick Park Hospital) Noman
Zakaria Rasheed
Zambon Martina
Zanini Nicola
ZE Durst Alexander
Zerbib Philippe
Zonta (Ospedale San Biagio Sandro
Publication venue: 'Elsevier BV'
Publication date: 01/01/2020
Field of study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

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Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

Author: A Kaldun Nossuli
Aamir Jamal
Adalbert Schiller
Adam Cheifetz
Adarsh Daswani
Adeera Levin
Adline Ghazi
Adrian Guinsburg
Adriana Cif
Adriana Gabriela Onaca
Adriana Ilavska
Adriana Villarino
Agarwal R.
Agnieszka Starzec
Ahmed Arif
Ahmed Awad
Aiping Yin
Akimichi Asano
Alan Jackson
Alan McMahon
Alan Perlman
Alberto Di Carlo
Alberto Esquenazi
Alejandra Oviedo
Alejandro Valdes Depeda
Aleksandra Kendereski
Alex Valenzuela
Alexander Dreval
Alexander Gonzalez
Alexander Shinkov
Alexander Turchin
Alexandre Klein
Alfonso Soto Gonzalez
Alfred Penfornis
Alfredo Chew Wong
Alfredo Wassermann
Ali Torshizi
Alicia Chilito
Alina Agafyina
Alison Dawson
Alva Hansraj
Amer Al-Karadsheh
Amorin Remus Popa
Amrendra Kumar
Amy Sprague
Ana Limos
Ana Maria Cusumano
Ana Maria Elosegui
Anabella Amigo
Anatoliy Kazmirchuk
Andrea Phillips
Andrea Stella
Andreas Maddux
Andrej Dzupina
Andres Alvarisqueta
Andrew Johnson
Andrew O'Shaughnessy
Andrew Steele
Andrian Yakov
Andrzej Januszewicz
Andrzej Madej
Angelina Angelova
Anibal Gastaldi
Anil Gupta
Anita Bhajan Manocha
Anjanette Tan
Anna Kaminska
Anna Maria Veronelli
Anna Strzelecka
Anna Zateyshchikova
Anselmo Bordonava
Antanas Navickas
Anthony Gunstone
Anthony Roberts
Antonio Ceriello
Antonio Galan Serrano
Antonio Scafuto Scotton
Antonio Terrelonge
Antônio Roberto Chacra
Anupama Gowda
Arjun D Sinha
Armando Perez
Ashot Mkrtumyan
Atanas Koundurdjiev
Augusto Vallejos
Aurelian-Emil Ranetti
Ayim Akyea-Djamson
Aysha Badat
Bakris G.
Baldev Singh
Barbara Greco
Barbara Kaczmarek
Barbara Rewerska
Barry M Brenner
Belia Martin Del Camp Blanco
Bernard Zinman
Bertrand Cariou
Bertrand Dussol
Bhasker Mehta
Bhimavarapu Sudhakar
Björn Paschen
Bompoint S.
Borys Mankovskyy
Botond Csiky
Boyan Nonchev
Brenner B. M.
Brett Kissela
Brian Nichol
Bruce Neal
Bruce Trippe
Bruno Geloneze Neto
Bull S.
Byung-Wan Lee
C B Keshavamurthy
Cannon C. P.
Capuano G.
Carlo Giorda
Carlos Alberto Cuneo
Carlos Arauz-Pacheco
Carlos Barrera
Carlos Perez
Carmel Hawley
Carmen Crisan
Carol Pollock
Carolyn Droste
Caroucel Chuateco
Caryl David
Cecilia Garcia Ballesteros
Cecilia Jimeno
Celso Amodeo
Cesar Javier Zaidman
Cesar Yoiti Hayashida
Chamberlain Obialo
Chang-Hsun Hsieh
Charles Cook
Charles Kaupke
Charytan D. M.
Chek Loong Loh
Chen Leia
Cheol-Young Park
Chih-Ching Lin
Christopher P Cannon
Christy Yao
Chu P. -L.
Chwen-Tzuei Chang
Chye Lee Gan
Clara Barrios
Claude Galphin
Claudia Goycoa
Claudia Moreira de Brito
Clodoaido Caringal
Cristian Serafinceanu
Cristina Toarba
Cristobal Morales Portillo
Csaba Kovesdy
Cynthia Bowman-Stroud
Cynthia Christiano
Cynthia Mustieles Rocha
Cyrus Desouza
Cássio Slompo Ramos
Dagmar Bartaskova
Dale Crawford Allison
Dalia Kozloviene
Dan Scharfstein
Dana Cosma
Daniel Coyne
Daniel Hiser
Daniel Kolansky
Daniel Panarotto
Daniel Pella
Daniel Weiner
Daniil Chizhov
Dariusz Sowinski
Darren K McGuire
Davesh Sennik
David C Wheeler
David Cherney 3rd
David Gorson
David Johnson
David M Charytan
David Packham
David Scott
David Wheeler
De Zeeuw D.
Debbie Cohen-Stein
Debbie Mascaro
Deepak Koppolu
Dennis Levinson
Derek Lewis
Detian Li
Devasmita Dev
Devesh Patel
Dewan Deepak
Dick de Zeeuw
Diego Aizenberg
Dinesh Jain
Dinesh Khullar
Diogo Belo
Dmitry Zateyshshikov
Domenico Santoro
Domingos d'Avila
Donald Brandon
Donald Fraser
Dong-Wan Chae
Dora Inés Molina de Salazar
Dorota Mlodawska-Choluj
Doru Negru
Edgar Arcos
Edoardo Mannucci
Eduardo Farias
Edward Watson
Edwards R.
Egle Gaupsiene
Egle Urbanaviciene
Ekaterina Velichkova
Elena Christofides
Elena Grineva
Elena Kolmakova
Elena Shutemova
Eleonora Harcsa
Elizabeth Barranco
Elizabeth Gelersztein
Elizabeth Kern
Elizete Keitel
Eloisa Tellez Chavez
Emanuela Orsi
Emil Martinka
Emyr Davies
Enrique Gonzalez
Eric Alamartine
Eric Hernandez Triana
Eric Thervet
Erick Turcios Juarez
Esteban Cercos
Eugenia Galindo-Ramos
Eva Peterfai
Evaly Chen
Evandro de Souza Portes
Evgueniy Vazelov
Fabian Otreras
Fabiana Loss de Carvalho Contieri
Fabio Malberti
Fadi Saba
Fadlo Fraige Filho
Favio Edmundo Enriquez Sosa
Fayzal Ahmed
Ferdinando Carlo Sasso
Fernanco Augusto Alves da Costa
Fernanda Cristina Camelo Sanches
Fernando Cereto Castro
Fernando Flores Lozano
Fernando Jimenez Florez
Fernando Krynski
Fernando M Edwin
Fernando Thomé
Fernando Trespalacios
Florence Santos
Florencia Kraft
Fracisco Javier Gonzalez Martinez
Fran Morren
Franciso Jose Tinahones Madueno
Frank Eder
Franklin Joseph
Franklin Paul Haase
Frantisek Saudek
François Dubé
François Madore
Freemu Varghese
Gabriela Cecilia Coloma
Gabriela Genova-Hristova
Gabriele von Ingersleben
Gaetano Serviddio
Galina Nagibovich
Gary Meininger
Gema Fernandez Fresnedo
Georg Plassmann
George Bakris
George Hon
George Newman
Gerald DaRoza
Gerald Keightley
Gerry Tan
Giacomo Garibotto
Giorgio Fuiano
Giovanni Frascà
Giovanni Gambaro
Giuseppe Derosa
Gizella Petro
Glenn Chertow
Gnyandev Patel
Godwin Simon
Goga Vukotic
Gopal Krishna
Grace Aquitania
Grace Lin
Graham Hillis
Graziano Di Cianni
Grazyna Orlowska-Kowalik
Grazyna Popenda
Greene T.
Greg Fulcher
Gregorio Obrador
Gregorio Obrador Vera
Grit Faulmann
Guadalupe Morales Franco
Guillermo Fragale
Guixia Wang
Gulam Latiff
Gustavo Cristian Greloni
Guy Chouinard
Gyongyi Csecsei
Gyorgy Paragh
Halyna Tomashkevych
Hans Prozesky
Harpreet Bajaj
Hasnain Khandwala
Hector Rodriguez
Heerspink H. J. L.
Helena Oosthuizen
Hendrik Nortje
Henry Watson
Hermann Haller
Hernan Finkelstein
Hernan Yupanqui
Hiddo J L Heerspink
Hiralal Maheshwari
Hiroko Oishi
Hiromi Aoki
Hiromi Rodriguez Pattzi
Hiroshi Kono
Hitoshi Akiyama
Holly Wang
Hong Mao
Hong Zhang
Hongguang Zheng
Hongli Lin
Horacio Sessa
Hugo Colombo
Hugo Laviada Molina
Hugo Roberto Kurtz Lisboa
Humberto Pavon
Hyuk-Sang Kwon
Iain MacDougall
Ian Fraser
Idalia Acosta
Ildiko Halmagyi
In-Kyung Jeong
Ines Bartolacci
Ingrid Abrahamsen
Ingrid Buganova
Inna Kolesnyk
Ioana Emilia Ferariu
Irene Noronha
Irina Glinkina
Irina Osipova
Iryna Dudar
Isabel Erika Rucker Joerg
Isabel Garcia
Isam Marar
Israel Hartman
Iuliia Komisarenko
Ivan Fushtey
Ivan Ory
Ivan Rychlik
Ivan Rychlík
Ivan Smirnov
Ivan Topchii
Ivan Villegas
Iveta Smatanova
Jaco Jurgens
Jakkidi Reddy
Jamal Hammoud
James Conway
James Januzzi
James Welker
Jan Culak
Jana Babikova
Jana Belobradkova
Jana Dzuponova
Janos Mucsi
Jardine M. J.
Jason Gaglia
Javier Narvarte
Javier Nieto Iglesias
Jayameena Peringat
Jayant Kumar
Jean Carlo Tibes Hachmann
Jean Welsh
Jean-Pierre Fauvel
Jeevren Reddy
Jeffrey Kropp
Jeffrey Stephens
Jeimeen Agra
Jelena Ignjatovic
Jesus Cuadrado
Jesus Egido de Los Rios
Jian Liu
Jiao Sun
Jinkui Yang
Jiri Lastuvka
Jiri Pumprla
Joaquin Pablo Gonzalez
Johannes Breedt
John Amerena
John Baker
John Ervin
John Evans
John Lentz
John Middleton
John Padron
John Sensenbrenner
John Updegrove
John Wakeling
Jonay Pantoja Perez
Jorge Archibaldo Glenny
Jorge Avendano
Jorge Ernesto Andres Diaz Ruiz
Jorge Hector Resk
Jorge Kusnir
Jorge Mordujovich
Jorgelina Sala
Jose Antonio Sánchez Arenales
Jose Chevaile Ramos
Jose David Gomez Rangel
Jose Esteban Jodar Gimeno
Jose Francisco Kerr Saraiva
Jose Hector Sanchez Mijangos
Jose L Górriz
Jose Luis Accini Mendoza
Jose Ma Portoles Perez
Jose Osvaldo Fretes
Jose Ricardo Correa Rotter
Joseph Abdallah
Joseph Aiello
Joseph Feuerstein
Joseph O'Hare
Joseph Proietto
Josier Nisnisan
José Vicente Sanchez Polo
João Lindolfo Cunha Borges
João Soares Felício
Juan Alfredo Tamayo Y Orozco
Juan Baas Cruz
Juan Carlos Santos
Juan Diego Higuera
Juan Frias
Juan Gonzalo Godoy Jorquera
Juan Pablo Albisu
Juan Pablo Moreira Diaz
Juan Peralta Calcaneo
Juan Rosas Guzman
Juan Villagordoa Mesa
JungEun Lee
Kamal Abouglila
Karel Peterka
Karina Hufert
Karlton Pettis
Katalin Keltai
Katalin Revesz
Katarina Halciakova
Katarina Lalic
Kathy Nicholls
Kati De Brouwer
Kazuhiro Yanagida
Kazunori Koyama
Kazuyuki Mizuyama
Kee Sing Ng
Kenneth Cohen
Kenneth Deck
Kenneth Hershon
Kenneth Liss
Kenneth W Mahaffey
Khalid Abdul Kadir
Khurram Wadud
Kim Travis
Kiril Hristozov
Kook-Hwan Oh
Krisztian Kiss
Kun Ho Yoon
Lachezar Lozanov
Lajos Major
Lalaine Delos Santos
Landman Lombard
Larisha Pillay-Ramaya
Larry Distiller
Larysa Pererva
Laszlo Deak
Laszlo Konyves
Laura Akright
Laura Coffee
Lawrence Distiller
Lawrence Lehrner
Lawrence Leiter
Lech Lazuka
Lee-Ming Chuang
Lenka Dohnalova
Leslie Spry
Levin A.
Li Yuan Lee
Lidia Bermudez
Ligia Petrica
Lilia Beatriz Schiavi
Liliana Monica Angelescu
Liliia Zub
Liliya Martynyuk
Lin Sun
Lincoln Chapin
Linong Ji
Lisa Rich
Liudmila Kvitkova
Lori Yost
Luca Chiovato
Luca De Nicola
Luca Zanoli
Lucas Rista
Luciane Mônica Deboni
Lucyna Hotlos
Ludger Rose
Luigi Gnudi
Luis Alberto Ramirez Roca
Luis Asmarats Mercadal
Luis David Abraira Munoz
Luis Enrique Herrera Jimenez
Luis Fernando Flota Cervera
Luis Henrique Canani
Luis Hernando Garcia Ortiz
Luis Isaias Juncos
Luis Quesada-Suarez
Luis Rodolfo Cartasegna
Luis Valderrama Cometa
Luis Venegas Carrillo
Luiz Alberto Andreotti Turatti
Luiza Despina Demian
László Rosivall
Ma Dovie Lallaine Ygpuara
Mahaffey K. W.
Manel Terns Riera
Manish Saxena
Manthi Hettiarachchi
Manuel Muñoz Lopez Mendoza
Manuel Muñoz Torres
Manuela Schmidt
Marc Rendell
Marcel Twahirwa
Marcelo Medina Fariña
Marcora Mandreoli
Marcus Gomes
Margarita Temelkova
Margarita Vejar
Margit Mileder
Margo Hudson
Maria Antonia Munar Vila
Maria Barnard
Maria Cecilia Cantero
Maria Florencia Fernandez
Maria Isabel Klyver
Maria Jaime
Maria Rosa Ulla
Maria Teresa Zanella
Maria Valdez
Marializa Bernardo
Marianna Zsom
Mario Alberto Berli
Mario Burgos Soto
Mark Davies
Mark Vannorsdall
Mark Warren
Markus Faghih
Marsha Tolentino
Marta Dominquez Lopez
Marta Molnar
Martin Lukac
Martin Valis
Martine Destree
Mary Anne Lim-Abrahan
Mary Lawrence
Mary Seeber
Maryna Vlasenko
María Alicia Fernández Montenegro
María Angustias Quesada Simón
Masahiko Takai
Masahiro Koizumi
Masakiyo Wakasugi
Masayo Yamada
Mastura Ismail
Matthew Abramowitz
Matthew Beacom
Meg J Jardine
Meg Jardine
Meininger G.
Melchor Alpizar Salazar
Melemadathil Sreelatha
Merce Perez Vera
Mercedes Velo Plaza
Michael Oliver
Michael Robinson
Michael Shanik
Michael Thompson
Michael Williams
Michal Nowicki
Michał Nowicki
Michelle Zaniewski-Singh
Mick Kumwenda
Miguel Nazzer Hissa
Migues Angel Reyes Rosano
Mihaela Biscoveanu
Mihaela-Magdalena Busegeanu
Mihaly Dudas
Milan Gupta
Min Jeong Kwon
Minara Shamkhalova
Minghui Zhao
Miodrag Djordjevic
Mircea Munteanu
Mitsuru Tsujimoto
Mohamed El-Shahawy
Mohamed Mookadam
Mohamed Railey
Mohamed Sekkarie
Mohanram Narayanan
Mohd Daud Che Yusof
Mohsen El Kossi
Mona Wahba
Monica Alexandra Terront Lozano
Monika Dhillon
Moogali Arvind
Moon-Kyu Lee
Moon-Suk Nam
Moustafa Moustafa
Muhammad Shakeel
Mukesh Joshi
Mykola Kolesnyk
Márcio Antônio Pereira
Nadia Zalunardo
Nadiya Tryshchuk
Nan Chen
Narayan Prasad
Naresh Aggarwal
Natalia Malaver
Nataliia Pashkovska
Natarajan Gopalakrishnan
Navdeep Tangri
Naveen Atray
Neal B.
Nebojsa Lalic
Neil Kumar
Nelson Kopyt
Nelson Rodriguez Papini
Nestor Horacio Garcia
Ngai Wah Cheung
Nicolae Hancu
Nicole Li
Nik Nur Fatnoon Nik Ahmad
Nina Patel
Nizar Daboul
Noble Gracious
Nomangesi Ngcakani
Nonna Kravchun
Nora Marchetta
Norman Muirhead
Norsiah Ali
Oleg Legun
Oleg Nagibovich
Oleg Uriasyev
Oleksandr Golovchenko
Oleksandr Samoylov
Oleksii Korzh
Olga Barbarash
Olga Barna
Olga Barysheva
Olga Benusova
Olga Godlevska
Olga Gyrina
Olga Sazonova
Olivert Gomez
Oomman Abraham
Osamu Tomonaga
Oscar Tarsicio Moreno Loza
Osvaldo Brusco
Pablo Antonio Novoa
Pablo Mele
Pablo Raffaele
Pablo Serrano Sanson
Paranthaman Vengadasalam
Patricia Del Carmen Gonzalez Colaso
Patrick English
Patrick Parfrey
Paul Ainsworth
Paul Frenk Baron
Paul Nixon
Paul Noonan
Paul Rheeder
Paulina Virginia Lanchiotti
Pavel Weiner
Peak Mann Mah
Pedro Calella
Pedro de Souza
Pedro Velasquez-Mieyer
Peggy Barnhill
Peggy Lin
Pere Alvarez Garcia
Perkovic V.
Peter Danos
Peter Fulop
Peter Van Buren
Peter Winocour
Petr Barton
Philip Gorelick
Philip Home
Philip Nicol
Philippe Zaoui
Phyllis August
Piermarco Piatti
Pierre Gourdy
Pierre-Jean Saulnier
Pietro Castellino
Pilar Trueba
Ping Tu
Pollock C.
Prasanth Surampudi
Pusadee Suchinda
Qinkai Chen
Rachel Bregman
Radica Alicic
Radu Jacob
Rafael Simo Canonge
Raied Abdullah
Rajendran Alappan
Rajiv Agarwal
Rajiv Ranjan
Raju Sree Bhushan
Rakesh Gulati
Rakhi Khanna
Rallabhandi Sankaram
Raman Purighalla
Ramesh Chandra Vyasam
Ramesh Thimmaiah
Ramon Berenguer
Ramon Moreda
Rangel Rangelov
Rao K Satyanarayana
Ravendran Govender
Ravi Sarin
Reddy Sreedhar
Reginald Parker
Rehan Symonds
Reinhold Jerwan-Keim
Remi Rabasa-Lhoret
Renan Montenegro Junior
Renata Bijata-Bronisz
Rhea Severina Comia
Rhonda Bentley-Lewis
Riad Darwish
Ricardo Alfonso Leon de la Fuente
Ricardo Dario Dran
Ricardo Rosero
Riccardo Bonadonna
Richard Ferkl
Richard Kovar
Richard Lindley
Richard Orozco Castellanos
Richard Solomon
Robert Busch
Robert Cohen
Robert Schreiman
Robert Takacs
Robert Walker
Roberto Abrão Raduan
Roberto Jorge da Silva Franco
Roberto Pecoits Filho
Roberto Pecoits-Filho
Roberto Simões de Almeida
Roberto Trevisan
Rodica-Ioana Avram
Rodolfo Andres Ahuad Guerrero
Rohana Abdul Ghani
Rohit Pankhaniya
Rolando Zamarripa Escobedo
Ronald Goldenberg
Ronald Harris
Ronald Watts
Ronaldo Arturo Gonzalez Orellana
Ronan Roussel
Ronnie Aronson
Rosa Isela Luna Ceballos
Rosângela Milagres
Ruben Dario Vargas Alonso
Rury Holman
Russell Scott
Sacha De Serres
Sahay Manisha
Saiful Shahrizal Bin Shudim
Sailaja Ventrapragada
Salah Abusnana
Salvatore De Cosmo
Sam Henein
Sam Philip
Samuel Cohen
Samuel Mujica Trenche
Samy Hadjadj
Sandor Keresztesi
Sandor Vangel
Sandra Berenice Saaveddra Sanchez
Sanjeev Rastogi
Sara Jaffer
Sarah Olelewe
Satoshi Ota
Satu Pesickova
Scott Kasner
Secundino Cigarran Guldris
Senan Sultan
Serge Cournoyer
Sergei Nedogoda
Sergey Vorobyev
Sergio Saul Irizar Santana
Shahabul Arfeen
Shahnaz Shahinfar
Shang-Jyh Hwang
Shelley Williams
Shenaz Ramtoola
Shenglian Gan
Sherry Sussman
Shizuo Kajiyama
Shozo Miyauchi
Silvia Ines Orio
Silvia Nicolai
Simon Davies
Simon Roger
Simon Young
Sin Gon Kim
Singhan Krishnan
Sini George
Slobodan Antic
Sohan Dua
Sonia Hermida
Soo Kun Lim
Sophie Borot
Souhila Ounadjela
Sreedhar Mandayam
Srikanth Bellary
Stanislav Zemek
Stanislaw Mazur
Stefan Dimitrov
Stephan Maxeiner
Stephen Grubb
Stephen Smith
Steven Fishbane
Stuart Handelsman
Suely Keiko Kohara
Sun Kim
Sun-Hee Park
Sunil Sheth
Susumu Kashine
Svetlana Goykhman
Svitlana D Bilyk
Swee Win Lam
Sylvia Rosas
Sylvia Shaw
Szilard Vasas
Sérgio Alberto Cunha Vêncio
Sérgio Yamada
Tadashi Iitsuka
Takamoto Kodera
Takashi Wada
Takayuki Watanabe
Tamara Malek Marin
Tamas Oroszlan
Tara Chang
Tareq Nassar
Tarissa Beatrice Zanata Petry
Tatiana Koroleva
Tatiana Morugova
Tatiana Raskina
Tatyana Zykova
Te-Lin Hsia
Terue Sakakibara
Tetiana Zlova
Tetsuji Niiya
Tetyana Pertseva
Tiago Schuch
Timothy Hall
Tom Christensen
Tom Greene
Tomas Drasnar
Tomas Smith Casabella
Tonatiu Diaz Escalante
Toshihiko Yanase
Toshio Kawada
Vadym Vizir
Vanassa Ratnasingam
Venessa Tsang
Venkata Behara
Vera Klokocnikova
Vera Krane
Veronica Anghel
Veselka Genadieva
Vesna Popovic-Radinovic
Viacheslav Marasaev
Victor Commendatore
Victor Saavedra Gajardo
Vijayaraman Arutchelvam
Viktor Margaritov
Viktor Zaviriukha
Viktoria Andreeva
Vimladhevi Govender
Vincent Pichette
Vincent Woo
Vira Tseluyko
Virginia Esther Visco
Vivek Sood
Vivekan Jha
Vladimir Dobronravov
Vladimir Khirmanov
Vladimir Tesar
Vlado Perkovic
Volker Burst
Volodymyr Botsyurko
Walter Guillermo Douthat
Walter Pharr
Wasim Hanif
Wataru Yumita
Wayne H-H Sheu
Wayne Turner
Wei Yen Kong
Weihong Song
Weiping Lu
Wendy Lane
Wenge Li
Wheeler D. C.
Wladmir Saporito
Xuemei Li
Xueqing Yu
Yamil Canaan
Yan Ren
Yannick Le Meur
Yaozhong Kong
Yasuro Kumeda
Yasushi Wakida
Yavin Y.
Yeong Hoon Kim
Yevgeniya Svyshchenko
Young Min Cho
Yulia Samoylova
Yung-Chuan Lu
Yuriy Mostovoy
Yuriy Shwartz
Yvette Ethel Yap
Zaynab Abejuela
Zdravko Kamenov
Zeid Khitan
Zhang H.
Zinman B.
Zishan Ali
Zuzana Ochodnicka
Ângela Regina Nazario Sabbag
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

Improved reference genome of Aedes aegypti informs arbovirus vector control

Author: A Dobin
A Fontaine
AA Enayati
AB Hall
AB Hall
AB Hall
AC English
Adam M. Phillippy
AK Jones
Albin Fontaine
Alex R. Hastie
Alexander S. Raikhel
Alistair C. Darby
Allison M. Weakley
Andrea Gloria-Soria
Andrew K. Jones
Anopheles gambiae
Arina D. Omer
Atashi Sharma
Aviva Presser Aiden
B Langmead
B Langmead
B Negre
Benjamin J. Matthews
Benjamin R. Evans
BJ Matthews
BK Peterson
BL Apostol
BM Gilchrist
BR Evans
Bradley J. White
C Bass
Carlos A. Brito-Sierra
Carolyn S. McBride
Catherine A. Hill
CL Moyes
Corey L. Campbell
CS Chin
CS Chin
D Charlesworth
D Duboule
Daniel E. Neafsey
David B. Sattelle
DE Neafsey
DJ Begun
DW Galbraith
E Frichot
E Goulielmaki
EB Lewis
EE Hare
Erez Lieberman Aiden
Eric Cox
F Hahne
F Ortelli
Frederick A. Partridge
G Benson
G Rašić
G Rašić
GAH McClelland
Gareth D. Weedall
Gareth J. Lycett
GN Artemov
Gordana Rašić
GR Margarido
H Li
Han Cao
HM Robertson
Hugh M. Robertson
Igor Antoshechkin
Igor Filipović
Igor V. Sharakhov
J Catchen
J Krumsiek
J. Spencer Johnston
Jacob E. Crawford
JD Buenrostro
Jeffrey R. Powell
Jill Muehling
JM Catchen
Joe Turner
Jonas Korlach
Joyce Lee
Karla Saavedra-Rodriguez
KW Broman
L Alphey
Leslie B. Vosshall
Li Zhao
Louis Lambrechts
LV Jiménez
Margaret Herre
Maria V. Sharakhova
ME Newton
Melissa Laird Smith
Michael R. Murphy
MJ Chaisson
MJ Gorman
MM Riehle
MV Sharakhova
N Lumjuan
NC Durand
Noah H. Rose
O Dudchenko
Olga Dudchenko
Omar S. Akbari
OS Akbari
P George
P Juneja
P Juneja
Paul Peluso
R Patro
Raissa G. G. Kay
Richard Hall
Richard S. Mann
RM Waterhouse
S Bhatt
S Guindon
S Heinz
S Merabet
S Merabet
Saki Chan
Sanjit S. Batra
Sara N. Mitchell
Sarah B. Kingan
Sergey Koren
Seth N. Redmond
SF Altschul
Shruti Sharan
SJ Thomas
SK Denny
SM Kiełbasa
Sourav Roy
SS Rao
Steven D. Buckingham
T Fansiri
TD Wu
Terence D. Murphy
Thanyalak Fansiri
V Nene
VA Timoshevskiy
VA Timoshevskiy
VA Timoshevskiy
Vamsi K. Kodali
Vidya Ramasamy
Vinita S. Joardar
WC Black IV
William C. Black
William J. Glassford
Y Benjamini
Y Liao
Y Liao
Yang Wu
Zhijian Tu
Zhilei Zhao
ZN Adelman
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2018
Field of study

Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector

LJMU Research Online (Liverpool John Moores University)

University of Liverpool Repository

Princeton University Open Access Repository

eScholarship - University of California

HAL-Pasteur

Oxford Brookes University: RADAR

University of Queensland eSpace

Whole-genome sequencing reveals host factors underlying critical COVID-19

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Abdel-Aziz M.
Abdelrazik M.
Abdollahi H.
Abdullah T.
Abecasis G.R.
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Abedalthagafi M.
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Abernathy C.
Abraheem A.
Abul-Husn N.S.
Acquilini D.
Adams C.
Adams E.L.
Adams K.
Adamsara A.
Adanini O.
Adeleye O.
Adra D.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Agasou A.
Agrawal S.
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Ahmad N.
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Ahmed A.
Ahmed C.
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Akhtar M.N.
Akinkugbe O.
Aksentijevich A.
Al Harthi F.
Al Mutairi A.
Al-Afghani H.
Al-Awdah L.
Alaamery M.
Alahmadey Z.Z.
Alaverdian D.
Alavere H.
Albader A.
Albaiceta G.M.
Albakri J.K.
AlBardis H.
Albeladi M.
Albesher N.
Albrich W.
AlDhawi N.
Aldridge J.
Aleagha A.E.
Alexander P.
Alfonso J.
Alghamdi B.
Alghamdi J.
Ali A.
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Ali I.A.M.
Ali S.
Aliannejad R.
Aljawini N.
AlJohani S.
Alkwai S.
Allan A.
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Allan J.
Alldis Z.
Allen L.
Allen M.
Allen S.
Allibone S.
Allison K.S.
Allos R.
Almaden-Boyle C.
AlMalik A.
Almalki F.
Almohammed I.
Almutairi M.
Alotaibi S.
Alowayn A.M.
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Alrashed M.
Alshareef A.
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Alvaro A.
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Xue X.
Yadav A.
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Zainy T.
Zak A.
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Zanella I.
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Zhao J.H.
Zheng C.
Zhou W.
Zitter L.
Zlatopolsky M.
Zongo O.
Zucchi P.
Zyndorf M.
Zöllner S.
Åsvold B.O.
Publication venue: Springer Science and Business Media LLC
Publication date: 07/07/2022
Field of study

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

White Rose Research Online

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Author: Abassi Yama
Abelin Jennifer G
Abolhalaj Milad
Abraham Tara S
Adam Ammar
Adams David
Adams Homer
Adams Sarah F
Adamus Tomasz
Addepalli Murali
Addepalli Murali
Adjei Alex A
Agapova Larissa
Agarwala Sanjiv
Ager Casey
Aggarwal Charu
Agnello Giulia
Agudo Judith
Aguilar Ethan G
Aguilera Todd
Ahamadi Malidi
Ahn Yong-Oon
Ahrens Eric T
Aizer Ayal
Ajina Reham
Akerley Wallace
Al-Muftah Mariam
Albershardt Tina C
Albershardt Tina C
Albrekt Ann-Sofie
Alekar Shilpa
Alemany Ramon
Alemany Ramon
Alexander Brian
Allbritton Omaira
Allen Clint T
Alley Evan W
Allison James
Allison James
Allison James
Alston Tesha
Alt Jürgen
Alters Susan
Amatulli Michael
Anand Snjezana
Anand Snjezana
Anand Snjezana
Anderson Clark
Anderson Mark
Andersson Bengt
Andre Pascale
Andtbacka Robert H I
Andtbacka Robert H I
Angiuoli Sam
Ansari Tameem
Anthony Scott
Antonarakis Emmanuel S
Antonia Scott J
Anwar Firoz
Aquino-Michaels Keston
Archer Jacob F
Arina Ainhoa
Armand Philippe
Armenta Paul
Armet Caroline M
Arnoux Thomas
Ascarateil Stephane
Askmyr David
Atkins Michael
Atkins Michael B
Atkinson Victoria
Au Katrina
Autio Karen A
Awad Mark
Bagarazzi Mark
Bai Dina
Baia Gilson
Baird Jason
Bajaj Anshika
Balatoni Timea
Balboni Tracy
Balch Leslie
Bang Andrew
Bao Riyue
Bao Yangyi
Bao Yangyi
Barakat David
Barberi Theresa
Barker Christopher A
Barnea Eytan
Barras David
Bartkowiak Todd
Bartlett David
Bartlett David
Bartlett David
Bartlett David
Barton Sunjay M
Barve Minal
Bauer Todd
Bauer Todd W
Bauman Julie
Baumgaertner Petra
Bauml Joshua
Beceren-Braun Figen
Beck Kristen
Becker Annette
Beckers Johannes
Beckett Michael A
Bedognetti Davide
Bedognetti Davide
Bedognetti Davide
Bell Bryan
Bell Charles J M
Bell Peter
Beltran Pedro
Bender Lewis H
Bender Steven
Bennett Mark K
Benz Steven
Bera Tapan
Berglund Peter
Berglund Peter
Berkey Sara
Bernatchez Chantale
Berry John S
Berzofsky Jay A
Bhardwaj Nina
Bian Zhen
Bianco Alberto
Biediger Ronald J
Bifulco Carlo
Bigley Alison
Bingham Patrick
Biniszkiewicz Detlev M
Bischoff Helge
Blake Zoe
Blake Zoe
Blakely Collin
Blazar Bruce R
Blogowski Wojciech
Bloom Anja C
Boehm Jesse
Bokovanov Vladimir
Bommareddy Praveen K
Bommareddy Praveen K
Bommareddy Praveen K
Bommareddy Praveen K
Booth Jamie
Bornschlegl Svetlana
Bose Nandita
Bossenmaier Birgit
Boughorbel Sabri
Boyer Jean
Bramante Simona
Branstetter Daniel
Brech Dorothee
Brenin David
Broaddus V. C
Brockstedt Dirk G
Brockstedt Dirk G
Brody Joshua
Bronson Roderick
Brooks Alan
Brooks Alan D
Broucek Joseph
Brown Alice
Brown Brian
Brown Brittany
Brown Gail L
Brown Sheila
Bruce Jeffrey N
Brunet Laura R
Bruno Tullia C
Bryan Jennifer
Bryant Richard
Buchbinder Elizabeth
Bucsek Mark
Budhu Sadna
Budhu Sadna
Budkowska Marta
Bueno Raphael
Buettner Florian
Buettner Nico
Bullock Kim
Bullock Kim
Burova Elena
Burrill Joel
Bussler Holm
Butterfield Lisa H
Butterfield Lisa H
Byrne-Steele Miranda
Cagney Daniel
Calderon Hugo
Callahan Margaret K
Campesato Luis F
Campogan Dwayne
Cao Felicia
Capasso Cristian
Capasso Cristian
Caplazi Patrick
Cappuccini Federica
Carcaboso Angel M
Carlino Matteo S
Carpi Sara
Carrasco Ruben
Carrera Diego A
Carrero Rosa M S
Carson Dennis A
Castellini Laura
Cathomas Richard
Cauvin Annick
Cauwenberghs Sandra
Caux Christophe
Cebon Jonathan S
Ceccarelli Michele
Celis Esteban
Cerignoli Fabio
Cerullo Vincenzo
Cerullo Vincenzo
Cervera-Carrascón Víctor
Cesareni Gianni
Cha John
Cha John
Cha John
Champion Brian
Chan Anissa S H
Chan Chanty
Chan Chanty
Chan Ivan
Chan Leo
Chan Timothy A
Chang Alfred E
Chang Alfred E
Chang Joe
Chang Nancy N
Chang Thomas
Chanuc Fabien
Chapelin Fanny
Chaplin Jenny
Chappel Scott C
Charych Deborah H
Charych Deborah H
Chaudhuri Amitabha
Chaussabel Damien
Chen Ada
Chen Ada
Chen Gang
Chen Jason
Chen Jason
Chen Xiaomu
Chen Xin
Chen Xiufen
Chen Yu
Chen Yu
Chenchik Alex
Chheda Zinal
Chiang Eugene
Chikina Maria
Chittenden Thomas
Chiu Hsiling
Cho Charles
Chongyung Fang
Chou Margaret
Choueiri Toni K
Choy Carmen
Clark Joseph I
Clavijo Paul E
Clifton Guy T
Clynes Raphael
Cobbold Mark
Cobbold Mark
Cobbold Mark
Coder Brandon
Coffman Robert L
Cohen Cyrille
Cohen Ezra E W
Cohen Roger
Colen Rivka
Colevas A. D
Collins Natalie
Colrain Jillian
Coltharp Carla
Concha-Benavente Fernando
Connolly Eileen P
Conwell Darwin
Conwell Darwin
Corrales Leticia P
Corrales Leticia P
Coukos George
Coukos George
Coussens Lisa M
Coussens Lisa M
Craggs Graham
Craig Andrew
Crittenden Marka
Cron Kyle R
Cronstein Bruce N
Crooks James
Crosby Andrea
Crosignani Stefano
Crowder Robert
Cruickshank Scott
Csuka Orsolya
Curbishley Stuart
Curiel Tyler
Curran Emily
Curran Michael
Curti Brendan
Curti Brendan
Da Costa Andre
Dai Fu
Dai Jie
Dai Peihong
Dalgleish Angus
Dalvie Deepak
Daniels Gregory A
Daud Adil
David Justin M
Davies Bronwyn
de Boisferon Marc H
de Groot Patricia
de Gruijl Tanja
De Henau Olivier
de Leon Laura
De Maeseneire Coraline
De Sanctis Francesco
de Silva Suresh
Deacon Donna
Deacon Donna H
DeBenedette Mark
DeBenedette Mark
Declerck Paul
Decock Julie
Decock Julie
DeFalco Jeff
Dela Cruz Filemon
Delgoffe Greg
Delgoffe Greg M
Delgoffe Greg M
Delgoffe Greg M
Delogu Lucia
Delorenzi Mauro
Demaria Sandra
Demaria Sandra
Deng Liang
Deng Weiwen
Deng Wentao
Denies Sofie
Denis Caroline
Desbien Anthony L
deVries Michele
Dhupkar Pooja
Diab Adi
Diab Adi
Diab Adi
Diaz Luis
DiCostanzo AriCeli
Diede Scott J
Dietz Allan B
Dillhoff Mary
Dillon Patrick
Dilworth Ryan
Dimberg Anna
Ding Yueyun
Doberstein Stephen K
Dobkin Julie
Doener Fatma
Dolegowska Barbara
Doleschall Zoltan
Doman Thompson
Dominguez George
Donahue Renee
Donahue Renee
Dorsey Frank C
Dovedi Simon
Downs-Canner Stephanie
Drake Charles
Drake Charles G
Drake Charles G
Driessens Gregory
Driscoll Kyla
Druker Brian J
Dubensky Thomas W
Dubensky Thomas W
Dudimah Duafalia
Duff Susan
Dumontet Charles
Dunai Cordelia
Dunai Cordelia
Dutcher Janice P
Duttagupta Priyanka
Duvvuri Uma
Dyson Mike
D’Apuzzo Massimo
Ebner Peggy
Edwards Robert
Edwards Robert P
Edwards Robert P
Eickhoff Jens
Eisenhower Mary
El Alaoui Meddy
El Alaoui Said
Eles Klara
Ellies Lesley
Elnaggar Omar
Elvecrog James
Emberley Ethan
Emerling Daniel
Eng Charis
Engelhard Victor H
English Jessie
Enstrom Amanda
Eremeev Artem
Eriksson Emma
Eriksson Emma
Eriksson Emma
Ertelt Kathleen
Eswarappa Rajesh
Evans Elizabeth
Evans Kathy
Facciabene Andrea
Facciabene Andrea
Facciabene Andrea
Facciponte John
Facciponte John
Falchook Gerald
Fantini Massimo
Fantini Massimo
Fantini Massimo
Farkas Emil
Farren Matthew
Faustman Denise
Fa’ak Faisal
Fa’ak Faisal
Femel Julia
Feng JunLi
Feng Yan
Feng Zipei
Feola Sara
Fernandez Christian
Fernando Ingrid
Ferris Robert L
Ferris Robert L
Ferris Robert L
Ferris Robert L
Fesenkova Valentyna
Field Jessica J
Fisher Kerry
Fisher Terry
Fitzharris Bernie
Flano Emilio
Flechtner Jessica B
Flies Dallas B
Flynn Patrick
Fogler William
Fong Lawrence
Formenti Silvia C
Formenti Silvia C
Foster Cathie
Foster Rosemary
Fotin-Mleczek Mariola
Fox Bernard
Francica Brian
Francis Julie-Ann
Frangou Costa
Franklin Marilyn
Franklin Wilbur
Frascaro Federica
Fraser Kathryn
Frederix Kim
Freimark Bruce
Freimark Bruce
Freimark Bruce
Frey Alan
Fridman Leticia
Friedman Alan
Friedman David
Fromm George
Früh Martin
Fu Yang-Xin
Fu Yichun
Fu Yichun
Fuertes Marraco Silvia A
Fugle Caroline W
Fuhrmann Steven
Fukaya Satoshi
Fulton Noreen
Fuoco Claudia
Fusciello Manlio
Fuseri Nicolas
Gabitzsch Elizabeth
Gabrail Nashat
Gabrilovich Dmitry
Gajewski Thomas
Gajewski Thomas F
Gajewski Thomas F
Gajewski Thomas F
Gajewski Thomas F
Gajewski Thomas F
Gajewski Thomas F
Galeassi Nadejda
Gamble Alicia
Gamble Alicia
Gameiro Sofia
Gameiro Sofia R
Gandhi Anita
Gao Chan
Gardai Shyra J
Gardner Kellie
Gartrell Robyn
Gartrell Robyn
Gartrell Robyn
Gasmi Billel
Gastineau Dennis A
Gaughan Elizabeth
Gauthier Audrey
Gauthier Kelsey S
Geissler Michael
Gergel Ivan
Geukens Nick
Gfeller David
Ghadially Hormas
Ghamsari Lila
Ghandi Leena
Ghisoli Maurizio
Giaccia Amato
Gibney Geoffrey
Giffin Louise
Gillies Stephen D
Giri Sanjeev
Gladstone Douglas
Glickman Laura H
Gnad-Vogt Ulrike
Godwin John
Gomes Bruno
Gong Jian
Gong Jian
Gonzales Rodney J M
Gooding William
Gooding William
Goodman Reid
Gopal Ajay
Gordon Keith
Gordon Nancy
Gottschalk Stephen
Gough Michael
Gowda Nagaraj
Goyal Sharad
Graff Jeremy
Graham Charles
Graves Edward
Gray Michael
Gray Michael
Greasley Samantha
Greenberg Norman
Greiff Lennart
Greiner John W
Grenga Italia
Grenga Italia
Gressett Monica M
Griesinger Frank
Grigoryeva Olga
Grigsby Iwen
Grivas Petros
Grogan Elizabeth W
Grogan Jane
Grose Mark
Grose Mark
Grose Mark
Grosh William
Gross Matt
Gross Matt
Grossenbacher Steven K
Grossmann Kenneth
Gruber Harry
Gu Xuemin
Guenther Garret
Guerriero Jennifer
Gugel Elena G
Guiducci Cristina
Guirado Elizabeth
Gulley James L
Gunatilaka Leslie A A
Guo Jie
Guo Zeng-qing
Gupta Ravi
Gupta Sachin
Gupta Sumati
Gustafson Michael P
Gutierrez Andres A
Guttridge Denis
Guy Emily I
Guzman Wilson
Hagihara Katsunobu
Hagner Patrick
Hailemichael Yared
Hailemichael Yared
Haining W. N
Hale Diane F
Hall Gerald
Hallmeyer Sigrun
Hamdy Freddie
Hammond Scott A
Han Jian
Han Yanyan
Hank Jacquelyn A
Hanks Brent A
Hanson Bill
Harari Paul M
Harbell Michael
Hardin Mark O
Hardwick James
Harrington Kevin
Harris Jaryse
Harris-Bookman Sarah
Hart Philip
Hasapidis Jeannette
Hassan Raffit
Havel Jonathan
Havunen Riikka
Havunen Riikka
Hayashi Tomoko
Haymaker Cara
Haynes Heather
Heinze Clinton
Hellmann Matthew D
Hellmann Matthew D
Hellmann Matthew D
Hellström Ann-Charlotte
Helming Laura
Hemmi Silvio
Hemminki Akseli
Hemminki Akseli
Hemminki Otto
Hendrickx Wouter
Hendrickx Wouter
Hendrickx Wouter
Henrich Ian
Heo Dae S
Herbert Garth S
Herbst Ronald
Heron Dwight
Herranz Mireia U
Hess Kenneth R
Heymach John
Higuchi Tomoe
Hilbe Wolfgang
Hill Adrian
Hill Andrew G
Hill Jonathan A
Hillringhaus Lars
Hipp Madeleine
Hirschhorhn-Cymerman Daniel
Ho Po
Hoch Ute
Hoch Ute
Hoch Ute
Hodge James
Hodge James
Hodge James W
Hodi F. S
Hodi F. S
Hodi F. S
Hofmeister Robert
Holland Pamela M
Hollevoet Kevin
Hollingsworth Robert E
Hollingsworth Robert E
Holmgaard Rikke
Holtzhausen Alisha
Honarmand Somayeh
Hong Bang-Xing
Hong David
Hong Henoch S
Hong Peter
Horst Basil
Horton Brendan
Horvath Szabolcs
Hotson Andrew
Hou Jinlin
Hou Xiaohong
Hou Yafei
Howell Alan
Hu Yangyang
Hu Yangyang
Hu-Lieskovan Siwen
Hua Hong
Huang Fei
Huang Jing
Huang Shiang
Huang Shiang
Huang Tony
Huang Yuanhiu
Huang Yuanhiu
Hudson Thomas E
Huelsmann Erica
Huffman Austin P
Humeau Laurent
Hunt Donald F
Hunt Donald F
Hurt Elaine
Hurt Elaine
Hurwitz Michael
Hutchins Jeff
Hutchins Jeff
Hutchins Jeff
Hwu Patrick
Hwu Wen-Jen
Hylander Bonnie
Ibrahim Nageatte
Illingworth Sam
Infante Jeffrey
Ioffe Ella
Irmler Martin
Irving Bryan A
Irving Bryan A
Izaki Daisuke
Jablons David
Jablonski Sandra
Jackson Doreen O
Jackson Natalie
Jacobson Caron
Jacques Judy
Jaen Juan C
Jaen Juan C
Jahan Naznin
Jahan Thierry
Jaini Ritika
Jaiswal Ashvin
Jameson Michael B
Jang Dadi
Janku Filip
Janne Pasi A
Janssen Louise
Jarblad-Leja Justyna
Jeraj Robert
Jessen Katti
Jhawar Sachin
Jhawar Sachin
Jia Dan T
Jin Ming
Johnson Brian
Johnson Bruce D
Johnson Karen
Johnson Melissa L
Jolly Douglas
Joly Nathalie
Jonas Adria
Jones Frank
Jones Jeremy
Jones Sian
Joshi Bharat H
Ju Xiaoming
Kadenhe-Chiweshe Angela
Kaiser Stephen
Kalinski Pawel
Kalinski Pawel
Kalinski Pawel
Kalinski Pawel
Kallen Karl-Josef
Kalos Michael
Kane Lawrence P
Kanerva Anna
Kang Kai
Kangas Takashi O
Kanne David B
Kantrowitz Joel
Kapp Kerstin
Kapralova Marina
Kariolis Mihalis
Karlsson-Parra Alex
Karpathy Roberta
Karpov Andrey
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Xu Chun-wei
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Young Gregory
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Young Kristina
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Young Steve W
Youssoufian Hagop
Yu Huakui
Yu Ling
Yu Naichen
Zafar Sadia
Zalevsky Jonathan
Zalevsky Jonathan
Zalevsky Jonathan
Zalevsky Jonathan
Zappasodi Roberta
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Zauderer Maurice
Zeh Herbert
Zelenetz Andrew D
Zeng Weiping
Zeng Xue
Zha Yuanyuan
Zhang Danhui
Zhang Jing
Zhang Ping
Zhang Qifang
Zhang Shannon S
Zhang Theresa
Zhang Winter
Zhang Yanping
Zhao Fei
Zhao Leyna
Zhao Xingli
Zheng Lianxing
Zheng Wenxin
Zheng Xianxian
Zheng Yi
Zhong Hong
Zhou Li
Zhou Xiangjun
Zippelius Alfred
Zloza Andrew
Zloza Andrew
Zloza Andrew
Zloza Andrew
Zloza Andrew
Zou Jun
Zuba-Surma Ewa
Zubkova Olga
Zureikat Amer
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2016
Field of study

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

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